DMT and Hyperbolic Geometry: 1 Million Views Special

My 2019 presentation The Hyperbolic Geometry of DMT Experiences just hit one million views on YouTube:

The casual QRI enjoyer may get the impression that this video encapsulates our current understanding of the phenomenology of DMT. The dedicated QRI reader/watcher, however, knows that we are light-years ahead in our understanding relative to where we were at the time. So I figured that this would be a good opportunity to highlight some of the DMT-specific insights that we have presented since that video came out. But before I do so, let me briefly discuss why this work is actually advancing our understanding (unlike most psychedelic phenomenology work out there) and then summarize some of the core points presented in that video so that we are all on the same page before moving on to the new models:


Introduction: What’s Useful Phenomenology?

At QRI we have put a lot of effort into characterizing what it means to describe an exotic state of consciousness in a way that is actually useful (see our guide for how to write good trip reports). Here are some key points:

Most people who try to make sense of the DMT-induced state of consciousness focus on the intentional content (the narrative) of the experience, which isn’t actually that helpful (consider how both a mescaline trip and a DMT trip can give rise to a hallucination about e.g. “meeting a dragon in another dimension”, yet the texture of such experiences will be very different!). Many others obsess over the question of whether what one experiences on DMT has a reality outside your brain or not (cf. Andrew Zuckerman has made it easy for you to test a DMT prime factorization experiment, were you to be so inclined). While interesting, I don’t think these approaches really advance our understanding very much; they in fact leave an enormous amount of low-hanging fruit uncollected.

Instead, a more fruitful approach is to focus on describing what we call the phenomenal character of the experience (yes, the dragon is important, but please also tell us how the scales on the skin of the dragon were arranged, whether they followed any wallpaper symmetry group, what their flicker frequency was, what patterns of local binding they expressed, and so on). The overwhelming majority of trip reports you can find in the literature and online don’t even try to do this. They are just quite content with a narrative account and superficial descriptions of the sensorial components of the experience (“I saw a lot of orange triangles”). But some psychonauts do try to rise to the challenge of describing the phenomenal character of the experience. Two examples are:

A step above doing this is where we find people such as Josikins (of Subjective Effect Index fame) who spend copious amounts of time trying to systematically catalogue exotic phenomenology by carefully describing and then labeling each effect with a concept handle. See also DMT-Nexus‘ systematic Hyperspace Lexicon which is perhaps a bit of a hybrid between focusing on intentional content and phenomenal character.

What’s missing here, however, is that the output ends up being a zoo of effects. Presumably, however, DMT and other psychedelics don’t have that many direct effects. Rather, they probably affect the properties of the nervous system in specific ways that in turn, downstream, give rise to a complex variety of effects. In other words, to really understand what’s going on, one should try to find a minimal set of core effects such that by combining them you get the complexity that we observe. Here is where we find people like Steven Lehar (see The Grand Illusion) and James L. Kent (see Psychedelic Information Theory). They are really experienced psychonauts who then go on to use their subject-matter expertise (cognitive science and signal processing, respectively) to explain the characteristics of the exotic states of consciousness they have experienced. They have both produced really excellent work with significant explanatory power.

At QRI we do something like that, but on a higher level. Namely, the exploration is integrated with philosophy of mind, neuroscience, and neurotechnology. What makes QRI’s psychedelic theory different than what you will see in academia is that:

  • We know of and take seriously a vastly larger experience base to work with (compared to e.g. some labs where you are not even allowed to discuss your own experiences with your colleagues!)
  • We use the framework of algorithmic reduction (and other key QRI paradigms) to try to simplify the complexity in terms of a minimal set of effects interacting with one another
  • Explore non-standard paradigms of computing (e.g. see Mike’s A Future for Neuroscience and more recently the video on Non-Linear Wave Computing), and
  • We have a crisp philosophy of mind that allows us to make modular progress on specific questions rather than being crippled by the “hard problem of consciousness” (e.g. solving the boundary problem or the translation problem can be done without having to solve everything else at once)

In other words, we actually pay attention to the details of experience no matter how weird they may be (did you know that seeing a hyperbolic honeycomb while on DMT can make your visual field “glitch”? Why does that happen?). We don’t let the theory define the facts and instead let the facts define the theory. And we try to tie it all together in light of what we know about how the nervous system works.

Example of a *structural* feature of experience: the fractal dimension of phenomenal objects. Empirically, the Hausdorff dimension of DMT phenomenal objects increases with the dose. (Ps. be careful not to look at objects with a high Hausdorff dimension while on DMT, such as cauliflowers – don’t ask me why, just don’t).


The Hyperbolic Geometry of DMT Experiences

The original article (slides; ELI5) upon which the video is based is over 8,000 words long and a lot of material is covered in it. Here I will merely highlight some of the key arguments, concepts, and talking points.

  • To a first approximation, the article does three things:
    • (1) provide detailed phenomenology focused on the structural and dynamic features that arise at each dose.
    • (2) postulate possible algorithmic reductions to explain the emergence of such structural and dynamic features.
    • (3) speculate on the information-processing properties of the state in question.
  • We point out that the reason why it is so difficult to recall the DMT experiences is that they take place in a phenomenal world with different geometry. Hence, what you do remember is whatever can exist both here and there! That said, you can modify the phenomenal objects you experienced as you come down in order to impress on them hints about what they were like up there.
  • We explain the concept of algorithmic reductions and how to apply it here.
  • Provide 17 reasons why DMT experiences are highly suggestive of hyperbolic geometry (from the presence of saddles in DMT psychedelic replications to the explicit accounts of Ralph Abraham who said his DMT experiences were distinctly non-Euclidean).
  • (1) Phenomenology:
    • Threshold (1-4mg): Crisp and high-resolution experience without obvious hallucinations. Intensified colors and sharper edges.
    • Chrysanthemum (4-8mg): The surfaces become fully saturated with wallpaper symmetry groups and then overflow, leading to a hyperbolization of such surfaces. At this level, the mind will still try to embed these constructs in 3D Euclidean space, so in practice you will see kale-like surfaces, saddles, helixes, corners, twists, etc. This often manifests as what looks like the blossoming of a flower or unwrapping of a present in the center of your attention.
    • Magic Eye (8-12mg): The Chrysanthemum becomes so curved that it can be used to render arbitrary 3D scenes of all sorts (e.g. ice cream shops, apparel, play pens, kitchen counters, etc.). We can think of this as a dynamic and animated depth map, which we call the world-sheet. If you pay attention, you will realize that the texture of the world-sheet is in fact made out of a widely contorted Chrysanthemum, with similarities to autostereograms (aka. Magic Eye visual illusions). 
    • Waiting Room (12-25mg): The curved world-sheet fully saturates 3D space; qualia continues to build to the point the that it simply does not fit 3D Euclidean space. Thus there is a forced hyperbolization of 3D phenomenal space, which also comes along a powerful multi-modal synchronization (cf. Kinesioöptic). This, in turn, makes the hallucinated world so engrossing that you lose contact with your surroundings. Often manifests as a hyper-realistic dome or series of interconnected rooms and exotic architectural structures with countless twists and turns.
    • Breakthrough (25mg+): The curvature and density of qualia is so extreme that the very topology of the worldsheet can change (e.g. via bifurcations and reconnections). One experiences radically exotic geometries of experience. There may be more than one geodesic between two given points, leading to markedly bizarre pseudo-acoustic properties. Sense of entering a sort of “interdimensional highway” that stitches together widely diverse and seemingly contradictory realities at once. (Today I would add that at this dose different regions of the experience may exhibit different pseudo-time arrows, and thus may have hybrid temporal qualities, as discussed here).
    • Amnesia (40mg+; depends): Not much to say here.
    • DMT objects, DMT space expansion, and DMT entities are described in terms of the unique features of each level.
  • (2) Algorithmic Reductions:
    • Control Interruption + Symmetry detection = Change in Metric: This algorithmic reduction combines the two core psychedelic effects of tracers (here discussed in light of Kent’s control interrupt model of psychedelic action) and lowering the symmetry detection threshold. The first one can be thought of as making the decay of qualia over time slower, and so the homeostatic level of qualia in one’s world-simulation reachers a higher level than normal. In turn, the rate at which “distances are being measured” with symmetry detection also changes. These two effects combined may give rise a network of distances between phenomenal objects that has a hyperbolic metric.
    • Dynamic System Account: Energy Sources, Sinks and Invariants: This algorithmic reduction bears a lot of similarities with predictive processing, except that it works at the algorithmic rather than computational level of abstraction.
      • We define the “Hamiltonian of Consciousness” (aka. the “temperature parameter”) as the sum total of the intensity-weighted qualia in an experience. It is noted that on DMT many energy invariants get activated: intense color can morph into acceleration which can morph into curvature and so on, as if they were trading a common currency (a unified “energy of consciousness” property).
      • Energy Sources: attention works as an energy source and on DMT this becomes intensified (almost as if the voltage of attention increased). Thus whatever you pay attention to becomes energized (brighter, faster, more curved, etc.).
      • Energy Sinks: The two main energy sinks are symmetry (not unlike how a soap bubble radiates out its energy until it settles as a perfect sphere) and semantic content (i.e. recognition). Essentially, when a part of the world-sheet starts to look symmetrical, it will “snap into symmetry” because that’s an energy minima in the neighborhood of configuration-space. And when parts of it start to resemble something you have seen or thought about before, it will snap into that configuration. We call the latter kind “Bayesian energy sinks” because they implement our perceptual priors.
      • On DMT the homeostatic balance between energy sources and sinks favors a much higher level of energy. Since curvature contributes to the Hamiltonian, most of the highly-energized states of mind are highly curved. This model wonderfully explains two aspects of tripping: first, it accounts for why what one ends up experiencing is a bizarre hybrid of symmetrical and semantic structures (e.g. faces with extra eyes, boats with point symmetry along extra degrees of freedom, etc.). And second, it explains why there are discontinuities between levels. This is because when you overwhelm the energy sinks the configuration of the world-sheet becomes less recognizable, and in turn this further blocks the ability to shed off the energy into Bayesian sinks. As a consequence, the balance between semantic content and symmetries favors symmetries on higher doses (since we lack the capacity to “recognize” semantically meaningful shapes in highly energized world-sheets).
    • Hyperbolic Micro-structure of Consciousness: This algorithmic reduction focuses on the low-level microstructure of experience. It postulates that the material properties of the world-sheet at the microscopic level are such that by energizing it one experiences a sort of thermal expansion and deformation on the parts of the world-sheet one pays attention to.
    • We note that these three algorithmic reductions might be complementary rather than mutually exclusive.
  • (3) Information Processing Properties:
    • We point out that these exotic states of consciousness may allow us to experience from the inside mathematical shapes for which mathematicians have so far had enormous difficulty visualizing and making sense of. In particular, knot complements (i.e. the space around a knot deformed so that the knot becomes the boundary at infinity), higher dimensional objects, and irreducibly complex (“prime”) shapes native to hyperbolic geometry can be encountered and interacted with. We speculate that perhaps someday breakthroughs in higher math might in fact primarily come from consciousness research centers.

Furthermore, the video includes some extra insights not present in the original article:

  • We add two more levels (which live at the interface between levels already discussed):
    • Between Threshold and Chrysanthemum there is a thin layer we call Symmetry Hotel where you still see the “real” world around you but every surface is fully saturated with wallpaper symmetry groups. Empirically, at this level the surfaces one sees on DMT can be tessellated with any of the 17 wallpaper symmetry groups and their combinations. Essentially, if you increase the energy parameter any more, then you will start to see some hyperbolization of the 2D surfaces and unlock the Chrysanthemum.
    • Between Magic Eye and Waiting Room there is a thin layer we call Crystal Worlds. It’s analogous to the Symmetry Hotel but one spatial dimension higher. Namely, the space around you becomes fully saturated with Euclidean space groups. If the energy parameter is raised any higher, then you will start to see a hyperbolization of (3D) space itself and unlock Waiting Room phenomenology.
  • In addition to the Hamiltonian of Consciousness (i.e. the temperature parameter) there is also a really important feature of experience: information content or complexity.
  • These two features define a state-space we call the Energy X Complexity landscape.
  • In order to provide an algorithmic reduction for the complexity of experience, we suggest that it is the result of feedback dynamics. This allows us to import an ontology of attractor states, which includes fixed points, limit cycles, chaos, and noise-drive spatial structures.
  • Note: In the presentation I highly recommended watching Space-Time Dynamics in Video Feedback to get a feel for this ontology. Today I would also recommend playing with the suitably psychedelic feedback-based phone app called Fraksl.
  • What defines a DMT trip is not only how far you traveled into the Energy X Complexity landscape, but also what your trajectory on it was (cf. Typical N,N-DMT Trip Progression According to an Anonymous Reader).
    • If you want to anneal a blissful state, starting in a minimally complex state and “going up” without moving right (i.e. getting caught up in any complexity) would be ideal.
    • For discovering and investigating mathematically interesting and exotic phenomena, aiming towards the upper center region would be ideal. This is where the machine elves show you absolutely mind-boggling irreducibly complex synesthetic patterns of qualia for which we have no names.
    • For processing stored inner tension or trauma, it might be necessary to go to the middle right region in order to induce entropic disintegration of patterns and then come back via the low-complexity region to anneal a harmonious state.
  • We concluded the presentation by suggesting that a way forward for science to investigate DMT-like states of consciousness would be to plan legal retreats with physicists, mathematicians, electrical engineers, and visual artists so that the models here presented could be explored, tested, and further developed out in the open.

More Recent DMT Insights

The descriptions shown below merely scratch the surface. Think of them as pointers rather than the insights themselves. For the videos in particular, even if you don’t have the time to see them in full, I nonetheless recommend clicking on them and reading their descriptions (rather than merely the excerpts pasted below). Of course there really isn’t a good substitute for watching the entire video if you want the detailed explanation.

  • November 15, 2019 Break Out of the Simulation Day: Televised Entity Contact, Injection Pulling Experiments, and the Brain as a Game Engine (article)
    • This essay proposes a novel way of testing the independent reality of DMT entities: one could in principle determine that the brain state is being influenced by an external force by looking for the dynamic signatures of injection pulling in neuroimaging data.
  • July 1, 2020 5-MeO-DMT vs. N,N-DMT: The 9 Lenses (article)
    • This article describes 9 key differences between the phenomenology of DMT and 5-MeO-DMT: (1) Space vs. Form: 5-MeO is more space-like than DMT. (2) Crystals vs. Quasi-Crystals: 5-MeO generates more perfectly repeating rhythms and hallucinations than DMT. (3) Non-Attachment vs. Attachment: 5-MeO seems to enable detachment from the craving of both existence and non-existence, whereas DMT enhances the craving. (4) Underfitting vs. Overfitting: 5-MeO reduces one’s model complexity whereas DMT radically increases it. (5) Fixed Points and Limit Cycles vs. Chaotic Attractors: 5-MeO’s effect on feedback leads to stable and predictable attractors while DMT’s attractors are inherently chaotic. (6) Modulation of Lateral Inhibition: 5-MeO may reduce lateral inhibition while DMT may enhance it. (7) Diffuse Attention vs. Focused Attention: 5-MeO diffuses attention uniformly over large regions of one’s experiential field, while DMT seems to focus it. (8) Big Chunks and Tiny Chunks vs. A Power Law of Chunks: 5-MeO creates a few huge phases of experience (as in phases of matter) with a few remaining specks, while DMT produces a more organic power law distribution of chunk sizes. (9) Integration vs. Fragmentation: 5-MeO seems to give rise to “neural integration” involving the entrainment of any two arbitrary subnetworks (even when they usually do not talk to each other), while DMT fragments communication between most networks but massively enhances it between some specific kinds of networks.
  • October 9, 2020 Modeling Psychedelic Tracers with QRI’s Psychophysics Toolkit: The Tracer Replication Tool (article)
    • This is the first attempt at quantitatively and qualitatively measuring the tracer characteristics of DMT hallucinations (try it yourself!). Preliminary findings suggest that DMT is special relative to other psychedelics in the following ways. First, it has pronounced tracer effects. Second, they flicker at a much higher frequency than other drugs (~30 Hz relative to ~15-20 for LSD and ~12 for 2C-B). Third, there are both strobe and replay effects galore. Fourth, there is a color pulsing effect at a very high frequency (also around 30 Hz). Unlike 5-MeO-DMT, which gives rise to monochromatic tracers, on DMT the color of the tracers alternates between their positive and negative afterimages.
  • Jan 8, 2021 Why Does DMT Feel So Real? Multi-modal Coherence, High Temperature Parameter, Tactile Hallucinations (video essay)
    • This explains why it is so hard to not take at face value the reality of the hallucinations on DMT. When we take psychedelics, we learn what “channels” of information become distorted and which ones can be trusted. It turns out that DMT can mess with many more channels relative to other psychedelics (such as LSD, mescaline, or 2C-B). In particular, DMT is exceptional in the degree of (1) cross-modal coherence that it induces, (2) heat, giving rise to a very high temperature parameter of experience, and (3) realistic tactile hallucinations. These three features combined might go a long way in explaining why DMT feels so real. Namely, that you can experience detailed tactile feelings like “crossing a veil” or “being invaded by energetic bugs” or “being operated on” that are coherent with the information you are receiving from other senses and are felt with a level of intensity much greater than the feelings one is used to in everyday life. This synergizes to create a very realistic feeling of touching parallel realities.
  • Feb 15, 2021 A Language for Psychedelic Experiences: Algorithmic Reductions, Field Operators, and Dimensionality (video essay)
    • From the description: We suggest that a remarkably fruitful strategy for pointing at a whole family of psychedelic effects comes in the form of “field operators” that change the qualitative properties of our experiential fields. I provide a detailed description of what we call the “world-sheet” of experience and how it encodes emotional and semantic content in its very structure. The world-sheet can have tension, relaxation, different types of resonance and buzzing entrainment, twisting, curling, divergence (with vortices and anti-vortices in the attention field-lines), dissonance, consonance, noise, release, curvature, holographic properties, and dimensionality. I explain that in a psychedelic state, you explore higher up regions in the “Hamiltonian of the field”, meaning that you instantiate field configurations with higher levels of energy. There, we observer interesting trade-offs between the hyperbolicity of the field and its dimensionality. It can instantiate fractals of many sorts (in polar, cartesian, and other coordinate systems) by multi-scale entrainment. Time loops and moments of eternity result from this process iterated over all sensory modalities. The field contains meta-data implicitly encoded in its periphery which you can use for tacit information processing. Semantic content and preferences are encoded in terms of the patterns of attraction and repulsion of the attention-field lines.
  • May 8, 2021 Healing Trauma with Neural Annealing (article & presentation)
    • This writeup does a lot of things. While the focus is on application (i.e. how to heal trauma with psychedelics), it also lays out a very significant amount of novel psychedelic theory. Excerpt: A lot of psychedelic phenomenology suggests that there is a duality between the vibe of the state and the geometric layout of the multi-modal hallucinations. In other words, each phenomenal object has a corresponding way of vibrating, and this is experienced as a holistic signature of such objects. (cf. Resonance and vibration of [phenomenal] objects). (See also: Hearing the shape of a drum). In the context of this presentation, the most important idea of this slide is that the duality between standing wave patterns and the vibe of the experience showcases how symmetry and valence are related. Blissful “heavenly realms” on DMT are constructed in ways where the resonance of the phenomenal objects with each other is consonant and their structure is symmetrical. Likewise, the screechy and painful quality of the DMT “hell realms” comes along with asymmetries, discontinuities, and missing components in the phenomenal objects that make up experiences. The overall vibe of the space is the result of the intrinsic vibratory modes of each phenomenal object in addition to each of the possible interactions between them (weighted by their phenomenal distance). An analogy readily comes to mind of an orchestra and the challenges that come with making it sound consonant. […] We hypothesize that DMT’s effects at the implementation level can be understood as the result of competing clusters of coherence across the hierarchy, whereas the main attractors of 5-MeO-DMT seem to involve global coherence. Modulating the average synaptic path length in a system of coupled oscillators can give rise to this sort of effect. By randomly adding connections to a network of coupled oscillators one first sees an emergent state of many competing patches of synchrony, and then, after a threshold is crossed, one starts seeing global synchrony emerge. Despite both drugs making the brain “more interconnected”, the slight difference in just how interconnected it makes it, may be the difference between the colorful chaos of DMT and the peaceful nothingness of 5-MeO-DMT. The competing clusters of coherence across the hierarchy can evolve to adapt to each other. The DMT realm is more of an ecosystem than it is a state per se (ex: Hyperspace Lexicon). And due to the duality between dissonance minimization and prediction error minimization, avoiding updating one’s belief in the direction of these realms being real causes intense cognitive dissonance. Some level of belief updating to fit the content of the hallucinations might be very difficult to resist. Indeed, the forced coherence across the layers of the hierarchy would be bypassing one’s normal ability to resist information coming from the lower layers.
      As you can see, contrary to what many people in the comments* seem to say, DMT visuals are in fact extremely important and not at all just a superficial aspect of the experience. Due to the duality between the vibe of the state and the geometric layout of the multi-modal hallucinations, it is always the case that the geometry of your experience will be a reflection of your emotional processing! Solving for harmony in your hallucinations will in turn have unexpected harmonizing effects at the emotional level as well.
  • May 31, 2021 DMT vs. 5-MeO-DMT: 12 Key Differences (video essay)
    • This video essay expands on the article and adds three key differences: (10) Global Coherence vs. Competing Clusters of Coherence: 5-MeO-DMT gives rise to a global coherent state (the so-called “unified energy field”), whereas DMT gives rise to an ecosystem of time-loops, each trying to capture as much of your attention as possible, which in turn results in coalition-building and evolution of patterns in the direction of being very “attention grabbing” (cf. reddit.com/r/place). (11) Really Positive or Really Negative Valence vs. Highly-Mixed Valence: 5-MeO-DMT gives rise to either a globally coherent state (high-valence) or two competing coherent states (negative-valence), whereas DMT tends to generate complex consonance/dissonance relationships between the clusters of coherence. (12) How they are different according the the Free Energy Principle: On 5-MeO-DMT the entire experience has to reinforce itself, whereas each cluster of coherence needs to model the rest of the experience in order to be reinforced by it on DMT. Thus 5-MeO-DMT makes experiences that express “the whole as the whole” whereas DMT makes each part of the experience represent the whole yet remains distinct.
  • Jun 20, 2021 Psychedelics and the Free Energy Principle: From REBUS to Indra’s Net (video essay)
    • The key achievement of this video is to discuss the Free Energy Principle and Predictive Processing at the implementation level of analysis in light of Neural Annealing, the Symmetry Theory of Valence, and Holistic Field Behavior. Here we realize that prediction errors feel bad not because they are inherently negative, but because the nervous system is implemented in such a way that they generate dissonance. More so, there is also a dissonance cost to model complexity (complex internal representations “self-intersect” and thus generate dissonance). This balances out so that our nervous system minimizing dissonance ends up generating relatively simple models with high levels of accuracy. In other words, it avoids both underfitting and overfitting merely by trying to minimize internal dissonance! The video also articulates how Bayesian Energy Sinks might be implemented. It concludes with a derivation of the “mystical” (or psychedelic, really) state of Indra’s Net, i.e. why on substances such as DMT it often feels like “everything reflects everything else”. Indra’s Net, it turns out, can be explained as a local energy minima of a highly energized system of coupled oscillators organized hierarchically so that each “competing cluster of coherence” minimizes its energy by predicting perfectly the behavior of the surrounding ones. In other words, each “competing cluster of coherence” needs to model its environment in order to synch up with it in a reinforcing way. This leads to attractor states where everything is a reflection of everything else.
  • Sep 24, 2021 Are Higher Dimensions Real? From Numerology to Precision Xenovalence – 4 5 6 8 10 12 16 20 24 32 (video essay)
    • This video explains how a system of coupled oscillators can in fact instantiate virtual higher dimensions. Namely, dynamic systems that behave as if they were embedded in a higher spatial dimension. There is a trade-off between degrees of freedom and higher virtual dimensions. It argues that indeed on DMT one can experience such higher dimensions and that in light of the Symmetry Theory of Valence there is a corresponding “generalized music theory” that explains why some of them feel good and others not. Additionally, there seems to be an algebra for how “DMT objects” with specific dimensionalities can be composed with one another (the 2D symmetry slabs found in Symmetry Hotel can be composed with each other to form 3D spatial structures native to the Crystal World level).
  • Jan 30, 2022 Qualia Computing: How Conscious States Are Used For Efficient And Non-Trivial Information Processing (video essay)
    • From the video description: The reason we are conscious is because being conscious allows you to recruit self-organizing principles that can run on a massively parallel fashion in order to find solutions to problems at [wave propagation] speed. Importantly, this predicts it’s possible to use e.g. a visual field on DMT in order to quickly find the “energy minima” of a physical state that has been properly calibrated to correspond to the dynamics of a world-sheet in that state. This is falsifiable and exciting.
  • Feb 26, 2022 Full-Spectrum Superintelligence: From Shape Rotator to Benevolent Rainbow God
    • From the video description: High-octane mental power, when pointed in a pointless direction, is not particularly useful. Thus, we must enrich our conception of intelligence to encapsulate philosophical, meditative, and existential cognition. And, perhaps the Crown Jewel of Intelligence: the ability to explore, make sense of, navigate, and recruit exotic states of consciousness for information processing and aesthetic purposes. In particular, I make the case that intelligence is truly about identifying *self-organizing principles* of physics that are energetically cheap which can *solve the problem for you* (cf. “Repulsive Shape Optimization”).
  • Mar 5, 2022 Non-Linear Wave Computing: Vibes, Gestalts, and Realms (video essay)
    • DMT both energizes one’s state of consciousness and also provides a new medium of wave propagation. At a sufficient dose (>5mg) it takes one’s consciousness to the non-linear regime. This video discusses the very nature of vibes, how gestalts arise, and how they assemble to form realms. It also explains how a vibe acquires its valence (partly through its ADSR envelope characteristics). If you only watch one video, make it this one.
  • Mar 15, 2022 Attention & Awareness: Oscillatory Complementarity, Non-Linearities, and the Pointlessness of It All (video essay)
    • This video explains how DMT objects emerge out of exotic attention-awareness patterns. From the video description: LSD non-duality can be understood as more diffuse elements of experience becoming the non-linear oscillatory complements of the field of awareness, such as “light”, “space”, and “being”. DMT’s competing clusters of coherence and their compositional properties also emerge naturally out of a hyper-energized field of awareness that generates oscillatory complements. 5-MeO-DMT is a straight path to insight territory, as it activates a new medium of wave-propagation orthogonal to the one in which our world-simulation is typically embedded. And so on… I also re-evaluate the models introduced in the original Qualia Computing article on the geometry of DMT experiences in light of this new paradigm. In particular, I delve into the concept of exotic attention in the form of wallpaper symmetry groups and Bayesian energy sinks.

DMT-related Media Appearances

Since the Harvard presentation, I have also given many other presentations and participated in podcasts, some of which touch upon DMT. Here is a selection of some of the most relevant ones:


Note: Of course all of this still needs to be synthesized, presented, and written up in ways that can interface more smoothly with academia and the world at large. That said, I constantly get emails and messages from people in academia (typically PhD students, but often also professors and even heads of labs) telling me that QRI’s psychedelic theory is the most illuminating content they are aware of when it comes to how to make sense of exotic states of consciousness. One relatively well-known academic described our models in private as “two steps ahead of the current understanding in academia”. Sadly, I am also aware of a few peer reviewed articles and publications that present our ideas as their own- ideas which we shared with the authors in private meetings, where they told us they were insightful and new to them at the time. I would kindly request to any academic reader of QRI to please cite our articles and videos if they inspired or informed their research in any way. It’s of course a matter of intellectual integrity to do so (and contrary to common misconception, you can in fact cite blogposts and YouTube videos in your scientific articles! In fact, not doing so when you got a key insight from them goes against the very spirit of science. Please do so when appropriate). Thank you, and remember that citing us for our meaningful contributions to the field will put a smile on my face! 🙂

(source)


Special thanks to: Everyone at QRI (especially Michael Johnson, for years of fruitful collaboration on these topics). Andrew Zuckerman and Kenneth Shinozuka who were instrumental for setting up this presentation and so many other things. Quintin Frerichs who 3D-printed and brought the cool shapes shown in the video**, not to speak of his outstanding internal technical contributions. Romeo Stevens for all the incredible support (he was also there in the audience!). Anders Amelin and Maggie Wassinge for their brilliant and holistic contributions to the conversation. Marcin Kowrygo and Hunter Meyer for stepping up in times of need and being such great and dedicated helpers in so many ways. The extended QRI network and anonymous psychonauts who have participated in fruitful discussions and informed our models. David Pearce for years of friendship and collaboration in this and related areas. Our donors for bravely supporting our projects despite how crazy they may seem from the outside view. And to YOU, dear reader. Thank you all!

Infinite bliss!


* You can find my response to the most common kinds of comments on the video here: Collecting Qualia Souvenirs.

**They are technically {5,3,4} hyperbolic honeycombs drawn in the Poincaré ball model. We got the files from Henry Segerman‘s website.

Review of Log Scales


This is my 2022 review of Logarithmic Scales of Pleasure and Pain: Rating, Ranking, and Comparing Peak Experiences Suggest the Existence of Long Tails for Bliss and Suffering (2019; QRI link; forum link), written for the EA Forum First Decade Review; permalink of the review; read all reviews and vote for submissions here.



I would like to suggest that Logarithmic Scales of Pleasure and Pain (“Log Scales” from here on out) presents a novel, meaningful, and non-trivial contribution to the field of Effective Altruism. It is novel because even though the terribleness of extreme suffering has been discussed multiple times before, such discussions have not presented a method or conceptual scheme with which to compare extreme suffering relative to less extreme varieties. It is meaningful because it articulates the essence of an intuition of an aspect of life that deeply matters to most people, even if they cannot easily put it into words. And it is non-trivial because the inference that pain (and pleasure) scales are better understood as logarithmic in nature does require one to consider the problem from multiple points of view at once that are rarely, if ever, brought up together (e.g. combining empirical deference graphs, descriptions of pain scales by their creators, latent-trait analysis, neural recordings, and psychophysics). 

Fundamentally, we could characterize this article as a conceptual reframe that changes how one assesses magnitudes of suffering in the world. To really grasp the significance of this reframe, let’s look back into how Effective Altruism itself was an incredibly powerful conceptual reframe that did something similar. In particular, a core insight that establishes the raison d’etre of Effective Altruism is that the good that you can do in the world with a given set of resources varies enormously depending on how you choose to allocate it: by most criteria that you may choose (whether it’s QALYs or people saved from homelessness), the cost-effectiveness of causes seem to follow much more closely (at least qualitatively) a long-tail rather than a normal distribution (see: Which world problems are the most pressing to solve? by Benjamin Todd; the long-tail on the left below). In turn, this strongly suggests that researching carefully how to invest one’s altruistic efforts is likely to pay off in very large ways: choosing a random charity versus a top 1% charity will lead to benefits whose scale differs by orders of magnitude.

Log Scales suggests that pain and pleasure themselves follow a long-tail distribution. In what way, exactly? Well, to a first approximation, across the entire board! The article (and perhaps more eloquently the subsequent video presentation at the NYC EA Meetup on the same topic) argues that when it comes to the distribution of the intensity of hedonic states, we are likely to find long-tails almost independently of the way in which we choose to slice or dice the data. This is analogous to, for example, how all of the following quantities follow long-tail distributions: avalanches per country, avalanches per mountain, amount of snow in mountains, number of avalanche-producing mountains per country, size of avalanches, number of avalanches per day, etc. Likewise, in the case of the distribution of pain, the arguments presented suggest we will find that all of the following distributions are long-tails: average pain level per medical condition, number of intensely painful episodes per person per year, intensity of pain per painful episode, total pain per person during life, etc. Thus, that such a small percentage of cluster headache patients accounts for the majority of episodes per year would be expected (see: Cluster Headache Frequency Follows a Long-Tail Distribution; the long-tail on the right above), and along with it, the intensity of such episodes themselves would likely follow a long-tail distribution.

This would all be natural, indeed, if we consider neurological phenomena such as pain to be akin to weather phenomena. Log Scales allows us to conceptualize the state of a nervous system and what it gives rise to as akin to how various weather conditions give rise to natural disasters: a number of factors multiply each other resulting in relatively rare, but surprisingly powerful, black swan events. Nervous systems such as those of people suffering from CRPS, fibromyalgia, and cluster headaches are like the Swiss Alps of neurological weather conditions… uniquely suited for ridiculously large avalanches of suffering.

Log Scales are not just of academic interest. In the context of Effective Altruism, they are a powerful generator for identifying new important, neglected, and tractable cause areas to focus on. For instance, DMT for cluster headaches, microdose ibogaine for augmentation of painkillers in sufferers of chronic pain, and chanca piedra for kidney stones (writeup in progress) are all what we believe to be highly promising interventions (of the significant, neglected, and tractable variety) that might arguably reduce suffering in enormous ways and that would not have been highlighted as EA-worthy were it not for Log Scales. (See also: Get-Out-Of-Hell-Free Necklace). On a personal note, I’ve received numerous thank you notes by sufferers of extreme pain for this research. But the work has barely begun: with Log Scales as a lens, we are poised to tackle the world’s reserves of suffering with laser-focus, assured in the knowledge that preventing a small fraction of all painful conditions is all that we need to abolish the bulk of experiential suffering.

But does Log Scales make accurate claims? Does it carve reality at the joints? How do we know?

The core arguments presented were based on (a) the characteristic distribution of neural activity, (b) phenomenological accounts of extreme pleasure and pain, (c) the way in which the creators of pain scales have explicitly described their meaning, and (d) the results of a statistical analysis of a pilot study we conducted where people ranked, rated, and assigned relative proportions to their most extreme experiences. We further framed this in terms of comparing qualitative predictions from what we called the ​​Normal World vs. Lognormal World. In particular, we stated that: “If we lived in the ‘Lognormal World’, we would expect: (1) That people will typically say that their top #1 best/worst experience is not only a bit better/worse than their #2 experience, but a lot better/worse. Like, perhaps, even multiple times better/worse. (2) That there will be a long-tail in the number of appearances of different categories (i.e. that a large amount, such as 80%, of top experiences will belong to the same narrow set of categories, and that there will be many different kinds of experiences capturing the remaining 20%). And (3) that for most pairs of experiences x and y, people who have had both instances of x and y, will usually agree about which one is better/worse. We call such a relationship a ‘deference’. More so, we would expect to see that deference, in general, will be transitive (a > b and b > c implying that a > c).” And then we went ahead and showed that the data was vastly more consistent with Lognormal World than Normal World. I think it holds up.

An additional argument that since has been effective at explaining the paradigm to newcomers has been in terms of exploring the very meaning of Just-Noticeable Differences (JNDs) in the context of the intensity of aspects of one’s experience. Indeed, for (b), the depths of intensity of experience simply make no sense if we were to take a “Just-Noticeable Pinprick” as the unit of measurement and expect a multiple of it to work as the measuring rod between pain levels in the 1-10 pain scale. The upper ends of pain are just so bright, so immensely violent, so as to leave lesser pains as mere rounding errors. But if on each step of a JND of pain intensity we multiply the feeling by a constant, sooner or later (as Zvi might put it) “the rice grains on the chessboard suddenly get fully out of hand” and we enter hellish territory (for a helpful visual aid of this concept: start at 6:06 of our talk at the 2020 EAGxVirtual Unconference on this topic).

From my point of view, we can now justifiably work under the assumption that the qualitative picture painted by Log Scales is roughly correct. It is the more precise quantitative analysis which is a work in progress that ought to be iterated over in the coming years. This will entail broadening the range of people interviewed, developing better techniques to precisely capture and parametrize phenomenology (e.g. see our tool to measure visual tracers), use more appropriate and principled statistical methods (e.g. see the comment in the original piece about the Bradley-Terry model and extreme value theory), experimental work in psychophysics labs, neuroimaging research of peak experiences, and the search for cost-effective pragmatic solutions to deal with the worst suffering. I believe that future research in this area will show conclusively the qualitative claims, and perhaps there will be strong consilience on the more precise quantitative claims (but in the absence of a true Qualiascope, the quantitative claims will continue to have a non-negligible margin of error).

Ok, you may say, but if I disagree about the importance of preventing pain, and I care more about e.g. human flourishing, why should I care about this? Here I would like to briefly address a key point that people in the EA sphere have raised in light of our work. The core complaint, if we choose to see it that way, is that one must be a valence utilitarian in order to care about this analysis. That only if you think of ethics in terms of classical Benthamite pain-minimization and pleasure-maximization should we be so keen on mapping the true distribution of valence across the globe. 

But is that really so?

Three key points stand out: First, that imperfect metrics that are proxies for aspects of what you care about (even when not all that you care about) can nonetheless be important. Second, that if you cared a little about suffering already, then the post-hoc discovery that suffering is actually that freaking skewed really ought to be a major update. And third, there really are reasons other than valence maximization as a terminal goal to care about extreme suffering: intense suffering is antithetical to flourishing since it has long-term sequelae. More so, even if confined to non-utilitarian ethical theories, one can make the case that there is something especially terrible about letting one’s fellow humans (and non-humans) suffer so intensely without doing anything about it. And perhaps especially so if stopping such horrors turn out to be rather easy, as is indeed the case.

Let’s tackle these points each in turn.

(1) Perhaps here we should bring a simple analogy: GDP. Admittedly, there are very few conceptions of the good in which it makes sense for GDP to be the metric to maximize. But there are also few conceptions of the good where you should disregard it altogether. You can certainly be skeptical of the degree to which GDP captures all that is meaningful, but in nearly all views of economic flourishing, GDP will likely have a non-zero weight. Especially if we find that, e.g. some interventions we can do to the economy would cause a 99.9% reduction in a country’s GDP, one should probably not ignore that information (even if the value one assigns to GDP is relatively small compared to what other economists and social scientists assign it). Likewise for extreme suffering. There might be only a few conceptions of the good where that is the only thing we ought to work on. But avoiding hellish states is a rather universally desired state for oneself. Why not take it at least somewhat into account?

In truth, this is not something that classical questions in Effective Altruism pre-Log Scales couldn’t overcome either. For instance, as far as I am aware, in practice QALYs are used more as a guide than as an absolute; their value within EA comes from the fact that in practice interventions are orders of magnitude different when it comes to their cost-effectiveness when assessed with QALYs. So even though the vast majority of EAs are not QALY absolutists, the differences in QALYs saved between interventions are large enough that as an approximate guide, the metric still generates huge amounts of consilience.

(2) In turn, the post-hoc finding that hellish states are much, much worse than one would intuitively believe really should at least rebalance one’s priorities somewhat. Is there really no amount of suffering that would do so? Unless one has a utility function akin to a ReLu activation function, going far enough down into the depths of hell ought to count for something. And…

(3) Speaking candidly, fully articulating the true significance of this finding will take us to philosophically polemical territory: philosophy of personal identity where person-affecting views will see the situation quite differently than person-moment-affecting views, philosophy of mind where the ontological status of pleasure and pain might be questioned, and intricate questions that arise at the interface between the views of virtue ethicists, deontologists, negative and classical utilitarians. Of course a negative utilitarian who believes in Empty Individualism and Eternalism at the same time will likely be especially horrified by this information. But, with that said, I would suggest that there are good reasons to care about Log Scales no matter how antithetical one’s views are to philosophical hedonism

In particular, I would argue that deontologists and virtue ethicists should still take note. The cultivation of virtue requires a minimum of wellbeing in order to maintain motivation to live. And perhaps deontologists might find extreme suffering particularly egregious from the point of view of “things so horrible that ought not to be”. Really, the people we interviewed for the cluster headache writeup told us that experiencing such levels of hellish suffering causes profound psychological transformations (e.g. one interviewee told us that experiencing the higher ends of pain in a cluster headache feels like a profound “spiritual violation” from which you may never recover – a feeling most certainly aggravated by the seeming indifference of people at large about their plight). Virtue ethicists and deontologists might as well recognize this cause area as work that is unconscionable not to perform, regardless of arguments based on the precise mathematical optimization of the prevention of negative valence.

And finally, in all seriousness, as the cognitive intelligentsia of the world begins to see clearly the nature of the distribution of pleasure and pain, we can expect there to be a big social benefit to being the one who destroys hell. Right now there isn’t a huge social reward to be obtained by working on this cause, but I predict this will change. And, pragmatically, it is sensible to present this cause in a motivating rather than depressing light: indeed, let’s give honor, glory, and endless admiration to whoever makes tangible progress in tearing hell down. And to all of the millionaires and billionaires reading this: this could be you! You could be the one who took on the mantle of preventing all future cluster headaches, established the field of anti-tolerance drugs for severe chronic pain, or got rid of kidney stones (and you did it before it was cool!). Let’s get to work!


7 Recent Videos: Buddhist Annealing, Is This a Simulation?, The Purple Pill, DMT vs. 5-MeO-DMT, Digital Sentience, Psychedelics and the Free Energy Principle, and Advanced Visions of Paradise

[Context: 3rd in a series of 7-video packages. See the previous two packages: 1st and 2nd]

[Featured image by Wendi Yan.]

Buddhist Annealing: Wireheading Done Right with the Seven Factors of Awakening (link)

This video discusses the connections between meditative flow (any feeling of change) and the two QRI paradigms of “Wireheading Done Right” and “Neural Annealing”. To do so, I explore how each of the “seven factors of awakening” can be interpreted as operations that you do to flow. In a nutshell: the factors are “energy management techniques”, which when used in the right sequences and dosages, tend to result in wholesome neural annealing.

I then go on to discuss two fascinating dualities: (1) The dual relationship between standing wave patterns and vibratory frequencies. And (2) the dual correspondence between annealing at the computational level (REBUS) and annealing in resonance networks.

(1) Describes how the crazy patterns that come out of meditation and psychedelics are not irrelevant. They are, in a way, the dual counterpart to the emotional processing that you are undergoing. Hence why ugly emotions manifest as discordant structures whereas blissful feelings come together with beautiful geometries.

(2) Articulates how simulated annealing methods in probabilistic graphical models such as those that underlie the synthesis of entropic disintegration and the free energy principle (Friston’s and Carhart-Harris’ REBUS model) describe belief updating. Whereas annealing at the implementation level refers to a dissonance-minimization technique in resonance networks. In turn, if these are “two sides of the same coin”, we can expect to find that operations in one domain will translate to operations in the other domain. In particular, I discuss how resisting information (“denial”, “cognitive dissonance”) has a corresponding subjective texture associated with muscle tension, “resistance”, viscosity, and hardness. Equanimity, in turn, allows the propagation of both waves of dissonance, consonance, and noise as well as bundles of information. This has major implications for how to maximize the therapeutic benefit of psychedelics.

Finally, I explain how we could start formalizing Shinzen Young’s observation that you can, not only “read the contents of your subconscious”, but indeed also “heal your subconscious by greeting it with enough concentration, clarity, and equanimity”. Negentropy in the resonance network (patches of highly-ordered “combed” coherent resonance across levels of the hierarchy) can be used to heal patches of dissonance. This is why clean high-valence meditative objects (e.g. metta) can absorb and dissipate the internal dissonance stored in patterns of habitual responses. In turn, this might ultimately allow us to explain why, speaking poetically, it is true that love can heal all wounds. 🙂

~Qualia of the Day: Nirvana Rose~

(Skip to ~10:00 if you don’t need a recap of Wireheading Done Right and Neural Annealing)

[ps. correction – I wrote a 30 page document about my retreat, not a 50 word document]

Relevant Links:


Is This a Simulation? (link)

Will You Take the Simulation Pill?

Warning: Once You Take It There Is No Going Back.

Apologies for the Clickbait. I Can’t Say More Unless You Take the Pill With Me. 🙂

~Qualia of the Day: The Red Pill – With Your Consent, We Will Take It Together~

Relevant Links:


The Purple Pill: What Happens When You Take the Blue and the Red Pill at the Same Time? (link)

The Purple Pill is the pill that gives you both high hedonic tone and an unprejudiced open-ended approach to the pursuit of truth. For losing truth is to lose it all, but to lose it all is only bad because it makes you and others suffer in the wider universe.” – The Purple Pill (Qualia Computing)

In this talk I explain that the “Blue vs. Red Pill” trope relies on a false dichotomy. You don’t need to choose between depressive realism and comforting illusions. Put differently, you don’t need to choose between truth and happiness. High hedonic tone is not incompatible with one’s representational accuracy of causal structures. The world, and the existence of experiential heaven and hell, can be understood without curling into a ball and crying your way to sleep. More so, effective and persistent action towards the good requires that you don’t believe in this false dichotomy, for sustainable altruistic productivity necessitates both accurate models and positive motivations. Thus, the aspiring paradise engineer ought to be willing to take the Purple Pill to move onwards.

I advocate having a balanced portfolio of (1) efforts to minimize experiential hell, (2) techniques to increase the hedonic baseline sustainably, and (3) methods to reliably experience peak states of consciousness in a sane way.

I do not think that spending 100% of one’s time in “destroying hell” is a sustainable approach to life because it does not allow you to “reinvest” in the conditions that gave rise to one’s goodness to begin with (otherwise you become more of a martyr than an effective player in the field!). More so, the relationship between suffering and productivity is non-trivial, which means that to just helping people who suffer extremely does not generally pay off in terms of productive action towards the cause in the future. Hence, improving baseline is just as important: it is precisely what allows people to go from near zero productivity to a high level of productivity. Finally, the benefits of having access to reliable, pro-social ultra-blissful states of consciousness should not be underestimated. They are an important piece of the puzzle because they motivate the “animal self” and are deeply reassuring. Thus, as a “package”, I see a lot of potential in simultaneously reducing negative extremes, improving the baseline, and achieving new heights of bliss. This, to me, is what I see as the path forward.

Topics I cover span: Trungpa’s “Spiritual Materialism” (the attitude of using exalted states of consciousness to “decorate our ego”), optimization problems/reinvesting in the good, sane in-group/out-group dynamics, the game theory of virtue signaling, and the importance of having an explicit commitment to the wellbeing of all sentient beings (to prevent value drift).

~Qualia of the Day: Spiritual Materialism~

Relevant Links:

Thanks Mike Johnson and David Pearce for many conversations on this topic.


DMT vs. 5-MeO-DMT: 12 Key Differences (link)

What are the differences between DMT and 5-MeO-DMT? And what gives rise to those differences? In this video we discuss 12 different ways to analyze the strange and unique effects of these substances. We go over the 9 lenses already discussed in Qualia Computing* and add three more.

Starting with three new lenses (5-MeO-DMT left/DMT right):

A) Global Coherence vs. Competing Clusters of Coherence: 5-MeO-DMT gives rise to a global coherent state (the so-called “unified energy field”), whereas DMT gives rise to an ecosystem of time-loops, each trying to capture as much of your attention as possible, which in turn results in coalition-building and evolution of patterns in the direction of being very “attention grabbing” (cf. reddit.com/r/place).

B) Really Positive or Really Negative Valence vs. Highly-Mixed Valence: 5-MeO-DMT gives rise to either a globally coherent state (high-valence) or two competing coherent states (negative-valence), whereas DMT tends to generate complex consonance/dissonance relationships between the clusters of coherence.

C) How they are different according the the Free Energy Principle: On 5-MeO-DMT the entire experience has to reinforce itself, whereas each cluster of coherence needs to model the rest of the experience in order to be reinforced by it on DMT. Thus 5-MeO-DMT makes experiences that express “the whole as the whole” whereas DMT makes each part of the experience represent the whole yet remains distinct.

And the original 9 lenses:

1) Space vs. Form: 5-MeO is more space-like than DMT.
2) Crystals vs. Quasi-Crystals: 5-MeO generates more perfectly repeating rhythms and hallucinations than DMT.
3) Non-Attachment vs. Attachment: 5-MeO seems to enable detachment from the craving of both existence and non-existence, whereas DMT enhances the craving.
4) Underfitting vs. Overfitting: 5-MeO reduces one’s model complexity whereas DMT radically increases it.
5) Fixed Points and Limit Cycles vs. Chaotic Attractors: 5-MeO’s effect on feedback leads to stable and predictable attractors while DMT’s attractors are inherently chaotic.
6) Modulation of Lateral Inhibition: 5-MeO may reduce lateral inhibition while DMT may enhance it.
7) Diffuse Attention vs. Focused Attention: 5-MeO diffuses attention uniformly over large regions of one’s experiential field, while DMT seems to focus it.
8) Big Chunks and Tiny Chunks vs. A Power Law of Chunks: 5-MeO creates a few huge phases of experience (as in phases of matter) with a few remaining specks, while DMT produces a more organic power law distribution of chunk sizes.
9) Integration vs. Fragmentation: 5-MeO seems to give rise to “neural integration” involving the entrainment of any two arbitrary subnetworks (even when they usually do not talk to each other), while DMT fragments communication between most networks but massively enhances it between some specific kinds of networks.

I also explain what is going on with the “Megaminx DMT worlds” and when DMT entities bully you into believing in their independent existence.

~Qualia of the Day: Rheoscopic Fluid~

Relevant Links:


Digital Sentience: Can Digital Computers Ever “Wake Up”? (link)

I start by acknowledging that most smart and well-informed people today believe that digital computers can be conscious. More so, they believe this for good reasons.

In general, 99.99% of the times when someone says that digital computers cannot be conscious they do so equipped with very bad arguments. This, of course, does not mean that all of these smart people who believe in digital sentience are right. In fact, I argue that they are making a critical yet entirely non-obvious mistake: they are not taking into account a sufficiently detailed set of constraints that any scientific theory of consciousness must satisfy. In this video I go over what those constraints are, and in what way they actually entail that digital sentience is literally impossible.

The talk is divided into three parts: (1) my philosophical journey, which I share in order to establish credibility, (2) classic issues in philosophy of mind, and (3) how we can solve all those issues with QRI’s theory of consciousness.

(Skip to 31:00 if you are not interested in my philosophical journey and you want to jump into the philosophy of mind right away).

(1) I’ve been hyper-philosophical all my life and have dedicated thousands of hours working on this topic: having discussions with people in the field, writings essays, studying qualia in all manners of exotic states of consciousness, and working through the implications of different philosophical background assumptions. I claim that QRI’s views here are indeed much more informed than anyone would assume if they just heard that we think digital computers cannot be conscious. In fact, most of us started out as hard-core computationalists and only switched sides once we fully grokked the limitations of that view! Until the age of 20 I was a huge proponent of digital sentience, and I planned my life around that very issue. So it was a big blow to find out that I was neglecting key pieces of the puzzle that David Pearce, and later Mike Johnson, brought up when I met them in person. In particular, they made me aware of the importance of the “phenomenal binding/boundary problem”; once I finally understood it, everything unraveled from there.

(2) We go over: Marr’s levels of analysis (and “interactions between levels”). The difference between functionalism, computationalism, causal structure, and physicalist theories of consciousness. The Chinese Room. Multiple Realizability. Epiphenomenalism. Why synchrony is not enough for binding. Multiple Drafts Theory of consciousness. And the difference between awareness and attention.

(3) We solve the boundary problem with topological segmentation: this allows us to also provide an explanation for what the causal properties of experience are. The integrated nature of fields can be recruited for computation. Topological boundaries are neither epiphenomenal nor frame-dependent. Thus, evolution stumbling upon holistic field behavior of topological pockets of the fields of physics would solve a lot of puzzles in philosophy of mind. In turn, since digital computers don’t use fields of physics for computation, they will never be unified subjects of experience no matter how you program them.

I also discuss issues with IIT’s solution to the binding problem (despite IIT’s whole aesthetic of irreducible causality, their solution makes binding epiphenomenal! The devil’s in the details: IIT says the Minimum Information Partition has “the highest claim of existence” but this leaves all non-minimal partitions untouched. It’s epiphenomenal and thus not actually useful for computation).

Thanks also to Andrew Zuckerman and other QRI folks for great recent discussions on this topic.

~Qualia of the Day: Dennett’s Intentional Stance~


Relevant Links/References:


Psychedelics and the Free Energy Principle: From REBUS to Indra’s Net (link)

Friston’s Free Energy Principle (FEP) is one of those ideas that seem to offer new perspectives on almost anything you point it at.

It seems to synthesize already very high-level ideas into an incredibly general and flexible conceptual framework. It brings together thermodynamics, probabilistic graphical models, information theory, evolution, and psychology. We could say that trying to apply the FEP to literally everything is not a bad idea: it may not explain it all, but we are bound to learn a lot from seeing when it fails.

So what is the FEP? In the words of Friston: “In short, the long-term (distal) imperative — of maintaining states within physiological bounds — translates into a short-term (proximal) avoidance of surprise. Surprise here relates not just to the current state, which cannot be changed, but also to movement from one state to another, which can change. This motion can be complicated and itinerant (wandering) provided that it revisits a small set of states, called a global random attractor, that are compatible with survival (for example, driving a car within a small margin of error). It is this motion that the free-energy principle optimizes.

Organisms that survive over time must minimize entropy injections from their environment, which means they need to minimize surprise, which unfortunately is computationally intractable, but the information theoretic construct of variational free-energy provides an upper bound on this ground truth surprise, meaning that minimizing it will indirectly minimize surprise. This cashes out in the need to maximize “accuracy – complexity” which prevents both overfitting and underfitting. In the video we go over some of the classical ideas surrounding the FEP: the dark room, active inference, explicit vs. implicit representations, and whether real dynamic systems can be decomposed into Markov blankets. Finally, we cover how the FEP naturally gives rise to predictive coding via hierarchical Bayesian models.

We then talk about Reduced BEliefs Under pSychedelics (REBUS) and explain how Carhart-Harris and Friston interpret psychedelics and the Anarchic Brain in light of the FEP. We then discuss Safron’s countermodel of Strengthened BEliefs Under pSychedelics (SEBUS) and the work coming out of Seth’s lab.

So, that’s how the FEP shows up in the literature today. But what about explaining not only belief changes and perceptual effects, but perhaps also getting into the actual weeds of the ultra bizarre things that happen on psychedelics?

I provide three novel ideas for how the FEP can explain features of exotic experiences:

(1) Dissonance-minimizing resonance networks would naturally balance model complexity due to an inherent “complexity cost” that shows up as dissonance and prediction error minimization when prediction errors give rise to out-of-phase interactions between the layers.

(2) Bayesian Energy Sinks: What you can recognize lowers the (physical) energy of one’s world-sheet. I then blend this with an analysis of symmetrical psychedelic thought-forms as energy-minimizing configurations. On net, we thus experience hybrid “semantic + symmetric” hallucinations.

(3) Indra’s Net: Each “competing cluster of coherence” needs to model its environment in order to synch up with it in a reinforcing way. This leads to attractor states where “everything reflects everything else”.

~Qualia of the Day: Indra’s Net~

Relevant Links:


Advanced Visions of Paradise: From Basic Hedonism to Paradise Engineering (link)

This video was recorded as a way for me to prepare for the speech I gave at the “QRI Summer Party 2021: Advanced Visions of Paradise” (see livestream here). You can think of it as the significantly more in-depth (and higher audio quality!) version of that speech.

The core message of this video is: thinking wholesome, genuinely useful, and novel thoughts about how to build paradise is hard. Doing so without getting caught up in low-dimensional aesthetics and pre-conceptions is very challenging. Most of the “visions of paradise” we find in our culture, media, and art are projections of implicit aesthetics used for human coordination, rather than deeply thought-out and high-dimensional perspectives truly meant to elevate our understanding and inspire us to investigate the Mystery of reality. Aesthetics tend to put the cart before the horse: they tacitly come with a sense of what is good and what is real. Aesthetics are fast, parallel, and collective ways of judging the goodness or badness of images, ideas, and archetypes. They give rise to internal dissonance when you present to them things that don’t fit well with their previous judgements. And due to naïve realism about perception, these judgements are often experienced as “divine revelations”.

To disentangle ourselves from tacit low-dimensional aesthetics, and inspired by the work of Rob Burbea (cf. Soulmaking), I go over what aesthetics consist of: Eros, Psyche, and Logos. Then, to explore high-quality aesthetics relevant to paradise engineering, I go over 7 camps of a hypothetical “Superhappiness Festival”, each representing a different advanced aesthetic: Hedonism, Psychiatry, Wholesome, Paleo, Energy, Self-Organization, and Paradise Engineering. For didactic purposes I also assign a Buddhist Realm (cf. “Opening the Heart of Compassion” by Short & Lowenthal) to each of the camps.

Note: the Buddhist realms are a very general lens, so a more detailed exposition would point out how each of the camps manifests in each of the Buddhist realms. Don’t put too much stock on the precise mapping I present in this video.

~Qualia of the Day: Pure Lands~

Picture by Wendi Yan (wendiyan.com) “The Tower of Paradise Engineering” (also the featured image of this post / image to appear in the forthcoming QRI Book)

For context, here is the party invite/description:

Dear Everyone!

Science fiction and futurism have failed us. Simply put, there is a remarkable lack of exploration when it comes to the role that consciousness (and its exotic states) will play in the unfolding of intelligent agency on Earth. This, of course, is largely understandable: we simply lack adequate conceptual frameworks to make sense of the state-space of consciousness and its myriad properties. Alas, any vision of the future that neglects what we already know about the state-space of consciousness and its potential is, in the final analysis, “missing the point” entirely.

Exotic states of consciousness are consequential for two reasons: (1) they may provide unique computational benefits, and (2) they may have orders of magnitude more bliss, love, and feelings of inherent value.
As Nick Bostrom puts it in Letter From Utopia:

(1) “Mind is a means: for without insight you will get bogged down or lose your way, and your journey will fail.

(2) “Mind is also an end: for it is in the spacetime of awareness that Utopia will exist. May the measure of your mind be vast and expanding.”

In light of the above, let us for once try to be serious consciousness-aware futurists. Then, we must ask, what does paradise look like? What does it feel like? What kinds of exotic synesthetic thought-forms and hyper-dimensional gems populate and imbue the spacetime of awareness that makes up paradise?

Come and join us for an evening of qualia delights and great company: experience and make curious smells, try multi-sensory art installations, and listen to a presentation about what we call “Advanced Visions of Paradise”. Equipped with an enriched experience base and a novel conceptual toolkit, we look forward to have you share your own visions of paradise and discuss ways to bring them into reality.

Infinite Bliss!

Ps. If you are being invited to this event, that means that we value you as a friend of QRI ❤

Pss. Only come if you are fully vaccinated, please!

Key Links:

~Music: People were asking me about the playlist of yesterday’s party. The core idea behind this playlist was to emulate the sequence of aesthetics I talked about in the speech. Namely, the songs are ordered roughly so that each of the 7 camps gets about 1 hour, starting in camp Hedonism and going all the way to camp Paradise Engineering: QRI Summer Party 2021: Advanced Visions of Paradise~


And that’s it for now!

Thank you for tuning in!

Infinite Bliss For All!

A Field Equation to Mend the World

Excerpt from The Science of Enlightenment (2005) by Shinzen Young (p. xv-xvii)

Author’s Preface

It took me quite a while to get to the point of publishing this book — many years actually. That may seem like a strange statement. How can someone not get the point of publishing something they themselves wrote? Let me explain.

A central notion of Buddhism is that there’s not a thing inside us called a self. One way to express that is to say that we are a colony of sub-personalities and each of those sub-personalities is in fact not a noun but a verb–a doing.

One of my doings is Shinzen the researcher. Shinzen the researcher is on a mission to “take the mist out of mysticism.” Contrary to what is often claimed, he believes that mystical experience can be described with the same rigor, precision, and quantified language that one would find in a successful scientific theory. In his opinion, formulating a clear description of mystical experience is a required prenuptial for the Marriage of the Millennium: the union of quantified science and contemplative spirituality. He hopes that eventually this odd couple will exuberantly make love, spawning a generation of offspring that precipitously improves the human condition.

Shinzen the researcher also believes that many meditation masters, current and past, have formulated their teachings with “less than full rigor” by making unwarranted, sweeping philosophical claims about the nature of objective reality based on their subjective experiences—claims that tend to offend scientists and, hence, impede the science-spiritually courtship.

Shinzen the researcher has a natural voice. It’s the style you would find in a graduate text on mathematics: definition, lemma, theorem, example, corollary, postulate, theorem. Here’s a sample of that voice:

It may be possible to model certain global patterns of brain physiology in ways that feel familiar to any trained scientist, i.e., equations in differential operators on scalar, vector, or tensor fields whose dependent variables can be quantified in terms of SI units and whose independent variables are time and space (where space equals ordinary space or some more esoteric differential manifold). It is perhaps even possible to derive those equations from first principles the way Navier-Stokes is derived from Cauchy continuity. In such fields, distinctive “flow regimes” are typically associated with relations on the parameters of the equations, i.e., F(Pj) → Q, where Q is qualitative change in field behavior. By qualitative change in field behavior, I mean things like the appearance of solitons or the disappearance of turbulence, etc. Through inverse methods, it may be possible to establish a correspondence between the presence of a certain parameter relation in the equations modeling a field in a brain and the presence of classical enlightenment in the owner of that brain. This would provide a way to physically quantify and mathematically describe (or perhaps even explain) various dimensions of spiritual enlightenment in a way that any trained scientist would feel comfortable with.

That’s not the voice you’ll be hearing in this book. This book is a record of a different Shinzen, Shinzen the dharma teacher, as he talks to students engaged in meditation practice. Shinzen the dharma teacher has no resistance at all to speaking with less than full rigor. He’s quite comfortable with words like God, Source, Spirit, or phrases like “the nature of nature.” In fact, his natural voice loves spouting the kind of stuff that makes scientists wince. Here’s an example of that voice:

The same cosmic forces that mold galaxies, stars, and atoms also mold each moment of self and world. The inner self and the outer scene are born in the cleft between expansion and contraction. By giving yourself to those forces, you become those forces, and through that, you experience a kind of immortality–you live in the breath and pulse of every animal, in the polarization of electrons and protons, in the interplay of the thermal expansion and self-gravity that molds stars, in the interplay of dark matter that holds galaxies together and dark energy that stretches space apart. Don’t be afraid to let expansion and contraction tear you apart, scattering you in many directions while ripping away the solid ground beneath you. Behind that seeming disorder is an ordering principle so primordial that it can never be disordered: father-God effortlessly expands while mother-God effortlessly contracts. The ultimate act of faith is to give yourself back to those forces, give yourself back to the Source of the world, and through that, become the kind of person who can optimally contribute to the Mending of the world.

Shinzen the hard-nosed researcher and Shinzen the poetic dharma teacher get along just fine. After all, they’re both just waves. Particles may bang together. Waves automatically integrate. Just one problem though. The researcher is a fussy perfectionist. He is very resistant to the notion of publishing anything that lacks full rigor. Spoken words return to silence from where they came from. Printed text sits around for centuries waiting for every tiny imprecision and incompleteness to be exposed.

So it took a while for me to see value in allowing my talks to be published in something close to their original spoken form.


See also:


This video discusses the connections between meditative flow (any feeling of change) and the two QRI paradigms of “Wireheading Done Right” and “Neural Annealing“. To do so, I explore how each of the “seven factors of awakening” can be interpreted as operations that you do to flow. In a nutshell: the factors are “energy management techniques”, which when used in the right sequences and dosages, tend to result in wholesome neural annealing.

I then go on to discuss two fascinating dualities: (1) The dual relationship between standing wave patterns and vibratory frequencies. And (2) the dual correspondence between annealing at the computational level (REBUS) and annealing in resonance networks.

(1) Describes how the crazy patterns that come out of meditation and psychedelics are not irrelevant. They are, in a way, the dual counterpart to the emotional processing that you are undergoing. Hence why ugly emotions manifest as discordant structures whereas blissful feelings come together with beautiful geometries.

(2) Articulates how simulated annealing methods in probabilistic graphical models such as those that underlie the synthesis of entropic disintegration and the free energy principle (Friston’s and Carhart-Harris’ REBUS model) describe belief updating. In contrast, annealing at the implementation level refers to a dissonance-minimization technique in resonance networks. In turn, if these are “two sides of the same coin”, we can expect to find that operations in one domain will translate to operations in the other domain. In particular, I discuss how resisting information (“denial”, “cognitive dissonance”) has a corresponding subjective texture associated with muscle tension, “resistance”, viscosity, and hardness. Equanimity, in turn, allows the propagation of both waves of dissonance, consonance, and noise as well as bundles of information. This has major implications for how to maximize the therapeutic benefit of psychedelics.

Finally, I explain how we could start formalizing Shinzen Young’s observation that you can, not only “read the contents of your subconscious“, but indeed also “heal your subconscious by greeting it with enough concentration, clarity, and equanimity”. Negentropy in the resonance network (patches of highly-ordered “combed” coherent resonance across levels of the hierarchy) can be used to heal patches of dissonance. This is why clean high-valence meditative objects (e.g. metta) can absorb and dissipate the internal dissonance stored in patterns of habitual responses. In turn, this might ultimately allow us to explain why, speaking poetically, it is true that love can heal all wounds. 🙂

~Qualia of the Day: Nirvana Rose~

(Skip to ~10:00 if you don’t need a recap of Wireheading Done Right and Neural Annealing)

The Fact That We Can Smell Functional Groups is Just Such a Thing

[Excerpt from The Secret of Scent (2006) by Luca Turin, pgs 108-111]

Some Strange Clues

It has been said,* correctly in my opinion, that theories define facts as much as the other way around. Nowhere is this more true than in structure-odour relations, where all knowledge is anecdotal. Anecdotal evidence has a sort of slippery, jelly-like quality to it, and theories are needed to congeal the stuff together into single, solid facts. ‘Anecdotal’ is often used as a pejorative term in scientific circles, meaning unreliable. In practice it often means isolated, and therefore hard to assess. Think of a new field of science as a large jigsaw puzzle. Pieces are discovered one by one, and at first they are unlikely to fit together to make a picture. Things can look distinctly unpromising, sometimes for decades. But if you can bear the pain of feeling stupid and the humiliation of being wrong, anecdotal evidence is the call of the wild, the surest sign of the undiscovered. Columbus set sail on the basis of anecdotal evidence. The Mayan hieroglyphs were deciphered using anecdotal evidence. Life-saving remedies based on plants, such as aspirin and digitalis, were found by scientists who paid attention to anecdotal evidence.

Scientific problems typically go through three phases. In the first phase, a few bold explorers discover a new land and map out its basic features. In the second phase, boatloads of immigrant scientists arrive and colonize the land. In the third phase, statues are erected on town squares, sometimes to the original discoverers, more often to the able administrators who build the roads and railways. Smell, as it happens, did not follow this pattern. Scientific colonies never thrived on this particular island. Every few years, a new set of scientists claims to have cleared the jungle, but their cities are eventually overgrown and get lost in the weeds.

In smell, the difficulty is compounded by two additional factors, one obvious, the other more subtle. The first is the supposed untrustworthiness of the smell sensation I’ve mentioned earlier which makes strong men and women doubt their own noses. The second is that when facts, especially anecdotal ones, remain unexplained for long enough, a kind of question fatigue sets in, and they become accepted without being understood. The situation brings to mind a quintessentially British cartoon I saw once where a dinosaur strides past a terraced house, and a couple see it from their living room. Wife: “What was that?” Husband: “Oh, just one of those Things.” The fact that we can smell functional groups is just such a Thing.

Functional groups, as we have seen, are the specific structures of one or more atoms that are responsible for the chemical behaviour of a substance. Examples are thiols (-SH), nitriles (-CN), and aldehydes (-C(=O)H). The little hyphen indicates that these groups are, of course, attached to something and that the Something varies hugely. But the remarkable thing is that the Something matters little to the smell of the molecules. What gives the game away, especially to the casual observer, is the fact that types of smell are named after chemical groups: sulphuraceous, nitrilic, aldehydic, corresponding respectively to -SH, -CN, -(H)C=O. This is particularly clear in the case of -SH. All molecules which contain an -SH group smell (a) strong and (b) reminiscent of rotten eggs.

A word about the description ‘rotten eggs,’ since only a tiny minority of readers will be old enough to remember them. Eggs nowadays come with time stamps and serial numbers, so they seldom get a chance to rot. The rotten eggs smell is today more likely to be experienced in an oriental market (the durian fruit), by opening the gas tap on the stove (a small amount of an -SH compound is added to make sure we notice it), or best of all by going to an Indian store and asking for kala namak or ‘black salt’. Black salt, as its name does not indicate, is actually pink and is a type of rock salt that must come from Hell, as it contains ample amounts of Hell’s Kitchen smell, namely the HSH molecule. HSH is -SH repeated and smells bad twice over. Put some kala namak on your tongue and you will see what I mean. The first thing you will notice is that it reminds you mostly of a very intense hard-boiled egg smell. Clearly, eggs, even when fresh, are itching to fall apart. If you’ve done any chemistry at school, you will also recall the classroom when the teacher was making one of those stinks for which chemistry is famous. Beware though, the culinary satanism of kala namak is beguiling: a tiny amount in blackcurrant ice cream, strawberry daiquiris, coffee, and chocolate does wonders, as long as you don’t let anyone know you did it.

Do all -SH compounds smell identical then, i.e. of rotten eggs? Not a bit, actually: they smell of all manner of things, from grapefruit to garlic via blackcurrants,  but they all have this sulphuraceous (i.e. from Hell) character. The grapefruit compound is particularly instructive. It is called pinanethiol. Thiol means -SH, so pinanethiol means pinane-SH.

Remove the -SH and the rest of the molecule (pinane) smells like pine needles, as it should, since pinane is a major component of turpentine oil, itself extracted from pine. Add the -SH back and, having smelled the pinane by itself and familiarized yourself with kala namak, you can clearly smell the parts of the molecule. That is to say you smell both the pine needles and the sulphur. Smell another very strong -SH compound like H₃C-SH, or methanethiol, for a few seconds till the nose (mercifully) tires of the hideous -SH smell, then go back to pinane-SH. Surprise! The sulphur note is now almost gone and the molecule no longer smells of pinane-SH, but instead smells of pinane tout court. This means that this molecule smells like the sum of its parts. In other words, -SH is a primary, though the other smells are not. But how does that work? How do we know what parts it’s made of? This, as we shall see, is the greatest mystery of smell. Looking for an answer will take us amazingly far afield.


* Paul Feyerabend, among others, convincingly argued this view in Against Method, required reading for those who believe the scientific method is something which can be written down and followed like a recipe.



Comments:

On a recent conversation I had with Luca, I shared with him the fact that there are anti-tolerance drugs that can lessen (and even reverse) the physiological tolerance to drugs such as painkillers. He was seriously surprised by this fact. Despite spending a whole career studying biological regulatory systems, he had never in his life heard of anti-tolerance drugs in academia. Upon hearing this, he shared that in his experience, most of the innovation in science comes from people who work hands-on in the field, as this exposes them to a much broader evidential base than you would encounter when doing research in a strictly theoretical way.

Thus, he has learned far more about consciousness from psychonauts than he ever has from academic psychopharmacologists, and has learned more about electronics from radio amateurs than professional electrical engineers. In other words, the people who actually tinker with the inner mechanisms of the systems they’re interested in are the people to ask for “weird and novel phenomena”, rather than (only) those who study the field academically angling for a university post or a narrow job in the industry. Same, of course, with the science of smell: actually tinkering with aromachemicals can give rise to discoveries one may never stumble upon by merely studying scent receptors in a lab. Needless to say, the best outcomes will come from seamlessly blending both worlds; but for that to happen we will have to embrace phenomenological reports as acceptable leads for research in science.

See Luca Turin’s recent series on the science of smell on youtube: The Secret of Scent (including a video on the objections to the vibrational theory of olfaction).

Break Out of the Simulation Day: Televised Entity Contact, Injection Pulling Experiments, and the Brain as a Game Engine

[Epistemic Status: Wild Speculations]

TL;DR I came up with a new way to test the reality of DMT entities!

Core idea: Look for signatures of injection pulling in the brain’s connectome-specific harmonic waves. This would distinguish between mere hallucinations (however weird they may feel) and hallucinations being driven by an external source.

Like the study about whether psychedelics can help you see through different Everett branches of the multiverse, I don’t expect the results of this experiment to come out positive. But it’s exciting to see a testable prediction on an otherwise so difficult-to-approach subject matter.


Televised Entity Contact

I think that we can basically assume that a certain percentage of people who vaporize DMT will believe that they contacted mind-independent beings. This is likely the result of hallucinations, but naïve realism and a bias to interpret more intense and detailed qualia as “more real than real external information” is so deeply ingrained that we can take it as a matter of fact that, say, 50%+ of people won’t be able to override their felt-sense of entity presence with heady philosophical epistemic rigor like discussions about the pseudo-time arrow, valence structuralism, or indirect realism about perception.

Is there anything we can do with that? Think of it from an economics arbitrage point of view. If we predict that X number of people will newly believe in DMT entities next year, is there an opportunity there?

I was thinking yesterday on a walk about how “Storm Area 51” is a reality check of sorts for the general public. As in – yes Area 51 is a thing, and no, you can’t just invade it with 100,000 people Naruto running towards it. It was predictable that would be the case, but going through the act in a collective and televised fashion was an interesting exercise in societal epistemology.

 

 

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Along those lines, I suggest that a “Break Out of the Simulation Day” event could be organized. That day we would have, on LIVE TV, people doing DMT trying to contact aliens as a medium, the camera going from one person to the next, always making sure that whoever has the microphone is currently peaking on DMT.

So if the DMT Elves are mind-independent sentient beings and want to send a coherent message to humanity, then that would be the time and place to do it. They would have all of our attention.


Perhaps it is unreasonable to expect DMT Elves to send a coherent message when, surprise surprise, they are on LIVE TV all of a sudden. And this is not only because they won’t have time to dress up. According to people who have tried DMT many times and believe it puts you in contact with other dimensions (cf. Dick Khan’s 600 DMT trip reports) there is an entire ecosystem of entities to contact, each of them with special gifts, powers, intentions, and styles. There are jesters, robots, greys, Archons, angels, demons, wireheading specialists, used alien spaceship dealers (those are the worst), etc. There are entire categories of entities whose sole purpose is to convince you that you are dead, or that you are in a simulation, or that the government is out to get you. There are entire species of entities of the sort that show you how to use sound to create thought-forms, and those that like to discuss with you the impact that the Greeks and Aztecs had on the aesthetics of the reptilians (i.e. interdimensional art historians). You cannot expect to be lucky and get a reasonable DMT entity who (1) will figure out what is going on, and (2) has good intentions for humanity. Perhaps we would be opening ourselves up to influence by incompetent, evil, or incompetent and evil entities. Worse, we would be doing so on LIVE TV!

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by Steven Haman (source)

Testing the Mind-Independent Existence of DMT Entities

Ok, so maybe televising the experiment is a bad idea. Back to the drawing board. Let’s ask: what are the main ways to prove the independent existence of DMT entities? How would serious researchers[1] approach this problem? As far as I can tell, there are three big categories of methods:

  1. Psi-based (having them tell you something about the world you would have no way of knowing otherwise)
  2. Computation-based (having them solve a problem that requires much more computational power than what is available to you with your brain alone)
  3. Quasi-Physical interference-based (have entities literally poke, shake, vibrate, excite, or inhibit your body or nervous system in ways that are impossible on their own)

The Psi-based category is the most well-known, and it includes tests such: (a) asking the entities what your family members are doing right now, (b) having them tell you what is inside a sealed box, (c) having them predict what tomorrow’s lottery numbers will be, and so on. While many people claim to have learned valuable information from DMT entities, I’ve yet to see credible reports of positive tests of this kind.

The computation-based category is perhaps best exemplified by Marko Rodriguez’ suggestion of having the entities factorize a large number for you. This method was popularized by Scott Alexander’s now-famous short story Universal Love, Said the Cactus Person, and then later Gwern made an estimate of the cost of such an experiment. It turns out that testing the hypothesis this way could be as cheap as one thousand (of 2015) dollars. Unfortunately, this test is very hard to conduct (saying 200 digits while on DMT and memorizing sets of numbers with dozens of digits the elves return to you as an answer is not an easy task). So other difficult-to-compute but easy-to-articulate and fast-to-memorize problems might be a better fit in this case. I predict it is only a matter of time before someone seriously tries a variant of this method and reports the results online. I would just caution that, depending on the computational task selected, one may inadvertently discover new computational applications of the DMT state rather than prove the existence of mind-independent DMT entities. After all, unusual states of consciousness may have unique computational trade-offs. See for example: Thinking in Numbers, How to Secretly Communicate with People on LSD, and the discussion about the possible applications for mathematical research of the hyperbolic phenomenal space disclosed during DMT intoxication. Indeed, I would not be surprised to find out that in the year 2100 many of the most important mathematical breakthroughs are taking place in consciousness research centers thanks to having identified states of consciousness capable of rendering exotic mathematical objects and their possible transformations. So before concluding the DMT Elf solved your computationally-demanding problem, it would be important to rule out that it wasn’t you (or the DMT-filled version of you) who solved the problem thanks to novel qualia varieties only disclosed in such a state. That said, this concern only applies to computational tasks that are not extremely difficult. If a DMT alien can factorize a 3000-digit number in 10 seconds then we could actually reasonably conclude that it exists in a mind-independent way.

Now, the 3rd approach is, IMO, both the most likely to work in practice, and also the most spooky and frightening were the results to come out positive. Here is why. I’ve recently received trip reports from rational psychonauts who have taken DMT hundreds of times, and it seems clear that there is a vast number of qualitatively distinct state-spaces disclosed by this substance. One of these such relatively rare idiosyncratic responses caught my attention, and I think it warrants closer scientific scrutiny. Namely, I’ve received reports that when the psychonaut is either tired or has been drinking (why anyone would dare take DMT while drunk is beyond me, but for science-I guess-someone already did it) there is a different kind of experience of a rather unpleasant nature that unfolds. This type of DMT experience is described as getting in contact with the “lower levels of the astral plane” in which parasitic etheric life-forms live (not my words). During such an experience, one may feel that these beings “jitter” your nervous system without asking for your permission to do so. And this is done in such a way that your body may literally get up and dance, as if possessed by a spirit, without your conscious control. In a less extreme presentation of this phenomenon, at the very least the entities seem to jerk one’s extremities whether or not you like it. For example, in one of these trip reports someone described having their arm being pulled and jerked left and right by a demon of sorts while at the same time insectoid life-forms crawled inside their body, into the veins of the tripper. Needless to say, this is a profoundly unpleasant experience, no doubt, but perhaps it is also one of the most empirically testable of the bunch.

Injection Pulling Experiments

The big-picture idea here would be to hook a person up to an EEG during such a state (or even place them in an fMRI if at all possible) in order to determine if the “jittering” experienced is endogenously or exogenously generated.2dof_outofphaseV2.15

How could we do this? Let’s take a step back for a second and recall Selen Atasoy’s study about the influence of LSD on the connectome-specific harmonic waves of the brain. The connectome-specific harmonic waves (CSHWs) are the “natural resonant modes” of a given brain. With this analysis, one can characterize a given “brain state” as a weighted sum of such resonant modes. In turn, one can then see how LSD affects one’s brain state by analyzing the CSHWs while under its influence. As it turns out, there are three major effects from LSD: (a) an overall increase in the power of all CSHWs, (b) the higher-frequency harmonics gain even more power relative to the lower-frequency ones, and (c) the repertoire of possible states dramatically increases, meaning that CSHWs that usually don’t co-occur are more likely to be simultaneously active while on LSD.dynabs-a

The thing to point out is that LSD in this case does not change which harmonic modes the brain has; it merely changes the energy distribution over those harmonics. On the other hand, we could in principle imagine that if the “DMT entity contact” brain state is not purely a hallucination, we would instead find out that such a state has a distinct “non-native harmonic pattern”. And this would manifest in the form of injection pulling and injection locking signatures in the reconstructed patterns of brain activity from the neuroimaging data.N4jchWg

An analogy with a musical instrument is possible: assume that your brain is a musical instrument and that the notes it plays sound like those of a guitar. In this analogy, taking LSD would entail increasing the volume of each note (and especially so for the higher notes) while also increasing the range of possible note-combinations. In other words, while LSD changes what you can play with the guitar, it does not change the fact that you are playing a guitar. That is, the brain states produced by LSD can be explained as different configurations of otherwise native vibratory patterns. In contrast, if DMT entity contact involves an external energy source with its own characteristic resonant modes, then the brain state that results from it would seem to have non-native vibratory patterns. It would be like having a guitar that produces saxophone sounds. You would know that on its own it is not physically capable of producing such sounds, and hence infer it is being externally influenced somehow.

ballspring_2

Are the jiggling patterns of your brain harmonics while on DMT best explained with or without an external metronome and its injection pulling effects?

Such an analysis might reveal that the jerking of the nervous system one experiences on those idiosyncratic DMT experiences is best explained with an injection pulling model and an external metronome marking the pace. In turn, this would imply that the brain is not merely hallucinating a scene, but rather, it is being influenced by an outside metronome. Now, that would be a scientifically-sound ground-breaking finding. And perhaps be so spooky we would all prefer to forget about it rather than contemplate its implications.[2]



Now, there is always the option to interpret all of the unusual phenomenal experiences on DMT with a scientific secular framework that excludes entities from other dimensions. At the Qualia Research Institute, the frameworks that we use to explain such unusual experiences involve what we call algorithmic reductions, namely, identifying a small set of data-structures and information-processing steps that when taken together are capable of generating the vast zoo of complex emergent effects. The advantage of this approach is two-fold. First, we avoid over-fitting by minimizing the information complexity of the model (few data structures and few operations is a vastly more parsimonious explanatory framework than ad-hoc spiritual or atomistic interpretations). And second, it allows us to generate predictions such as the possible existence of exotic phenomenal states that haven’t yet been reported in the literature. Indeed, verifying that its predictions are accurate is one way of validating an algorithmic reduction.

In the case of DMT, we have algorithmic reduction models that explain the unusual properties of space as well as their associated exotic phenomenal time. And while providing compelling explanations for the exotic space and time one can experience in such a state is foundational, we recognize that this is still a first step. I admit that such models still do not go far enough. We still need to explain the nature and unusual character of “entity contact” experiences. So what do we make of them?

The Brain as a Game Engine

Our best guess- for the time being- involves reformulating the nature of the state-space of consciousness to include a layer of “game parameters”. This was first brought up in the essay “Harmonic Society“:

Consider what happens when someone takes LSD. Most people expect that they will simply get to experience new sensations like brighter colors, tracers, or synesthesia. This is true to a point, for light doses. But on medium doses, in addition to exploring the state-space of sensory configurations, one also experiences new aesthetics, which this model would define as ways of organizing a lot of sensations in ways that feel right. More so, an aesthetic is also a way of delivering uninhibited sensations in a way that feels good at the level of the whole experience, from moment to moment. Most people have no clue that there is a vast space of possibilities here.

 

On higher doses, people are surprised to find an even more general way of exploring the state-space of consciousness. Namely, one instantiates alternate games. The DMT “vibe” that people report can be thought of as more than a “context switch”. It is, rather, a more radical change that we could describe as a “game switch”. The “Jester” that people talk about regarding DMT experiences is an archetype that the mind uses to signal the “rule violation” quality of the state. There is so much going on that one’s experience splits into multiple games at once trying to find some common ground, and this feeling of game-incompatibility feels very alien. A sort of anti-virus system in the mind is triggered at that point, and labels the inconsistency with a feeling of weirdness so that you know not to update your actions based on the (currently globally inconsistent) experience of multiple superimposed games. Rule violation through fast changes in implicit games of social status causes you to interpret what is going on as having extreme stakes. Interacting with DMT Aliens, Gods, Elves, etc. feels like the upper limit of potential social status transfer that your world simulation affords (like meeting a president or a king). The state-space of consciousness contains all of these alternate games and metagames, and we have not even begun to catalogue them.

 

Harmonic Society (3/4): Art as State-Space Exploration and Energy Parameter Modulation

In other words, taking DMT does not merely propel you to other regions of the state-space of possible sensory impressions, but it also grants you access to alternate aesthetics[3] and game setups. If you think of your brain not only as a sensory-processing tool, but in fact as a kind of high-level game engine, realizing that God and the Devil can be real in your experience shows that they are possible characters of the games your brain can render. In such a case, we will eventually find that the brain states that render DMT entities are, however exotic, still produced by combining the native resonant modes of one’s own nervous system. No need to invoke neuronal injection pulling from the etheric plane.

Of note is that such a “Game Engine” paradigm would go a long way in explaining unusual experiences such as Free-Wheeling Hallucinations where one becomes able to control almost all features of one’s experience with an incredible level of detail. Indeed we can describe a Free-Wheeling Hallucination state as having access to an experience editor, as illustrated in the Memory Facility Scene of Blade Runner 2049:

Unsurprisingly, we can anticipate that when one is given root access to the parameters of one’s own inner world-simulation, one is likely to focus on creating experiences entirely filled with enjoyable super-stimuli. Whether this involves sex-worlds or proofs of the existence of a benevolent God might be a function of what is it that one craves the most. The intense concern with theodicy and the nature of death while on psychedelic drugs might have something to do with having the ability to change the most essential parameters of one’s internal world simulation. After all, if “living in a world” where God exists and is loving is more enjoyable than the alternative, one’s own hedonic maximization algorithms would try to “realize that’s the truth” if given the option to forge evidence. The same could be going on with DMT entities, for a world in which DMT is an interdimensional portal technology is vastly more interesting (or at least dramatic) than the alternative.

In the end, studying DMT experiences do not need to involve actual entity contact to be of profound significance to the science of consciousness. If you think of your brain as a qualia machine engine, DMT is about the best (or second-best [4]) qualia fuel there is. There are vast regions of the state-space of consciousness that can only be accessed with DMT, many of which contain extremely computationally interesting qualia, and many others which contain intrinsically valuable states (aka. heaven worlds). If, on top of that, it also enables interdimensional beings to injection pull your brain harmonics, we could think of that as icing on the cake.



[1] Serious and Unserious Consciousness Researchers

On a tangential note, here is a quote I recently heard at a consciousness conference:

Thomas Metzinger, the famous and brilliant German neuroscientist and philosopher of mind*, was once asked at a conference presentation he was giving whether he had ever tried psychedelics. His response? “There are two kinds of consciousness researchers. There are the serious ones, and the unserious ones. The serious ones take advantage of all the tools at their disposal to crack this mystery. All I will say is that I am NOT an unserious consciousness researcher.”

*He is best known for being the writer of the books “Being No One” and “The Ego Tunnel“, friends with the Foundational Research Institute, a strong proponent of a variant of eliminativism about consciousness, and a negative utilitarian specializing in AI ethics.



[2] Implications

If the injection pulling experiment does reveal that DMT entities are indeed mind-independent sentient beings in alternate dimensions, then what?

We shall cross that bridge when we get there, but in the meantime, let me entertain you with a wild hypothesis: DMT Elves are us at a higher level of spiritual and psychological development. In such a case, we might want to revise Integral Theory’s levels to include DMT Elves. Expect Ken Wilber’s next book to contain the following:

Larval Stages of the Soul Before Ascension

1) Mythical, 2) Machiavellian, 3) Religious Traditional, 4) Scientific Secular, 5) Postmodern Multiculturalist, 6) Burner, 7) DMT Elf, 8) Full-Spectrum Supersentient Superintelligence, 9) Hedonium Plasma Wave, and finally 10) Pure Love.



[3] An open question for all my DMT-using readers: are DMT visuals more akin to Art Deco, or Art Nouveau?

14947935_1114901531879801_3386970468615130288_n



[4] On a Serious Note

My prediction is that the single most important tool to investigate consciousness is 5-MeO-DMT. It is probably the most important consciousness tool ever discovered. While I’ve seen serious consciousness researchers and academics admit in private that they have tried psychedelics, I almost never encounter people who have tried 5-MeO. I expect this to change over the course of the next decade as the word gets out that no, 5-MeO is not “yet another psychedelic” but it’s the “real deal” when it comes to disclosing profoundly insightful states of consciousness with implications for personal identity, ethics, the state-space of qualia, the nature of valence (i.e. harmony vs. dissonance), phenomenal time, causality, and the importance of quantum coherence for phenomenal binding. If you have explored this compound and would like to share your insights, please get in touch. We always welcome high-quality trip reports.



 

 

Self-transforming machine thought-forms.
Valued for their intrinsic qualia;
sometimes used for qualia computing.


Featured image source: Machinist Sculpture Chris Bathgate

Carhart-Harris & Friston 2019 – REBUS and the Anarchic Brain

Reposted from Enthea with permission from the writer: 


Drs. Robin Carhart-Harris and Karl Friston recently published a beautiful paper – REBUS and the Anarchic Brain (a).

It’s great for two reasons:

  1. It presents a plausible unified theory of how psychedelics work.
  2. It’s a wonderful jumping-off point into the literature. Every paragraph is full of pointers to research that’s come out in the last 5 years, and boy are there a lot of rabbit holes to go down – it’s filled out my reading list for the next several months.

Carhart-Harris is the director of Imperial College London’s newly minted Centre for Psychedelic Research; Friston is a famous neuroscientist.

REBUS is a (somewhat dubious) acronym for RElaxed Beliefs Under pSychedelics. The basic idea: psychedelics reduce the weight of held beliefs and increase the weight of incoming sensory input, allowing the beliefs to be more readily changed by the new sensory information.

REBUS pulls together Carhart-Harris’ Entropic Brain theory and Friston’s Free Energy Principle, both of which relate to the hierarchical predictive coding model of cognition. There’s a lot of jargon & nuance here, but the essential idea of hierarchical predictive coding is pretty straightforward:

  • The brain generates mental models that predict upcoming sensory inputs. (The predictions are called “priors,” as in “prior beliefs.”)
  • These predictive models are layered on top of each other in a hierarchy – the higher levels send predictions down the hierarchy; the lower levels report sense data upwards.
  • In cases where the model’s top-down predictions do not match the bottom-up sensory input, the model either (a) updates its priors based on the new sense data, or (b) ignores the sense data and maintains its priors.

(Scott Alexander’s review of Surfing Uncertainty has a lot more on predictive coding.)

Carhart-Harris & Friston theorize that the main thing psychedelics are doing is relaxing the weight of the brain’s top-down prediction-making (“REBUS”) and increasing the weight of the bottom-up sense information (“the Anarchic Brain”). This allows bottom-up information to have more influence on our conscious experience, and also on the configuration of the hierarchy overall.

Carhart-Harris & Friston analogize this process to annealing – heating up a metal dissolves its crystalline structure, then a new structure recrystallizes as the metal cools:

The hypothesized flattening of the brain’s (variational free) energy landscape under psychedelics can be seen as analogous to the phenomenon of simulated annealing in computer science – which itself is analogous to annealing in metallurgy, whereby a system is heated (i.e., instantiated by increased neural excitability), such that it attains a state of heightened plasticity, in which the discovery of new energy minima (relatively stable places/trajectories for the system to visit/reside in for a period of time) is accelerated (Wang and Smith, 1998).

Subsequently, as the drug is metabolized and the system cools, its dynamics begin to stabilize – and attractor basins begin to steepen again (Carhart-Harris et al., 2017). This process may result in the emergence of a new energy landscape with revised properties.

Psychedelics “heat up” the brain, increasing plasticity and weakening the influence of prior beliefs. As the psychedelic stops being active, the brain “cools” – the hierarchy re-forms, though perhaps in a different configuration than the pre-psychedelic configuration.

This explains how psychedelic trips can cause changes that last long after the substance has exited the body – in those cases, the psychedelic facilitated a change in the organization of the brain’s cognitive hierarchy.

Psychedelic therapy is showing promise for mental disorders associated with too-rigid thought patterns – depression, anxiety, addictions, maybe OCD, maybe eating disorders. In predictive-coding lingo, “disorders that may rest on particularly rigid high-level priors that dominate cognition.”

In these disorders, new information can’t revise the existing story of how things are, because strong priors suppress the new info before it can update anything.

The REBUS model straightforwardly explains how psychedelics help with disorder like this – by relaxing the strong top-down priors and boosting the bottom-up inputs, bottom-up inputs have more ability to effect the system. Here’s an illustration from the paper:

rebus-schema

The top sketch is a brain where strong top-down priors dominate. New sensory inputs are suppressed and can’t update the hierarchy. The bottom sketch is the same brain while on a psychedelic – the top-down priors have been relaxed and bottom-up sensory information flows more freely through the system, causing a bigger impact.

Okay, nice theory, but can we observe this in the brain? Is there any evidence for it?

Carhart-Harris & Friston place the default mode network at top of the brain’s predictive hierarchy. The default mode network is the network of brain regions that’s most active when the brain isn’t engaged with any specific task. It also appears to be the seat of one’s sense of self. The default mode network is intensely relaxed by strong psychedelic experiences – this is subjectively felt as ego dissolution, and allows for the propagation of bottom-up sense data (which are also boosted by psychedelics).

Carhart-Harris & Friston identify two mechanisms by which psychedelics may relax the default mode network – activation of 5-HT2AR serotonin receptors (there are lots of these receptors in the default mode network), and disruption of α and βwave patterns, which seem to propagate top-down expectations through the brain (and are correlated with default mode network activity).

In addition to the brain-scan-style evidence they cite throughout the paper, Carhart-Harris & Friston dedicate a long section to behavioral evidence (“Behavioral Evidence of Relaxed Priors under Psychedelics”). Briefly, there are several studies showing that surprise & consistency-making responses to sensory stimuli are reduced while on psychedelics, which is what we’d expect if the influence of top-down priors was lessened.

To sum up, REBUS and the Anarchic Brain places psychedelics in a predictive coding framework to give a unified theory of what psychedelics do – they decrease the influence of top-down prediction-making and increase the influence of bottom-up sense data. The theory has the nice quality of tying many disparate psychedelic phenomena together with an underlying explanation of what’s going on. Plus, it gives a brain-based explanation for why psychedelic therapy is helpful for disorders like depression, anxiety, and addiction.



See also: Mike Johnson’s pieces A Future for Neuroscience and The Neuroscience of Meditation which summarize a lot of the research by the Qualia Research Institute (QRI) on this topic. In particular, much like this paper by Carhart-Harris and Friston, at QRI we’ve been working on integrating the neuroscientific paradigms of Entropic Brain, Connectome-Specific Harmonic Waves, Predictive Coding, and our own contribution of Neural Annealing into a unified theory of psychedelic action for a number of years.

Our first mention of Neural Annealing in relation to psychedelics was in Algorithmic Reduction of Psychedelic States in 2016, and we are pleased to see that the concept is becoming a live idea in academic neuroscience in 2019.*

From our point of view, an extremely promising area of research that mainstream neuroscience has yet to explore is the Symmetry Theory of Valence. In particular, we claim that the very reason why Neural Annealing improves not only global control, belief, and behavioral consistency, but also mood and sense of wellbeing is because it smooths and symmetrifies your neural patterns of activation. Will this turn out to become part of mainstream neuroscience in the future? Well, since QRI was calling Neural Annealing years in advance, perhaps in retrospect you’ll also see that we were on the money when it came to the mathematics of valence. Only time (and funding) will tell.


*It should be noted that unbeknownst to us Steven Lehar might be the first person to discuss neural annealing in the context of psychedelic states of consciousness. In his 2010 book “The Grand Illusion” he talks about annealing on LSD and ketamine. Here are some key articles about it: Free-Wheeling Hallucinations, The Resonance and Vibration of [Phenomenal] Objects, The Phenomenal Character of LSD + MDMA, and From Point-of-View Fragmentation to Global Visual Coherence: Harmony, Symmetry, and Resonance on LSD.


Featured image credit: Michael Aaron Coleman

Cluster Headache Frequency Follows a Long-Tail Distribution

[Warning: Disturbing content ahead. Why talk about it? This is an ethically very serious topic and it deserves more attention. But please beware that thinking about this might be bad for one’s mental health.]


One of the key insights that shows why Effective Altruism is so important is that the positive effect on the world that results from donating to various charities follows a long-tail distribution:

health interventionsCost-effectiveness of health interventions as found in the Disease Controls Priorities Project 2. See “The moral imperative towards cost-effectiveness in global health” by Toby Ord for more explanation. [Taken from: The world’s biggest problems and why they’re not what first comes to mind]

It is for this, among other, reasons why focusing on the best interventions really pays off. Where else can we expect long-tails to appear?


In Get-Out-Of-Hell-Free Necklace we discussed how introducing a new metric into the Effective Altruist ecosystem could shed light on neglected cost-effective interventions. We presented the Hell-Index:

A country’s Hell-Index could be defined as the yearly total of people-seconds in pain and suffering that are at or above 20 in the McGill Pain Index (or equivalent)*. This index captures the intuition that intense suffering can be in some ways qualitatively different and more serious than lesser suffering in a way that isn’t really captured by a linear pain scale.

In a future article we will discuss how the quality of suffering as a function of different medical and psychological conditions very likely follows a long-tail distribution. That is, some conditions such as Cluster Headaches (which affect about 1 in 1000 people worldwide) produce pain that is orders of magnitude worse than the pain experienced in other kinds of medical conditions, such as migraines (which are themselves already described as orders of magnitude worse than tension headaches). In other words, a 0-10 pain-scale is better thought of as a logarithmic compression of the true levels of pain rather than a linear scale. So concentrating on the worst conditions could really pay off for reducing suffering in bulk amounts.

Now: the long-tailed nature of suffering may extend beyond the quality of suffering, and show up also in its quantity. That is, the frequency with which people experience episodes of intense suffering, even among those who experience the same kind of suffering, is unlikely to be normally distributed.

Intuitively, one may think that how much suffering people endure on a given year follows a normal distribution. This intuition says that if the median number of hell-seconds people endure in a year is, say, 1,000, then people who are at the 90% percentile of hell-seconds experienced per year will be experiencing something like 1,500 or at most 2,000. If suffering follows a long-tail distribution, in reality the 90% percentile might be experiencing something more akin to 10,000 hell-seconds per year, the 99% percentile something akin to 100,000, and the 99.9% something akin to 1,000,000. If true, such a heavy skew of the distribution would suggest that we should concentrate our energies on addressing the problems of the people who are unlucky to be on the upper ranges, rather than be overly concerned with “the typical person”*.

Unfortunately, I come to share the bad news that suffering probably follows a very long-tail distribution:

It is generally acknowledged that Cluster Headaches are some of the most painful experiences that people endure. Having a single Cluster Headache, lasting anywhere between 15 minutes to 4 hours, is already an ethically unacceptable situation that should never happen to begin with. It is disheartening to know that 1 in 1,000 people experience such extreme pain. But the truth of the matter is yet much worse than we intuitively think…

We recently analyzed a survey** of Cluster Headache patients that was conducted with the intention of determining the reasons why sufferers do or do not use psychedelics to relieve their pain. As it turns out, LSD, psilocybin, and DMT all get rid of Cluster Headaches in a majority of sufferers. Given the safety profile of these agents, it is insane to think that there are millions of people suffering needlessly from this condition who could be nearly-instantly cured with something as simple as growing and eating some magic mushrooms.

We will get back to this in more depth in later articles, but for the time being what we want to highlight is the responses to the question “About how many cluster headaches do you get in a typical year?”.

After cleaning the data***, we end up with 270 participants. We then ranked the values from smallest to largest, and visualize them:

270_ranked

Honestly I am a bit suspicious of the very top numbers (I do not know how you can fit 25,000 Cluster Headaches in a year, so perhaps the participant interpreted the question as “lifetime number of Cluster Headaches”). So, just to be safe, we cut the top 20 highest numbers and visualize the bottom 250 values:

first_250_

This is clearly a long-tail distribution. And since many people online do claim to have 3 or more Cluster Headaches a day, I am inclined to believe this curve. To zoom in on some parts of the distribution, here are some additional histograms that focus on the lower percentiles:

If we take the logarithm of the number of yearly Cluster Headaches, the distribution looks remarkably normal:

log_of_estimated_total_half_bins_till_12

Natural log of the responses to the question “About how many cluster headaches do you get in a typical year?”

Using a Shapiro-Wilk normalcy test does not rule out a Gaussian distribution (p >0.05). Although this in no way shows that that the distribution is log-normal (which would require more specialized statistical analysis), it is at least suggestive of it.

I should also point out that the distribution is really close to the 80/20 Pareto principle – we see that the top 20% of the participants contain about 83% of the CH incidents per year. Below you will find the percent of the total number of incidents accounted for by the bottom x% of the respondents:

  1. The bottom 10% accounts for .06% of incidents
  2. The bottom 20% accounts for 0.36% of incidents
  3. The bottom 30% accounts for .95% of incidents
  4. The bottom 40% accounts for 1.82% of incidents
  5. The bottom 50% accounts for 3.17% of incidents
  6. The bottom 60% accounts for 5.54% of incidents
  7. The bottom 70% accounts for 9.56% of incidents
  8. The bottom 80% accounts for 17% of incidents
  9. The bottom 90% accounts for 30% of incidents
  10. The bottom 95% accounts for 43% of incidents

Below we also include the number of yearly Cluster Headaches experiences at different percentiles:

  1. 10% percentile experiences 5 CH/year
  2. 20% percentile experiences 17 CH/year
  3. 30% percentile experiences 30 CH/year
  4. 40% percentile experiences 45 CH/year
  5. 50% percentile experiences 70 CH/year
  6. 60% percentile experiences 105 CH/year
  7. 70% percentile experiences 200 CH/year
  8. 80% percentile experiences 365 CH/year
  9. 90% percentile experiences 730 CH/year
  10. 95% percentile experiences 1095 CH/year
  11. 98% percentile experiences 2190 CH/year

I believe that this information is crucial to consider when assessing cost-effective interventions to help people who endure intense suffering.


Here are some additional results from the survey.

cluster_headache_tryptamine_use

The following graphs are about the beliefs and attitudes of Cluster Headache sufferers who do not use tryptamines (LSD, psilocybin, DMT, etc.) to treat their condition:

 

I think it is fair to say that the survey shows that one of the biggest barriers preventing CH patients from using tryptamines to treat their condition is simply the difficulty of acquiring them. Since a number of interviews we’ve conducted have shown that even sub-hallucinogenic doses of DMT can abort cluster headaches (writeup coming soon), more education could easily address the barrier of being concerned about hallucinogenic side effects. The social stigma seems like a minor problem, and the legal implications (the hardest to change, perhaps), are a big concern to about half of the participants (ratings of 4 or 5/5). Hence the importance of passing new laws allowing people with this condition to use them without repercussions.

Do CH sufferers who do not use tryptamines think they would work?

no_use_cluster_headache_belief_in_effectiveness

And do they work? Here is what the CH sufferers who do use them say:

use_cluster_headache_effective

Effectiveness

use_cluster_headache_kind

Tryptamines used

If we interpret a 2 or 3 in the 0 to 5 scale as an equivalent to a “maybe”, and a 4 or 5 as a “yes” to the question “do they work?” we see a big difference between non-users beliefs in their effectiveness and their reported effectiveness by users. 24% of people who use tryptamines to treat their CHs report that “They have completely eliminated the cluster headaches” and in total 68% mark it as either a 4 or a 5 in the scale (which we can interpret as “working” even if not “completely eliminating them”). This is compared to only 30% of non-users who believe the tryptamines would work. This large discrepancy also suggests that outreach and education could help sufferers give this approach a try.

Finally, we also looked at whether the users and non-users had different number of incidents per year (reasoning that perhaps those who experience more incidents would be more desperate to try legally and socially risky treatments). We notices that there is a very slight difference in the mean (and mean-log) for the number of CH incidents a year between the 20% of sufferers who treat their CHs with tryptamines and those who don’t. I won’t report the difference in the mean because the skew of the distribution makes such a metric deceptive, but the log-mean of yearly incidents of tryptamine users is 4.73 whereas for all the rest it is 4.10 (which reaches statistical significance of p < 0.05 based on a t-test). That said, we don’t think this is a very practically relevant difference. The distributions look roughly the same:

tryptamine_vs_non_tryptamine_users

The similarity between these two distributions also suggests that there is a long way to go to make sure that those who are the worse off get prompt access to tryptamines.

The End.


See also https://clusterbusters.org/, which is an organization that aims to make psychedelics legally available to people who suffer from this condition. Please consider donating to them to help this very important cause. Also consider donating to MAPS which is championing the use of psychedelics for mental health applications. Finally, consider also donating to organizations that care and strategize about how to reduce intense suffering, such as: QRI, FRIOPIS, and The Neuroethics Foundation.


*There are instrumental considerations here – if experiencing more than, say, 5,000 hell-seconds in a year is very likely to make you depressed and ineffective, then it might pay-off to also spend resources on keeping as many people as possible below that level. In particular, to be an effective Effective Altruist it pays off not to be heavily depressed and nihilistic.

**Thanks to Harlan Stewart for taking the initiative to conduct this survey. He advertised it on the Facebook groups and subreddits of Cluster Headache sufferers and got 371 responses.

***Some people provided numerical answers, which we used directly. Some other people provided ranges, in which case we used the middle point between the values provided (e.g. “200 to 300” was coded as “250”). Some people provided lower bounds, in which case we simply used such lower bound (e.g. “500+” was coded as “500”). We discarded the data of people who didn’t provide an answer in any of those formats – which left 270 participants. A more strict analysis that uses *only* the numerical responses results in the same observations listed above (e.g. the distribution is equally long-tailed and it appears to be log-normal).


[Cross-posted in Effective Altruism Forum]

Frequency Specific Microcurrent for Kidney-Stone Pain

Excerpt from The Resonance Effect: How Frequency Specific Microcurrent is Changing Medicine (2017) by Carolyn McMakin 

Kidney Stone Pain

Everyone who has ever had a kidney stone will tell you that the kidney-stone pain is the worst. Emergency rooms treat it with morphine, and nothing else seems to touch it.

The phone rang on a summer Sunday morning and I hardly recognized the friend who grunted through gritted teeth to ask if “my machine” could treat kidney-stone pain. I told him that I’d never treated it before, but I’d be willing to try if he could make it to my house. He shuffled from the front door to the couch bent forward at the waist, sweating in pain. I put one wet graphite glove under his back and the other glove on his abdomen. He tried hard not to moan as I covered him with a soft blanket and placed my hand on top of the glove on his abdomen.

Education said that kidney-stone pain had to be about spasm in the ureter, the tube that carries the stone from the kidney to the bladder. The frequency for spasm was 29 hertz on channel A. The frequency for the ureter was 60 hertz on channel B. It did absolutely nothing: no warmth, no relaxation or softening, nothing. Maybe there was bleeding caused by the rough stone shredding the ureter as it traveled? I tried 18 hertz to stop bleeding on channel A. The glove didn’t get warm, and the pain didn’t change.

I really didn’t want my gray-faced friend to be my first failure. Reaching for inspiration, I tried the always-reliable 40 hertz to reduce inflammation. Nothing changed. Desperation amplified the small murmur of my intuition in my head, “Don’t get sloppy! Be thorough.”

There is a sequence of frequencies leading up to inflammation. The sequence was 20 hertz for “pressure or pain reaction,” 30 hertz for irritation, 40 hertz for inflammation. I never ran the whole sequence because 40 hertz always worked and I had no idea what a “pressure or pain reaction” might be. The buttons clicked down from 40 hertz to 20 hertz on channel A, and two things happened in seconds. The glove resting on his abdomen got hot — not just warm, it was hot. His abdomen started to soften. The feeling is hard to describe. It feels like a balloon feels when it has been sitting on the floor overnight. The tissue softens and stays soft while the correct frequency is working, and it returns to normal when the frequency is finished.

His voice was a little slurred when he fell asleep a few minutes later as he said, “Is that supposed to make me feel woozy?” His deep relaxed breathing said he was out of pain.

There are frequencies for the stone, so I tried those after twenty quiet minutes of watching him doze. The glove got hot, the abdomen softened, and ten minutes later he bolted awake and yelped, “The stone’s moving.” True to its promise, 20 hertz on A and 60 hertz on B reduced the pain again and put him back to sleep. Forty minutes later he left, pain-free, and passed the stone that night with no increase in pain.

I told this story at the Advanced Course in Australia a few weeks later, and one of the Australian practitioners reported that she treated her husband for kidney stone pain with 20 hertz on A and 60 hertz on B. He was out of pain in an hour and passed the stone uneventfully.

Every case of kidney stones treated since then has responded exactly the same way. When the patient has gripping lower back pain from lifting suitcases during a long dehydrating flight but treating the muscles doesn’t help, experience finally admits it’s not the muscle. Intuition says, “I wonder if it’s a kidney stone?” The learning curve is very steep and short when the glove gets hot, the muscles begin to relax, the pain goes down in minutes, and the patient falls asleep.

When one specific frequency combination, and only one, works every time anyone uses it, and when it does something that is otherwise impossible, then it can’t be impossible. It’s got to be resonance.

Every Child is a Genetic Experiment: FAAH Clinical Trials for Hedonic Recalibration as Educated Guesses Rather than Reckless Experimentation

by David Pearce, in response to Quora question: How do you break the hedonic treadmill?

 

The easiest pain to bear is someone else’s.
(François de La Rochefoucauld)

Could two small genetic tweaks get rid of most of the world’s mental and physical pain?
A tentative answer is: just conceivably. More cautiously, the problem of suffering should be genetically soluble this century. Before launching into a long list of caveats and complications – and outright scepticism – it’s worth considering a case study. The subject has waived anonymity.

Jo Cameron is a retired Scottish schoolteacher, a socially responsible vegan and pillar of the local community. Jo has gone though life in a perpetual state of “mild euphoria”. She has unusually high levels of anandamide (from the Sanskrit for “bliss”) and is never anxious, though her serenity may vary. Jo doesn’t feel pain, or at least not in any sense most of us would recognise: childbirth felt like “a tickle”. She is hyperthymic, but not manic. Unlike previously reported cases of congenital analgesia, Jo didn’t die young or find the need to adopt a “cotton-wool” existence to avoid bodily trauma. She came to the attention of medical researchers only when her disdain of painkillers for what “ought” to have been an excruciating medical procedure – a trapeziectomy on her right thumb – intrigued her doctor. “I had no idea until a few years ago there was anything that unusual about how little pain I feel – I just thought it was normal.
With CRISPR genome-editing, lifelong bliss could be normal.

Jo Cameron is first known case of someone with mutations in both the FAAH gene and its newly-discovered sister gene, FAAH-OUT, which modulates the FAAH gene. The FAAH gene (short for Fatty Acid Amide Hydrolase) is a protein-coding gene responsible for degrading bioactive fatty amides, most notably the endogenous cannabinoid anandamide. Previous mutations of FAAH are known, but the FAAH-OUT gene was previously reckoned a pseudogene. Single FAAH mutations are associated with high pain-tolerance, reduced anxiety and a sunny outlook without Jo’s “extreme” syndrome of well-being. Jo’s son has the single mutation.

Other case studies may be cited. I often use (again with prior consent) the example of my transhumanist colleague Anders Sandberg (“I do have a ridiculously high hedonic set-point”) – although Anders’ pain-sensitivity lies within the normal range. The pain-modulating SCN9A gene, which has dozens of alleles conferring varying pain (in)tolerance, is much better studied (cfHow much do our pain thresholds differ?).

What biologists call the Environment of Evolutionary Adaptation (EEA) ensures such outliers are rare. Although Jo Cameron shows accelerated wound-healing, not being a “normal”, neurotic mother on the African savannah would have carried a fitness-cost. Predators are unforgiving of relaxed moms. Our sugary “wildlife documentaries” barely hint at the cruelties of Nature. Pain, fear and anxiety are intimately linked. “Only the paranoid survive”, said Intel boss Andy Grove; and this bleak diagnosis can be true of market capitalism to this day. But we are not living on the African savannah – or even in a world of unfettered free markets. Looking ahead, all kinds of risks can be offloaded to artificial intelligence. AI and smart prostheses can potentially manage risks moreeffectively than bias-ridden humans. Intuitively, for sure, tampering with our reward circuitry will be hazardous. Genetically modifying or creating superhappy organisms with relative pain-insensitivity and enhanced zest for life will lead to increased personal risk-taking. Yet the story is more complicated. A great deal of risky and self-destructive behaviour in today’s world involves not happy, pain-free people, but the pain-ridden, depressive and psychologically disturbed. Life-loving optimists typically value life more – and seek to preserve and protect it. Anecdotally, I don’t think it’s a coincidence that some of the happiest people I know dedicate their lives to the study and prevention of existential risk.

So a practical question arises.
Should a large, well-controlled clinical trial of CRISPR babies be launched, with some babies carrying Jo’s two mutations, others a single FAAH mutation like her son, and controls?
If the trial is successful, then the controls and (in due course) the wider human population could enjoy remedial gene-therapy to share the benefits.

One of the few publications to recognise the far-reaching significance of Jo’s case is the magazine Wired (cfCrispr Gene Editing Could One Day Cut Away Human Pain). Instead of the double mutation promising “only” better drugs to treat pain, humanity can now tackle the problem of suffering at its source.

Bioconservative critics will be appalled at the idea: “Doctor Mengele!” “Eugenics!” “Designer babies!” “Gattaca!” “Brave New World!” Being malaise-ridden is normal and natural. Creating superbabies would be hubris. Where will it lead? How do we know gene-editing won’t be used by despots to create a race of fearless superwarriors?
In more measured language, how can experimentation with the lives of sentient beings without prior informed consent be ethically justified?

Indeed. Yet all babies born today are unique and untested genetic experiments. All baby-making entails creating involuntary suffering. None of our genetic experiments first passed muster with a medical ethics committee. Any proposal to create transhuman superbabies will probably strike our descendants as genetic remediation, not enhancement. If we reject the arguments of anti-natalists, who view Darwinian life as malware, then all prospective parents are committed to practising genetic experimentation – just not under that inflammatory label. So what’s at issue is not the principle of genetic innovation, only whether we should harness the new tools of CRISPR-Cas9 genome-editing to conduct our experiments more responsibly. If aspiring writers can benefit from proofreaders and editors, why not aspiring parents too – where the stakes are higher?

Your question asks about breaking the hedonic treadmill (cfWhat would people who never suffered be like?). Breaking or otherwise dismantling the hedonic treadmill is worth distinguishing from recalibration of its dial-settings. Hedonic adaptation can be broken in human and non-human animals by experimentally inducing “learned helplessness” and behavioural despair in response to chronic, uncontrollable stress. Hedonic adaptation can be broken at the other extreme by using intracranial self-stimulation of the mesolimbic dopamine system. “Wireheading” shows virtually no tolerance. Pathological cases of a broken hedonic treadmill occur “naturally” in chronic unipolar depression and, much more rarely, in euphoric unipolar mania. Attempts to cheat the hedonic treadmill via drugs are fraught with pitfalls. The most powerful mood-brighteners, namely the opioids, activate the hedonic treadmill rather than mitigate it. Some opioid users end up with a habit hundreds of times their starting dose. Natural selection did not design living organisms to be happy.

Functionally, therefore, genetic recalibration is a more fruitful strategy than abolishing the hedonic treadmill, both for the individual and society at large. For what it’s worth, I personally think we should aim for a hyperthymic civilisation built on a biology of invincible well-being. Future sentience will be underpinned by gradients of bliss. However, nothing so grandiose need be envisaged in order to warrant human CRISPR trials of happy babies. Grant some fairly modest ethical assumptions, e.g. other things being equal, intelligent moral agents should act so as to reduce the burden of suffering, or at least not wantonly add to it. For any genetic intervention that alters default hedonic tone, conserving information-sensitivity to “good” and “bad” stimuli is critical. In other words, we should aim to retain the hedonic treadmill but transform its negative feedback-mechanisms into a hedonistic treadmill – where “hedonism” is understood not in the amoral popular sense of a life of drink, drugs and debauchery, but as embracing Mill’s “higher pleasures”. Hence the hedonistic imperative. If clinical trials of superbabies go well, prospective parents world-wide could be offered the opportunity to have happy, heathy babies via CRISPR genome-editing, preimplantation genetic screening and counselling.

A biohappiness revolution would be extremely cost-effective. Depression, anxiety disorders and chronic pain-syndromes significantly reduce economic growth worldwide. By conserving hedonic adaptation, but ratcheting up hedonic range and hedonic set-points, humanity can conserve and enhance empathetic understanding, social responsibility and critical insight while enriching default quality of life. By conserving hedonic adaptation, we can also conserve cherished traditional values, if so desired. Yesterday’s utopias involved overriding the preferences of others, whether for their own notional good or in pursuit of some higher cause. By contrast, elevating your pain-tolerance and raising your hedonic set-point would radically enrich your life but wouldn’t challenge your values and preferences – unless one of your core values is preserving the genetic status quo.

What could go wrong with a biohappiness revolution?
Cue for vast treatises and a sci-fi movie.
However, as well as seriously – indeed exhaustively – researching everything that could conceivably go wrong, I think we should also invesigate what could goright. The world is racked by suffering. The hedonic treadmill might more aptly be called a dolorous treadmill. Hundreds of millions of people are currently depressed, pain-ridden or both. Hundreds of billions of non-human animals are suffering too. If we weren’t so inured to a world of pain and misery, then the biosphere would be reckoned in the throes of a global medical emergency. Thanks to breakthroughs in biotechnology, pain-thresholds, default anxiety levels, hedonic range and hedonic set-points are all now adjustable parameters in human and non-human animals alike. We are living in the final century of life on Earth in which suffering is biologically inevitable. As a society, we need an ethical debate about how much pain and misery we want to preserve and create.