Harmonic Society (1/4): Art as Family Resemblance + Cool Kid Theory

Note – The full essay’s title is: Harmonic Society: 8 Models of Art for a Scientific Paradigm of Aesthetic Qualia

The following essay was recently published in the Berlin-based art magazine Art Against Art (issue).

The essay offers eight different models of art: models 1 through 4 have been discussed in academic literature and the current intellectual zeitgeist, while models 5 through 8 are new, original, and the direct result of recent insights about consciousness as uncovered by modern neuroscience, philosophy of mind, and the work of the Qualia Research Institute.

Below you will find the abstract, introduction, and the first 2 (out of 8) models of art. I will be sharing 2 new models each week until I’ve shared all 8 of them.



Contemporary writing about art is in exactly the same place as writing about nature was before Darwin came along. Before Darwin there was no single intellectual matrix upon which to fix all of these impressions and ideas. There was no way of organizing all of that information. And this seems to me to be the situation we are in with the arts, as well.

 

– Brian Eno, “What is Art Actually For?” (2012)

Abstract

We start by assuming that there are real stakes in art. This motivates the analysis of this subject matter, and it focuses where we place our gaze. We examine a total of eight models for “what art might be about”, divided into two groups. The first group of four are some of the most compelling contemporary models, which derive their strength from fields such as philosophy of language, economics, evolutionary psychology, and anthropology. These models are: (1) art as a word only definable in a family resemblance way with no necessary or sufficient features, (2) art as social signaling of desirable genetic characteristics, (3) art as Schelling point creation, and (4) art as the cultivation of sacred experiences. These four models, however enlightening, nonetheless only account for what David Marr might describe as the computational level of abstraction while leaving the algorithmic and implementation levels of abstraction unexamined. They explain what art is about in terms of why it exists and what its coarse effects are, but not the nature of its internal representations or its implementation. Hence we propose a second group of four models in order to get a “full-stack” view of art. These models are: (5) art as a tool for exploring the state-space of consciousness, (6) art as a method for changing the energy parameter of experience, (7) art as activities that induce neuronal annealing (which implements novel valence modulation, i.e. surprising pain/pleasure effects), and (8) art as an early prototype of a future affective language that will allow diverse states of consciousness to make sense of each other. These frameworks address how art interfaces with consciousness and how its key valuable features might be implemented neurologically. We conclude with a brief look at how embracing these new paradigms could, in principle, lead to the creation of a society free from suffering and interpersonal misunderstanding. Such a society, aka. Harmonic Society, would be designed with the effect of guaranteeing positive valence interactions using principles from a post-Galilean science of consciousness.

Introduction

We shall start this essay by making the assumption that there are real and substantial stakes when it comes to art. Not all of my readers will agree with this point, and those who do might in fact secretly worry that they are overvaluing art for selfish reasons. I come here to suggest that there could be very real and substantial stakes in art, and that to realize this you do not need to buy into sentimentalism, fanaticism, wishful thinking, or traditionalist attitudes. You could start with the sheer amount of human attention that is devoted to art in one way or another. Art seems to make a lot of people do things, and do them with a lot of their energy and focus. Indeed, many people point at their intimations with art as personally defining moments. Some say their best self is expressed in their creation, consumption, or participation in art. So what is all of this fuss about?

Alas, most things of grand significance have been analyzed by countless people. The sheer magnitude of certain human activity is not a justification for caring about it at the margin, considering the often corresponding sheer magnitude of other people already analyzing and scientifically probing the field. That is, of course, unless you have a reason to think that you have something that everyone else has been missing all this time. And this is the case for you and me right now. The new perspectives on art on this essay come from thinking very deeply about consciousness, qualia, and the possible implementations of the pleasure-pain axis, aka. valence. We will see how investigating these questions cashes out in novel insights about art. In turn, these models, as well as the empirically testable predictions they generate, might have the ability to reframe what is going on with art in a way that allows us to predict how and when it will bring about good and desirable effects.

The 8 Models

  1. Art as family resemblance (Semantic Deflation)
  2. Art as Signaling (Cool Kid Theory)
  3. Art as Schelling-point creation (a few Hipster-theoretical considerations)
  4. Art as cultivating sacred experiences (self-transcendence and highest values)
  5. Art as exploring the state-space of consciousness (ϡ☀♘🏳️‍🌈♬♠ヅ)
  6. Art as something that mess with the energy parameter of your mind ()
  7. Art as puzzling valence effects (emotional salience and annealing as key ingredients)
  8. Art as a system of affective communication: a protolanguage to communicate information about worthwhile qualia (which culminates in Harmonic Society).

Models 1 through 4 are already present in the memetic ecosystem of today. They focus on external aspects of art, such as why it reproduces and how it impacts social behavior. From the point of view of Marr’s levels of analysis, these four models focus on the behavioral/computational level of analysis.[1] Namely, what art looks like from the outside, and how it reproduces. Models 5 through 8 are novel perspectives that arise out of examining artistic experiences in light of Marr’s algorithmic and implementation-level accounts of consciousness. That is, how the internal information-processing and implementational features of brains give rise to art. In turn, these four models give rise to a new understanding for when art does or does not do its job.

1. Semantic Deflation

This model says that asking “what is art?” is, more often than not, an utterly confused question. Perhaps in antiquity it would make sense to talk about the essence of art, expecting there to be a set of necessary and sufficient conditions for something to be art. According to the semantic deflation model of art, starting out with the expectation of finding a crisp set of requirements for something to be art is starting off on the wrong foot, for believing that there is an essence of art is to simply not pay attention to the large set of inconsistent use cases for that word, which challenges the existence of such an essence.

The semantic deflation model is supported by key insights from 20th Century philosophy of language, such as found in the works of Russell, Frege, Carnap, Quine, and especially those of the late Wittgenstein. Of particular relevance when it comes to defining art we could point at Wittgenstein’s concept of family resemblance. Developed in his book Philosophical Investigations, the concept of family resemblance posits that many words which seem at first to point at something with a core essence are, in fact, pointing to referents which have overlapping similarities but no universally shared attributes.

Like the concept of a game, which refers to activities as diverse as checkers and cellular automata, and which cannot be easily defined in terms of e.g. point systems, physical movement, number of players, etc., we likewise cannot expect art to be definable in terms of media, intent, social effects, or craft. All we can aspire to is to identify common and characteristic features.

According to this view, the models of art that take objective beauty seriously on Platonic or traditionalist grounds are fundamentally misguided. Callbacks to retraditionalize society to preserve its past – more genuine – aesthetics are perceived as parodies of themselves, trying to undo an intrinsically irreversible process of cultural learning. Nowadays few people seriously believe that art should be conceived of as a tool exclusively for the glorification of traditional values and religious symbolism. It is also not fashionable to think of art in sincere non-ironic ways. Those who wish to earnestly engage with art must remind themselves that the days in which its meaning could be grounded on universally agreed definitions is gone.

Although sobering and clarifying, I argue that this view leaves a lot of value on the table. Sure, art has no common essence, but that does not mean that all of the uses of the word are pointing at things of equal value. Semantic deflation does not provide us with guidance for identifying and promoting good art. Indeed, as Wittgenstein might put it, “[p]hilosophy may in no way interfere with the actual use of language, it can in the end only describe it. For it cannot give it any foundation either. It leaves everything as it is.” (Philosophical Investigations, pg.49).

Interestingly, the semantic deflation model of art can itself be conceived of as an aesthetic. This aesthetic rewards those who can help others transcend narrow conceptions of what art is. Exemplary movements like Dadaism and Pop Art could be thought of as pushing the aesthetic of semantic deflation to the limit.

Art is what you can get away with.” – Andy Warhol.

But what if there is something worth preserving, reifying, and defining clearly in art? Semantic deflation should perhaps be thought of as a first step in figuring out what is valuable about art, rather than a final destination. To move beyond it, one should avoid reviving a naïve essentialist view of art, and instead identify conceptual focal points that genuinely enrich our conception of art. Rather than destroying preconceptions, we could instead refactor, discover, and build new and enlightened ones. Transcending absolutist deflationary views of art is indeed more appealing when there is an alternative in sight that is both better and more real than what you get by merely deconstructing and breaking down naïve views. And this is what we will attempt to do as we move on to other models of art.

2. Cool Kid Theory

In his book “The Mating Mind”, Geoffrey Miller discusses art in light of evolutionary psychology. In this view, art, rather than being a thing, is a culturally sanctioned activity devised to allow people to display their genetic fitness, by showing off above-average features of their phenotypes. Art is, in this view, at its core, an outlet for courtship. Incredible performances like those of Liszt and Rachmaninoff are not just for the pleasure of music. The incredible difficulty of performing the musical compositions is itself the show. The difficulty is not a side-effect of discovering new soundscape frontiers that produce blissful and extraordinary experiences to degrees that couldn’t be possible without the difficulty of execution. Rather, the difficulty of performing the musical pieces is part and parcel of what makes them so extraordinary. They are indeed erotic displays of fitness traits (cf. Lisztomania) crafted to cause an impression in fertile ground.

Indeed, we are constructed in such a way that we can emotionally hack and be hacked by others to assess each others’ suitability as potential family, friends, and neighbors. Unfakeable fitness displays typically require prodigious amounts of waste. As Geoffrey puts it: “Every sexual ornament in every sexually reproducing species could be viewed as a different style of waste.” (The Mating Mind, pg. 128. cf. An Infinite Variety of Waste) Only extremely fit organisms can afford to spend resources on non-survival tasks.

Fashion, too, in this light, is a sort of collective activity of systematic waste. Keeping up with the latest trends shows that you have a lot of free time (which, contrary to popular belief, is perceived as more sexy than the alternative). Only the wealthy, disciplined, or well-organized can manage to sustain energy- and time-consuming hobbies for years and years.

This theory of art has a problem, though, which is that on its own it does not explain art as a cultural institution. We could very well imagine that aesthetics-based displays of genetic fitness would be circumscribed to individual efforts but in practice we see groups of people coming together to work out the potentialities, possibilities, limits, and implications of particular aesthetics. We don’t only generate extraordinarily wasteful works of art ourselves, but do so contextually within art movements and aesthetic languages. Why is this?

I believe there is a layer of organization above individual signaling displays. To fully grasp it, we need to talk about what I have named “Cool Kid Theory”. This theory postulates that above-average and particularly well-rounded individuals, aka. Cool Kids, figure out ways of enticing others to show their peacock feathers, so to speak. Being a Cool Kid is not to excel oneself, but rather, to have the precise kind of strategic mediocrity that gives others the urge to show how they can improve upon your craft. At its extreme, a Cool Kid commands a group of people who practice a particular type of craft, which ultimately becomes an artistic gang. If you are a Cool Kid you can decide who is cool and who is not by choosing what challenges to measure the performance of people with.

Who wants to be a Cool Kid? The answer is, for the most part, anyone who can get away with it. It is so evolutionarily adaptive to be a Cool Kid that we have a number of psychological programs that can be triggered with a sequence of social cues that can make almost anyone into a Cool Kid.

Part and parcel of being a Cool Kid is to know how to induce the fear of missing out in others. It is about detecting when a particular challenge is headed towards an imminent dead end and course-correct to keep people engaged.

Here is an example. If you ever encounter a group of dancers in public transportation, you will notice that there is a Cool Kid who binds them together. The Cool Kid selects for people who have unique talents, and collectively accumulates a solidly impressive bag of tricks. Everyone in the group takes turns showing their best trick. For instance, the group might have someone who sings, someone who plays an instrument, and someone who owns a subwoofer (sometimes that’s all it takes). You might also see that there is a guy who can do the weird elbow twist thingy, the one who can break dance and do nine spins on his back, the one who can beat-box to the tune of the song, and the one who moonwalks while playing a harmonica. An effective Cool Kid is one who can corral all of these specialists and be the artistic glue who controls the overarching aesthetic. And this aesthetic is what defines a set of challenges used for impressive fitness displays.

The art world can be thus conceived of as a large super-cluster of Cool Kid gangs cornering the economy of attention. The competitive nature of Cool Kids is sure to produce a constant stream of novel stimuli, endlessly varied trends and fashions, as well as competitive and indeed sometimes even virulent attacks between aesthetics. For he who controls the aesthetic, controls your ability to be popular.

To be continued…



[1] Marr’s levels of analysis is a framework to analyze information-processing systems. First we have the computational level, which describes what the system does from a third-person point of view. This level is concerned with questions like what the system is capable of, and how quickly it can succeed at it. Second is the algorithmic level of analysis, which focuses on the internal representations and operations used to transform the inputs into the outputs. And third is the implementation level of analysis, which is concerned with the physical realization of the algorithms described in the second level.

Atman Retreat: Safe, Legal Psilocybin Experiences in Jamaica

Atman Retreat provides safe, legal psychedelic experiences outside of Montego Bay, Jamaica.

  • Upcoming retreat dates:
    • September 23-26 (7 spots left; as of September 2nd)
    • September 27-30 (5 spots left; as of September 2nd)
    • November 13-16
    • November 17-20
       
  • Atman recently introduced tiered pricing and a low-income ticket program.

About Atman Retreat (source)

Psychedelics are known to produce profound, meaningful, transformative experiences when used in a safe and intentional manner.1 However, many people don’t have access to psychedelics, or to a safe setting within which to use them. Others simply don’t want to break the law. Until we adopt more compassionate, evidence-based drug policy, there are few ways for people to experience these extraordinary states of consciousness safely and legally. Atman Retreat exists to fill this gap.

Our core mission is to help people explore the full potential of the psychedelic experience, in all its healing, transformative, and transcendent qualities. Retreats are held in Jamaica, where psilocybin mushrooms are legal. Participants stay at a spacious villa, with comfortable rooms and a scenic private beachfront. Our team of experienced facilitators is passionate about creating space for inner transformation, insight, and breakthroughs.

Whether you’re completely new to psychedelics, or a seasoned psychonaut interested in a different kind of journey, Atman Retreat is a complete 4-day experience that allows you to explore psychedelics safely, legally, and in a setting designed to maximize their benefits.

When you feel ready, you can apply here.



Why am I sharing this announcement? I think that Atman Retreat is especially suited to Qualia Computing readers for the following three reasons:

  1. I know some of the people who started it and I can confirm that they are good, rational, and tactful people trying to make the world a better place.
  2. The retreat is open-ended in nature. Sadly, most legal psychedelic retreats come with heavy “memetic baggage” in the form of unquestioned beliefs about spirituality or strong ideological commitments. At the very least, the focus of most legal psychedelic retreats is explicitly therapeutic. Atman Retreat is a good place to simply explore your own mind and study the nature of consciousness without having to accept any spiritual, therapeutic, or ideological framework. For example, their website has a research section which lists and summarizes recent studies on the effects of psilocybin, which shows a willingness by the staff to engage with a scientific approach to psychedelics.
  3. The participants in previous cohorts of Atman Retreat have been very aligned with both Effective Altruism and the scientific study of consciousness. In other words, the attendees are typically smart, curious, ethical, and epistemologically sound.

To this, I will add that one of the visions of the Qualia Research Institute is to create an empirical consciousness research center in which psychedelics are taken by the brightest scientists, philosophers, and engineers to explore alien state-spaces of consciousness directly.

Indeed, consciousness research is currently at a pre-Galilean state, where brain scientists refuse to “look through the telescope” so to speak (or at least if they do, they are not talking about it publicly). Scientific culture is such that discussing the EEG measurements of members of the general public under the influence of psychedelics is acceptable but as soon as one talks about one’s own direct experience with such compounds one’s scientific credibility becomes suspect.

We can change this, and one of the first steps is to establish a legal framework for consciousness researchers to be able to engage in fruitful self-experimentation. Real scientific progress on consciousness will only take place with a twin track that combines both analysis of third-person data and the use of an empirical research methodology of direct experience by the researchers themselves. By pointing to the Atman Retreat I am hoping to elevate it to the status of a sort of Schelling point for rational psychonauts to converge on for the time being.

Perhaps this is a crucial first step in establishing a legally-viable Super-Shulgin Academy* for a post-Galilean science of consciousness.

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Jamaica is waiting for you!



*From the QRI Glossary

Super-Shulgin Academy (coined by David Pearce; ref: 12345678): This is a hypothetical future intellectual society that investigates consciousness empirically. Rather than merely theorizing about it or having people from the general population describe their odd experiences, the Super-Shulgin Academy directly studies the state-space of consciousness by putting the brightest minds on the task. The Super-Shulgin Academy (1) trains high-quality consciousness researchers and psychonauts, (2) investigates the computational trade-offs between different states of consciousness, (3) finds new socially-useful applications for exotic states of consciousness, (4) practices the art and craft of creating ultra-blissful experiences, and (5) develops and maintains a full-stack memeplex that incorporates the latest insights about the state-space of consciousness into the most up-to-date Theory of Everything.

Featured image: source.

Logarithmic Scales of Pleasure and Pain: Rating, Ranking, and Comparing Peak Experiences Suggest the Existence of Long Tails for Bliss and Suffering

TL;DR

Based on: the characteristic distribution of neural activity, personal accounts of intense pleasure and pain, the way various pain scales have been described by their creators, and the results of a pilot study we conducted which ranks, rates, and compares the hedonic quality of extreme experiences, we suggest that the best way to interpret pleasure and pain scales is by thinking of them as logarithmic compressions of what is truly a long-tail. The most intense pains are orders of magnitude more awful than mild pains (and symmetrically for pleasure).

This should inform the way we prioritize altruistic interventions and plan for a better future. Since the bulk of suffering is concentrated in a small percentage of experiences, focusing our efforts on preventing cases of intense suffering likely dominates most utilitarian calculations.

An important pragmatic takeaway from this article is that if one is trying to select an effective career path, as a heuristic it would be good to take into account how one’s efforts would cash out in the prevention of extreme suffering (see: Hell-Index), rather than just QALYs and wellness indices that ignore the long-tail. Of particular note as promising Effective Altruist careers, we would highlight working directly to develop remedies for specific, extremely painful experiences. Finding scalable treatments for migraines, kidney stones, childbirth, cluster headaches, CRPS, and fibromyalgia may be extremely high-impact (cf. Treating Cluster Headaches and Migraines Using N,N-DMT and Other Tryptamines, Using Ibogaine to Create Friendlier Opioids, and Frequency Specific Microcurrent for Kidney-Stone Pain). More research efforts into identifying and quantifying intense suffering currently unaddressed would also be extremely helpful. Finally, if the positive valence scale also has a long-tail, focusing one’s career in developing bliss technologies may pay-off in surprisingly good ways (whereby you may stumble on methods to generate high-valence healing experiences which are orders of magnitude better than you thought were possible).

Contents

Introduction:

  1. Weber’s Law
  2. Why This Matters

General ideas:

  1. The Non-Linearity of Pleasure and Pain
    1. Personal Accounts
    2. Consciousness Expansion
    3. Peak Pleasure States: Jhanas and Temporal Lobe Seizures
    4. Logarithmic Pain Scales: Stings, Peppers, and Cluster Headaches
  2. Deference-type Approaches for Experience Ranking
    1. Normal World vs. Lognormal World
    2. Predictions of Lognormal World

Survey setup:

  1. Mechanical Turk
  2. Participant Composition
  3. Filtering Bots

Results:

  1. Appearance Base Rates
  2. Average Ratings
  3. Deference Graph of Top Experiences
    1. Rebalanced Smoothed Proportion
    2. Triadic Analysis
  4. Latent Trait Ratings
  5. Long-tails in the Responses to “How Many Times Better/Worse” Question

Discussion:

  1. Key Pleasures Surfaced
    1. Birth of Children
    2. Falling in Love
    3. Travel/Vacation
    4. MDMA/LSD/Psilocybin
    5. Games of Chance Earnings
  2. Key Pains
    1. Kidney Stones/Migraines
    2. Childbirth
    3. Car Accidents
    4. Death of Father and Mother
  3. Future Directions for Methodological Approaches
    1. Graphical Models with Log-Normal Priors
  4. Closing Thoughts on the Valence Scale
  5. Additional Material
    1. Dimensionality of Pleasure and Pain
    2. Mixed States
    3. Qualia Formalism
  6. Notes

Introduction

Weber’s Law

Weber’s Law describes the relationship between the physical intensity of a stimulus and the reported subjective intensity of perceiving it. For example, it describes the relationship between how loud a sound is and how loud it is perceived as. In the general case, Weber’s Law indicates that one needs to vary the stimulus intensity by a multiplicative fraction (called “Weber’s fraction”) in order to detect a just noticeable difference. For example, if you cannot detect the differences between objects weighing 100 grams to 105 grams, then you will also not be able to detect the differences between objects weighing 200 grams to 210 grams (implying the Weber fraction for weight perception is at least 5%). In the general case, the senses detect differences logarithmically.

There are two compelling stories for interpreting this law:

In the first story, it is the low-level processing of the senses which do the logarithmic mapping. The senses “compress” the intensity of the stimulation and send a “linearized” packet of information to one’s brain, which is then rendered linearly in one’s experience.

In the second story, the senses, within the window of adaptation, do a fine job of translating (somewhat) faithfully the actual intensity of the stimulus, which then gets rendered in our experience. Our inability to detect small absolute differences between intense stimuli is not because we are not rendering such differences, but because Weber’s law applies to the very intensity of experience. In other words, the properties of one’s experience could follow a long-tail distribution, but our ability to accurately point out differences between the properties of experiences is proportional to their intensity.

We claim that, at least for the case of valence (i.e the pleasure-pain axis), the second story is much closer to the truth than the first. Accordingly, this article rethinks the pleasure-pain axis (also called the valence scale) by providing evidence, arguments, and datapoints to support the idea that how good or bad experiences feel follows a long-tail distribution.

As an intuition pump for what is to follow, we would like to highlight the empirical finding that brain activity follows a long-tail distribution (see: Statistical Analyses Support Power Law Distributions Found in Neuronal Avalanches, and Logarithmic Distributions Prove that Intrinsic Learning is Hebbian). The story where the “true valence scale” is a logarithmic compression is entirely consistent with the empirical long-tails of neural activity (in which “neural avalanches” account for a large fraction of overall brain activity).

The concrete line of argument we will present is based on the following:

  1. Phenomenological accounts of intense pleasure and pain (w/ accounts of phenomenal time and space expansion),
  2. The way in which pain scales are described by those who developed them, and
  3. The analytic results of a pilot study we conducted which investigates how people rank, rate, and assign relative proportions to their top 3 best and worst experiences

Why This Matters

Even if you are not a strict valence utilitarian, having the insight that the valence scale is long-tailed is still very important. Most ethical systems do give some weight to the prevention of suffering (in addition to the creation of subjectively valuable experiences), even if that is not all they care about. If your ethical system weighted slightly the task of preventing suffering when believing in a linear valence scale, then learning about the long-tailed nature of valence should in principle cause a major update. If indeed the worst experiences are exponentially more negative than originally believed by one’s ethical system, which nonetheless still cared about them, then after learning about the true valence scale the system would have to reprioritize. We suggest that while it might be unrealistic to have every ethical system refocus all of its energies on the prevention of intense suffering (and subsequently on researching how to create intense bliss sustainably), we can nonetheless expect such systems to raise this goal on their list of priorities. In other words, while “ending all suffering” will likely never be a part of most people’s ethical system, we hope that the data and arguments here presented at least persuade them to add “…and prevent intense forms of suffering” to the set of desiderata.

Indeed, lack of awareness about the long-tails of bliss and suffering may be the cause of an ongoing massive moral catastrophe (notes by Linch). If indeed the degree of suffering present in experiences follows a long-tail distribution, we would expect the worst experiences to dominate most utilitarian calculus. The biggest bang for the buck in altruistic interventions would therefore be those that are capable of directly addressing intense suffering and generating super-bliss.

General Ideas

The Non-Linearity of Pleasure and Pain

true_pleasure_scale

True long-tail pleasure scale (warning: psychedelics increase valence variance – the values here are for “good/lucky” trips and there is no guarantee e.g. LSD will feel good on a given occasion). Also: Mania is not always pleasant, but when it is, it can be super blissful.

true_pain_scale

True long-tail pain scale

As we’ve briefly discussed in previous articles (1, 2, 3), there are many reasons to believe that both pleasure and pain can be felt along a spectrum with values that range over possibly orders of magnitude. Understandably, someone who is currently in a state of consciousness around the human median of valence is likely to be skeptical of a claim like “the bliss you can achieve in meditation is literally 100 times better than eating your favorite food or having sex.” Intuitively, we only have so much space in our experience to fit bliss, and when one is in a “normal” or typical state of mind for a human, one is forced to imagine “ultra blissful states” by extrapolating the elements of one’s current experience, which certainly do not seem capable of being much better than, say, 50% of the current level of pleasure (or pain). The problem here is that the very building blocks of experiences that enable them to be ultra-high or ultra-low valence are themselves necessary to imagine accurately how they can be put together. Talking about extreme bliss to someone who is anhedonic is akin to talking about the rich range of possible color experiences to someone who is congenitally fully colorblind (cf. “What Mary Didn’t Know“).

“Ok”, you may say, “you are just telling me that pleasure and pain can be orders of magnitude stronger than I can even conceive of. What do you base this on?”. The most straightforward way to be convinced of this is to literally experience such states. Alas, this would be deeply unethical when it comes to the negative side, and it requires special materials and patience for the positive side. Instead, I will provide evidence from a variety of methods and conditions.

Personal Accounts

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I’ve been lucky to not have experienced major pain in my life so far (the worst being, perhaps, depression during my teens). I have, however, had two key experiences that gave me some time to introspect on the non-linear nature of pain. The first one comes from when I accidentally cut a super-spicy pepper and touched it with my bare hands (the batch of peppers I was cutting were mild, but a super-hot one snuck into the produce box). After a few minutes of cutting the peppers, I noticed that a burning heat began to intensify in my hands. This was the start of experiencing “hot pepper hands” for a full 8 hours (see other people’s experiences: 1, 2, 3). The first two to three hours of this ordeal were the worst, where I experienced what I rated as a persistent 4/10 pain interspersed with brief moments of 5/10 pain. The curious thing was that the 5/10 pain moments were clearly discernible as qualitatively different. It was as if the very numerous pinpricks and burning sensations all over my hands were in a somewhat disorganized state most of the time, but whenever they managed to build-up for long enough, they would start clicking with each other (presumably via phase-locking), giving rise to resonant waves of pain that felt both more energetic, and more aversive on the whole. In a way, this jump from what I rated as 4/10 to 5/10 was qualitative as well as quantitative, and it gave me some idea of how something that is already bad can become even worse.

My second experience involves a mild joint injury I experienced while playing Bubble Soccer (a very fun sport no doubt, and a common corporate treat for Silicon Valley cognotariats, but according to my doctor it is also a frequent source of injuries among programmers). Before doing physical therapy to treat this problem (which mostly took care of it), I remember spending hours introspecting on the quality of the pain in order to understand it better. It wasn’t particularly bad, but it was constant (I rated it as 2/10 most of the time). What stuck with me was how its constant presence would slowly increase the stress of my entire experience over time. I compared the experience to having an uncomfortable knot stuck in your body. If I had a lot of mental and emotional slack early in the day, I could easily take the stress produced by the knot and “send it elsewhere” in my body. But since the source of the stress was constant, eventually I would run out of space, and the knot would start making secondary knots around itself, and it was in those moments where I would rate the pain at a 3/10. This would only go away if I rested and somehow “reset” the amount of cognitive and emotional slack I had available.

The point of these two stories is to highlight the observation that there seem to be phase-changes between levels of discomfort. An analogy I often make is with the phenomenon of secondary coils when you twist a rope. The stress induced by pain- at least introspectively speaking- is pushed to less stressed areas of your mind. But this has a limit, which is until your whole world-simulation is stressed to the point that the source of stress starts creating secondary “stress coils” on top of the already stressed background experience. This was a very interesting realization to me, which put in a different light weird expressions that chronic pain patients use like “my pain now has a pain of its own” or “I can’t let the pain build up”.

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DNA coils and super-coils as a metaphor for pain phase-changes?

Consciousness Expansion

What about more extreme experiences? Here we should briefly mention psychedelic drugs, as they seem to be able to increase the energy of one’s consciousness (and in some sense “multiply the amount of consciousness“) in a way that grows non-linearly as a function of the dose. An LSD experience with 100 micrograms may be “only” 50% more intense than normal everyday life, but an LSD experience with 200 micrograms is felt as 2-3X as intense, while 300 micrograms may increase the intensity of experience by perhaps 10X (relative to normal). Usually people say that high-dose psychedelic states are indescribably more real and vivid than normal everyday life. And then there are compounds like 5-MeO-DMT, which people often describe as being in “a completely different category”, as it gives rise to what many describe as “infinite consciousness”. Obviously there is no such thing as an experience with infinite consciousness, and that judgement could be explained in terms of the lack of “internal boundaries” of the state, which gives the impression of infinity (not unlike how the surface of a torus can seem infinite from the point of view of a flatlander). That said, I’ve asked rational and intelligent people who have tried 5-MeO-DMT in non-spiritual settings what they think the intensity of their experiences was, and they usually say that a strong dose of 10mg or more gives rise to an intensity and “quantity” of consciousness that is at least 100X as high as normal everyday experiences. There are many reasons to be skeptical of this, no doubt, but the reports should not be dismissed out of hand.

Antoine's_Necklace_Iteration_2

Secondary knots and links as a metaphor for higher bliss

As with the above example, we can reason that one of the ways in which both pain and pleasure can be present in *multiples* of one’s normal hedonic range is because the amount of consciousness crammed into a moment of experience is not a constant. In other words, when someone in a typical state of consciousness asks “if you say one can experience so much pain/pleasure, tell me, where would that fit in my experience? I don’t see much room for that to fit in here”, one can respond by saying that “in other states of consciousness there is more (phenomenal) time and space within each moment of experience”. Indeed, at Qualia Computing we have assembled and interpreted a large number of experiences of high-energy states of consciousness that indicate that both phenomenal time, and phenomenal space, can drastically expand. To sum it up – you can fit so much pleasure and pain in peak experiences precisely because such experiences make room for them.

Let us now illustrate the point with some paradigmatic cases of very high and vey low valence:

Peak Pleasure States: Jhanas and Temporal Lobe Seizures

On the pleasure side, we have Buddhist meditators who experience meditative states of absorption (aka. “Jhanas”) as extremely, and counter-intuitively, blissful:

The experience can include some very pleasant physical sensations such as goose bumps on the body and the hair standing up to more intense pleasures which grow in intensity and explode into a state of ecstasy. If you have pain in your legs, knees, or other part of the body during meditation, the pain will actually disappear while you are in the jhanas. The pleasant sensations can be so strong to eliminate your painful sensations. You enter the jhanas from the pleasant experiences exploding into a state of ecstasy where you no longer “feel” any of your senses.

9 Jhanas, Dhamma Wiki

There are 8 (or 9, depending on who you ask) “levels” of Jhanas, and the above is describing only the 1st of them! The higher the Jhana, the more refined the bliss becomes, and the more detached the state is from the common referents of our everyday human experience. Ultra-bliss does not look at all like sensual pleasure or excitement, but more like information-theoretically optimal configurations of resonant waves of consciousness with little to no intentional content (cf. semantically neutral energy). I know this sounds weird, but it’s what is reported.

insula

“Streamlines from the insula to the cortex” – the insula (in red) is an area of the brain intimately implicated in the super-bliss that sometimes precedes temporal lobe epilepsy (source)

Another example I will provide about ultra-bliss concerns temporal lobe epilepsy, which in a minority of sufferers gives rise to extraordinarily intense states of pleasure, or pain, or both. Such experiences can result in Geschwind syndrome, a condition characterized by hypergraphia (writing non-stop), hyper-religiosity, and a generally intensified mental and emotional life. No doubt, any experience that hits the valence scale at one of its extremes is usually interpreted as other-worldly and paranormal (which gives rise to the question of whether valence is a spiritual phenomenon or the other way around). Famously, Dostoevsky seems to have experienced temporal lobe seizures, and this ultimately informed his worldview and literary work in profound ways. Here is how he describes them:

“A happiness unthinkable in the normal state and unimaginable for anyone who hasn’t experienced it… I am then in perfect harmony with myself and the entire universe.”

 

– From a letter to his friend Nikolai Strakhov.

“I feel entirely in harmony with myself and the whole world, and this feeling is so strong and so delightful that for a few seconds of such bliss one would gladly give up 10 years of one’s life, if not one’s whole life. […] You all, healthy people, can’t imagine the happiness which we epileptics feel during the second before our fit… I don’t know if this felicity lasts for seconds, hours or months, but believe me, I would not exchange it for all the joys that life may bring.”

 

– from the character Prince Myshkin in Dostoevsky’s novel, The Idiot, which he likely used to give a voice to his own experiences.

Dostoevsky is far from the only person reporting these kinds of experiences from epilepsy:

As Picard [a scientist investigating seizures] cajoled her patients to speak up about their ecstatic seizures, she found that their sensations could be characterised using three broad categories of feelings (Epilepsy & Behaviour, vol 16, p 539). The first was heightened self-awareness. For example, a 53-year-old female teacher told Picard: “During the seizure it is as if I were very, very conscious, more aware, and the sensations, everything seems bigger, overwhelming me.” The second was a sense of physical well-being. A 37-year-old man described it as “a sensation of velvet, as if I were sheltered from anything negative”. The third was intense positive emotions, best articulated by a 64-year-old woman: “The immense joy that fills me is above physical sensations. It is a feeling of total presence, an absolute integration of myself, a feeling of unbelievable harmony of my whole body and myself with life, with the world, with the ‘All’,” she said.

 

– from “Fits of Rapture”, New Scientist (January 25, 2014) (source)

All in all, these examples illustrate the fact that blissful states can be deeper, richer, more intense, more conscious, and qualitatively superior to the normal everyday range of human emotion.

Now, how about the negative side?

Logarithmic Pain Scales: Stings, Peppers, and Cluster Headaches

“The difference between 6 and 10 on the pain scale is an exponential difference. Believe it or not.”

Insufferable Indifference, by Neil E. Clement (who experiences chronic pain ranging between 6/10 to 10/10, depending on the day)

Three pain-scale examples that illustrate the non-linearity of pain are: (1) the Schmidt sting pain index, (2) the Scoville scale, and (3) the KIP scale:

image

(1) Justin O. Schmidt stung himself with over 80 species of insects of the Hymenoptera order, and rated the ensuing pain on a 4-point-scale. About the scale, he had to say the following:

4:28 – Justin Schmidt: The harvester ant is what got the sting pain scale going in the first place. I had been stung by honeybees, yellow jackets, paper wasps, etc. the garden variety stuff, that you get bitten by various beetles and things. I went down to Georgia, which has the Eastern-most extension of the harvester ant. I got stung and I said “Wooooow! This is DIFFERENT!” You know? I thought I knew everything there was about insect stings, I was just this dumb little kid. And I realized “Wait a minute! There is something different going on here”, and that’s what got me to do the comparative analysis. Is this unique to harvester ants? Or are there others that are like that. It turns out while the answer is, now we know much later – it’s unique! [unique type of pain]. 

[…]

7:09 – Justin Schmidt: I didn’t really want to go out and get stung for fun. I was this desperate graduate student trying to get a thesis, so I could get out and get a real job, and stop being a student eventually. And I realized that, oh, we can measure toxicity, you know, the killing power of something, but we can’t measure pain… ouch, that one hurts, and that one hurts, and ouch that one over there also hurts… but I can’t put that on a computer program and mathematically analyze what it means for the pain of the insect. So I said, aha! We need a pain scale. A computer can analyze one, two, three, and four, but it can’t analyze “ouch!”. So I decided that I had to make a pain scale, with the harvester ant (cutting to the chase) was a 3. Honey bees was a 2. And I kind of tell people that each number is like 10 equivalent of the number before. So 10 honey bee stings are equal to 1 harvester ant sting, and 10 harvester ant stings would equal one bullet ant sting.

[…]

11:50 – [Interviewer]: When I finally worked up the courage to [put the Tarantula Hawk on my arm] and take this sting. The sting of that insect was electric in nature. I’ve been shocked before, by accidentally taking a zap from an electrical cord. This was that times 10. And it put me on the ground. My arm seized up from muscle contraction. And it was probably the worst 5 minutes of my life at that point.

Justin Schmidt: Yeah, that’s exactly what I call electrifying. I say, imagine you are walking along in Arizona, and there is a wind storm, and the power line above snaps the wire, and it hits you, of course that hasn’t happened to me, but that’s what you imagine it feels like. Because it’s absolutely electrifying, I call it debilitating because you want to be macho, “ah I’m tough, I can do this!” Now you can’t! So I tell people lay down and SCREAM! Right?

[Interviewer]: That’s what I did! And Mark would be like, this famous “Coyote, are you ok? Are you ok?”

Justin Schmidt: No, I’m not ok!

[Interviewer]: And it was very hard to try to compose myself to be like, alright, describe what is happening to your body right now. Because your mind goes into this state that is like blank emptiness. And all you can focus on is the fact that there’s radiating pain coming out of your arm.

Justin Schmidt: That’s why you scream, because now you’re focusing on something else. In addition to the pain, you’re focusing on “AAAAAAHHHHH!!!” [screams loudly]. Takes a little bit of the juice off of the pain, so maybe you lower it down to a three for as long as you can yell. And I can yell for a pretty long time when I’m stung by a tarantula hawk.

 

Origin of STINGS!, interview of Justin O. Schmidt

If we take Justin’s word for it, a sting that scores a 4 on his pain scale is about 1,000 times more painful than a sting that scores a 1 on his scale. Accordingly, Christopher Starr (who replicated the scale), stated that any sting that scores a 4 is “traumatically painful” (source). Finally, since the scale is restricted to stings of insects of the Hymenoptera order, it remains possible that there are stings whose pain would be rated even higher than 4. A 5 on the sting pain index might perhaps be experienced with the stings of the box jellyfish that produces Irukandji syndrome, and the bite of the giant desert centipede. Needless to say, these are to be avoided.

Moving on…

(2) The Scoville scale measures how spicy different chili peppers and hot sauces are. It is calculated by diluting the pepper/sauce in water until it is no longer possible to detect any spice in it. The number that is associated with the pepper or sauce is the ratio of water-to-sauce that makes it just barely possible to taste the spice. Now, this is of course not itself a pain scale. I would nonetheless anticipate that taking the log of the Scoville units of a dish might be a good approximation for the reported pain it delivers. In particular, people note that there are several qualitative jumps in the type and nature of the pain one experiences when eating hot sauces of different strengths (e.g. “Fuck you Sean! […] That was a leap, Sean, that was a LEAP!” – Ken Jeong right after getting to the 135,000 Scoville units sauce in the pain porn Youtube series Hot Ones). Amazon reviews of ultra-hot sauces can be mined for phenomenological information concerning intense pain, and the general impression one gets after reading such reviews is that indeed there is a sort of exponential range of possible pain values:

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I know it may be fun to trivialize this kind of pain, but different people react differently to it (probably following a long-tail too!). For some people who are very sensitive to heat pain, very hot sauce can be legitimately traumatizing. Hence I advise against having ultra-spicy sauces around your house. The novelty value is not worth the probability of a regrettable accident, as exemplified in some of the Amazon reviews above (e.g. a house guest assuming that your “Da’Bomb – Beyond Insanity” bottle in the fridge can’t possibly be that hot… and ending up in the ER and with PTSD).

I should add that media that is widely consumed about extreme hot sauce (e.g. the Hot Ones mentioned above and numerous stunt Youtube channels) may seem fun on the surface, but what doesn’t make the cut and is left in the editing room is probably not very palatable at all. From an interview: “Has anyone thrown up doing it?” (interviewer) – “Yeah, we’ve run the gamuts. We’ve had people spit in buckets, half-pass out, sleep in the green room afterwards, etc.” (Sean Evans, Hot Ones host). T.J. Miller, when asked about what advice he would give to the show while eating ultra-spicy wings, responded: “Don’t do this. Don’t do this again. End the show. Stop doing the show. That’s my advice. This is very hot. This is painful. There’s a problem here.”

07e7c9915f52b1945603f0c83a48e4fe

Trigeminal Neuralgia pain scale – a condition similarly painful to Cluster Headaches

(3) Finally, we come to the “KIP scale”, which is used to rate Cluster Headaches, one of the most painful conditions that people endure:

The KIP scale

KIP-0 No pain, life is beautiful
KIP-1 Very minor, shadows come and go. Life is still beautiful
KIP-2 More persistent shadows
KIP-3 Shadows are getting constant but can deal with it
KIP-4 Starting to get bad, want to be left alone
KIP-5 Still not a “pacer” but need space
KIP-6 Wake up grumbling, curse a bit, but can get back to sleep without “dancing”
KIP-7 Wake up, sleep not an option, take the beast for a walk and finally fall into bed exhausted
KIP-8 Time to scream, yell, curse, head bang, rock, whatever works
KIP-9 The “Why me?” syndrome starts to set in
KIP-10 Major pain, screaming, head banging, ER trip. Depressed. Suicidal.

The duration factor is multiplied by the intensity factor, which uses the KIP scale in an exponential way – a KIP 10 is not just twice as bad as a KIP 5, it’s ten times as intense.

Source: Keeping Track, by Cluster Busters

As seen above, the KIP scale is acknowledged by its creator and users to be logarithmic in nature.

In summary: We see that pleasure comes in various grades and that peak experiences such as those induced by psychedelics, meditation, and temporal lobe seizures seem to be orders of magnitude more energetic and better than everyday sober states. Likewise, we see that across several categories of pain, people report being surprised by the leaps in both quality and intensity that are possible. More so, at least in the case of the Schmidt Index and the Kip Scale, the creators of the scale were explicit that it was a logarithmic mapping of the actual level of sensation.

While we do not have enough evidence (and conceptual clarity) to assert that the intensity of pain and pleasure does grow exponentially, the information presented so far does suggest that the valence of experiences follows a long-tail distribution.

Deference-type Approaches for Experience Ranking

The above considerations underscore the importance of coming up with a pleasure-pain scale that tries to take into account the non-linearity and non-normality of valence ratings. One idea we came up with was a “deference”-type approach, where we ask open-ended questions about people’s best and worst experiences and have them rank them against each other. Although locally the data would be very sparse, the idea was that there might be methods to integrate the collective patterns of deference into an approximate scale. If extended to populations of people who are known to have experienced extremes of valence, the approach would even allow us to unify the various pain scales (Scoville, Schmidt, KIP, etc.) and assign a kind of universal valence score to different categories of pain and pleasure.* That will be version 2.0. In the meantime, we thought to try to get a rough picture of the extreme joys and affections of members of the general public, which is what this article will focus on.

Normal World vs. Lognormal World

There is a world we could call the “Normal World”, where valence outliers are rare and most types of experiences affect people more or less similarly, distributed along a Gaussian curve. Then there is another, very different world we could call the “long-tailed world” or if we want to make it simple (acknowledging uncertainty) “Lognormal World”, where almost every valence distribution is a long-tail. So in the “Lognormal World”, say, for pleasure (and symmetrically for pain), we would expect to see a long-tail in the mean pleasure of experiences between different categories across all people, a long-tail in the amount of pleasure within a given type of experience across people, a long-tail for the number of times an individual has had a certain type of pleasure, a long-tail in the intensity of the pleasure experienced with a single category of experience within a single person, and so on. Do we live in the Normal World or the Lognormal World?

Predictions of Lognormal World

If we lived in the “Lognormal World”, we would expect:

  • That people will typically say that their top #1 best/worst experience is not only a bit better/worse than their #2 experience, but a lot better/worse. Like, perhaps, even multiple times better/worse.
  • That there will be a long-tail in the number of appearances of different categories (i.e. that a large amount, such as 80%, of top experiences will belong to the same narrow set of categories, and that there will be many different kinds of experiences capturing the remaining 20%).
  • That for most pairs of experiences x and y, people who have had both instances of x and y, will usually agree about which one is better/worse. We call such a relationship a “deference”. More so, we would expect to see that deference, in general, will be transitive (a > b and b > c implying that a > c).

To test the first and second prediction does not require a lot of data, but the third does because one needs to have enough comparisons to fill a lot of triads. The survey results we will discuss bellow are congruent with the first and second prediction. We did what we could with the data available to investigate the third, and tentatively, it seems to hold up (with ideas like deference network centrality analysis, triadic analysis, and tournament-style approaches).


Survey Setup

The survey asked the following questions: current level of pleasure, current level of pain, top 3 most pleasurable experiences (in decreasing order) along with pleasure ratings for each of them and the age when they were experienced, and the same for the top 3 most painful experiences. I specifically did not provide a set of broad categories (such as “physical” or “emotional”) or a drop-down menu of possible narrow categories (e.g. going to the movies, aerobic exercise, etc.). I wanted to see what people would say when the question was as open-ended as possible.

I also included questions aimed more directly at probing the long-tailed nature of valence: I asked participants to rate “how many times more pleasant was the #1 top experience relative to the #2 top experience” (and #2 relative to #3, and the same for the top most painful experiences).

I also asked them to describe in more detail the single most pleasant and unpleasant experiences, and added a box for comments at the end in order to see if anyone complained about the task (most people said “no comment”, many said they enjoyed the task, and one person said that it made them nostalgic). I also asked about basic demographics (age and gender). Participants earned $1.75 for the task, which seems reasonable given the time it took to complete in most cases.

Mechanical Turk: Participant Composition

The survey was run on Mechanical Turk. I requested “Masters” qualifications for 90/110 of the survey responses. To be a Mechanical Turk Master you need to have a good track record of task approval, which I reasoned would increase the rate of well thought-out high-quality responses (this turned out to be true). The participants’ genders were fairly balanced (50/97 women, 47/97 men), and the average age was 36.5 years (sd = 10):

age_distribution_no_bots

Age distribution

Bots (easy to spot – unless extremely sophisticated)

While reading the responses I discovered that some of them seemed to be generated by bots. Apparently task requesters started noticing the presence of bots a couple of years ago. This is obviously a problem for academics trying to use the service for their research, and for machine learning professionals using the service for data-tagging. Having been both of those things in the past, I can say that a few years ago I did not see any submissions that looked suspiciously bot-like. Though low-quality rushed responses did seem to be relatively common back then, I never observed bot-like responses to open-ended questions. Unfortunately this time I was able to spot several responses clearly written by bots. For example, one respondent answered the question “write a brief essay about your #1 best experience” with:

The reason these types of assignments are given so often is that anyone can write about their own experience and it doesn’t require any outside resources or research. However, even though anyone can tell a story about their life, that does not mean anyone can write a good essay about that experience. As a professor and teacher for 30 years, I’ve read thousands of essays and can tell you there is a distinct difference from telling a story about yourself and writing an excellent personal experience essay. The difference between good and great:

And it ends that way, with a colon indicating that the respondent is about to explain what the difference between good and great is. But it never does it. This answer, great, it is not.

In most cases the difference between a genuine response and a bot response was very obvious. That said, I erred on the side of caution for filtering bots and I got rid of answers even if they seemed just a little suspicious. This left me with 97 out of the 110 original responses. The following analysis was conducted on those 97 responses.

Preprocessing

Since the responses were open-ended I had to tag each of them with an experience category. To do this I read each response and identified the key theme in them and classified them with a label that was specific enough to distinguish it from nearby experiences (e.g. different types of fractures), but not so specific that we would never get more than one response per category (e.g. “breaking the middle finger in elementary school”). In general, most responses fell into very unambiguous categories (e.g. “When my father passed away” and “Watching my father die and take his last few breaths.” were both classified as “Father death”). About 10% of the responses were relatively ambiguous: it wasn’t clear what the source of the pain or pleasure was. To deal with those responses I used the label “Unspecified”. When some detail was present but ambiguity remained, such as when a broad type of pain or pleasure was mentioned but not the specific source I tagged it as “Unspecified X” where X was a broad category. For example, one person said that “broken bones” was the most painful experience they’ve had, which I labeled as “Unspecified fracture”.


Results

I should preface the following by saying that we are very aware of the lack of scientific rigor in this survey; it remains a pilot exploratory work. We didn’t specify the time-scale for the experiences (e.g. are we asking about the best minute of your life or the best month of your life?) or whether we were requesting instances of physical or psychological pain/pleasures. Despite this lack of constraints it was interesting to see very strong commonalities among people’s responses:

Appearance Base Rates

There were 77 and 124 categories of pleasure and pain identified, respectively. On the whole it seemed like there was a higher diversity of ways to suffer than of ways to experience intense bliss. Summoning the spirit of Tolstoy: “Happy families are all alike; every unhappy family is unhappy in its own way.”

Here are the raw counts for each category with at least two appearances:

pleasure_baserates_97_only_2andup_

Best experiences appearances (with at least two reports)

pain_baserates_97_only_2andup_

Worst experience appearances (with at least two reports)

For those who want to see the full list of number of appearances for each experience mentioned see the bottom of the article (I also clarify some of the more confusing labels there too)**.

A simple way to try to incorporate the information about the ranking is to weight experiences rated as top #1 with 3 points, those as top #2 with 2 points, and those as the top #3 with 1 point. If you do this, the experiences scores are:

pleasure_baserates_97_weighted_

Weighted appearances of best experiences (#1 – 3 points, #2 – 2 points, #3 – 1 point)

pain_baserates_97_weighted_

Weighted appearances of worst experiences (#1 – 3 points, #2 – 2 points, #3 – 1 point)

Average ratings

Given the relatively small sample size, I will only report the mean rating for pain and pleasure (out of 10) for categories of experience for which there were 6 or more respondents:

For pain:

  1. Father death (n = 19): mean 8.53, sd 2.3
  2. Childbirth (n = 16): mean 7.94, sd 2.16
  3. Grandmother death (n = 13): mean 8.12, sd 2.5
  4. Mother death (n = 11): mean 9.4, sd 0.62
  5. Car accident (n = 9): mean 8.42, sd 1.52
  6. Kidney stone (n = 9): mean 5.97, sd 3.17
  7. Migraine (n = 9): mean 5.36, sd 3.11
  8. Romantic breakup (n = 9): mean 7.11, sd 1.52
  9. Broken arm (n = 6): mean 8.28, sd 0.88
  10. Broken leg (n = 6): mean 7.33, sd 2.02
  11. Work failure (n = 6): mean 5.88, sd 3.57

(Note: the very high variance for kidney stones and migraine is partly explained by the presence of some very low responses, with values as low as 1.1/10 – perhaps misreported, or perhaps illustrating the extreme diversity of experiences of migraines and kidney stones).

And for pleasure:

  1. Falling in love (n = 42): mean 8.68, sd 1.74
  2. Children born (n = 41): mean 9.19, sd 1.64
  3. Marriage (n = 21): mean 8.7, sd 1.25
  4. Sex (n = 19): mean 8.72, sd 1.45
  5. College graduation (n = 13): mean 7.73, sd 1.4
  6. Orgasm (n = 11): mean 8.24, sd 1.63
  7. Alcohol (n = 8): mean 6.84, sd 1.59
  8. Vacation (n = 6): mean 9.12, sd 0.73
  9. Getting job (n = 6): mean 7.22, sd 1.47
  10. Personal favorite sports win (n = 6): mean 8.17, sd 1.23

Deference Graph of Top Experiences

We will now finally get to the more exploratory and fun/interesting analysis, at least in that it will generate a cool way of visualizing what causes people great joy and pain. Namely, the idea of using people’s rankings in order to populate a global scale across people and show it in the form of a graph of deferences. While the scientific literature has some studies that compare pain across different categories (e.g. 1, 2, 3) I was not able to find any dataset that included actual rankings across a variety of categories. Hence why it was so appealing to visualize this.

The simplest way of graphing experience deferences is to assign a node to each experience category and add an edge between experiences with deference relationships with a weight proportional to the number of directed deferences. For example, if 4 people have said that A was better than B, and 3 people have said that B was better than A, then there will be an edge from A to B with a weight of 4 and an edge from B to A with a weight of 3. Additionally, we can then run a graph centrality algorithm such as PageRank to see where the “deferences end up pooling”.

The images below do this: the PageRank of the graph is represented with the color gradient (darker shades of green/red representing higher PageRank values for good/bad experiences). In addition, the graphs also represent the number of appearances in the dataset for each category with the size of each node:

The main problem with the approach above is that it double (triple?) counts experiences that are very common. Say that, for example, taking 5-MeO-DMT produces a consistently higher-valence feeling relative to having sex. If we only have a couple of people who report both 5-MeO-DMT and sex as their top experiences, the edge from sex to 5-MeO-DMT will be very weak, and the PageRank algorithm will underestimate the value of 5-MeO-DMT.

In order to avoid the double counting effect of commonly-reported peak experiences we can instead add edge weights on the basis of the proportion with which an experience defers to the other. Let’s say that f(a, b) means “number of times that b is reported as higher than a”. Then the proportion would be f(a, b) / (f(a, b) + f(b, a)). Now, this introduces another problem, which is that pairs of experiences that appear together very infrequently might get a very high proportion score due to a low sample size. In order to prevent this we use Laplace smoothing and modify the equation to (f(a, b) + 1) / (f(a, b) + f(b, a) + 2). Finally, we transform this proportion score from the range of 0 to 1 to the range of -1 to 1 by multiplying by 2 and subtracting one. We call this a “rebalanced smoothed proportion” w(a, b):

CodeCogsEqn

Rebalanced smoothed proportion

I should note that this is not based on any rigorous math. The equation is based on my intuition for what I would expect to see in such a graph, namely a sort of confidence-weighted strength of directionality, but I do not guarantee that this is a principled way of doing so (did I mention this is a pilot small-scale low-budget ‘to a first approximation’ study?). I think that, nonetheless, doing this is still an improvement upon merely using the raw deference counts as the edge weights. To visualize what w(a, b) looks like I graphed its values for a and b in the range of 0 to 20 (literally typing the equation into the google search bar):

To populate the graph I only use the positive edge weights so that we can run the PageRank algorithm on it. This now looks a lot more reasonable and informative as a deference graph than the previous attempts:

pleasure_97_balanced_2

Best experiences deference graph: Edge weights based on the rebalanced smoothed proportions, size of nodes is proportional to number of appearances in the dataset, and the color tracks the PageRank of the graph. Edge color based on source node.

 

pain_network_97_balanced

Worst experiences deference graph: Edge weights based on the rebalanced smoothed proportions, size of nodes is proportional to number of appearances in the dataset, and the color tracks the PageRank of the graph. Edge color based on source node.

By taking the PageRank of these graphs (calculated with NetworkX) we arrive at the following global rankings:

pleasure_pagerank_97_

PageRank of the graph of best experiences with edge weights computed with the rebalanced smoothed proportion equation

pain_pagerank_97__

PageRank of the graph of worst experiences with edge weights computed with the rebalanced smoothed proportion equation

Intuitively this ranking seems more aligned with what I’ve heard before, but I will withhold judgement on it until we have much more data.

Triadic Analysis

With a more populated deference graph we can analyze in detail the degree to which triads (i.e. sets of three experiences such that each of the three possible deferences are present in the graph) show transitivity (cf. Balance vs. Status Theory).

In particular, we should compare the prevalence of these two triads:

triad_analysis

Left: 030T, Right: 030C (source)

The triads above are 030T, which is transitive, and 030C, which is a loop. The higher the degree of agreement between people and the higher the probability of the existence of an underlying shared scale, we would expect to see more triads of the type 030T relative to 030C. That said, a simple ratio is not enough, since the expected proportion between these two triads can be an artifact of the way the graph is constructed and/or its general shape (and hence the importance of comparing against randomized graphs that preserve as many other statistical features as possible). With our graph, we noticed that the very way in which the edges were introduced generated an artifact of a very strong difference between these two types of triads:

In the case of pain there are 105 ‘030T’, and 3 ‘030C’. And for the pleasure questions there were 98 ‘030T’, and 9 ‘030C’. That said, many of these triads are the artifact of taking into account the top three experiences, which already generates a transitive triad by default when n = 1 for that particular triad of experiences. To avoid this artifact, we filtered the graph by only adding edges when a pair of experiences appeared at least twice (and discounting the edges where w(a, b) = 0). With this adjustment we got 2 ‘030T’, and 1 ‘030C’ for the pain questions, and 1 ‘030T’, and 0 ‘030C’ for the pleasure question. Clearly there is not enough data to meaningfully conduct this type of analysis. If we extend the study and get a larger sample size, this analysis might be much more informative.

Latent Trait Ratings

A final approach I tried for deriving a global ranking of experiences was to assume a latent parameter for pain or pleasure of different experiences and treating the rankings as the tournament results of participants with skill equal to this latent trait. So when someone says that an experience of sex was better than an experience of getting a new bike we imagine that “sex” had a match with “getting bike” and that “sex” won that match. If we do this, then we can import any of the many tournament algorithms that exist (such as the Elo rating system) in order to approximate the latent “skill” trait of each experience (except that here it is the “skill” to cause you pleasure or pain, rather than any kind of gaming ability).

Interestingly, this strategy has also been used in other areas outside of actual tournaments, such as deriving university rankings based on the choices made by students admitted to more than one college (see: Revealed Preference Rankings of US Colleges and Universities).

I should mention that the fact that we are asking about peak experiences likely violates some of the assumptions of these algorithms, since the fact that a match takes place is already information that both experiences made it into the top 3. That said, if the patterns of deference are very strong, this might not represent a problem.

To come up with this tournament-style ranking I decided to go for a state-of-the-art algorithm. The one that I was able to find and use was Microsoft Research’s algorithm called TrueSkill (which is employed to rank players in Xbox LIVE). According to their documentation, to arrive at a conservative “leaderboard” that balances the estimated “true skill” and the uncertainty around it, they recommend ranking by the expected skill level minus three times the standard error around this estimate. If we do this, we arrive at the following experience “leaderboards”:

pleasure_97_trueskill_conservative

Conservative TrueSkill scores for best experiences (mu – 3*sigma)

pain_97_trueskill_conservative

Conservative TrueSkill scores for worst experiences (mu – 3*sigma)

Long-tails in Responses to “How Many Times Better/Worse” Question

The survey included four questions aimed at comparing the relative hedonic values of peak experiences: “Relative to the 1st most pleasant experience, how many times better was the 2nd most pleasant experience?” (This was one, the other three were the permutations of also asking about 2nd vs. 3rd and about the bad experiences):

(Note: I’ll ignore the responses to the comparison between the 2nd and 3rd worst pains because I messed up the question -I forgot to substitute “better” for “worse”).

I would understand the skepticism about these graphs. But at the same time, I don’t think it is absurd that for many people the worst experience they’ve had is indeed 10 or 100 times worse than the second worst. For example, someone who has endured a bad Cluster Headache will generally say that the pain of it is tens or hundreds of times worse than any other kind of pain they have had (say, breaking a bone or having skin burns).

The above distributions suggest a long-tail for the hedonic quality of experiences: say that the hedonic quality of each day is distributed along a log-normal distribution. A 45 year old has experienced roughly 17,000 days. Let’s say that such a person’s experience of pain each day is sampled from a log-normal distribution with a Gaussian exponent with a mean of 10 and a standard deviation of 5. If we take 100 such people, and for each of them we take the single worst and the second worst days of their lives, and then take the ratio between them, we will have a distribution like this (simulated in R):

If you smooth the empirical curves above you would get a distribution that looks like these simulations. You really need a long-tail to be able to get results like “for 25% of the participants the single worst experience was at least 4 times as bad as the 2nd worst experience.” Compare that to the sort of pattern that you get if the distribution was normal rather than log-normal:

As you can see (zooming in on the y-axis), the ratios simply do not reach very high values. With the normal distribution simulated here, we see that the highest ratio we achieve is around 1.3, as opposed to the empirical ratios of 10+.*** If you are inclined to believe the survey responses- or at least assign some level of credibility to the responses in the 90th-percentile and below-, the data is much more consistent with a long-tail distribution for hedonic values relative to a normal distribution.

Discussion

Key Pleasures Surfaced

Birth of children

I have heard a number of mothers and father say that having kids was the best thing that ever happened to them. The survey showed this was a very strong pattern, especially among women. In particular, a lot of the reports deal with the very moment in which they held their first baby in their arms for the first time. Some quotes to illustrate this pattern:

The best experience of my life was when my first child was born. I was unsure how I would feel or what to expect, but the moment I first heard her cry I fell in love with her instantly. I felt like suddenly there was another person in this world that I cared about and loved more than myself. I felt a sudden urge to protect her from all the bad in the world. When I first saw her face it was the most beautiful thing I had ever seen. It is almost an indescribable feeling. I felt like I understood the purpose and meaning of life at that moment. I didn’t know it was possible to feel the way I felt when I saw her. I was the happiest I have ever been in my entire life. That moment is something that I will cherish forever. The only other time I have ever felt that way was with the subsequent births of my other two children. It was almost a euphoric feeling. It was an intense calm and contentment.

—————

I was young and had a difficult pregnancy with my first born. I was scared because they had to do an emergency c-section because her health and mine were at risk. I had anticipated and thought about how the moment would be when I finally got to hold my first child and realize that I was a mother. It was unbelievably emotional and I don’t think anything in the world could top the amount of pleasure and joy I had when I got to see and hold her for the first time.

—————

I was 29 when my son was born. It was amazing. I never thought I would be a father. Watching him come into the world was easily the best day of my life. I did not realize that I could love someone or something so much. It was at about 3am in the morning so I was really tired. But it was wonderful nonetheless.

—————

I absolutely loved when my child was born. It was a wave of emotions that I haven’t felt by anything before. It was exciting and scary and beautiful all in one.

No luck for anti-natalists… the super-strong drug-like effects of having children will presumably continue to motivate most humans to reproduce no matter how strong the ethical case against doing so may be. Coming soon: a drug that makes you feel like “you just had 10,000 children”.

Falling in Love

The category of “falling in love” was also a very common top experience. I should note that the experiences reported were not merely those of “having a crush”, but rather, they typically involved unusually fortunate circumstances. For instance, a woman reported being friends with her crush for 7 years. She thought that he was not interested in her, and so she never dared to confess her love for him… until one day, out of the blue, he confessed his love for her. Other experiences of falling in involve chance encounters with childhood friends that led to movie-deserving romantic escapades, forbidden love situations, and cases where the person was convinced the lover was out of his or her league.

Travel/Vacation

The terms “travel” and “vacation” may sound relatively frivolous in light of some of the other pleasures listed. That said, these were not just any kind of travel or vacation. The experiences described do seem rather extraordinary and life-changing. For example, talking about back-packing alone in France for a month, biking across the US with your best friend, or a long trip in South East Asia with your sibling that goes much better than planned.

MDMA/LSD/Psilocybin

It is significant that out of 97 people four of them listed MDMA as one of the most pleasant experiences of their lives. This is salient given the relatively low base rate of usage of this drug (some surveys saying about 12%, which is probably not too far off from the base rate for Mechanical Turk workers using MDMA). This means that a high percentage of people who have tried MDMA will rate it as as one of their top experiences, thus implying that this drug produces experiences sampled from an absurdly long-tailed high-valence distribution. This underscores the civilizational significance of inventing a method to experience MDMA-like states of consciousness in a sustainable fashion (cf. Cooling It Down To Partying It Up).

Likewise, the appearance of LSD and psilocybin is significant for the same reason. That said, measures of the significance of psychedelic experiences in psychedelic studies have shown that a high percentage of those who experience such states rate them among their top most meaningful experiences.

About-two-thirds-of-participants-who-received-psilocybin-reported-a-mystical-experience

Games of Chance Earnings

Four participants mentioned earnings in games of chance. These cases involved earning amounts ranging from $2,000 all the way to a truck (which was immediately sold for money). What I find significant about this is that these experiences are at times ranked above “college graduation” and other classically meaningful life moments. This brings about a crazy utilitarian idea: if indeed education is as useless as many people in the intellectual elite are saying these days (ex. The Case Against Education) we might as well stop subsidizing higher education and instead make people participate in opt-out games of chance rigged in their favor. Substitute the Department of Education for a Department of Lucky Moments and give people meaningful life experiences at a fraction of the cost.

Key Pains Surfaced

Kidney Stones and Migraines

The fact that these two medical issues were surfaced is, I think, extremely significant. This is because the lifetime incidence of kidney stones is about 10% (~13% for men, 7% for women) and for migraines it is around 13% (9% for men, 18% for women). In the survey we saw 9/93 people mentioning kidney stones, and the same number of people mentioning migraines. In other words, there is reason to believe that a large fraction of the people who have had either of these conditions will rate them as one of their top 3 most painful experiences. This fact alone underscores the massive utilitarian benefit that would come from being able to reduce the incidence of these two medical problems (luckily, we have some good research leads for addressing these problems at a large scale and in a cost-effective way: DMT for migraines, and frequency specific microcurrent for kidney stones)

Childbirth

Childbirth was mentioned 16 times, meaning that roughly 30% of women rate it as one of their three most painful experiences. While many people may look at this and simply nod their heads while saying “well, that’s just life”, here at Qualia Computing we do not condone that kind of defeatism and despicable lack of compassion. As it turns out, there are fascinating research leads to address the pain of childbirth. In particular, Jo Cameron, a 70 year old vegan schoolteacher, described her childbirth by saying that it “felt like a tickle”. She happens to have a mutation in the FAAH gene, which is usually in charge of breaking down anandamine (a neurotransmitter implicated in pain sensitivity and hedonic tone). As we’ve argued before, every child is a complete genetic experiment. In the future, we may as well try to at least make educated guesses about our children’s genes associated with low mood, anxiety, and pain sensitivity. In defiance of common sense (and the Bible) the future of childbirth could indeed be one devoid of intense pain.

Car accidents

Car accidents are extremely common (the base rate is so high that by the age of 40 or so we can almost assume that most people have been in at least one car accident, possibly multiple). More so, it seems likely that the health-damaging effects of car accidents, by their nature, follow a long-tail distribution. The high base rate of people mentioning car accidents in their top 3 most painful experiences underscores the importance of streamlining the process of transitioning into the era of self-driving cars.

Death of Father and Mother

This one does not come as a surprise, but what may stand out is the relatively higher frequency of mentions of “death of father” relative to “death of mother”. I think this is an artifact of the longevity difference between men and women. This is in agreement with the observed effect of age: about 15% vs. 25% of people under and over 40 had mentioned the death of their father, as opposed to a difference of 5% vs. 25% for death of mother. The reason why the father might be over-represented might simply be due to the lower life expectancy of men relative to women, and hence the father, on average, dying earlier. Thus, it being reported more frequently by a younger population.

Future Directions for Methodological Approaches:

Graphical Models with Log-normal Priors

After trying so many analytic angles on this dataset, what else is there to do? I think that as a proof of concept the analysis presented here is pretty well-rounded. If the Qualia Research Institute does well in the funding department, we can expect to extend this pilot study into a more comprehensive analysis of the pleasure-pain axis both in the general population and among populations who we know have endured or enjoyed extremes of valence (such as cluster headache sufferers or people who have tried 5-MeO-DMT).

In terms of statistical models, an adequate amount of data would enable us to start using probabilistic graphical models to determine the most likely long-tail distributions for all of the key parameters of pleasure and pain. For instance, we might want to develop a model similar to Item Response Theory where:

  1. Each participant samples experiences from a distribution.
  2. Each experience category generates samples with an empirically-determined base rate probability (e.g. chances that it happens in a given year), along with a latent hedonic value distribution.
  3. A “discrimination function” f(a, b) that gives the probability that experience of hedonic value a is rated as more pleasant (or painful) relative an experience with a hedonic value of b.
  4. And a generative model that estimates the likelihood of observing experiences as the top 3 (or top x) based on the parameters provided.

In brief, with an approach like the above we can potentially test the model fit for different distribution types of hedonic values per experience. In particular, we would be able to determine if the model fit is better if the experiences are drawn from a Gaussian vs. a log-normal (or other long-tailed) distribution.

Finally, it might be fruitful to explicitly ask about whether participants have had certain experiences in order to calibrate their ratings, or even have them try a battery of standardized pain/pleasure-inducing stimuli (capsaicin extract, electroshocks, stings, massage, orgasm, etc.). We could also find the way to combine (a) the numerical ratings, (2) the ranking information, and (3) the “how many times better/worse” responses into a single model. And for best results, restrict the analysis to very recent experiences in order to reduce recall biases.

Closing Thoughts on the Valence Scale

To summarize, I believe that the case for a long-tail account of the pleasure-pain axis is very defensible. This picture is supported by:

  1. The long-tailed nature of neuronal cascades,
  2. The phenomenological accounts of intense pleasure and pain (w/ phenomenological accounts of time and space expansion),
  3. The way in which pain scales are constructed by those who developed them, and
  4. The analytic results of the pilot study we conducted and presented here.

In turn, these results give rise to a new interpretation of psychophysical observations such as Weber’s Law. Namely, that Just Noticeable Differences may correspond to geometric differences in qualia, not only in sensory stimuli. That is, that the exponential nature of many cases where Weber’s Law appears are not merely the result of a logarithmic compression on the patterns of stimulation at the “surface” of our sense organs. Rather, the observations presented here suggest that these long-tails deal directly with the quality and intensity of conscious experience itself.


Additional Material

Dimensionality of Pleasure and Pain

Pain and pleasure may have an intrinsic “dimensionality”. Without elaborating, we will merely state that a generative definition for the “dimensionality of an experience” is the highest “virtual dimension” implied by the patterns of correlation between degrees of freedom. The hot pepper hands account I related suggested a kind of dimensional phase transition between 4/10 and 5/10 pain, where the patterns of a certain type (4/10 “sparks” of pain) would sometimes synchronize and generate a new type of higher-dimensional sensation (5/10 “solitons” of pain). To illustrate this idea further:

First, in Hot Ones, Kumail Nanjiani describes several “leaps” in the spiciness of the wings, first at around 30,000 Scoville (“this new ghost that appears and only here starts to visit you”), and second at around 130k Scoville (paraphrasing: “like how NES to Super Nintendo felt like a big jump, but then Super Nintendo to N64 was an even bigger leap” – “Now we are playing in the big leagues motherfucker! This is fucking real!”). This hints at a change in dimensionality, too.

And second, Shinzen Young‘s advice about dealing with pain involves not resisting it. He discusses how suffering is generated by the coordination between emotional, cognitive, and physical mental formations. If you can keep each of these mental formations happening independently and don’t allow their coordinated forms, you will avoid some of what makes the experience bad. This also suggests that higher-dimensional pain is qualitatively worse. Pragmatically, training to do this may make sense for the time being, since we are still some years away from sustainable pain-relief for everyone.

Mixed States

We have yet to discuss in detail how mixed states come into play for a log-normal valence scale. The Symmetry Theory of Valence would suggest that most states are neutral in nature and that only processes that reduce entropy locally such as neural annealing would produce highly-valenced states. In particular, we would see that high-valence states have very negative valence states nearby in configuration space; if you take a very good high-energy state and distort it in a random direction it will likely feel very unpleasant. The points in between would be mixed valence, which account for the majority of experiences in the wild.

Qualia Formalism

Qualia Formalism posits that for any given system that sustains experiences, there is a mathematical object such that the mathematical features of that object are isomorphic to the system’s phenomenology. In turn, Valence Structuralism posits that the hedonic nature of experience is encoded in a mathematical feature of this object. It is easier to find something real if you posit that it exists (rather than try to explain it away). We have suggested in the past that valence can be explained in terms of the mathematical property of symmetry, which cashes out in the form of neural dissonance and consonance.

In contrast to eliminativist, illusionist, and non-formal approaches to consciousness, at QRI we simply start by assuming that experience has a deep ground truth structure and we see where we can go from there. Although we currently lack the conceptual schemes, science, and vocabulary needed to talk in precise terms about different degrees of pleasure and pain (though we are trying!), that is not a good reason to dismiss the first-person claims and indirect pieces of evidence concerning the true amounts of various kinds of qualia bound in each moment of experience. If valence does turn out to intrinsically be a mathematical feature of our experience, then both its quality and quantity could very well be precisely measurable, conceptually crisp, and tractable. A scientific fact that, if proven, would certainly have important implications in ethics and meta-ethics.


Notes:

* It’s a shame that Coyote Peterson didn’t rate the pain produced by the various wings he ate on the Hot Ones show relative to insect stings, but that sort of data would be very helpful in establishing a universal valence scale. More generally, stunt-man personalities like the L.A. Beast who subject themselves to extremes of negative valence for Internet points might be an untapped gold mine for experience deference data (e.g. How does eating the most bitter substance known compare with the bullet ant glove? Asking this guy might be the only way to find out, without creating more casualties).

**Base rate of mentions of worst experiences:

[('Father death', 19), ('Childbirth', 16), ('Grandmother death', 13), ('Mother death', 11), ('Car accident', 9), ('Kidney stone', 9), ('Migraine', 9), ('Romantic breakup', 9), ('Broken arm', 6), ('Broken leg', 6), ('Work failure', 6), ('Divorce', 5), ('Pet death', 5), ('Broken foot', 4), ('Broken ankle', 4), ('Broken hand', 4), ('Unspecified', 4), ('Friend death', 4), ('Sister death', 4), ('Skin burns', 3), ('Skin cut needing stitches', 3), ('Financial ruin', 3), ('Property loss', 3), ('Sprained ankle', 3), ('Gallstones', 3), ('Family breakup', 3), ('Divorce of parents', 3), ('C-section recovery', 3), ('Love failure', 2), ('Broken finger', 2), ('Unspecified fracture', 2), ('Broken ribs', 2), ('Unspecified family death', 2), ('Broken collarbone', 2), ('Grandfather death', 2), ('Unspecified illness', 2), ('Period pain', 2), ('Being cheated', 2), ('Financial loss', 2), ('Broken tooth', 2), ('Cousin death', 2), ('Relative with cancer', 2), ('Cluster headache', 2), ('Unspecified leg problem', 2), ('Root canal', 2), ('Back pain', 2), ('Broken nose', 2), ('Aunt death', 2), ('Wisdom teeth', 2), ('Cancer (eye)', 1), ('Appendix operation', 1), ('Dislocated elbow', 1), ('Concussion', 1), ('Mono', 1), ('Sexual assault', 1), ('Kidney infection', 1), ('Hemorrhoids', 1), ('Tattoo', 1), ('Unspecified kidney problem', 1), ('Unspecified lung problem', 1), ('Unspecified cancer', 1), ('Unspecified childhood sickness', 1), ('Broken jaw', 1), ('Broken elbow', 1), ('Thrown out back', 1), ('Lost sentimental item', 1), ('Abortion', 1), ('Ruptured kidney', 1), ('Big fall', 1), ('Torn knee', 1), ('Finger hit by hammer', 1), ('Injured thumb', 1), ('Brother in law death', 1), ('Knocked teeth', 1), ('Unspecified death', 1), ('Ripping off fingernail', 1), ('Personal anger', 1), ('Wrist pain', 1), ('Getting the wind knocked out', 1), ('Blown knee', 1), ('Burst appendix', 1), ('Tooth abscess', 1), ('Tendinitis', 1), ('Altruistic frustration', 1), ('Leg operation', 1), ('Gallbladder infection', 1), ('Broken wrist', 1), ('Stomach flu', 1), ('Running away from family', 1), ('Child beating', 1), ('Sinus infection', 1), ('Broken thumb', 1), ('Family abuse', 1), ('Miscarriage', 1), ('Tooth extraction', 1), ('Feeling like your soul is lost', 1), ('Homelessness', 1), ('Losing your religion', 1), ('Losing bike', 1), ('Family member in prison', 1), ('Crohn s disease', 1), ('Irritable bowel syndrome', 1), ('Family injured', 1), ('Unspecified chronic disease', 1), ('Fibromyalgia', 1), ('Blood clot in toe', 1), ('Infected c-section', 1), ('Suicide of lover', 1), ('Dental extraction', 1), ('Unspecified partner abuse', 1), ('Infertility', 1), ('Father in law death', 1), ('Broken neck', 1), ('Scratched cornea', 1), ('Swollen lymph nodes', 1), ('Sun burns', 1), ('Tooth ache', 1), ('Lost custody of children', 1), ('Unspecified accident', 1), ('Bike accident', 1), ('Broken hip', 1), ('Not being loved by partner', 1), ('Dog bite', 1), ('Broken skull', 1)]

Base rate of mentions of best experiences:

[('Falling in love', 42), ('Children born', 41), ('Marriage', 21), ('Sex', 19), ('College graduation', 13), ('Orgasm', 11), ('Alcohol', 8), ('Vacation', 6), ('Getting job', 6), ('Personal favorite sports win', 6), ('Nature scene', 5), ('Owning home', 5), ('Sports win', 4), ('Graduating highschool', 4), ('MDMA', 4), ('Getting paid for the first time', 4), ('Amusement park', 4), ('Game of chance earning', 4), ('Job achievement', 4), ('Getting engaged', 4), ('Cannabis', 3), ('Eating favorite food', 3), ('Unexpected gift', 3), ('Moving to a better location', 3), ('Travel', 3), ('Divorce', 2), ('Gifting car', 2), ('Giving to charity', 2), ('LSD', 2), ('Won contest', 2), ('Friend reunion', 2), ('Winning bike', 2), ('Kiss', 2), ('Pet ownership', 2), ('Children', 1), ('First air trip', 1), ('First kiss', 1), ('Public performance', 1), ('Hugs', 1), ('Unspecified', 1), ('Recovering from unspecified kidney problem', 1), ('College party', 1), ('Graduate school start', 1), ('Financial success', 1), ('Dinner with loved one', 1), ('Feeling supported', 1), ('Children graduates from college', 1), ('Family event', 1), ('Participating in TV show', 1), ('Psychedelic mushrooms', 1), ('Opiates', 1), ('Having own place', 1), ('Making music', 1), ('Becoming engaged', 1), ('Theater', 1), ('Extreme sport', 1), ('Armed forces graduation', 1), ('Birthday', 1), ('Positive pregnancy test', 1), ('Feeling that God exists', 1), ('Belief that Hell does not exist', 1), ('Getting car', 1), ('Academic achievement', 1), ('Helping others', 1), ('Meeting soulmate', 1), ('Daughter back home', 1), ('Winning custody of children', 1), ('Friend stops drinking', 1), ('Masturbation', 1), ('Friend not dead after all', 1), ('Child learns to walk', 1), ('Attending wedding of loved one', 1), ('Children safe after dangerous situation', 1), ('Unspecified good news', 1), ('Met personal idol', 1), ('Child learns to talk', 1), ('Children good at school', 1)]

For clarity – “Personal favorite sports win” means that the respondent was a participant in the sport as opposed to a spectator (which was labeled as “Sports win”). The difference between “Sex” and “Orgasm” is that Sex refers to the entire act including foreplay and cuddles whereas Orgasm refers to the specific moment of climax. For some reason people would either mention one or the other, and emphasize very different aspects of the experience (e.g. intimacy vs. physical sensation) so I decided to label them differently.

*** It is possible that some fine-tuning of parameters could give rise to long-tail ratios even with a normal distribution (especially if the mean is, say, a negative value and the standard deviation is very wide). But in the general case a normal distribution will have a fairly narrow range for the ratios of the “top value divided by the second top value”. So at least as a general qualitative argument, I think, the simulations do suggest a long-tailed nature for the reported hedonic values.

Treating Cluster Headaches Using N,N-DMT and Other Tryptamines

by Quintin Frerichs

To extend this recent EA Forum Post, I wanted to share the results of Qualia Research Institute’s research into using tryptamines to abort and prevent cluster headaches. While the quotes and statistics contained here can provide some notion of the pain experienced by cluster headache sufferers, I think it is truly unimaginable. This report contains specific interventions to be pursued in both a philanthropic and for-profit business capacity. While for-profit options are beyond our scope, those interested in supporting philanthropic interventions should consider donating to ClusterBusters (the most important nonprofit dedicated to researching treatments for cluster headaches), or QRI (which does foundational research on ways to reduce intense suffering).

Mission: Instantly and safely abort cluster headaches and treat migraines, the #2 and #10 (respectively) most painful medical conditions according to NHS. Emphasis is placed on chronic cluster headaches, which account for as much as 80% of all clusters and currently lack an effective treatment option. 


 

I. Problem:

 

“Even child birth is 1/10th the pain of a cluster headache, seriously this name needs to change… call it ultra super migraine.” (source)

  • A back of the envelope calculation indicates there are roughly 14 thousand people enduring a cluster headache right now.[1]
  • 14.2% of US adults 18 or older reported having migraine or severe headache in the previous 3 months in the 2012 NHIS. The overall age-adjusted 3-month prevalence of migraine in females was 19.1% and in males 9.0%, but varied substantially depending on age. (source)
  • Current treatments are either ineffective, costly, unsafe, or some combination of the three. The most effective treatments available for cluster headaches include oxygen, which requires the patient to carry an oxygen tank with them at all times, and triptans, which can be used a maximum of three times daily (an issue for chronic sufferers especially) and have side effects from pain to heart attack and stroke. The most effective treatments for migraines include triptans and opioids (which have high addiction potential). Emgality, a more promising treatment for episodic cluster headaches, has recently entered the market, but its long-term risk profile and efficacy have not yet been established. 
  • Bob Wold founded “Cluster Busters” in 2002 with the explicit purpose of trying to get psychedelics to be prescription medication (see his lecture Treating Cluster Headaches with Psychedelics). He tried over 75 different prescription medications and was at the end of the rope when he found psychedelics could be helpful:
  • As noted in this Qualia Computing article, the survey surfaced that about 83% of all cluster headaches are experienced by 20% of the sufferers, most of which are classified as ‘chronic’. No existing medication has been approved for use to treat chronic cluster headaches. Vaporizing DMT could be the first such treatment, offering instant relief for cluster headaches as often as they arise in a (potentially large) percentage of sufferers.

 

II. Solution:

One of the most incredible experiences of my life was when I first aborted a CH [cluster headache] with DMT. That feeling of going from a place of excruciating pain…and feeling the pain fizzle away and die in a matter of seconds” (source)

It is known by a majority of cluster headache sufferers that psychedelics can be highly effective treatments. Due to the legal status of psychedelics, no randomized controlled trial (RCT) has been conducted, but analysis has been done on online forum responses and anonymous surveys, and interviews have been recorded. Evidence from these reports points to a number of important factors: tryptamines (the class of psychedelics which includes compounds like N,N-DMT and psilocybin, the active chemical in ‘magic mushrooms’) seem especially effective, sub-psychoactive and non-psychedelic doses can be therapeutic, and psychedelics can also decrease the frequency of headaches on long time horizons. While smoking/vaporizing is the fastest method of administration available, information from a private correspondence suggests that the FDA may be averse to approving inhalants. Intramuscular administration, utilizing Rick Strassman’s protocol, could be an alternative that would achieve rapid relief without the use of an inhalation device[2]. Since the pain being experienced is so severe, having a faster method of administration is critical. 

From the relevant academic literature:

  • The indoleamine hallucinogens, psilocybin, lysergic acid diethylamide, and lysergic acid amide, were comparable to or more efficacious than most conventional medications. These agents were also perceived to shorten/abort a cluster period and bring chronic cluster headache into remission more so than conventional medications.” (source)
  • Also, for DMT, it was suggested that singular or infrequent dosage could have potential long-term beneficial effects on headache disorders: ‘Even a single dose, or perhaps a couple, can be a lifelong benefit.’” (source)
  • “Of interest, an open-label study found that similar compounds (2-bromo-LSD) without psychedelic effect were promising for this purpose” (source)

From online surveys: 

  • A survey of members of online cluster headache forums revealed that 68% of respondents who used tryptamines had a 4 or 5 out of 5 relief. 5 indicates “completely eliminated the cluster headaches”. 
  • This survey again suggests that the main barrier to use is lack of access and hallucinogenic effects. As we found in an interview with an anonymous sufferer (see below), hallucinogenic effects may be avoidable. 
no_use_cluster_headache_difficulty_acquiring

Difficulty getting. 0 – Extremely easy to acquire, 5 – Nearly impossible to acquire

no_use_cluster_headache_legal_concern

Legal risk. 0 – Not concerned at all, 5 – Extremely concerned

no_use_cluster_headache_side_effect_concern

Side effects. 0 – Not concerned at all, 5 – Extremely concerned

From interviews with cluster headache sufferers who have tried N,N-DMT:


III. Philanthropic Opportunities

Due to the Schedule I status of psychedelics in the United States, pursuing this intervention in the US will not be feasible for a number of years (see Section IV for more information on pursuing FDA approval for DMT for cluster headaches/migraines). 

A possible solution would be to create an online education campaign publicizing the results of this report to cluster headache sufferers, designated as ‘information-only’, and pursuing the use of psychedelics to treat cluster headaches and migraines in countries where tryptamines are legal, including Brazil, Jamaica and the Netherlands. In addition, given the gravity of the disorder, it could be cost-effective to fly patients to such countries for months at a time.

While we believe that traditional metrics such as the QALY do not accurately capture the suffering caused by a cluster headache (see upcoming post on the true pain/pleasure scale), a rough QALY calculation would be as follows (focusing on chronic cluster headache sufferers rather than average, since they compromise up to 83% of total headaches[3]):

  1. Facebook AD campaign:
    1. An estimated 370,000 Americans suffer from cluster headaches, 68% of whom are on Facebook[4] (=251,000). About 15% of these suffer from chronic cluster headaches (=37,740). According to Sprout Social, the average estimated cost per click of an ad campaign is $1.72. Assuming 1/10 who click are cluster headache sufferers, to reach all chronic sufferers would take (ballpark) $650,000.
    2. Assuming about 30% of those who view the ad will pursue the treatment (rough estimate-those who put 2 or less on survey results for questions of legality, difficulty to acquire etc.) and that in 68% of cases it cured or nearly cured their clusters (based on survey results), then the resulting increase in QALYs would be (37,740 people * 0.3 * 0.68) * [0.760 (QALY coefficient) * 1 QALY – ( -0.429 (QALY coefficient)* (0.47QALY)) [5]] = $650,000/7, 404QALY = $87.70 per QALY.  
    3. These ads could also be targeted to users in countries where psilocybin and DMT are legal for use recreationally, increasing conversion rate. Further targeting could be done on Facebook groups (and other social media groups) which are associated with cluster headache treatment

IV. For-profit Opportunities 

The recent emergence of psychedelics in for-profit business settings also affords the opportunity for entrepreneurs to seek legal rescheduling of N,N-DMT in the US for the purpose of treating cluster headaches and/or migraines. Below is an outline of the process of navigating the FDA IND process, which could result in a change in legal status: 

Market Size:

‘Orphan disease’ status:  

There are two main classifications of cluster headaches, chronic and episodic. Episodic cluster headaches are characterized by periods of headaches (up to 8 times per day) of a week to a full year, which remit for periods from a month up to a year. Chronic cluster headaches, on the other hand, either last for longer than a year or have remittance periods of less than a month[6]. A meta-analysis from the NIH estimates that cluster headaches affect 124/100,000 in the U.S., meaning an estimated 370,000 people suffer from cluster headaches a year[7]. Of these, about 15%, or 60,000, suffer from chronic cluster headaches.

The FDA grants ‘orphan disease’ status to diseases which affect fewer than 200,000 persons in the U.S per year, and offers incentives to those pursuing treatments through the FDA’s IND process for such diseases, such as longer periods of exclusivity (monopoly on drug manufacture and sale) for the treatment after approval.  

  • The global market for migraine drugs (which encompasses cluster headache drugs) in 2017 was $1.7 billion.
    • Healthcare and lost productivity costs associated with migraine are estimated to be as high as $36 billion annually in the U.S. Current estimates of cluster headaches’ annual cost in the U.S. is ~$3.5 billion.
  • Share of market
    • 5 years after launch (with FDA approval, with a 5-year monopoly) – serve 20% of chronic migraine sufferers (800,000), serve 20% of cluster headache sufferers (40,000)
      • Platform’s average annual revenue per patient (migraines): $452/patient/year
        • Tryptapens – $20
        • 1g of DMT is ~$100, approximately 50 doses (although an anecdote indicate 3mg may be sufficient). Compare to triptans, at ~$115 per 9 doses. Assuming 20% markup: 
          • Chronic migraines at 20mg doses: $120/g*0.02g/dose*15 doses/month *12 months = $432/patient/year.
      • Platform’s average annual revenue per patient (cluster headache): $344/patient/year-low estimate, $6932/patient/year – high estimate
        • Tryptapen – $20
        • There is significant variance in frequency of cluster headaches: estimates range from [$120/g*0.02g/dose*30 doses/month *3 months = $324, $120/g*0.02g/dose*120 doses/month*12 months = $6912/patient/year].
      • Annual revenue, 5 years after launch: $13.6M [low cluster headache estimate] – $344M [high cluster headache estimate]
      •  Annual revenue, 5 years after launch (migraines): $344M 
    • The 5-year (or more, if ‘orphan disease’ status is gained) monopoly provided by the FDA would allow for further R&D, and as-yet undetermined projects. Some promising directions:

Why now?

  • FDA on track to approve MDMA therapy in 2021, psilocybin therapy in 2022
    1. FDA approval will catalyze a large increase in demand for psychedelic services
    2. There is sufficient evidence to attempt bringing DMT for headaches through the FDA process as it becomes increasingly open to psychedelic interventions
  • Reasons to start before FDA approval of MDMA and psilocybin:
    1. A “psychedelic renaissance” is underway: funding for psychedelic research has skyrocketed, and multiple psychedelic decriminalization initiatives (1, 2) have recently passed. Riding the current wave of activist and public support is advantageous to our efforts. 
    2. More time to build relationship with the FDA (important for seeking DMT clearance)
    3. More time to build relationships with organizations currently seeking FDA approval for therapeutic uses of psychedelics (MAPS & Compass Pathways)

Challenges: 

Regulatory:

  • Taking on the FDA IND process can be challenging and high risk from an investment standpoint. The average cost of successfully completing Phase 1-3 trials (after which the drug can be rescheduled and approved for medical use) is $100m, requires about 9-11 years and has a 6.7% success rate (private correspondence). 
    • The Multidisciplinary Association for Psychedelic Studies (MAPS) has recently raised $26.7M for Phase 3 MDMA trials alone[8]. Total, MAPS has spent in the ballpark of $30M. If Phase 3 trials demonstrate statistically-significant results, MDMA could be selectively rescheduled for use in therapeutic settings, but would require subsequent Phase 4 trials. 
  • The FDA is risk-averse and has incurred backlash from their last notable rescheduling of fentanyl in 1985[9]. Convincing the FDA to pursue rescheduling for treatment of a relatively rare disease with other available medications will likely be difficult. 
  • The success or failure of MAPS in receiving approval for MDMA will be crucial for defining the regulatory landscape for other psychedelics. Should they fail, bringing another similar substance through the process may prove much more difficult. 

Competition: 

  • As discussed in Section I, most available migraine and cluster headache drugs are ineffective, expensive, and/or have heavy risk profiles. Emgality, a new migraine drug approved last month, has received FDA ‘breakthrough therapy’ status for its ability to decrease the frequency of episodic cluster headaches and has shown promise as a palliative for migraines as well[10]. Emgality has not been approved for use in treating chronic cluster headaches, however, and does not achieve the same rapidity of administration as the DMT vape pen (see Section III). Thus, our solution is still critical for relieving symptoms instantly, and maintains the advantage of being eligible to treat chronic cluster headaches, an ‘orphan disease’. 

Business model: 

  • We would design studies to fulfill the three-step FDA drug review process:
    1. Phase 1 studies (typically involve 20 to 80 people).
    2. Phase 2 studies (typically involve a few dozen to about 300 people).
    3. Phase 3 studies (typically involve several hundred to about 3,000 people).

Use of Funds

  • Expenses for research and operations staff
    • Technicians 
    • Analysis consultants
    • Researchers with clinical experience
    • Legal counsel (paperwork)
  • Phase 1 FDA trial (our connections to expertise in the field would reduce the cost compared to average Phase 1 trials)

Data on Cost of Trials

The following information is from the MDMA/PTSD Trials led by MAPS. However, the treatment for PTSD involves: multiple therapy sessions and an MDMA-trained psychotherapist. Therapy sessions also last 6-8 hours. Presumably, some of these costs would not apply to a DMT/CH trial, so we expect trials for DMT/CH to be cheaper than the MDMA/PTSD Trials.

However, cluster headaches are not well suited to the therapeutic environment that is used to treat mental health conditions (they arise unpredictably, and require instant relief). This means there are likely significant cost-saving opportunities in the experimental design protocol.  

Summary of costs for MAPS IND Process:

Screen Shot 2019-06-06 at 12.34.09 AM


[1] Assume a world population of 7.7 billion people, and 53 out of 100,000 yearly prevalence suffering from this. Going by public health records, we see that the average number of cluster headache attacks that a sufferer experiences is about 30 a year (with a huge variance, where some people get only about 5 a year and some get them multiple times a day). Attacks last on average 1 hour (but range from 20 minutes to 3 hours). Hence, the number of people currently experiencing a CH is: 0.00053*7,700,000,000*(30/(24*365)) = 13,976.03 ~= 14 thousand

[2] Perspectives on DMT Research

[3] According to survey

[4] https://www.facebook.com/business/help/1461718327429941

[5]  For chronic sufferers, an average of between 1-8 CH per day, 1-4 hours per CH, for ~0.47 years/year having CH

[6] https://www.mayoclinic.org/diseases-conditions/cluster-headache/symptoms-causes/syc-20352080

[7] https://www.ncbi.nlm.nih.gov/pubmed/18422717

[8] https://maps.org/research/mdma/ptsd/phase3/timeline

[9] https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf

[10] https://investor.lilly.com/news-releases/news-release-details/fda-approves-emgalityr-galcanezumab-gnlm-first-and-only

Triple S Genetic Counseling: Predicting Hedonic-Set Point with Commercial-Grade DNA Testing as an Effective Altruist Project

The term “Transhumanism” has many senses. It is a social movement, a philosophy, a set of technologies, and a conceptual rallying flag. David Pearce pins down the core sentiment behind the term like this:

If we get things right, the future of life in the universe can be wonderful beyond the bounds of human imagination: a “triple S” civilisation of superlongevity, superintelligence and superhappiness.

– David Pearce, in The 3 Supers

The concept of a “triple S” civilization is very widely applicable. For example, one can imagine future smart homes designed with it in mind. Such smart homes would have features to increase your longevity (HEPA filters, humidity control, mold detectors, etc.), increase your intelligence (adaptive noise-canceling, optimal lighting, smart foods), and happiness (mood-congruent lighting, music, aromas, etc.). Since there are trade-offs between these dimensions, one could specify how much one values each of them in advance, and the smart home would be tasked with maximizing a utility function based on a weighted average between the three S’s.

Likewise, one could apply the “triple S” concept to medical care, lifestyle choices, career development, governance, education, etc. In particular, one could argue that a key driver for the realization of a triple S civilization would be what I’d like to call “triple S genetic counseling.” In brief, this is counseling for prospective parents in order to minimize the risks of harming one’s children by being oblivious to the possible genetic risk for having a reduced longevity, intelligence, or happiness. Likewise, in the more forward-looking transhumanist side of the equation, triple S genetic counseling would allow parents to load the genetic dice in their kid’s favor in order to make them as happy, long-lived, and smart as possible.

Genetic counseling, as an industry, is indeed about to explode (cf. Nature’s recent article: Prospective parents should be prepared for a surge in genetic data). Predictably, there will be a significant fraction of society that will question the ethics of e.g. preimplantation genetic diagnosis for psychological traits. In practice, parents who are able to afford it will power ahead, for few prospective parents truly don’t care about the (probabilistic) well-being of their future offspring. My personal worry is not so much that this won’t happen, but that the emphasis will be narrow and misguided. In particular, both predicting health and intelligence based on sequenced genomes are very active areas of research. I worry that happiness will be (relatively) neglected. Hence the importance of emphasizing all three S’s.

In truth, I think that predicting the hedonic set-point of one’s potential future kids (i.e. the average level of genetically-determined happiness) is a relatively more important project than predicting IQ (cf. A genome-wide association study for extremely high intelligenceBGI). In addition, I anticipate that genetic-based models that predict a person’s hedonic set-point will be much more accurate than those that predict IQ. As it turns out, IQ is extremely polygenetic, with predictors diffused across the entire genome, and it is a very evolutionary recent axis of variance across the population. Predictors of hedonic-set point (such as the “pain-knob gene” SCN9A and it’s variants), on the other hand, are ancient and evolutionarily preserved across the phylogenetic tree. This makes baseline happiness a likely candidate for having a straight-forward universal physiological implementation throughout the human population. Hence my prediction that polygenetic scores of hedonic-set point will be much more precise than those for IQ (or even longevity).

Given all of the above, I would posit that a great place to start would be to develop a model that predicts hedonic set-point using all of the relevant SNPs offered by 23andMe*.  Not only would this be “low-hanging fruit” in the field of genetic counseling, it may also be a project that is way up there, close to the top of the “to do” list in Effective Altruism (cf. Cause X; Google Hedonics).

I thought about this because I saw that 23andMe reports on health predispositions based on single SNPs. From a utilitarian point of view, of particular interest are SNPs related to the SCN9A gene. For example, I found that 23andMe has the rs6746030 SNP, which some studies show can account for a percentage of the variance associated with pain in Parkinson’s and other degenerative diseases. The allele combination A/A is bad, making you more prone to experience pain intensely. This is just one SNP, though, and there ought to be a lot of other relevant SNPs, not only of the SCN9A gene but elsewhere too (e.g. involved in MAO enzymes, neuroplasticity, and pleasure centers innervation).

Concretely, the task would involve making two models and then combining them:

The first model uses people’s responses to 23andMe surveys to come up with a good estimate of a person’s hedonic set-point. Looking at some of the questions they ask, I would argue that there are more than enough dimensions to model how people vary in their hedonic set-point. They ask about things such as perception of pain, perception of spiciness, difficulty sleeping, stress levels, whether exercise is pleasant, etc. From a data science point of view, the challenge here is that number of responses provided by each participant is very variable; some power users respond to every question (and there are hundreds and hundreds), while most people respond to a few questions only, and a substantial minority respond to no questions at all. Most likely, the distribution of responses per participant follows a power law. So the model to build here has to be resilient against absent data. This is not an insurmountable problem, though, considering the existence of Bayesian Networks, PGMs, and statistical paradigms like Item Response Theory. For this reason, the model would need to both predict the most likely hedonic set-point of each participant, and provide confidence intervals specific to the participant based on the quality and relevance of the questions answered.

The second model would involve clustering and dimensionality reduction applied to the SNPs that are likely to be relevant for hedonic set-point. For example, one dimension would likely be a cluster of SNPs that are associated with “maximum intensity of pain”, another might be “how quickly pain subsides once it’s stimulated”, another “how much does pleasure counter-balance pain”, and so on. Each of these dimensions is likely to be determined by different neural circuits, and interact in non-linear ways, so they deserve their own separate dimension.

And finally, one would make a third model that combines the two models above, which predicts the hedonic set-point of a person derived from the first model using the genetic dimensions found by the second model. If you are an up-and-coming geneticist, I would like to nudge you in the direction of looking into this. As a side effect, you might as well get filthy rich in the process, as the genetic counseling field explodes in the next decade.


Bonus Content: What About Us?

Admittedly, many people will note that predicting a fraction of the variance of people’s hedonic set point with commercial DNA testing products will only really alleviate suffering in the medium to long term. The people who will benefit from this technology haven’t been born yet. In the meantime, what do we do about the people who currently have low hedonic set-points? Here is a creative, politically incorrect, and enticing idea:

Let’s predict which recreational drugs have the best cost-benefit profile for individuals based on their genetic makeup.

It is no secret that people react differently to drugs. 23andMe, among others, is currently doing research to predict your particular reaction to a drug based on your genetic makeup (cf. 23andMe can now tell you how you’ll react to 50+ common drugs). Unfortunately for people with anxiety, depression, chronic pain, and other hedonic tone illnesses, most psychiatric drugs are rather subtle and relatively ineffective. No wonder, compared to heroin, an SSRI is not likely to make you feel particularly great. As David Pearce argued in his essay Future Opioids, there is substantial evidence that many people who become addicts are driven to take recreational substances due to the fact that their endogenous opioid system is dysfunctional (e.g. they may have bad variants of opioid receptors, too many endorphin-degrading enzymes, etc.). The problem with giving people hard drugs is not that they don’t work in the short term; it is that they tend to backfire in the long-term and have cumulative negative health effects. As an aside, from the pharmaceutical angle, my main interest is the development of Anti-tolerance Drugs, which would allow hard drugs to work as mood-enhancers indefinitely.

This is not to say that there aren’t lucky people for whom the cost-benefit ratio of taking hard drugs is, in fact, rather beneficial. In what admittedly must have been a tongue-in-cheek marketing move, in the year 2010 the genetic interpretation company Knome (now part of Tute Genomics) studied Ozzy Osbourne‘s entire genome in order to determine how on earth he has been able to stay alive despite the gobs and gobs of drugs he’s taken throughout his life. Ozzy himself:

“I was curious, [g]iven the swimming pools of booze I’ve guzzled over the years—not to mention all of the cocaine, morphine, sleeping pills, cough syrup, LSD, Rohypnol…you name it—there’s really no plausible medical reason why I should still be alive. Maybe my DNA could say why.”

Ozzy Osbourne’s Genome (Scientific American, 2010)

Tentatively, Knome scientists said, Ozzy’s capacity to drink entire bottles of Whisky and Gin combined with bowlfuls of cocaine and multiple packs of cigarettes over the course of… breakfast… without ending up in the hospital may be due to novel mutations in his alcohol dehydrogenase gene (ADH4), as well as, potentially, the gene that codes for CLTCL1, a protein responsible for the intake of extra-cellular material into the cell’s inside. These are wild speculations, to be clear, but the general idea is brilliant.

Indeed, not everyone reacts in the same way to recreational drugs. A recent massive study on the health effects of alcohol funded by the Bill and Melinda Gates Foundation (cf. No amount of alcohol is good for your overall health) suggests that alcohol is bad for one’s health at every dosage. This goes against the common wisdom backed up with numerous studies that light-drinkers (~1 alcohol unit a day) live longer and healthier lives than teetotalers. The new study suggests that this is not a causal effect of alcohol. Rather, it so happens that a large fraction of teetotalers are precisely the kind of people who react very badly to alcohol as a matter of poor metabolism. Hence, teetotalers are not unhealthy because they avoid alcohol; they avoid alcohol because they are unhealthy, which explains their shorter life expectancy on average. That said, the study did show that 1 alcohol unit a day is, although damaging, very minimally so:

Anyhow, the world’s cultural fascination with alcohol is bizarre to me, considering the existence of drugs that have a much better hedonic and cost-benefit profile (cf. State-Space of Drug Effects). Perhaps finding out with genetic testing that you are likely to be an above-average alcohol metabolizer might be good to lessen your worry about having a couple of drinks now and then. But the much bigger opportunity here would be to allow you to find drugs that you are particularly compatible with. For example, a genetic test might determine based on a polygenetic score that you might benefit a whole lot from taking small amounts of e.g. Khat  (or some such obscure and relatively benign euphoriant). That is, that your genetic make-up is such that Khat will be motivation enhancing, empathy-increasing, good for your heart and lungs, reduce the rate of dopamine neuron death, etc. while at the same time producing little to no hangovers, no irritability, no sleep issues, or social dysfunction. Even though you may have thought that you are “not an uppers person”, perhaps that’s because, genetically, every other upper you have ever tried is objectively terrible for your health. But Khat wouldn’t be. Wouldn’t this information be useful? Indeed, I would posit, this might be a great step in the right direction in order to achieve the goal of  Wireheading Done Right.


*23andMe is here used as a shorthand for services in general like this (including Ancestry, Counsyl, Natera, etc.)

Featured image credit: source.

Lucid LSD Trip Report from an Anonymous Reader

Writer: Anonymous (here substituted as “Bill”)

Dose: 2 blotters

I remember at one point feeling and saying that I was on the “sandy beaches of time.” Normally there are story arcs to events. There’s peak arousal and closure. But the hoffman [“LSD blotter”] was sustained arousal. In an expected upbeat I found a downbeat. All downbeats. So I found myself with extra moments unexpectedly. Moments that normally would have been blank or dim transitions were just as full as the moments they connected. The idea of the “sandy beaches of time” came from the feeling of rolling around in the sand on the inclines. Imagine you’re floating in water and then you wash on shore. Then you’re on the sand. That’s a feeling of unexpected support. You’re lying passively and find yourself on solid ground somehow. That’s how I felt that I found myself (without trying or initiating a thought) supported unexpectedly in additional moments. This reminds me of the experience I had on a stronger dose in 2016 (same number of blotters but higher potency due to freshness) where I always felt “in the middle of my thought.” It’s like there’s a moment of height and openness at the peak of the thought where you expand open to figure out how you’re going to fit together the structural pieces of the highest level of organization of the thought. But I was continually in the middle of the thought and never finishing a thought, I felt. I tried a lot harder to have complete well formed thoughts back then too, so the experience would have been more notable. In general this time I was least excited or interested at all. Quite passive and peaceful, but not exploring with great energy or amusement. It was a lower dose. I thought it was going to be difficult and possibly be my first bad trip, but when I did them I saw as always that psychedelics are nice to me and weed is the only one who occasionally gets medieval. When I figure out my van and living situation I will definitely seek out more hoffmans and things like it, because they have a certain potential to make my mind work better and they don’t seem to make me insane at all. On weed I can picture some bad day it getting me into a fetal position, but on psychedelics I have a relaxed “power pose.”

I also slightly expanded my sense of unifying with the perceptual (and otherwise conceived/imagined) environment. I’m putting on equal footing (there’s that equal footing theme again… In an article (link) the author used the phrase on “equal footing” once.  I had an idea to explain the equal footing phenomenon but I forget what it was). I feel like my implicit understanding of “merge your awareness with the world around you” increased and so I didn’t have to try so hard to figure it out. At this point I started to reflect on the kind of spiritual poverty of the spiritual ideas and theories I had and would often think about. The ideas I have often come from a dim dull state of mind. Anyway the merging came at the same time as understanding objects on their own terms. So rather than forcing a single texture onto two objects to see them both, I would see both objects with their own unique shapes and the only thing bridging them together was my awareness. That felt like the cubism people talk about in psychedelics (by the way Brahms is notoriously full of time distortions and musical cubism and disintegrations. The very long lines and irregular rhythms (implying a much lengthier process to “resolve,” i.e., achieve a full round of symmetry) are like the decreased decay of stuff in the mindstream. You can use sentences, words, sounds, symbols in a way that sustain moments of that openness, the middle-of-the-thought, and use sleight of hand to keep it from compensating or closing back down.). So I’d put on equal footing perceptions and all the notions I had which would be replaced by syntheses. Like I’d see a plane out the window and have a notion of the distance I was from it and then the notion of the angle of the distance line on my body and the plane, maybe picturing the underside of the plane and then the point of view from the plane looking back down, and I thought these images were all valid, and with the cubism going on it seemed to put the plane and the skyspace relationship to me on equal footing as myself, so I would see and not identify with my physical body and it’s vantage point and I would begin to get a sense of omniscience. Normally I’d reject this and say, “Well, look, we can take the pieces of the collage and infer that there’s only one body with eyes who can see and a brain that can think… it’s not like the plane actually sees or thinks” and yet I was going beyond that somehow. The panpsychism I’ve long subscribed to is like particulate panpsychism. It’s just like molecules and atoms have basic building blocks of complicated mechanical chemical processes, likewise simple consciousness properties of the oxygen atom and the carbon atom are modified by complex activities. However, the way I always thought of it wasn’t very smart. It wasn’t distributed consciousness at all. Nor did the consciousnesses of particles grow or interact or form “consciousness molecules” out of consciousness atoms. It was only the ability of surrounding forces to dance upon a carbon atom’s surface that I could imagine some experience arising. As for the human state—there are billions of consciousnesses and you just happen to be the one seeing this or hearing that or having the feeling of talking. In fact, all these examples of phenomenal experience would be vastly too complicated. But it’s no problem when you don’t believe in binding to suppose that I’m not a single person who talks and hears single sounds, but I’m an army of tiny mind particles that contribute their own tiny dust threads to experience… an experience that remains unbound and separate from all the other threads. So something like mind dust.

The cubism, by the way, was like dissociation, except that, like with the sandy beaches of time rushing in to provide an unexpected moment of support, there was always some unexpected maximally abstract unity support rushing in to bridge the disperate cubist pieces. That bridge was found in ongoing openness to find out. It was like an exercise in faith, and, in turn trust and compassion.

Anyway, that’s one kind of panpsychism. Another kind is nihilistic. Something about my coefficients was altered. Something normally was disproportional in my approach to panpsychism. Something similarly was out of place in the approach to open individualism. Well, the hoffman seemed to tune me a bit and adjust the amount of belief and nihilism and so on I was going into it with to give me a fuller experience. It turns out that what I see as “taking at face value” is actually an important state of openness. One doesn’t truly take it at face value because one isn’t ever pretending to have complete knowledge, but one does take something without devoting so much resource to reconceiving it in order to conform to one’s beliefs. The hoffman experience was generally very in favor of bottom up mindfulness. Let go of socially motivated reasoning and imaginary conversations trying to prove yourself to ignorant people with no imaginations who want to ruin everything good… just put your energy into understanding something with openness and then you’ll see it. I got higher understandings or understandings I realized I otherwise wouldn’t get.

The experience really gave me a strong sense of the doom of my life while at the same time making me light hearted about it and trying to show me around. Normally I’m scared that a psychedelic is going to be like weed and be scary, but it never is. In fact the hoffman took me around my room to see that in some areas where there was some mess or something that I projected an ugly identity onto (like I see my shoes and the first thing I think is, “That’s asperger’s shoes. Those are the shoes someone with asperger’s wears.” So I have my social “identity disturbance” imbued into virtually all the objects around me. Any object that signifies someone else in my life is imbued with boogeymen and gremlins of the relationship I have with that person). I’m oppressed by my room and the needless flavoring of everything with stigma and shame… it’s so comprehensive that I’ve lost the sensitivity to it. It’s like a fish in water, I’m drowning in stigma to the point that I take it for granted and no longer realize there’s any other way of being. So the hoffman tried to show me around my room and show me there aren’t any boogey man and reconnect me to the personality I do have which isn’t aspergery and is fine and contradicts the stigmas. Every time I look in the mirror I see someone more attractive than I expected to see. I think this started in middle school. I always always always underestimate my appearance by quite a bit. And I load my self image with all those bad stigmas. Going to the mirror is like a reality check, but it’s worn out because I’m largely desensitized to it. But the hoffman helped me see that being aspergery or any other stigma was an unnecessary self-fulfilling trap I didn’t have to go down because I did have… I was in good standing and nothing meant I had to be aspergers. My posture my voice my skin etc.., all was fine.

But the hoffman did go over my life. I expected it would attack me about my relationship with my family (which I stigmatize myself for… “I must be some kind of deranged monster” is a load I begin every thought on the matter with) and turn me vegan, but it’s never what you expect. It wasn’t a fear based assault but it was really sane and reasonable. It gave me a sense of the trap I’m in. I ordinarily only feel one part of the trap at once, like I’m in a maze going from one dead end to another. But the hoffman gave me a sense of all the traps of my life I’m in at once. Yet I was lighthearted and amused and smiling about it. I was ego dead but I didn’t even know it. It’s like my ego left without making a sound. Another thing is that it isn’t necessarily key to have no ego, but it is key to be in the moment which is often conflated with having no ego. Like if you’re alone walking and having an inner monologue conversation, that’s probably being lost in thought having some imaginary future conversation and that exemplifies the problems and life-of-it’s-own of the ego. But it actually could be that one is checking into the present moment continuously and one is having that conversation for the nobody, for the consciousness. After all, the consciousness divided and packaged into different points of view and bodies in an audience is the same as the consciousness you have, so why not have the conversation before it? I used to regiment being in the moment, a certain grid of checkpoints of checking in. But that top-down systematic way of being mindful doesn’t work because I find shortcuts and seem to be beyond the age where I can keep going back to the beginner’s mind in a subject and question everything I know to the point where I am not allowed those shortcuts. Further those shortcuts are easy to take without knowing it. They masquerade as true mindfulness. So an informal bottom up spontaneous not regimented continuous mindfulness is important. I like the short ego stories mentioned… (to be continued… must use bathroom now)

I like the idea of short duration egos/stories Mike Johnson mentioned in his recent meditation article. I used to have long systematic stories with regimented moderately high frequency check ins with the present moment proportional to what I used to call “salience essentialism” (a silly name, but the idea of making some element of information that’s only found in a state of lots of reflection and skepticism and metacognitions essential). But, as I said, I can’t do that regimentation anymore, so I’m going with Mike Johnson’s idea of short egos linked together. To have short ego stories that remain close to the present it’s key not only to bring a story to a natural end soon but also to not linger on that ending. If you linger on that ending rather than immediately continuing the moment, keep it rolling in a new moment, then you end up just getting lost in a nothingness epilogue to the story. Useless. You can’t end and then stop with nothing to continue with. So key to keeping short ego stories is also continually making them. Always be shedding light on the situation (keep no secrets. The ego performer has no secrets to keep as the actor. Continually to unravel it in any situation it finds itself. Don’t worry about nullifying a previous performance…because the previous performance was never meant to fool you as complete reality. Hold onto no pretense, but continue to act while shedding light always. A dance without deceit.)

Rather than being mindful to grasp the moment, to pas a yes/no test, I be mindful anew each time. Every time I be mindful is a new way of being mindful, and it’s about quickly jumping to the moment. When you’re really mindful like this listening to Beethoven’s cello sonata, you can’t tell if it’s you that’s singing or the cello. It feels like your own mind almost. I used to be a yes/no tester. I would have a preconceived idea of reality I strove for. But now I’m not doing that. I’m letting go of all my notions and quickly coming to the moment with openness.

One more word on the cubism thing. It’s related very much, I think, to the feeling of open individualism as well as the sandy beaches of time thing because each item has with it it’s own competing structure. Normally we resolve things into one system, but this cubism takes different elements on-their-own-terms, which means there are terms and structures and systems and orientations attached to them. In these systems are simulated the ego and its orientation to things. It’s like when you have some words and are deciding what sentence to make of them you ordinarily subordinate certain words to other words (the main verb being at the highest level of organization), but instead this cubism would have competing sentences for different words. It wouldn’t force the collapse of one structure or system for the other. Likewise the feeling of always being in the middle of one’s thought (or the sandy beaches of time) is like the noncollapse of the thought structure. There are many overlapping thoughts, all of them in the middle, rather than one thought with a start and a finish spanning several moments. You see? I think a similar thing can explain the proliferation of selfhood in objects in one’s perceptual/imagined environment. You go beyond your ordinary selfhood sense structure and see no problem attaching it to multiple things, like anthropomorphizing things with your sense of orientation and first person perspective. This gives rise to a sense of perspective that is beyond seeing and hearing and all the ordinary things. Yet what is it? Alas, perspective as a concept is only as advanced as the abstraction of perceptions and imaginations and so on, so we don’t actually have a more advanced concept of perception/perspective-having. What we have is the abstraction that’s forced upon us by the cubism and multiplication of competing perspective-having structures attached to different objects. All we know is that whatever it is must go beyond any individual object and is seen only when you’re continually opening up to the idea by watching the cubism unfold. So it’s easy to understand how this is all just a conceptual trick of the mind, but it has a very good way of taking everything you know and all your beliefs and spinning those into the picture to convince you of something beyond all that still. And I really do like to believe the idea of a perspective that transcends my human situated perspective of sense organs and a center of imaginations. I’d like the floating above everything and seeing the symphony. I see how MC Escher pictures are very evocative here, because you have competing “structures” or competing whatevers…  competing resolutions. MC Escher is a form of cubism in this way.

Another thing I notice is a decrease in bad compulsions. Generally psychedelics relieve anxiety and obsessions and stuff like that. I have this nasty habit of looking at attractive people and getting a pang of pain and loneliness and stuff. My work involves me being on social media all day long, so I often see a lot of attractive people and it’s just a pang of badness. But fighting with the compulsion is no good either. Flee it. I’ve got to stop correcting past mistakes. Short ego story. Don’t go down one road and then smack your forehead and then reverse and go back down another road. Nobody wants to see you back up. It’s not valuable. You’re not submitting or apologizing to anyone. Once you go down one road simply poof out of existence and then poof back into existence on the right road. No ego story of grinding corrections and punishments and obstacles. Just skip ahead to the right spot the moment you notice a better spot. Ordinarily seeing or hearing attractive people makes me tense up and go ouch and feel a dose of desperation and so on. This time I’m not doing that. I find that I’m lucky that I haven’t had that and a state of not clinging and so on is naturally here (I’m not anxiously monitoring my clinging level). I think it’s good to just zip to the right moment, the right thought and not spend time wrestling with the thing trying to undo it explicitly. Learn the habit of bypassing it, not reversing it. Don’t even expedite reversal. There should be no struggle to correct anything. Rather just jump freely to a better state of mind. But that’s easier said than done. I think it’s very hard to see the possibility of freedom in the present when faced with very strong recurrent thoughts or states of mind that one doesn’t want. It feels like the only hope of getting out of there is by contending with it, reversing it. But I’m suggesting that actually one can unlearn ever going down the wrong path in the first place (as opposed to learning to make the mistake and then the correction) and that is found in the present, the elusive present we overlook (or underlook). In fact, the present moment isn’t known to you yet while you’re still trying to struggle to escape the undesirable thought pattern. Trust that it will show you the way and open up to you as you open up to it. It will progressively open up, and you’ll say, “Oh, I see now.” 

So short stories are good, being in the moment is good. The intentional object is particularly tyrannical (ref) when it lives in a long story. Short stories can still have intentional objects. Things can have purposes, there can be a point, but the point should be found in the present (or the very very near future). When you find yourself having imaginary conversations for the future, then quickly start speaking that to the present. Whom are you talking to? Nobody. The nobody of the now (or yourself, or the non-people of the now) is a perfectly interesting audience.  You have within your consciousness basically what any audience can actually supply anyway. Consciousness differentiated through filters of points of view and personality and so on is only just the same as what you have in your “solitary” conversation.

Well anyway, I found myself having a bit of a love for the present. I like knowing that fulfillment is found in the present. It is beautiful and wholesome. I like not being chained to anxieties and compulsions. I like the spontaneousness of the higher rate of mindfulness. I don’t normally have so much mindfulness and trying with much effort to be mindful backfires. As explained above about reversing mistakes, today I was quickly and without making a fuss finding myself snapping back into the present. Rather than trying to make an ordeal of an error report trying to diagnose the lapse in mindfulness and see to it that it doesn’t happen again, I let go of that controlling and just join the present moment “ready to rock” as [person] from [previous job] would put it.

Here’s part of the trip report. I wrote the other half of it in a paper notebook:

5:10PM I recorded everything earlier in a notebook.

Wow so much easier to type fast. Anyway I see how the ego and the self, I created a dark scary world of doubt and fear and shame for this Bill character. It’s just a character. Bring as many emotional resolutions as possible to make the story have as happy an ending as can be, but ultimately just don’t forget it’s all fiction.

And I guess that’s key. The fears of the hellishness of being a “bad human” and so on…all fictions of the Bill story in the world, in consensus reality. Make the story look nice, but see through it. It’s just a story for some TV viewer. I’m so predictable, what I’m paranoid about, what my hang ups are, etc… How the grass is greener on the other side of being social.

But this trip, rather than dipping me in guilt and attacking me with my own problems is actually more like a refresher on how these places aren’t full of boogeymen like I think they are, and if I just realized this I’d have a better day. But ultimately the desperateness and the loneliness and so on…gosh what a drag. On and on and on being upset about my life. I cultivate a sense of loss before fulfilling it. I should instead not have any needs and just pursue excitement… It’s interesting to think about whether you can get anywhere in life or have a very interesting time without those needs and voids held open by fear.

5:19PM I think I watch Minecraft playthroughs as a surrogate for socializing. Now without getting emotional or caught up in the Bill story, let’s just assess whether this is necessary.

5:25PM I’m listening to music. I’m admiring the majesty of some things in it. CPE bach. Just like Huxley said about my nonself being the non self of that chair leg, I identify as a non self with the non self of the grand music at points. Anyway, I notice how a lot of my enjoyment of music is really grinding and unpleasant. Forceful and full of pain like fighting through wounds, forcing your way through barbed wire. It’s senseless, isn’t it? If I can control it and enjoy music without this forceful stuff, this suffering forcefulness and longing and neediness and narrowness.

5:30PM Those headphones cause such misery. I get lost in those things. I’m getting a bit morbid, aren’t I? I’m not coming down but I’m tired and maybe my blood sugar is lower or something.

9:51PM Watched the Terence McKenna in Prague with Ram Das and Shulgin and others (link 1, link 2). Fascinating. Then I listened to this I noticed how this time I did acid my mind didn’t expand very much at all. I feel old and like my brain is stuck in certain ways of seeing things. I do have a gentle calling to feel myself situated in terms of nature and evolution and the mystery of the universe…I just want to see the open night sky like our ancestors did, but not clouded by all these paved roads and jobs and clocks and so on. Missing the moment for some future goal, measured by time and streets and so on. I liked what Watts said about playing a musical instrument for the enjoyment of music and not to do secondary things like make money or impress an audience. Now one could say that their goal is to impress audiences and so one isn’t “playing music” but one is “impressing audiences” and happening to play music. But I like the idea of only playing music in an innocent way because of the pleasure the noise gives. Unlocking the song by learning the music is rewarded by the music as it comes along. Not the prospect of performing or this becoming a dance of your ego or something. That’s kind of the problem. At least not living acts for the present well enough. That’s what I meant a couple weeks ago about having present moment self goals. Have goals for the moment. Don’t do stuff for later. The goal shouldn’t be set on some fulfillment of something later on. Why? Because people who say things like that have broken heads and my head is broken so I say stuff like that. Anyway, when I play music it should be to produce sound. When I try to get a self image, a social ego, a sense of my social personality, it shouldn’t be aimed at a future date. I should be genuine where I am, even if I’m alone. That is the moment. When it happens, it isn’t practice for some future performance. I’m not scripting. Rather, that is it. That was the moment to make the joke or be clever or do something. If I’m alone, that’s who I do it for. I do it for myself and nobody. I don’t do it for anybody, at least nobody to be abstracted and conceived in a later date. What happens happens then…what happens in the moment stays in the moment. Right now, who am I journaling with? Whom am I talking to? Wow, I can’t even believe I’ve got the depth to question that. Above I mentioned how not expanded my mind felt. Well I’m not very reflective, and the fact I just brought up the question who I am journaling for shows that thing. A lot of life has been lived in these journals. Some good, a lot bad. I can imagine myself throwing my journals away. I can imagine my laptop getting stolen or destroyed or lost. I no longer am hoarding up notes on philosophy projects. So what is this all for? Well, it’s all for itself. And right now it feels better. This feels like a good use of my time and a legitimate experience of living. Nothing lacks. I don’t need to add on some need to escape here and strive for a better place. Apples and oranges. This is adequate in itself. What I do, I must enjoy doing for the sake of itself. I don’t read books to build a vocabulary and a wit so I can talk to people. I have to enjoy reading the books and having that vocabulary and wit as the reader. Not for some future moment. The journey of a book isn’t an overture to something else. It is the journey. I need really to start becoming intrinsically motivated by everything I do, see things as ends in themselves. Really end. Not mindfulness to some other place. I make this mistake all the time. I think of the future now, of the future present moment mindfulness state. I’ve got to enjoy the mindfulness I already have before I can progress further…or rather before it can progress to unfold and intensify. I have to appreciate the experience of education I’m getting by reading a book, raw education however unglamorous and rudimentary, before my education can grow and intensify.

Sunk cost is big when trying to improve yourself (referring back to Alan Watts talk there). If I haven’t already implemented these notes about living in the present moment, then why do I think I can? Seems like the game has run stale. I’ve been narrowly focused and in sunk cost and escapism and I need to just let go of the outcome and step back and observe. Just like what I said about the stand-up comedian’s ego filtering out the amount of feedback based on how massively they’d have to renovate their act—they’re unwilling to open themselves up to just assess what’s wrong and fix it because they’re trying to open up to a small amount, one repair guy and see what he says and see if he recommends a follow up repair guy when he can’t figure it out, and then two slightly more in-depth expert repair guys come by and so on….why is this progression of repairmen economical? It is if you have no idea what’s wrong with your electricity in your house, but if you are a standup comedian and your ability to correct your act depends on your ability to recognize what’s wrong with it and you have access to that consultation, why limit yourself by peeking through a half closed eye? Why not just open up and see the whole situation? You won’t waste time…oh so much time you’ll spend fighting your way back up from the later stage repair men to earlier repair men…correcting later stage specific advanced diagnoses but still something’s wrong but it’s simpler than before. Just always wrestling with the errors in your performance trying to keep them in the simple no biggie zone rather than in the serious fail zone. But if only you were willing to open your eyes fully to see the true extent of the problems, then you could fix them all.

10:30PM Down with an edible. Wow, surprised how powerful the acid still is. Let’s see I took one at 12:33PM and the other at 1:49PM. Well, and I just took an edible. A tinge of regret because it’ll dull and otherwise contaminate the acid, but I’m getting tired so it wasn’t like I was going to get much out of it anyway. Alas, I’m still looking for gold to fill my notebooks for for later reading. I still take notes for the future. I should see notes as what they really are, which is just prosthetics for the experience of narratives in the present moment. Nothing more. (And I’m often blind to that possibility! I’m blind to the potential of the present! I only think in terms of future stuff. I just overlook the present.)

10:36 Wow that Alan Watts talk though. I know I always can’t help but put in my disclaimers. I don’t even feel like going through the various examples of why I have critical reasoning bla bla bla (don’t think of me as a stupid sheep). Just how helpless I seem to be in my current mode of doing things to get myself to live in the present and for the present. I don’t make decisions. I don’t decide what meanings my words have. I rather sit there passively waiting for the right words to come and fill in. I could do with some asserting myself more. But when the moment is right, when it gives energy rather than drains.

And rather than striving for an answer for a theory about consciousness or something or reality or whatever crazy… that is so rewarding that it can be done for itself in the moment. Think about consciousness. The mystery of the ever elusive background. The unknown is stimulating. It is exciting. Seeing the implications of the unknown and questioning old frameworks is enjoyable. It just is. 🙂

11:30PM Just took my second edible. (Saw: Alan Watts – Nature of God)

12:31AM Only do things for the now. Don’t solve problems for the future. Propose solutions for the future in the now. It’s a present act. You’re just exercising talking and proposing and speculating recreationally for the present. You ‘re not putting your will into the future. And the idea I have is that the bleakness of my life is in my head. Living in a van can be positive. I can have a happier social life. But doubts just feed. They’re demonic. They love sadness like heroin. They love to feed on the anxieties about not being able to make friends, of how poor my track record has been, how my life used to be in my control and going in a direction has now fallen so dramatically in a different way….The doubt tempts you. The decisions stop being made in the present moment. IT says “Hold on now. Think about this…” as it proceeds, foot in the door, to tempt you to sadness and doubt, as if there’s some social reward for having a sufficiently pessimistic view.

Anti-Tolerance Drugs

It would indeed be extraordinary if – alone among the neurotransmitter systems of the brain – the endogenous opioid families were immune from dysfunction. Enkephalins are critical to “basal hedonic tone” i.e. whether we naturally feel happy or sad. Yet the therapeutic implications of a recognition that dysfunctional endogenous opioid systems underlie a spectrum of anxiety-disorders and depression are too radical – at present – for the medical establishment to contemplate. In consequence, the use of opioid-based pharmacotherapies for “psychological” pain is officially taboo. The unique efficacy of opioids in banishing mental distress is neglected. Their unrivalled efficacy in treating “physical” nociceptive pain is grudgingly accepted.

 

Future Opioids, by David Pearce

Albert Camus wrote that the only serious question is whether to kill yourself or not. Tom Robbins wrote that the only serious question is whether time has a beginning and an end. Camus clearly got up on the wrong side of bed, and Robbins must have forgotten to set the alarm. There is only one serious question. And that is: Who knows how to make love stay? [emphasis mine] Answer me that and I will tell you whether or not to kill yourself.

 

– Still Life with Woodpecker by Tom Robbins

As eloquently argued by David Pearce in Future Opioids, the problem with opioids and other euphoriant drugs is not that they make you feel good, but that the positive feelings are short lived. In their stead, tolerance, withdrawal, and dependence ultimately set in after repeated use. We take the position that these negatives are not a necessary outcome of feeling free from physical or psychological malaise, for the brain has clever negative feedback mechanisms that prevent us from wireheading chemically. Rather, we believe that tackling these negative feedback mechanisms directly might be they key that unlocks never-ending bliss. Note that even if excellent anti-tolerance drugs were to be developed and commercialized for therapeutic use, we would still need to find solutions to the problems posed by wireheading. Specifically, disabling the negative feedback mechanisms in place that prevent us from feeling well all the time still leaves unsolved the problem of avoiding getting stuck in counterproductive patterns of behavior and becoming at risk of turning into a pure replicator (for proposed solutions to these problems see: Wireheading Done Right). Still, we strongly believe that finding safe and effective anti-tolerance drugs is a step in the right direction in the battle against suffering throughout the living world.

We thus provide the following list of promising anti-tolerance drugs in the hopes of: (1) piquing the interest of budding psychopharmacologists who may be weighting-in on promising research leads, (2) show a proof of concept against the fake and fatalistic truism that “what goes up has to go down” (cf. The Hedonistic Imperative), and last but not least, (3) provide hope to people suffering from physical or psychological distress who would benefit from anti-tolerance drugs, such as those who experience treatment-resistant anxiety, depression, chronic pain, or chemical dependence.

It is worth noting that this list is just a draft, and we will continue to revise it as the science progresses. Please let us know in the comment section if you are aware of compounds not included in this list (of special interest are tier 1 and tier 2 compounds).

Tier System

The list is organized by tiers. Tier 1 includes compounds for which there is evidence that they can reverse tolerance. Tier 2 deals with compounds that seem to either block or attenuate the development of tolerance, meaning that co-administering them with a euphoric agonist reduces the speed at which this euphoriant creates tolerance. Tier 3 includes potentiators. That is, compounds that enhance the effects of other substances without at the same time increasing tolerance to the extent that would be expected given the intensity of the subjective effects. Tier 4 lists compounds that, while not exactly tolerance-related, are still worth mentioning by virtue of reducing the intensity of drug withdrawals. And finally, Tier 5 includes euphoriants that have a favorable pharmacological profile relative to their alternatives, although will still produce tolerance long-term. Typically, a substance belonging to Tier X will also belong to Tier X + 1 and above (except for Tier 5) but we omit repetitions to avoid redundancy (e.g. proglumide not only reverses tolerance, but prevents tolerance, is a potentiatior, and reduces withdrawals).

Opioid System

Tier 1

  1. Ibogaine (see: Low dose treatment)
  2. Proglumide
  3. Naltrexone (specifically in Ultra Low Doses)
  4. Ibudilast (AV-411)

Tier 2

  1. Agmatine (may also help with chronic pain on its own)
  2. Curcumin (found in Turmeric; only works in high-availability forms)
  3. Thymoquinone (found in Nigella Sativa/black seed oil)

Tier 3

  1. DXM (specially potentiates the analgesia, which may be of use for chronic pain sufferers)
  2. Hydroxyzine (beware of its effects on sufferers of Akathisia/Restless Legs Syndrome; also bad in the long term for one’s cognitive capacity)
  3. L-Tyrosine
  4. Magnesium (possibly tier 2 but only weakly so)

Tier 4

  1. L-Aspartic Acid
  2. Ashwagandha
  3. JDTic
  4. Gabapentin
  5. Clonidine

Tier 5

  1. Tianeptine (its effects on the delta opioid receptor attenuates its tolerance when used in therapeutic doses)
  2. Mitragynine (thanks to its partial agonism rather than full agonism it is less dangerous in high doses relative to alternatives; specifically, mitragyne does not have dangerous respiratory depression properties on its own, so switching heroin addicts to it would arguably save countless lives)

 

GABA System

Tier 1

  1. Flumazenil (note: very dose-dependent)

Tier 2

  1. Tranylcypromine
  2. Ginsenosides
  3. Homotaurine
  4. Fasoracetam

Tier 3

  1. Dihydromyricetin

See also.

Dopamine System

Insufficient datapoints for a tier system. Here are the few promising leads:

  1. D-serin
  2. D-cycloserine
  3. Sulbutamine
  4. Bromantane
  5. Memantine

See also.


Tanks to Adam Karlovsky for help compiling these lists.

Psychedelic Turk: A Platform for People on Altered States of Consciousness

An interesting variable is how much external noise is optimal for peak processing. Some, like Kafka, insisted that “I need solitude for my writing; not ‘like a hermit’ – that wouldn’t be enough – but like a dead man.” Others, like von Neumann, insisted on noisy settings: von Neumann would usually work with the TV on in the background, and when his wife moved his office to a secluded room on the third floor, he reportedly stormed downstairs and demanded “What are you trying to do, keep me away from what’s going on?” Apparently, some brains can function with (and even require!) high amounts of sensory entropy, whereas others need essentially zero. One might look for different metastable thresholds and/or convergent cybernetic targets in this case.

– Mike Johnson, A future for neuroscience

My drunk or high Tweets are my best work.

– Joe Rogan, Vlog#18

Introduction

Mechanical Turk is a service that makes outsourcing simple tasks to a large number of people extremely easy. The only constraint is that the tasks outsourced ought to be the sort of thing that can be explained and performed within a browser in less than 10 minutes, which in practice is not a strong constraint for most tasks you would outsource anyway. This service is in fact a remarkably effective way to accelerate the testing of digital prototypes at a reasonable price.

I think the core idea has incredible potential in the field of interest we explore in this blog. Namely, consciousness research and the creation of consciousness technologies. Mechanical Turk is already widely used in psychology, but its usefulness could be improved further. Here is an example: Imagine an extension to Mechanical Turk in which one could choose to have the tasks completed (or attempted) by people in non-ordinary states of consciousness.

Demographic Breakdown

With Mechanical Turk you can already ask for people who belong to specific demographic categories to do your task. For example, some academics are interested in the livelihoods of people within certain ages, NLP researchers might need native speakers of a particular language, and people who want to proof-read a text may request users who have completed an undergraduate degree. The demographic categories are helpful but also coarse. In practice they tend to be used as noisy proxies for more subtle attributes. If we could multiply the categories, which ones would give the highest bang for the buck? I suspect there is a lot of interesting information to be gained from adding categories like personality, cognitive organization, and emotional temperament. What else?

States of Consciousness as Points of View

One thing to consider is that the value of a service like Mechanical Turk comes in part from the range of “points of view” that the participants bring. After all, ensemble models that incorporate diverse types of modeling approaches and datasets usually dominate in real-world machine learning competitions (e.g. Kaggle). Analogously, for a number of applications, getting feedback from someone who thinks differently than everyone already consulted is much more valuable than consulting hundreds of people similar to those already queried. Human minds, insofar as they are prediction machines, can be used as diverse models. A wide range of points of view expands the perspectives used to draw inferences, and in many real-world conditions this will be beneficial for the accuracy of an aggregated prediction. So what would a radical approach to multiplying such “points of view” entail? Arguably a very efficient way of doing so would involve people who inhabit extraordinarily different states of consciousness outside the “typical everyday” mode of being.

Jokingly, I’d very much like to see the “wisdom of the crowds enhanced with psychedelic points of view” expressed in mainstream media. I can imagine an anchorwoman on CNN saying: “according to recent polls 30% of people agree that X, now let’s break this down by state of consciousness… let’s see what the people on acid have to say… ” I would personally be very curious to hear how “the people on acid” are thinking about certain issues relative to e.g. a breakdown of points of view by political affiliation. Leaving jokes aside, why would this be a good idea? Why would anyone actually build this?

I posit that a “Mechanical Turk for People on Psychedelics” would benefit the requesters, the workers, and outsiders. Let’s start with the top three benefits for requesters: better art and marketing, enhanced problem solving, and accelerating the science of consciousness. For workers, the top reason would be making work more interesting, stimulating, and enjoyable. And from the point of view of outsiders, we could anticipate some positive externalities such as improved foundational science, accelerated commercial technology development, and better prediction markets. Let’s dive in:

Benefits to Requesters

Art and Marketing

A reason why a service like this might succeed commercially comes from the importance of understanding one’s audience in art and marketing. For example, if one is developing a product targeted to people who have a hangover (e.g. “hangover remedies”), one’s best bet would be to see how people who actually are hungover resonate with the message. Asking people who are drunk, high on weed, on empathogenic states, on psychedelics, specific psychiatric medications, etc. could certainly find its use in marketing research for sports, comedy, music shows, etc.

Basically, when the product is consumed in the sort of events in which people frequently avoid being sober for the occasion, doing market research on the same people sober might produce misleading results. What percent of concert-goers are sober the entire night? Or people watching the World Cup final? Clearly, a Mechanical Turk service with diverse states of consciousness has the potential to improve marketing epistemology.

On the art side, people who might want to be the next Alex Grey or Android Jones would benefit from prototyping new visual styles on crowds of people who are on psychedelics (i.e. the main consumers of such artistic styles).

As an aside, I would like to point out that in my opinion, artists who create audio or images that are expected to be consumed by people in altered states of consciousness have some degree of responsibility in ensuring that they are not particularly upsetting to people in such states. Indeed, some relatively innocent sounds and images might cause a lot of anxiety or trigger negative states in people on psychedelics due to the way they are processed in such states. With a Mechanical Turk for psychedelics, artists could reduce the risk of upsetting festival/concert goers who partake in psychedelic perception by screening out offending stimuli.

Problem Solving

On a more exciting note, there are a number of indications that states of consciousness as alien as those induced by major psychedelics are at times computationally suited to solve information processing tasks in competitive ways. Here are two concrete examples: First, in the sixties there was some amount of research performed on psychedelics for problem solving. A notorious example would be the 1966 study conducted by Willis Harman & James Fadiman in which mescaline was used to aid scientists, engineers, and designers in solving concrete technical problems with very positive outcomes. And second, in How to Secretly Communicate with People on LSD we delved into ways that messages could be encoded in audio-visual stimuli in such a way that only people high on psychedelics could decode them. We called this type of information concealment Psychedelic Cryptography:

These examples are just proofs of concept that there probably are a multitude of tasks for which minds under various degrees of psychedelic alteration outperform those minds in sober states. In turn, it may end up being profitable to recruit people on such states to complete your tasks when they are genuinely better at them than the sober competition. How to know when to use which state of consciousness? The system could include an algorithm that samples people from various states of consciousness to identify the most promising states to solve your particular problem and then assign the bulk of the task to them.

All of this said, the application I find the most exciting is…

Accelerating the Science of Consciousness

The psychedelic renaissance is finally getting into the territory of performance enhancement in altered states. For example, there is an ongoing study that evaluates how microdosing impacts how one plays Go, and another one that uses a self-blinding protocol to assess how microdosing influences cognitive abilities and general wellbeing.

A whole lot of information about psychedelic states can be gained by doing browser experiments with people high on them. From sensory-focused studies such as visual psychophysics and auditory hedonics to experiments involving higher-order cognition and creativity, internet-based studies of people on altered states can shed a lot of light on how the mind works. I, for one, would love to estimate the base-rate of various wallpaper symmetry groups in psychedelic visuals (cf. Algorithmic Reduction of Psychedelic States), and to study the way psychedelic states influence the pleasantness of sound. There may be no need to spend hundreds of thousands of dollars in experiments that study those questions when the cost of asking people who are on psychedelics to do tasks can be amortized by having them participate in hundreds of studies on e.g. a single LSD session.

Quantifying Bliss (36)

17 wallpaper symmetry groups

This kind of research platform would also shed light on how experiences of mental illness compare with altered states of consciousness and allow us to place the effects of common psychiatric medications on a common “map of mental states”. Let me explain. While recreational materials tend to produce the largest changes to people’s conscious experience, it should go without saying that a whole lot of psychiatric medications have unusual effects on one’s state of consciousness. For example: Most people have a hard time pin-pointing the effect of beta blockers on their experience, but it is undeniable that such compounds influence brain activity and there are suggestions that they may have long-term mood effects. Many people do report specific changes to their experience related to beta blockers, and experienced psychonauts can often compare their effects to other drugs that they may use as benchmarks. By conducting psychophysical experiments on people who are taking various major psychoactives, one would get an objective benchmark for how the mind is altered along a wide range of dimensions by each of these substances. In turn, this generalized Mechanical Turk would enable us to pin-point where much more subtle drugs fall along on this space (cf. State-Space of Drug Effects).

In other words, this platform may be revolutionary when it comes to data collection and bench-marking for psychiatric drugs in general. That said, since these compounds are more often than not used daily for several months rather than briefly or as needed, it would be hard to see how the same individual performs a certain task while on and off the medicine. This could be addressed by implementing a system allowing requesters to ask users for follow up experiments if/when the user changes his or her drug regimen.

Benefit to Users

As claimed earlier on, we believe that this type of platform would make work more enjoyable, stimulating, and interesting for many users. Indeed, there does seem to be a general trend of people wanting to contribute to science and culture by sharing their experiences in non-ordinary states of consciousness. For instance, the wonderful artists at r/replications try to make accurate depiction of various unusual states of consciousness for free. There is even an initiative to document the subjective effects of various compounds by grounding trip reports on a subjective effects index. The point being that if people are willing to share their experience and time on psychedelic states of consciousness for free, chances are that they will not complain if they can also earn money with this unusual hobby.

698okoc

LSD replication (source: r/replications)

We also know from many artists and scientists that normal everyday states of consciousness are not always the best for particular tasks. By expanding the range of states of consciousness with economic advantages, we would be allowing people to perform at their best. You may not be allowed to conduct your job while high at your workplace even if you perform it better that way. But with this kind of platform, you would have the freedom to choose the state of consciousness that optimizes your performance and be paid in kind.

Possible Downsides

It is worth mentioning that there would be challenges and negative aspects too. In general, we can probably all agree that it would suck to have to endure advertisement targeted to your particular state of consciousness. If there is a way to prevent this from happening I would love to hear it. Unfortunately, I assume that marketing will sooner or later catch on to this modus operandi, and that a Mechanical Turk for people on altered states would be used for advertisement before anything else. Making better targeted ads, it turns out, is a commercially viable way of bootstrapping all sorts of novel systems. But better advertisement indeed puts us at higher risk of being taken over by pure replicators in the broader scope, so it is worth being cautious with this application.

In the worst case scenario, we discover that very negative states of consciousness dominate other states in the arena of computational efficiency. In this scenario, the abilities useful to survive in the mental economy of the future happen to be those that employ suffering in one way or another. In that case, the evolutionary incentive gradients would lead to terrible places. For example, future minds might end up employing massive amounts of suffering to “run our servers”, so to speak. Plus, these minds would have no choice because if they don’t then they would be taken over by other minds that do, i.e. this is a race to the bottom. Scenarios like this have been considered before (1, 2, 3), and we should not ignore their warning signs.

Of course this can only happen if there are indeed computational benefits to using consciousness for information processing tasks to begin with. At Qualia Computing we generally assume that the unity of consciousness confers unique computational benefits. Hence, I would expect any outright computational use of states of consciousness is likely to involve a lot of phenomenal binding. Hence, at the evolutionary limit, conscious super-computers would probably be super-sentient. That said, the optimal hedonic tone of the minds with the highest computational efficiency is less certain. This complex matter will be dealt with elsewhere.

Concluding Discussion

Reverse Engineering Systems

A lot of people would probably agree that a video of Elon Musk high on THC may have substantially higher value than many videos of him sober. A lot of this value comes from the information gained about him by having a completely new point of view (or projection) of his mind. Reverse-engineering systems involves doing things to them to change the way they operate in order to try to reconstruct how they are put together. The same is true for the mind and the computational benefits of consciousness more broadly.

The Cost of a State of Consciousness

Another important consideration would be cost assignment for different states of consciousness. I imagine that the going rates for participants on various states would highly depend on the kind of application and profitability of these states. The price would reach a stable point that balances the usability of a state of consciousness for various tasks (demand) and its overall supply.

For problem solving in some specialized applications, for example, I could imagine “mathematician on DMT” to be a high-end sort of state of consciousness priced very highly. For example, foundational consciousness research and phenomenological studies might find such participants to be extremely valuable, as they might be helpful analyzing novel mathematical ideas and using their mathematical expertise to describe the structure of such experiences (cf. Hyperbolic Geometry of DMT Experiences).

Unfortunately, if the demand for high-end rational psychonauts never truly picks up, one might expect that people who could become professional rational psychonauts will instead work for Google or Facebook or some other high-paying company. More so, due to Lemon Markets people who do insist on hiring rational psychonauts will most likely be disappointed. Sasha Shulgin and his successors will probably only participate in such markets if the rewards are high enough to justify using their precious time on novel alien states of consciousness to do your experiment rather than theirs.

In the ideal case this type of platform might function as a spring-board to generate a critical mass of active rational psychonauts who could do each other’s experiments and replicate the results of underground researchers.

Quality Metrics

Accurately matching the task with the state of consciousness would be critical. For example, you might not necessarily want someone who is high on a large dose of acid to take a look at your tax returns*. Perhaps for mundane tasks one would want people who are on states of optimal arousal (e.g. modafinil). As mentioned earlier, a system that identifies the most promising states of consciousness for your task would be a key feature of the platform.

If we draw inspiration from the original service, we could try to make an analogous system to “Mechanical Turk Masters“. Here the service charges a higher price for requesting people who have been vetted as workers who produce high quality output. To be a Master one needs to have a high task-approval rating and have completed an absurd number of them. Perhaps top score boards and public requester prices for best work would go a long way in keeping the quality of psychedelic workers at a high level.

In practice, given the population base of people who would use this service, I would predict that to a large extent the most successful tasks in terms of engagement from the user-base will be those that have nerd-sniping qualities.** That is, make tasks that are especially fun to complete on psychedelics (and other altered states) and you would most likely get a lot of high quality work. In turn, this platform would generate the best outcomes when the tasks submitted are both fun and useful (hence benefiting both workers and requesters alike).

Keeping Consciousness Useful

Finally, we think that this kind of platform would have a lot of long-term positive externalities. In particular, making a wider range of states of consciousness economically useful goes in the general direction of keeping consciousness relevant in the future. In the absence of selection pressures that make consciousness economically useful (and hence useful to stay alive and reproduce), we can anticipate a possible drift from consciousness being somewhat in control (for now) to a point where only pure replicators matter.


Bonus content

If you are concerned with social power in a post-apocalyptic landscape, it is important that you figure out a way to induce psychedelic experiences in such a way that they cannot easily be used as weapons. E.g. it would be key to only have physiologically safe (e.g. not MDMA) and low-potency (e.g. not LSD) materials in a Mad Max scenario. For the love of God, please avoid stockpiling compounds that are both potent and physiologically dangerous (e.g. NBOMes) in your nuclear bunker! Perhaps high-potency materials could still work out if they are blended in hard-to-separate ways with fillers, but why risk it? I assume that becoming a cult leader would not be very hard if one were the only person who can procure reliable mystical experiences for people living in most post-apocalyptic scenarios. For best results make sure that the cause of the post-apocalyptic state of the world is a mystery to its inhabitants, such as in the documentary Gurren Lagann, and the historical monographs written by Philip K. Dick.


*With notable exceptions. For example, some regular cannabis users do seem to concentrate better while on manageable amounts of THC, and if the best tax attorney in your vicinity willing to do your taxes is in this predicament, I’d suggest you don’t worry too much about her highness.

**If I were a philosopher of science I would try to contribute a theory for scientific development based on nerd-sniping. Basically, how science develops is by the dynamic way in which scientists at all points are following the nerd-sniping gradient. Scientists are typically people who have their curiosity lever all the way to the top. It’s not so much that they choose their topics strategically or at random. It’s not so much a decision as it is a compulsion. Hence, the sociological implementation of science involves a collective gradient ascent towards whatever is nerd-sniping given the current knowledge. In turn, the generated knowledge from the intense focus on some area modifies what is known and changes the nerd-sniping landscape, and science moves on to other topics.

Why don’t more effective altruists work on the Hedonistic Imperative?

By David Pearce (in response to a Quora question)

 

Life could be wonderful. Genetically phasing out suffering in favour of hardwired happiness ought to be mainstream. Today, it’s a fringe view. It’s worth asking why.

Perhaps the first scientifically-literate blueprint for a world without suffering was written by Lewis Mancini. “Brain stimulation and the genetic engineering of a world without pain” was published in the journal Medical Hypotheses in 1990. As far as I can tell, the paper sunk almost without a trace. Ignorant of Mancini’s work, I wrote The Hedonistic Imperative (HI) in 1995. I’ve plugged away at the theme ever since. Currently, a small, scattered minority of researchers believe that replacing the biology of suffering with gradients of genetically preprogrammed well-being is not just ethical but obviously so.

Alas, perceptions of obviousness vary. Technically, at least, the abolitionist project can no longer easily be dismissed as science fiction. The twenty-first century has already witnessed the decoding of the human genome, the development and imminent commercialisation of in vitro meat, the dawn of CRISPR genome-editing and the promise of synthetic gene drives. Identification of alleles and allelic combinations governing everything from pain-sensitivity to hedonic range and hedonic set-points is complementing traditional twin studies. The high genetic loading of subjective well-being and mental ill-health is being deciphered. The purely technical arguments against the genetic feasibility of creating a happy living world are shrinking. But genetic status quo bias is deeply entrenched. The sociopolitical obstacles to reprogramming the biosphere are daunting.

You ask specifically about effective altruists (EAs). Some effective altruists (cfEffective Altruism: How Can We Best Help Others? by Magnus Vinding) do explore biological-genetic solutions to complement socio-economic reform and other environmental interventions. Most don’t. Indeed, a significant minority of EAs expressly urge a nonbiological focus for EA. For example, see Why I Don’t Focus On The Hedonistic Imperative by the influential EA Brian Tomasik. I can’t offer a complete explanation, but I think these facts are relevant:

1) Timescales. Lewis Mancini reckons that completion of the abolitionist project will take thousands of years. HI predicts that the world’s last unpleasant experience will occur a few centuries hence, perhaps in some obscure marine invertebrate. If, fancifully, consensus existed for a global species-project, then 100 – 150 years (?) might be a credible forecast. Alas, such a timescale is wildly unrealistic. No such consensus exists or is plausibly in prospect. For sure, ask people a question framed on the lines of “Do you agree with Gautama Buddha, ‘May all that have life be delivered from suffering’?” and assent might be quite high. Some kind of quantified, cross-cultural study of radical Buddhist or Benthamite abolitionism would be interesting. Yet most people balk at what the scientific implementation of such a vision practically entails – if they reflect on abolitionist bioethics at all. “That’s just Brave New World” is a common response among educated Westerners to the idea of engineering “unnatural” well-being. Typically, EAs are focused on measurable results in foreseeable timeframes in areas where consensus is broad and deep, for instance the elimination of vector-borne disease. Almost everyone agrees that eliminating malaria will make the world a better place. Malaria can be eradicated this century.

2) The Hedonic Treadmill. In recent decades, popular awareness of the hedonic treadmill has grown. Sadly, most nonbiological interventions to improve well-being may not have the dramatic long-term impact we naïvely hope. However, awareness of the genetic underpinnings of the hedonic treadmill is sketchy. Knowledge of specific interventions we can plan to subvert its negative feedback mechanisms is sketchier still. Compared to more gross and visible ills, talk of “low hedonic set-points” (etc) is nebulous. Be honest, which would you personally choose if offered: a vast national lottery win (cfHow Winning The Lottery Affects Happiness) or a modestly higher hedonic set-point? Likewise, the prospect of making everyone on Earth prosperous sounds more effectively altruistic (cfCan “effective altruism” maximise the bang for each charitable buck?) than raising their hedonic defaults – even if push-button hedonic uplift were now feasible, which it isn’t, or at least not without socially unacceptable consequences.

3) The Spectre of Eugenics. Any confusion between the racial hygiene policies of the Third Reich and the project of genetically phasing out suffering in all sentient beings ought to be laughable. Nonetheless, many people recoil at the prospect of “designer babies”. Sooner or later, the ”e”-word crops up in discussions of genetic remediation and enhancement. If we assume that bioconservative attitudes to baby-making will prevail worldwide indefinitely, and the reproductive revolution extends at best only to a minority of prospective parents, then the abolitionist project will never happen. What we call the Cambrian Explosion might alternatively be classified as the Suffering Explosion. If we don’t tackle the biological-genetic roots of suffering at source – “eugenics”, if you will – then pain and suffering will proliferate until Doomsday. Without eugenics, the world’s last unpleasant experience may occur millions or even billions of years hence.

4) Core Values. Self-identified effective altruists range from ardent life loversfocused on existential risks, AGI and the hypothetical Intelligence Explosion to radical anti-natalists and negative utilitarians committed to suffering-focused ethics (cfWhat are the main differences between the anti-natalism/efilism community and the negative utilitarian/”suffering-focused ethics” wing of the effective altruism community?). There’s no inherent conflict with HI at either extreme. On the one hand, phasing out the biology of suffering can potentially minimise existential risk. Crudely, the more we love life, the more we want to preserve it. On the opposite wing of EA, radical anti-natalists oppose reproduction because they care about suffering, not because of opposition to new babies per se. Technically speaking, CRISPR babies could be little bundles of joy – as distinct from today’s tragic genetic experiments. In practice, however, life-loving EAs are suspicious of (notionally) button-pressing negative utilitarians, whereas radical anti-natalists view worldwide genetic engineering as even more improbable than their preferred option of voluntary human extinction.

5) Organisation and Leadership. Both secular and religious organizations exist whose tenets include the outright abolition of suffering. EAs can and do join such groups. However, sadly, I don’t know of a single organisation dedicated to biological-genetic solutions to the problem of suffering. Among transhumanists, for instance, radical life-extension and the prospect of posthuman superintelligence loom larger than biohappiness – though article 7 of the Transhumanist Declaration is admirably forthright: a commitment to the well-being of all sentience. Also, I think we need star power: the blessing of some charismatic billionaire or larger-than-life media celebrity. “Bill Gates says let’s use biotechnology to phase out the genetic basis of suffering” would be a breakthrough. Or even Justin Bieber.

For my part, I’m just a writer/researcher. We have our place! My guess is that this century will see more blueprints and manifestos and grandiose philosophical proposals together with concrete, incremental progress from real scientists. The genetic basis of suffering will eventually be eradicated across the tree of life, not in the name of anything “hedonistic” or gradients of intelligent bliss, and certainly not in the name of negative utilitarianism, but perhaps under the label of the World Health Organisation’s definition of health (cfConstitution of WHO: principles). Taken literally, the constitution of the WHO enshrines the most daringly ambitious vision of the future of sentience ever conceived. Lifelong good health (“complete physical, mental and social well-being”) for all sentient beings is a noble aspiration. Regardless of race or species, all of us deserve good health as so defined. A biology of information-sensitive gradients of physical, mental and social well-being (HI) is more modest and workable thanks to biotech. Optimistically, life on Earth has only a few more centuries of misery and malaise to go.

Marijuana-induced “Short-term Memory Tracers”

[On the subjective effects of marijuana]: It’s one thing to describe it verbally and another thing to experience it yourself. I had this dissociated feeling that was really intense. I had memory tracers. So it wasn’t like, you know, people on LSD or stuff will talk about how “your hand is tracing over and over again” and it was almost like that with my memory. My short term memory was repeating over and over again. So it’d be things like getting in a car, and getting in the car over and over again, putting on a seat belt over and over and over again, and it was like short term memory tracers. And it was overall extremely intense. Had an altered perception of space. You know… distance. That’s something I [also] got on mushrooms, which I talked about in a previous video, but it’s like you see something far away and you don’t really know if it’s really far away, or if it is just really small. So if you see a car that’s like 50 feet away, you don’t know if it is 50 feet away or if it is just a matchbox car that’s really close to you. So it kind of had that; it altered the way I saw space. And, to be honest, I freaked the fuck out, because this isn’t what I thought marijuana was supposed to be. I thought it was a sedative. I thought it made you relaxed. I didn’t know it tripped you the fuck out. So, uh, my response was: I thought I was dying. I remember being in the backseat of the car and saying “is this normal?” And the guy in the front seat– he was this Indian dude, his name was Deepak– I swear to God it was like, uh, my Kumar, and he turns back and and was like “Are you tripping, man? Are you feeling it, man?” and that just made me even more fucked up in the head. Because he was saying it in his Indian accent, and I was like “What’s going on? What’s going on?”, and I thought I had to go to the hospital. Uh, let’s fast-forward in the experience, so about one hour later, or 30 minutes later, I don’t really know, it started to turn more in what I expected it to be. Which was this sedative, I started feeling more relaxed, like the trip started subsiding, and I was left with this trip afterglow of relaxation, feeling giggly, feeling really hungry, and you know kind of like the standard marijuana high. And this happened every time I smoked marijuana in the beginning. I was uncomfortable for the first 30 minutes to an hour. I learned to kind of enjoy it, but for the most part I was waiting it out. And then I’d get relaxed and chill. And I wouldn’t really call it paranoia, it was really just tripping so hard I was kind of like “wow, like, I’m really fucking tripping, I hope I don’t act weird in front of a bunch of people” Maybe that is paranoia, I don’t know.

 

[…10 more minutes talking about marijuana…]

 

And I don’t know why the fuck marijuana is still illegal in 2017. I feel like I a fucking pilgrim. Like, seriously? A war veteran can go and almost die for his country. He could come back, and drink alcohol, buy an assault riffle, and get prescribed speed, but smoke a joint? Nah, you are a fucking criminal! I mean, that doesn’t make any fucking sense. I’ve been doing this push, that I said that if by January 2018 Marijuana wasn’t legal I’d shave my hair. I’m not gonna shave my head. I am gonna cut all of my hair off, and I’m really sad about that. Usually when I cut my hair off I send it to Korea at a random address because I just like to say “my hair is in Korea”. And I’m sure whoever opens it is like “why the fuck am I getting this?” But this time I’m gonna throw it up into eBay just because I want to see if anybody bids on it. I’m gonna do it 99 cents free shipping. But yeah, getting my hair cut is simply really weird: when I get to the stylist and say “can you put this on a bag? I’m gonna sell this.” Uh, but yeah, that really is it for Marijuana as far as my overall experience with the substance.

– What’s smoking marijuana like? The positive and negative effects of smoking cannabis and dabs by Youtube addiction recovery coach Cg Kid