High Valence 5-MeO-DMT + Nitrous Oxide Trip Report from an Anonymous Reader

Here’s an interesting report I received a few days ago. It’s noteworthy due to the author’s familiarity with QRI paradigms, emphasis on the phenomenal character rather than on the intentional content of the experience, and its interest in observing the structural properties of valence. [Comments and links added by me].

25/03/2021 – Conversations with my ‘self’ and cheat codes to bliss

Demographic information:

Age: 24
Gender: Male
Ethnicity: European descent
Weight: 70-75kg
Height: 170-180cm

Substances consumed:

T- 1:30 45g raw cacao (solid) [NOTE: it’s unsafe to combine 5-MeO-DMT and MAOIs. I do not know if cacao’s MAOIs in these doses could possibly represent a problem, but out of an abundance of caution I’d recommend against it.]
T+/- 0:00 ~30mg(?) 5-MeO-DMT (freebase)
T+ 0:25-1:30 13 double balloons of nitrous oxide
T+ 0:35 ~50mg cannabis

Set and setting:

I prepared my room by cleaning the air with my HEPA purifier, increasing the temperature to a comfortable degree, turning off all the lights (except for a dull red light in the corner), and collecting various soft blankets and pillows into a heap on my bed.

I prepared my mind by drinking cacao, re-reading some of my favourite 5-MeO-DMT trip reports and accounts of its phenomenology, and meditating for 20 minutes.

Past experiences:

Two past experiences with 5-MeO-DMT at low doses:

  1. A dose of 10-15mg (plugged) in which I experienced ~45 minutes of very slight effects. Around 15 minutes into the experience I decided to experiment with nitrous oxide, which I discovered increased the feeling of connectedness and bliss considerably, but still not to the level of combining high doses of other drugs with nitrous. Around 30 minutes into the experience and past the ‘peak’ I vaporised a small amount of cannabis, which brought back the intensity of the 5-MeO-DMT for a brief period (~10 mins) in conjunction with the nitrous.
  2. A dose of ~5mg (vaporised) to test ‘the machine’ pipe that I built. The energy / intensity I felt was perhaps 5 times greater than my past experience with 5-MeO-DMT (not counting the nitrous and cannabis synergy), but only lasted for about 10 minutes.

Two past experiences of N,N-DMT at low doses:

  1. A mild dose of ayahuasca.
  2. A moderate dose of changa (to the ‘Magic Eye Level’).

Lots of experience (~50+) with conventional psychedelics (e.g., LSD, Mescaline, Psilocybin, 2C-B), often mixed with other psychoactive compounds (e.g., cannabis, ketamine, MDMA, nitrous oxide, Syrian rue).

Philosophical background:

I have studied analytic philosophy near full-time for the past eight years with a focus on philosophy of mind, philosophy of biology, applied ethics, well-being, and value theory. During this time, I have developed a strong personal ontology of experientialism (i.e., subjective experiences are important to answering philosophical questions in a fundamental rather than instrumental sense).

I have actively followed LessWrong & its blogging community for the past three years, and first encountered QRI and Qualia Computing approximately two years ago. For the past year, perhaps 70-80% of my recreational research consumption has consisted of QRI content or adjacent material. I broadly agree with QRI paradigms – in particular, the notion that the best way to understand subjective experiences involves analyzing their structural rather than representational content. About three months ago, I also converted from empty individualism to open individualism.

Phenomenology report:

I was gifted about ~40mg of 5-MeO-DMT from a friend. Unfortunately, they did not weigh it out, nor do I have a precision scale, so the actual quantity of the substance I received could have been +/- 10mg from the estimated quantity.1 I had already used one quarter of this amount (10mg) to test my vaporisation apparatus, of which I wasted half (5mg), so I assumed that I had 30mg left. After talking with some friends and weighing up the risks, I decided that I would try to vaporise the remaining quantity in one go. I strongly discourage anybody reading this report from being so reckless; my rationale was that (1) I have limited access to 5-MeO-DMT and I did not want to waste this rare opportunity, (2) I have extensively researched the phenomenology of 5-MeO-DMT consumption and knew what to expect, and (3) my prior on having a ‘bad trip’ on conventional psychedelics is very low.2

Earlier in the evening I consumed 45g of raw cacao, which I grated up and boiled in a small pot of soy milk (with monk fruit extract added to sweeten the mix). The subjective effects of unprocessed cacao at high doses are very slight and similar to coffee (probably due to its mild caffeine content), but with more of an empathetic and euphoric quality. That said, I suspect that an individual’s expectations also play a nontrivial role in producing these effects.

After preparing my room and meditating for a short period to lower my heart rate (which I measured using a pulse oximeter), I fired up ‘the machine’. Due to the small size of the device, the chamber filled up fairly quickly and I lost some vapor, so after about 20 seconds I began to slowly inhale the contents of the chamber while continuing to heat the steel mesh with my butane torch. Soon enough I began to feel the effects of the substance, and once I lost the ability to coordinate my hands I placed the device gently on my bed, wrapped myself up in a soft blanket, and lay down with my eyes closed. In the background, I had the song ‘Structures from Silence’ by Steve Roach playing quietly.

My memories of the peak are very limited, and that is because I lost the capacity to experience the passing of time, the boundaries of space, and even the first-person phenomenology of thought. While I have had psychedelic experiences resembling descriptions of ego death before, I don’t believe that I have ever had an experience in which my attention – the focussing of my awareness on particular aspects of my experience – was entirely absent from my consciousness. Without this capacity, the appearance of duality within my experience collapsed, such as the distinction between subject and object, internal and external, or mind and body. This corresponds with nondual accounts of 5-MeO-DMT that I have previously read where people experience ‘becoming one with the universe’ or ‘pure consciousness’.

An important takeaway from this trip was that while the valence of the experience was very high, it felt qualitatively different from ordinary instances of high valence experiences, such as physical pleasure. If I had to describe the general qualia of being on 5-MeO-DMT, I would use the terms ‘significant’ or ‘meaningful’ rather than ‘good’ or ‘enjoyable’ [see a similar observation made on this trip report]. Consider the feeling of encountering something so profoundly important that it cuts deep into your conception of intrinsic value, and then increase the intensity of that feeling by a few orders of magnitude. However, I could not point out where in my field of experience the feeling of ‘significance’ was located, suggesting global rather than local coherence.3 Additionally, while the information content of the experience was extremely low, the feeling of ‘connectedness’ was extremely high.4 I remember observing this as I was coming up and coming down from the peak – the perception of ‘synchrony’ between different modes of my experience directly mapped onto its perceived intensity.

After I had regained my attention, the first thing I noticed within my body was how heavily I was breathing – louder and faster than if I had just finished a sprint [I don’t know how common this is, and/or if it might be related to the cacao consumed before the experience]. From past experiences of ego-disillusion, I know that once I have passed an energy threshold my nervous system will instantiate a ‘self-preservation’ algorithm which involves breathing heavily. Soon after noticing this, I became aware that I was on 5-MeO-DMT and so I was not alarmed. My body then began to cry; however, as my consciousness was still experiencing disembodiment, ‘I’ did not identify with the crying state and simply observed this process as it unfolded.

After a short period, my body rolled over onto its front and began talking sweetly to ‘me’ – the disembodied awareness – as if different aspects of my internal personality model wanted to reassure the light of consciousness trapped within that it was loved and supported, and to thank it for always being there to assist in the survival of the organism that sustained us both. This was totally fascinating to experience, especially as I became increasingly lucid until eventually it was ‘me’ who was talking! In other words, I experienced a gradual merging of two distinct ‘selves’ – the metaphysical ‘me’ (i.e., my conscious awareness) with the ontological ‘me’ (i.e., my ‘self’ model) – until one had completely osmosed into the other and an equilibrium was reached. I feel very fortunate to hold a system of philosophical beliefs that is sophisticated enough to make sense of this experience without detracting from its perceived significance. Also, yay to self-love! <3

Immediately after this ‘cool down’ period, I decided to try and use up whatever was left within the vaporisation device, which turned out to be quite a lot!5 I’d say that while I didn’t go into ‘blackout’ territory, I certainly re-entered nonduality, and soon enough experienced my self-model talking to my consciousness again. I then decided to experiment with potential synergies between 5-MeO-DMT and other psychoactive substances I had lying around in order to document their effects. Given the success of my past experience on a very low dose of 5-MeO-DMT (plugged) and nitrous oxide, I cracked two bulbs into my nitrous canister, prepared as much 5-MeO-DMT as I had left in the glass device and inhaled it, and then quickly discharged the pressurised gas into a large balloon which I subsequently inhaled, repeating this process several times.

The resulting experience was, somewhat surprisingly, higher valence than my 5-MeO-DMT breakthrough.6 On its own, nitrous isn’t that interesting to experience, but it has remarkable synergistic properties when combined with other drugs – especially psychedelics. It is difficult to describe the exact ways in which the phenomenology of nitrous interacts with the phenomenology of 5-MeO-DMT, but I can confidently say that the valence I experienced was more blissful / pleasurable but less spiritually significant. In a general sense, I would argue that nitrous functions as a sort of magnifying glass on certain aspects of experience by slowing down the speed at which your consciousness processes sensory information (which includes thought), and in this specific case it amplified the blissful qualia that resulted from having high levels of consonance between different regions of my nervous system. I also noticed that if I wrapped myself in my softest blanket immediately after inhaling the nitrous and consciously wriggled my body around, the tactile sensations gave me my first visuals; tens of thousands of tiny specs of qualia dotted across my world-sheet, moving together in a synchronous pattern corresponding to the feeling of soft fabric rubbing against my skin.

After vaporising absolutely everything in the glass chamber, I then proceeded to vaporise some cannabis to observe how it would interact with the residual effects of the 5-MeO-DMT that still remained in my body. The resulting effects were then more typical of ordinary nitrous experiences, except that they were far more tranquil with a deeper sense of love, compassion, and serenity. During the peak of each balloon, I had the first-person sense of ‘being’ a thought process, constructing low-information ontological models that entirely made up my world simulation. Coming out of each balloon involved constantly updating this ontological model to account for a steady flow of prediction errors as I was increasingly capable of comprehending complexity within patterns of information contained within my experience, until I would eventually realise that I had taken nitrous.7

Concluding remarks:

I would like to reiterate that guesstimating the dose of a highly volatile and dose-dependent drug such as 5-MeO-DMT is extremely dangerous – especially without taking steps to work your way up the dosage ladder to become acquainted with its effects. As such, I would not recommend doing what I did for the vast majority of people interested in taking 5-MeO-DMT. Despite this risk, I had what was probably the most intense experience of my life and it was net-positive in valence, so I consider it a success. I am looking forward to future experimentation with this substance – especially in conjunction with nitrous oxide – and would like to work on developing a better understanding of how nitrous works and why it produces such a wide range of effects with different drug cocktails.8


1. I do not endorse eyeballing drug doses – especially high-energy substances such as 5-MeO-DMT that have the potential to create extremely unpleasant states of consciousness. [This is such an important point that I considered not sharing this report based on this fact alone in order to not encourage unsafe practices. In the end I figured that the content was valuable enough that sharing it with this note was worth it nonetheless. The point remains: NEVER eyeball milligram-sensitive drugs like 5-MeO-DMT.]

2. This observation is based on past experiences in which I have consumed high doses of psychedelics – often in conjunction with other substances – and observed the various autonomic responses of my body and mind.

3. This is not the case with ordinary high valence experiences in which I can usually locate its ‘source’ within specific sensations (e.g., tactile, visual, auditory).

4. I cannot remember whether I opened my eyes, but I’m sure even that if I did, this would not have altered any aspect of the experience in the moment.

5. I hypothesized that it would be more efficient to use the remaining 5-MeO-DMT as soon as I could physically operate the device in order to make use of the residual effects of the previous dose that I had consumed.

6. Perhaps this is more the result of my having extensive experience with nitrous and limited experience with 5-MeO-DMT, or my 5-MeO-DMT experience was more mixed / dissonant than I remember.

7. For some, the vibe of nitrous can be quite frightening, as if they are the subject of one big cosmic joke. However, for the philosophically minded who are also on the right combination of substances, it can be an extremely intellectually rewarding experience, shedding light on the internal workings of their mind.

8. A combination I am even more excited to experiment with is MDMA + 5-MeO-DMT + Nitrous Oxide, which I would assign a nontrivial chance to being the most blissful synergy between all known substances.

Featured image by: Marek Piwnicki on Unsplash

See other high-quality trip reports:

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