The Manifesto of Tactilism

In the same genre as: The Qualia Manifesto, Rainbow God, The Super-Shulgin Academy, Perfumery as an Art Form, and Harmonic Society. [April 13 Note: I’m sharing this manifesto because of the extraordinary extent to which it values an often-disregarded qualia variety in a systematic and enthusiastic way. It is in no way in support of the politics or behaviors of its author.]

The Manifesto of Tactilism

by F.T. Marinetti
Milan, 11 January 1921.

Read at the Theatre de I’Oeuvre (Paris), the World Exposition of Modern Art (Geneva), and published inComoedia in January 1921

Futurism, founded by us in Milan in 1909, gave to the world a hatred of the Museum, the Academy and Sentimentalism; it gave the world Action-Art, the defence of youth against all senility, the glorification of illogical and mad innovative genius, the artistic sensibility of mechanisation, of speed, of the music hall, and of the simultaneous interpenetration of modern life, words in freedom, plastic dynamism, noise-intoners, synthetic theatre. Futurism today redoubles its creative effort.

Last summer, at Antignano, where the street named after Amerigo Vespucci, discoverer of America, curvingly coasts along the sea, I invented Tactilism. Red flags waved from the workshops taken over by the workers.

I was naked in the silky water that was torn by rocks, foamy scissors knives razors, among the iodine-filled mattresses of seaweed. I was nude in the sea of flexible steel, which had a fertile and virile breathing. I drank from the goblet of the sea filled to the rim with genius. The sun, with its long roasting flames, vulcanised my body and bolted the keel of my forehead rich with sails. A working-class boy, Who smelled of salt and hot stone, looked, smiling, at my first tactile board:

Having fun making little boats?!

I answered: “Yes, I’m building a craft that will take the human spirit to unknown waters.” Here are my reflections, the reflections of a swimmer: The unrefined and elemental majority of men came out of the Great War concerned only to conquer a greater material well-being. The minority, composed of artists and thinkers, sensitive and refined, instead displays the symptoms of a deep and mysterious ill that is probably a consequence of the great tragic exertion that the war imposed on humanity.

This illness displays, as symptoms, a sad listlessness, an excessively feminine neurasthenia, a hopeless pessimism, a feverish indecision of lost instincts, and an absolute lack of will.

The rough and elemental majority of men tumultuously hurls toward the revolutionary conquest of the Communist paradise and definitively storms the problem of happiness, convinced that it has solved it by satisfying all material needs and appetites.

The intellectual minority ironically scorns this breathless attempt, and no longer enjoying the ancient pleasures of Religion, of Art, of Love, which previously constituted its privilege and its shelter, brings life, which it no longer knows how to enjoy, to a cruel trial, and abandons itself to refined pessimism, sexual inversions, and to the artificial paradises of cocaine, opium, ether, etc. That majority and this minority both denounce Progress, Civilisation, the mechanical powers of Speed, of Comfort, of Hygiene, Futurism in short, as being responsible for their past, present, and future misfortunes.

Almost everyone proposes a return to a savage life, contemplative, slow, solitary, far from the hated cities.

As for us Futurists, we who bravely face the agonising drama of the post-war period, we are in favour of all the revolutionary attacks that the majority will attempt. But, to the minority of artists and thinkers, we yell at the top of our lungs: Life is always right!
The artificial paradises with which you attempt to murder her are useless. Stop dreaming of an absurd return to the savage life. Beware of condemning the superior powers of society and the marvels of speed. Heal, rather, the illness of the post-war period, giving humanity new and nutritious joys. Instead of destroying human throngs, it is necessary to perfect them. Intensify the communication and the fusion of human beings. Destroy the distances and the barriers that separate them in love and friendship. Give fullness and total beauty to these two essential manifestations of life: Love and Friendship.

In my careful and anti-traditional observations of all the erotic and sentimental phenomena that unite both sexes, and of the no-less-complex phenomena of friendship, I have understood that human beings speak to each other with their mouths and with their eyes, but do not manage a true sincerity because of the lack of sensitivity of the skin, which is still a mediocre conductor of thought.

While eyes and voices communicate their essences, the senses of touch of two individuals communicate almost nothing in their clashes, intertwining, or rubbing. Thus, the need to transform the handshake, the kiss, and the coupling into continuous transmissions of thought.

I started by submitting my sense of touch to an intensive treatment, pinpointing the confused phenomena of will and thought on various points on my body, and especially on the palms of my hands. This training is slow but easy, and all healthy bodies can, through this training, give surprising and exact results.

On the other hand, unhealthy sensibilities, which draw their excitability and their apparent perfection from the very weakness of the body, will achieve great tactile power less easily, without duration or confidence. I have created a first educational scale of touch, which is, at the same time, a scale of tactile values for Tactilism, or the Art of Touch.

First scale, level, with four different categories of touch.

First category: extremely confident touch, abstract, cold.

  • Sandpaper,
  • Silver-coated paper.


Second category: touch without heat, persuasive, reasoning.

  • Smooth silk,
  • Silk crepe.

Third category: exciting, lukewarm, nostalgic.

  • Velvet,
  • Wool from the Pyrenees,
  • Wool,
  • Silk-wool crepe.

Fourth category: almost irritating, hot, determined.

  • Granulous silk,
  • Plaited silk,
  • Spongy cloth.

Second scale, volumes

Fifth category: soft, hot, human.

  • Suede,
  • Horsehair or dog hair,
  • Human hair,
  • Marabou.

Sixth category: hot, sensual, spirited, affectionate.

  • Rough iron
  • Soft brush,
  • Sponge,
  • Wire brush,
  • Plush,
  • Human or peach fuzz,
  • Bird down.

Through this separation of tactile values, I have created:

1. Simple tactile boards that I will present to the public in our contactilations or conferences on the Art of touch.

I have arranged the previously catalogued tactile values in wise harmonic or antithetical combinations.

2. Abstract or suggestive tactile boards (hand journeys).

These tactile boards have arrangements of tactile values that allow hands to wander over them, following coloured trails and experiencing a succession of suggestive sensations, whose rhythm, in turn languid, cadenced, or tumultuous, is regulated by exact directions.

One of these abstract tactile boards made by me, and that has as a title Sudan-Paris, contains, in the part representing Sudan, rough, greasy coarse, prickly, burning tactile values (spongy material, sponge, sandpaper, wool, brush, wire brush); in the part representing The Sea, there are slippery, metallic, fresh tactile values (silver-coated paper); in the part representing Paris, there are soft, delicate, caressing tactile values, hot and cold at the same time (silk, velvet, feathers, down).

3. Tactile boards for the opposite sexes.

In these tactile boards, the arrangement of tactile values allows the hands of a man and a woman, tied together, to take a tactile journey together and evaluate it. These tactile boards are extremely varied, and the pleasure that they give is enriched by the harnessing of rival sensibilities, which will attempt to feel more acutely and better explain their rival sensations. These tactile boards are destined to replace the brutalising game of chess. [Emphasis mine]

4. Tactile pillows.

5. Tactile sofas.

6. Tactile beds.

7. Tactile shirts and dresses.

8. Tactile rooms.

In these tactile rooms, we will have floors and walls made of large tactile boards. Tactile values of mirrors, running water, rocks, metals, brushes, lightly electrified wires, marble, velvet, rugs that will give the bare feet of the male and female dancers varied pleasures.

9. Tactile streets.

10. Tactile theatres.

We will have theatres arranged for Tactilism. Seated spectators will rest their hands on long, running tactile ribbons that will produce tactile sensations with different rhythms. It will also be possible to place these ribbons on small rotating wheels, accompanying them with music and light.

11. Tactile boards for the improvisation of words in freedom.

The tactilist will express aloud the sensations that his hands’ journey transmits to him. His will be a free-word improvisation, that is, freed from all rhythm, prosody and syntax, an improvisation essential and synthetic and with as little of the human element
as possible. The improvising tactilist may be blindfolded, but it is preferable to wrap him in the light of a projector. The new initiates, who have not yet trained their tactile sensibilities, will be blindfolded. But, as for the true tactilists, the full light of a projector is preferable, since darkness has the drawback of concentrating sensitivity into an excessive abstraction.

The education of the sense of touch.

1. It will be necessary to keep the hands gloved for many days, during which the brain will attempt to condense in them the desire for varied tactile sensations.

2. To swim underwater, in the ocean, trying to distinguish tactilely the plaited currents and different temperatures.

3. Enumerate and recognise every evening, in absolute darkness, all of the objects in the bedroom. It was precisely with giving myself over to this exercise in the underground darkness of a trench in Gorizia, in 1917, that I made my first tactile experiments.

I never claimed to have invented the tactile sensibility, which has already manifested itself in genial forms in the Jongleuse and in the Hors~nature of Rachilde. Other writers and artists had premonitions of tactilism. Moreover, the plastic art of tactilism has been in existence for a long time. My great friend Boccioni, futurist painter and sculptor, felt as a tactilist when he created, in 1919, his plastic ensemble Fusion of a Head and a Window, with materials that are absolute contraries in tactile weight and value: iron, porcelain, and women’s hair.

The Tactilism created by me is clearly distinct from the plastic arts. It has nothing to do with, nothing to gain from, and everything to lose by association with painting or sculpture. It is necessary to avoid, as much as possible in the tactile boards, a variety in colour, which lends itself to plastic impressions. It will be difficult for painters and sculptors, who tend naturally to subordinate tactile values to visual values, to create significant tactile boards. Tactilism seems to me particularly suited to young poets, pianists, typists, and to all erotic, refined, and potent temperaments.

Tactilism, nevertheless, must avoid not only collaboration with plastic arts but also morbid erotomania. It must, simply, have as a goal tactile harmony, and it must indirectly collaborate in the perfecting of spiritual communication between human beings through the epidermis.

The identification of five senses is arbitrary, and one day we will certainly discover and catalogue numerous other senses. Tactilism will contribute to this discovery.

F. T. Marinetti, 1921

(source; also, here is my reading of the Manifesto; related: domestic cozy)

Qualia Production Presents: “The Seven Seals of Security” (and Other Communications from QRI Sweden)

By Maggie Wassinge and Anders Amelin (now QRI Sweden and HR helpers; see previous letters)


Jewelry by Anders and Maggie (see: Quantifying Bliss for the reference to “C, D, N”)

Hi everyone!

It’s Anders and Maggie in Stockholm, Sweden, here. Volunteers in human resource coordination for the QRI.

We would like to hereby announce our commitment to donate fifty thousand dollars to the Qualia Research Institute for research related to the mathematical modeling of phenomenological valence.

We are pretty much just your ordinary Swedish transhumanist couple. With a passion for finding out from first principles how things work. We whole-heartedly agree with Elon Musk that at the end of the day, excellence is the only passing grade. Over the last couple of years we have arrived at the solid conclusion that the biggest bonanza in effective altruism could only be realized by first of all solving valence. Symbolically, in comedy form, this is like first spending the necessary computational resources to arrive at the conciseness of 42 as “the answer”, before it can be determined what the right questions must then be. In our book it is with no doubt the Qualia Research Institute which corresponds to “Deep Thought” in what Elon Musk has called “the best philosophy book ever”: The Hitch-Hiker’s Guide to the Galaxy. Seriously here, it is advisable to balance this with a bit of David Pearce also, but indeed we do believe an encouraging “Don’t Panic” is in fact compatible with the laws of nature in this universe. Immense reward is there for those who roll up their sleeves and start working systematically from first principles.

But again, excellence is the only passing grade. The universe is no picnic. It is a field of seemingly infinite potentialities, all of which are open to exploration and exploitation. It is still unknown what the proto-states of sentience are intrinsically like, but it is clear that biological evolution works as an optimization engine for valence polarization. A “passing grade” for a long-term sustainable and prospering technological civilization must involve a universally global first-principles solution to the horrific downside of this: suffering. That solution must be combined with optimal development of the state space of positive valence and intelligence. It seems plausible that experienced negative valence is a computationally economic way for evolution to drive behavior when the implementation is in biochemistry. However, information processing can also be done non-consciously, and it stands to reason that all the informational saliency achieved via negative valence experience can instead be had via non-conscious processes which would be available to future suitably modified embodiments of intelligence.

The QRI is the only real player in this game so far, as our civilization takes its first baby steps towards maturity. In the domain of effective altruism, the Qualia Research Institute today corresponds to what bitcoin was when first launched. The difference is that the QRI doesn’t just promise to be a novel medium of exchange, but a novel competence about the first principles of well-being!

During the couple of years it took for us to come to the above conclusions, we set aside every penny we could spare. That became the fifty thousand we are now committing to the QRI. If enough others with the same visions were to do the same thing, soon enough it could begin adding up to real money. Money which at this foundational stage stands at quite a favorable exchange rate with respect to the ultimate currency of the universe: positive emotional valence.

Infinite bliss to everyone from a couple of Scandinavian old-timers!HEA-2020-01-19


High Entropy Alloy (Al + Ti + Cr + Mo + W) and Low-Entropy Non-Alloy (Ti) – made by Anders and Maggie. If non-materialist physicalist idealism (i.e. panpsychism that respects physics) is true, what do these bundles of baryonic matter feel like from the inside?

Letter IV: On Psychonautics

Psychedelic trippers put effort into trying to interpret what it all means ontologically. Plant spirits may be at work, or one taps into the collective unconscious or is simulated by some alien superintelligence.

The QRI could perhaps guide interested psychonauts in the direction of writing more scientifically productive reports.

A scientifically minded tripper needs to start with the realization that human beings are perfect psychonauts because our brains have an enormous excess capacity over what is minimally required to perform any one of the tasks that we do in everyday waking life. The highly unusual aspect of human brains is that they can produce general intelligence. This is rare in nature but when you have it, you assume it to be the normal state of affairs.

Trippers are often in disbelief over the ability of human brains to produce the fantastic content of psychedelic experiences. As if there is suddenly a superpower there which one never uses when sober. How can that be? It must be something supernatural going on, right? Actually, no. Not that we should rule out the “supernatural” a priori but it is not necessary.

The human mind uses a superpower all the time. One which is hidden in plain view, we might say. It is the superpower of selecting from a huge range of possibilities for what the mind could be doing, and homing in on exactly the one choice in every moment that is most appropriate right then and there. When those tight constraints are relaxed the human brain becomes a system which can explore far and wide in qualia state-space.

Intelligence is a phenomenon which uses multiple optimization points to converge on some invariance. At the theoretical efficiency maximum this takes surprisingly (to us) little raw processing power. A jumping spider does not display less strategic and tactical intelligence than a human does when hunting. The spider’s neural network is very much smaller than the human’s but the evolutionary fitness search available for evolving small, numerous and quickly reproducing creatures is much larger than for animals like us. For us it is not so much a question of evolution having optimized what every cell does, but one of having added more and more cells to increase overall performance.

The spider’s brain probably contains far less sub-optimal “spaghetti code” than the human’s. It is possible that the spider has access to exquisitely fine-tuned qualia for the crucial task of sneaking up on big, highly dangerous prey and bringing it down without botching the job. On the other hand, there might not be much opportunity for spiders to evolve general intelligence since they have already done away with everything that is “useless” for their sober everyday lives.


“Does my brain contain less spaghetti code than yours?”

A human brain is a mass of excitation-inhibition “spaghetti” which defies belief. An almost ultimate jack of all trades but master of none which cannot quite produce the hunting skills of the spider but can instead do a billion other things that the spider could not even in principle learn how to do.

It is the billion other things that we could do but don’t, which is the human superpower, not the few things that we actually do on a sober basis. This is a power which can be harnessed for psychonautics. You’ve got an inner-space warp drive in your head. Aptly named. 🖖

Letter V: Exciting Research Leads

Here are some suggestions for titles of essays and research papers the QRI could write if we had the resources.

  1. “Alloy, anneal, quench and temper: Forging a blade to cut mind at the joints”
  2. “Play me like a violin: A compressibility analysis of neuro-acoustic patterns captured during person to person interaction”
  3. “Leadership and consonance: Aggregate neuro-acoustic compressibility as a proxy for computational efficiency of human group intelligence”
  4. “Neural annealing through laughter: Neuro-acoustics of humor as a factor for healthy mental adjustment”
  5. “The tree of music: An annealable branching tuning-fork model for nervous systems”
  6. “Same but different: Suggesting a qualia analogue for the comparative planetology of Earth and Titan”
  7. “Music of life: Consonance, dissonance, noise and symmetry as explanatory elements for evolution from single cells to human minds”
  8. “Compartments of harmony bounded by dissonance: A neuro-acoustic model of domain specificity in cognition”

The Seven Seals of Security or Safety Through Uncertainty – Transhumanist Satire

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Letter VI: Earth as an Engine of Qualia Diversity

Handwaving Johnson & Gómez-Emilsson’s law about the surprisingly large size of qualia state space:

Presume that consciousness and matter are interconnected information structures. Can any useful parallels be drawn from the matter domain of outer space to the consciousness domain of inner space? Consider that planets, as a group, are subject to variation and (anthropic) selection. An interconnection point is provided by observation selection: Certain planetary properties far from the universe median are going to be found by intelligent conscious observers for their own planet of origin. A small subset of conscious observers are the ones who, like humans, have general intelligence and broad curiosity. Those observers are the few who observe more and more aspects of their own planet as well as adjacent space and the state space of matter at large, and ultimately perhaps also of consciousness at large. The evolutionary reproductive selection of such observers is not the default condition of all life but rather it is conditional upon even more unusual properties of their planet of origin than for the average life-bearing planet.

Conclusion: Earth is likely to be a highly unusual planet, and human consciousness is likely to be a highly unusual seat of experience. They are causally linked. A structural property they share could be a high level of diversity but never reaching cosmically global extremes on any single parameter. A Jill of all trades planet is married to a Jack of all trades mind.

While fairly good at impressively many trades, Jack and Jill are master and mistress of none. For a tentative and very loose analogy which may be better than nothing, let’s say planet Earth is like the human mind. The other planets in the Solar System are like altered human minds and some animal minds. Some basic properties like gravity, roundness and rotation are common to all the planets. Corresponding to suggested basic features of biologically evolved sentience, such as valence and some sensory modalities.

Then we follow Slartibartfast to the fjords of Norway. Here we see how Earth differs in diversity compared with the other “animals”. The planet’s surface is an energetic 3-phase regime. Solid crust, liquid water and solid water under highly dynamic conditions. Not widely separated like on Europa but forming extended areas of contact where unusual complexity emerges. It’s worth an award, really. (No, not Belgium…).

Human cognition is like Earth with its’ coasts and mountain ranges. A “just right” quantity and proportionality of ingredients is what allowed self-organization of Earth’s environmental complexity and its’ endurance over time via the mechanism of prolonged core solidification and plate tectonics. An unusual state of affairs in nature. It’s not unexpected in principle, only rare in actual existence. The same may go for evolution of the general cognition accessible to human minds.

A type of mind which is generally competent over multiple domains of agency cannot function as such if not many crucial parameters in its’ architecture fall within a tight range of “just right and not too much nor too little”. Or, in Swedish, “lagom”. If you loosen that constraint, such as by ingesting 5 grams of mushrooms blindfolded, your mind will clearly no longer function on your job or even in your body. But in exchange for giving up on that functionality as agent, you can max out on stuff like… well, it’s beyond words.

General intelligence is not compatible with an easy achievement of extreme states of consciousness, though as a less frequently added mental ingredient for a group intelligence (like human hunter-gatherers) extreme states can be hypothesized to enhance abilities of that group intelligence.

But what does the current human “master of none” in qualia rendering imply for the future of consciousness, and what about cosmic matter beyond the neighboring planets?

Beyond the Solar System we find many types of stars, black holes, dark matter and various ultra-thin, ultra-dense, ultra-cold, or ultra-hot configurations of matter in the wider domain of spacetime. Nature usually has not developed nonliving matter into configurations with even remotely as high a complexity as for living matter, simply because of no evolutionary selection pressures. Some nonbiological matter objects could be strong qualia generators just by chance, though. The Sun comes speculatively and punlessly to mind. Doing an IIT and a CDNS analysis on its’ surface magnetized plasma wave patterns may not be entirely far-fetched. But the big promise for expanding the diversity of actualized sentience comes through engineering. Jack and Jill is the couple who can pull that off, and their offspring can then grow up in that fabulous new landscape of experience. For they can become masters and mistresses. Dominatrices, even. The reason being that while the parents are tightly constrained experientially, the kids need not be.

For an efficiently organized advanced technological civilization, the constraints of being a highly general and resilient intelligence can be placed high up on the group level. Individual seats of experience with the sizes of today’s human or animal brains, say, can then be allowed to render experiential states more specialized to feel meaningful, enjoyable and worthwhile. (A dystopian version could instead generate unimaginable suffering, of course. Need to watch out…).

Earth is by far the most diverse planet in the Solar System, but it does not have the deepest ocean, the tallest mountain, the highest gravity, the hottest days, the most explosive volcanoes or the most intense thunderstorms. Human minds who have only experienced their evolved biologically functional mental states have not reached the consciousness state space equivalents of the extreme environments on the other planets. They have never snowboarded down the tellurobismutite condensate slopes on Maxwell Montes or been ejected on a ballistic trajectory by a sulfur dioxide plume from Tvashtar Patera. These things may be comparable to being a bat or taking psilocybin. As different from sober human experience as they are, they still merely hint at the range of possible experiences in the qualia state space opening up beyond. If all goes well, there will be psychonauts of the future who are children of Earth and able to engineer any form of matter and energy into conscious brain architectures. They would become what Max Tegmark has called “Life 3.0”.

Either that or, in a hopefully not terribly more likely scenario portrayed by imagined future historians, humanity stayed obsessed with the circulation of money to the detriment of all else.

This planet has – or rather had – a problem, which was this: most of the people living on it were unhappy for pretty much of the time. Many solutions were suggested for this problem, but most of these were largely concerned with the movement of small green pieces of paper, which was odd because on the whole it wasn’t the small green pieces of paper that were unhappy.” ― Douglas Adams, The Hitchhiker’s Guide to the Galaxy 🌎


Earth as an Engine of Qualia Diversity

Making Amazing Recreational Drug Cocktails


Imagine that you were tasked with creating a molecule to represent the spirit of California. I think that I would just glue together two MDMA molecules and call it a day.



It turns out Californidine is indeed a real molecule, named after the California Poppy. I am still wrapping my head around the fact that Californidine can be described as two MDMA molecules sharing the nitrogen atom and with the end of the carbon chain of each MDMA molecule bonded at the 2-position of the benzene ring of the other one (minus a hydrogen atom). Interestingly, this compound has no psychedelic or empathogenic action. At best, it can be described as a very mild and unreliable relaxing agent of “herbal strength” akin to the active ingredients of chamomile, valerian, or ashwagandha. So, joining two powerful heart-openers gives rise to a mild sleep-inducer? Perhaps this is a metaphor for something.


Californidine and MDMA

But that’s not what I want to talk to you about today. While gluing together psychoactive molecules may not have a (cartoonishly) desirable additive effect, doing so does express the spirit of what I want to propose today. And that is the impulse to use a creative and fun approach to drug design, letting your imagination run wild to avoid prematurely discarding one’s crazy ideas.

Notable Leads for Great Drug Combos

Over the last 10 years I’ve read many (many!) trip reports and have talked to hundreds of experienced psychonauts (see also: r/replications). It is largely thanks to a subset of these psychonauts, which for lack of a better term could be described as the subset of rational psychonauts, that I’ve been able to assemble empirically testable models for psychedelic phenomenology (some examples: Algorithmic Reduction of Psychedelic States, Hyperbolic Geometry of DMT Experiences, Quantifying Bliss, How to Secretly Communicate with People on LSD, etc.). Although my focus has largely been on the effects of individual drugs, I’ve become very cognizant of the fact that drug combinations can produce effects not accessible with individual substances. In other words, when it comes to mixing psychoactive substances, the sum is more often than not different from the sum of its parts. Some of these effects seem extremely significant both from a scientific and a philosophical point of view.

But first, an important disclaimer: mixing drugs is dangerous and you should never do it unless you really know what you are doing. The pile of celebrity deaths caused by multiple drug intoxication is only scratching the surface. Indeed, there are many combinations of drugs that are deadly even when the individual drugs taken on their own are relatively safe. For example, while 5-MeO-DMT is relatively safe when vaporized (save for egregiously negligent uses of the drug and the occasional drowning in one’s own vomit), taking 5-MeO-DMT orally in combination with an MAOI leads to extremely toxic reactions, such as severe hypertensive symptoms, overheating, and serotonin syndrome. Don’t do it. As a very rough guide for how mixtures of psychoactives behave, study the chart below.


Welcome to the practice of combining drugs. You may die. (source)

That said, just as drug combinations have a dangerous side, they also likely harbor hidden gems that are very safe, enjoyable, and mind-expanding in ways inaccessible via single drugs. As a general overview, some examples of the possible benefits of drug combinations include: (1) Enhanced euphoria, e.g. see speedball which is massively euphoric but also very dangerous, (2) reduced psychological discomfort (e.g. anxiolytics with psychedelics), (3) uniquely interesting effects, e.g. LSD + MDMA (see below), and (4) reduced physical side-effects and medical risks, e.g. calcium blockers to reduce MDMA neurotoxicity, 5HT2B antagonists to reduce cardiotoxicity of psychedelics, etc. as we’ll discuss. In addition, it is worth mentioning that from a therapeutic point of view, we also have the “more dakka effect“, where some conditions only respond to combining enough drugs (e.g. oncology). It’s possible chronic pain or severe depression may legitimately require multiple drugs to be adequately dealt with. Now let us examine in more detail some particularly interesting categories of drug combinations:

Psychedelics + Anxiolytics: According to many reports, phenibut in small doses seems to significantly reduce the anxiety that comes up on psychedelics. I am ambivalent about sharing this information given the fact that phenibut can become a huge problem for some people, but I think that on the whole it is wise for people to know that an over-the-counter “nootropic” can actually help avoid fear, discomfort, and panic attacks during a psychedelic experience.

Cannabis + Psychedelics: I generally find two kinds of psychedelic drug users. Those who cannot think of having a psychedelic trip without at some point smoking a joint, vaping, or eating a cannabis edible. And then those who would never dare to combine the two because they once had a terrifying experience with the combo. Interestingly, some of the people I’ve met over the years who seem to be able to easily handle massive doses of psychedelics (e.g. 500 micrograms of acid) respond terribly to weed, and especially badly if they are already tripping. Cannabis both modifies and potentiates psychedelic states of mind. It has a tendency to make the experience more conceptual rather than sensory or mystical. The combination also greatly increases the probability of getting stuck in time loops.

Empathogens + Psychedelics: One of the best descriptions of MDMA + LSD (also called candy-flipping) that I’ve found comes from Steven Lehar (emphasis added):

Under LSD and ecstasy I could see the flickering blur of visual generation most clearly. And I saw peculiar ornamental artifacts on all perceived objects, like a Fourier representation with the higher harmonics chopped off. LSD by itself creates sharply detailed ornamental artifactslike a transparent overlay of an ornamental lattice or filigree pattern superimposed on the visual scene, especially in darkness. Ecstasy smooths out those sharp edges and blurs them into a creamy smooth rolling experience. I would sometimes feel some part of my world suddenly bulging out to greater magnification, like a fish-eye lens distortion appearing randomly in space, stretching everything in that portion of space like a reflection in a funhouse mirror.

– Steven Lehar (The Phenomenal Character of LSD + MDMA)

Not everyone responds well to this combination, and given the nature of these substances, it seems likely that the dosages and the relative timing have a large influence on how the experience develops. I’ve heard three relatively “established” ways in which people use this combination. First, you have the school that says that you should take the MDMA at or slightly after the peak of the effects of LSD, that is 4-4:30h after taking it. The reasoning here is that you don’t want to be caught coming down from the MDMA while still having a long time to go on LSD since the acid could enhance the feelings of the comedown. The delayed gratification also pays-off by giving you several hours to face the problems you want to solve unaided and see how far you can get before the mood boost of MDMA gives you the determination to be contented with it.

The second school of thought about candy-flipping says that the biggest factor in how psychedelic experiences turn out is how they start. So what you want to do is take the MDMA 1 to 1:30 hours before the acid. This way, you only embark upon the inner journey when you are already in a really, really good chill state of mind. Some people report that the acid picks up the empathogenic quality of the state, amplifies it, and carries it on for much longer than if you had only taken MDMA alone.

There are many proponents and detractors to both of these schools. What I’ve seen more or less everyone agree on is to avoid taking substantial doses of LSD and MDMA (e.g. 200micrograms LSD + 120mg MDMA) at the same time. Apparently this is simply just too overwhelming and synergistic to be enjoyable, often causing a lot of nausea and palpitations.

The third school, however, is to take only a small dose of both at the same time. Say, 35micrograms LSD and 35mg MDMA. This apparently is an extremely positive combination. The experience is not mild due to the synergy, and it seems to provide an open, creative, level-headed mindset for many hours without much of a comedown or hangover. As with everything here, your mileage may vary.

Psychedelics + Dissociatives: Psychedelics and dissociatives have profound non-linear mixing effects. According to multiple sources, the right combination of LSD, Ketamine, and THC can give rise to a “free-wheeling hallucination“. This is a state of consciousness in which you gain a great degree of conscious control over the contents of the hallucinated world, so that you can project your will by saying “let there be a chair in front of me” and you will see it manifest in exquisite detail. You can rotate, translate, invert, fibrate, and project the chair in any way you want, as if you were now able to use your brain as a very general game engine of consciousness. That said, even when this doesn’t happen, the combination of psychedelics and dissociatives is ridiculously synergistic. People report getting stuck in extremely energetic time-loops akin to those caused by psychedelics and cannabis, but more powerful (cf. trip report of DMT + nitrous oxide). Steven Lehar calls the effect where the presence of a psychedelic changes the quality of a dissociative as “dissociative coloring”. I’ve been amazed at the fact that there is no mistaking when someone has previously experienced LSD and nitrous together. You don’t get reactions like “it didn’t do much for me”. This combo usually has a special place in the memory of a person who has experienced it. Eyes brighten, curiosity sparks. I’ve been asked on multiple occasions “what do you think is going on with the strange synergy between LSD and nitrous?” Now, 5-MeO-DMT and DMT are very different, and the LSD + nitrous state seems to have some resemblance with the 5-MeO-DMT state. They share that strange feeling of becoming a kind of saturated resonance box. The feeling is one of becoming a vessel full of coordinated and coherent vibrations that unearth and dissolve internal boundaries and blockages. The process inherently blocks your ability to conceptualize in a dualistic way. The cognitive content of the state is better captured by a huge blinking sign that reads “THIS, THIS, THIS” on repeat rather than the more usual “that thing over there connected to this over here, modulated by what happens there” kind of cognitive state we are more familiar with. DMT on its own is very different than this, in that the mental formations and patterns of binding that emerge are extremely specific, detailed, and irreducibly complex. Not so on the upper ranges of the dissociative and psychedelic cocktail, where the resonance is profound and the asymmetries needed to store complex information are constantly smoothed out by the ongoing full-body bath of reverb. (cf. Neural Annealing).

Dissociatives + Empathogens: According to several trip reports and credible personal communications, taking ketamine while on MDMA can bring back “the magic” that one only ever experienced with MDMA the first few times using it. Also MDMA and nitrous have profound research-worthy synergy.

Potentiation: Shulgin reported that substances that don’t feel psychedelically active on their own may nonetheless potentiate the effects of other psychedelics. For instance:

(with 160 mg of MDPR followed at 2h by 100μg LSD) This proved to be almost too intoxicating, and a problem arose that had to have a solution. The entire research group was here, and all were following this same regimen. Two hours into the second half of the experiment a telephone call came that reminded me of a promise I had made to perform in a social afternoon with the viola in a string quartet. Why did I answer the phone? My entire experience was, over the course of about 20 minutes, pushed down to a fragile threshold, and I drove about 10 minutes to attend a swank afternoon event and played an early Beethoven and a middle Mozart with an untouched glass of expensive Merlot in front of me. I could always blame the booze. I declined the magnificent food spread, split, and returned to my own party. Safely home, and given 20 more minutes, I was back into a rolling +++ and I now know that the mind has a remarkable ability to control the particular place the psyche is in. 

(Entry on MDPR, from PIHKAL)

More common than the above, ayahuasca is intrinsically a drug combo primarily of the potentiation kind. As mentioned before, cannabis not only alters but also potentiates the effects of psychedelics. It is worth mentioning there is a community of people who believe that noopept (a cholinergic nootropic, see below) can potentiate MDMA. While there is some evidence that MDMA is itself mildly cholinergic– and thus provides a sense of mental clarity in addition to the loved-up feeling- too much cholinergic action tends to make people feel rigid, robotic, and hyper-cerebral. I am therefore personally skeptical of the benefits of combining something like noopept with MDMA, as the potentiation of some of its qualities may come at the cost of reduced emotional sensitivity. Why trade a feeling of renewed innocence and receptivity with calculating prowess? I doubt this is the best use of a roll.

Anti-tolerance Drugs: This is a category of combinations with tremendous potential to relieve suffering, to the extent that I think of it as a humanitarian tragedy that there are no concerted research efforts currently in this direction. Sufferers of chronic pain and treatment-resistance depression could make use of drugs that help them keep the tolerance to the drugs they depend upon for having a livable life under control. I know this has a lot of the ring of turtles all the way down (“when are you going to get the anti-tolerance drugs for anti-tolerance drugs? And then the anti-tolerance for anti-tolerance for…”) but I am sincere when I say that looking here may pay off in spades. Already we see ibogaine doing other-worldly magnificent things to cure addiction and reverse tolerance. Who knows what a large targeted research program with this focus may discover. Some examples of anti-tolerance drugs include proglumide, ibogaine, and black seed oil for opioids, and flumazenil for benzodiazepines.

Prevent Physical Side Effects: Epidemiological data suggests that chronic or heavy use of 5HT2B agonists may lead to heart valve disease (cf. Fen-Phen), which does not bode well for the long-term (as opposed to acute) safety of many psychedelic compounds. Now, neuroscientist Thomas Ray believes that 5HT2B may be necessary for some of the characteristic psychedelic action of entheogens, so blocking it altogether may come at the cost of eliminating the reason why the drug is interesting. That said, we do know that 5-MeO-DMT is profoundly psychedelic and yet has negligible 5HT2B activity. It would be very useful to know what happens when one combines psychedelics with heavy 5HT2B affinity, like 2C-B and DOB, with 5HT2B antagonists (usually prescription medicines). Would blocking 5HT2B agonism avoid cardiotoxicity? And what would the drug feel like then? Another interesting lead is the affinity of compounds like 2C-E and 2C-T-2 to the 5HT3 receptor, which is predominantly in the gut and modulates feelings like nausea. Additionally, since 5HT3 antagonists are antiemetic it really stands to reason that taking one before e.g. tripping on shrooms may give you a much less, ahem, visceral experience. Finally, I would like to explore the implications of the fact that of all of the compounds in Ray’s study the only one with significant affinity for calcium channels is MDMA. Would this be related to its neurotoxicity? And would taking a calcium channel blocker prevent it? It might still be wise regardless simply as a way to lessen the cardiac load of the compound.

Nootropic Stacks (cf. the Qualia Pill):  Many people who explore nootropics make “stacks”. That is, rather than taking only piracetam, they might take a combination of piracetam, aniracetam, pramiracetam, coluracetam, and l-tyrosine. I suspect that this is popular because most nootropics are pretty mild and often hard to notice, and people want to be able to feel the effects. I generally do not think this is sensible, though, as we don’t understand these substances well enough. More so, branded “nootropic stacks” can have upwards of 30 different psychoactive substances crammed together in half a dozen pills you are supposed to take daily. While I do think there are likely gems to be found in the vast combinatorial space of cognition-boosting chemicals, I simply do not see any way in which the current major brands of nootropic stacks could have done the type of research needed to find them. I therefore do not personally recommend you go out and try such combos, at least not until we know a lot more about how to do combinations properly. If you want to try nootropic stacks, I’d recommend you start with small doses of two or three well-researched nootropics at most and do your own research thoroughly before settling on a particular combination.


LSD + DMT Visual Replication

Psychedelics and Psychedelics: A classic psychedelic combo that I’ve heard a lot about is LSD + DMT. The state that emerges from this combination is apparently unique, though if you take enough DMT the LSD fades into the background. Apparently psychedelics tend to have a characteristic spectral effect on your brain’s harmonics (see: Connectome-Specific Harmonic Waves on LSD), which manifests in the form of experiencing “vibes of different frequencies” specific to the drug you are taking. The case of LSD and DMT is very interesting, since their characteristic frequencies are sufficiently far apart (to put a number on it, LSD may be in the vicinity of 18Hz while DMT may be close to 30Hz) that they can be separated easily. You thus get a spectral effect of two peaks interfering with one another, oftentimes creating a powerful 3D grid of Moiré patterns, like a super-charged version of the “regular” DMT Chrysanthemum. As a method for spectral analysis, studying the beat patterns of psychedelic drug combos could go a long way in formulating a systematic characterization of their phenomenology. Speculatively, this may even allow us to come up with specific psychedelic drug cocktails that produce maximally consonant harmonious effects.

Idiosyncratic Responses

A final thought to add to this section concerns the fact that people respond differently to drugs. One can reason that if drug A affects 20% of people in a different way while drug B affects 10% of people in a different way, that A + B would lead to 4 different kinds of responses. More so, the more drugs you pile on top of each other, the more specific and individualized the response would be. I think that this is likely true in the general case, but I would argue that it is not universally true. A useful analogy here is with the way people respond to the scent of different molecules: you may lack the gene that encodes the receptor for a particular molecule, but perfumes usually have 30 or more scent-contributing molecules, so the experience of a perfume may be more similar between people than their experience of individual molecules. At the extreme, we have the phenomenon of “white noise scent” where once you mix 40+ molecules in equal (intensity-adjusted) proportions that span scent-space, it all starts smelling the same. The notion of “scent entropy” can be imported to drugs as well: I would expect a kind of inverted U-curve for “how idiosyncratic” the responses to drug combinations are as a function of the total entropy of the combo.

Drug Cocktails From First Principles

The way we aim to understand psychoactive substances at the Qualia Research Institute is in terms of the way they modify the neuroacoustic profile of the brain. And while this is what I see as the most promising approach moving forward, I believe that there is nonetheless a lot of low-hanging fruit at the receptor level of analysis.

The first time I’d thought of trying to emulate the effects of a drug using a cocktail of other drugs came up years ago when I found out that MDMA is likely neurotoxic. At the time I thought perhaps it was just a matter of getting the right dopaminergic, serotonergic, and oxytocinergic activity going for you to replicate the MDMA high. It’s a good thought, and some people have taken it to heart, such as the creators of “Poly”, an MDMA-like cocktail (cf. Kisspeptine). But as we’ll see, MDMA is more complex than that, and we may need to consider far more variables to make a “credible MDMA substitute”.

Looking beyond drug combos of only two or three drugs, and with a nod to concepts from the field of high-entropy alloys (HEAs), we could start thinking about the secret gems to be found in the vast combinatorial space of “high-entropy drug combos”. But what kind of principles could we use to safely combine 5+ drugs? The full story will probably be much, much more complicated than the following approach, but it is still nonetheless worth exploring as a first pass. Namely, to break down each drug in terms of their receptor affinity profile and then use those affinities additively to create arbitrary “synthetic” receptor affinity profiles. There are many reasons why this might not work: receptor affinity may not work linearly or have a clear rule-based behavior. For instance, it is still unclear if a single drug that has affinity for key serotonin receptors (say 5HT2A, 5HT2B, and 5HT7) in addition to working as an NMDR antagonist would produce the same feeling of “synergistic action” as there is between psychedelics and dissociatives. More so, there could be additional intra-cellular signaling specific to each molecule, so that two molecules that work as agonists with the exact same 5HT2B affinity may have different downstream effects inside the neuron, and then those intracellular effects might have phenomenological properties of their own. But leaving all of those caveats and unknowns aside for a moment, what would it look like to create drug cocktails with this method?


True for both people and drugs!

After giving it some thought I realized that the problem can be reduced to a non-negative least squares (NNLS) optimization (non-negative because, as they say: “you can always take more drugs, but you cannot take less drugs”). It turns out there are already open source implementations of algorithms that solve this optimization problem (for both R and Python)*. So I downloaded the data from the famous Thomas Ray study of psychedelic receptor affinity and played with the data and the non-negative least squares method in a Jupyter notebook for a bit. The first thing I tried was to create a compound like 2C-B but better. Under dubious- but not entirely random- assumptions, I set the desired receptor affinity to be that of 2C-B but with the following modifications: to have the 5HT2B affinity be as low as possible in order to minimize cardiotoxicity concerns, and borrow from MDMA’s unique profile the hypothesis that the Imidazoline receptor is related to heart-opening effects. Additionally, I modified the receptor profile so that the drug would give you more focus than 2C-B by having a higher affinity for the dopamine receptors. To top it off, I racked up the desired receptor affinity for 5HT7, as it has been implicated in providing the more utterly mind-blowing power of psychedelics. I entered these modifications into the NNLS optimizer and the output I got was**:

0.48*2C-B + 0.337*5-MeO-DMT + 0.116*MDMA + 0.043*cis-2a + 0.016*6-F-DMT + 0.005*Mescaline

I see, so since 2C-B is still the backbone of the desired affinity pattern, it appears in high proportion in the mixture as a kind of “base” on top of which the modifications are made. It makes sense that 5-MeO-DMT would come next as it is pretty selective for 5HT7 (remember, the most literally mind-blowing chemical), and MDMA would follow due to the desire for Imidazoline affinity. That by the way, is also probably partly why the formula contains a pinch of Mescaline, to round up that Imidazoline for good measure. I then decided to relax the 5HT7 requirement and instead increase the 5HT6 and 5HT5A, and got the following formula:

0.038*Lisuride + 0.273*2C-B + 0.056*DMT +0.079*Mescaline + 0.15*MDMA + 0.377*RR-2b + 0.018*Ibogaine

And this now looks pretty different. After playing like this for a while, it occurred to me to use this technique to basically try to reconstruct a drug using a non-negative linear combination of the remaining drugs available. Imagine for example that you are stuck in quarantine at your house and you don’t have any 2C-B to kill time (I know! Very relatable isn’t it?), but you do somehow happen to have an assortment of hundreds of other unscheduled random research chemicals. Could you combine them in such a way that you approximate the effects of 2C-B? Well, let’s see.

Here are the “drug reconstructions” the method derives (again, please, don’t try this at home):

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I am pleasantly surprised to see the formulas actually do seem pretty intuitive to me. Take for example the DIPT reconstruction. The top two ingredients are 5-MeO-DIPT and DPT, which are the two closest structural analogues of DIPT in the dataset. Or take the one for DOB: this is the amphetamine version of 2C-B, so it makes sense that both an amphetamine psychedelic (Aleph-2) and 2C-B would make up the top two ingredients. Or consider 5-MeO-DMT, with its most prominent ingredient being 5-MeO-TMT, which is one carbon atom away in terms of structure. Or see how Mescaline’s heart-opening effects are well represented by its reconstruction with MDMA and MDA, while TMA contributes the receptor affinity characteristic of the trimethoxy class of functional groups, along with another Mescaline-like phenethylamine, 4C-T-2. Alas, here is where an imperfect understanding of drug interactions could come and bite us in the ass: if 4C-T-2 is anything like 2C-T-2, it might have some MAOI action, which could be potentially very dangerous to combine with compounds like MDMA. Needless to say, before you go out and try these crazy drug cocktails, we first need a thorough understanding of each drug well beyond just its affinity to “only” 30 or so receptors.

Now, not every reconstruction makes sense to me, and really only a few substances have what I would call a descent mean squared error. See the receptor affinity tables below for examples of both successful and unsuccessful reconstructions (only non-zero entries shown):

DOB and 2C-T-2 have some of the lowest errors in the sample, meaning that their reconstructions are pretty good, while Ibogaine and MDMA have two of the worst error rates, and their reconstructions are still obviously pretty far from the goal. Naturally, if we were ever to test this method in the lab (with e.g. a drug discrimination paradigm) we would probably start with the most accurate reconstructions first. For instance, train rats to distinguish between 2C-B and DOB, and see if administering the (2C-B-containing) “DOB reconstruction” makes the rats think they got DOB rather than 2C-B.

Master Druggist (Synapse? Dendrite?)

I would like to conclude this essay with an interesting speculation: what if we developed drug combos like we develop perfumes? It is my appreciation that it takes a very high level of intelligence, domain expertise, and psychological robustness to be able to contribute usefully to the field of psychonautics. Sasha Shulgin spent over 30 years taking hundreds of completely new drugs, and I would very much trust his judgement about what makes a great psychedelic drug combo than I would trust a random BlueLight or Erowid user. (As an aside: Shulgin was extremely cautious in his approach, but he certainly wasn’t doing some of the low-hanging fruit on safety, such as wearing a heart monitor or measuring his blood pressure when taking a new drug, for starters. Future systematic psychonautic work should also record as much biometric data as is feasible). You wouldn’t put on a perfume made by someone who has only ever worn Axe, would you? Training a “Nose” takes up to 7 years, and it involves becoming deeply familiar with the scent of a long list of molecules, accords, and perfumes. Likewise, I’d expect that in order to be qualified to find extremely good drug combinations, one would first need to become familiar with the effect of many different individual drugs, “natural drug accords” (e.g. peyote), and designed drug cocktails. Only once you have an intuitive sense of how e.g. the sigma receptor interacts with the 5HT1A receptor would I trust your judgement about adding a pinch of agmatine to your already convoluted mixture of 20 psychoactive substances. A Super-Shulgin Academy could train people to be professional drug cocktail makers (if perfumers are called “Noses” would we call Super-Shulgin certified cocktail makers “Dendrites”?). As discussed above, this assumes that we can do this safely, which I suspect will be possible once we map out the space of dangerous combinations and receptors we shouldn’t mess with to avoid side effects like cardiotoxicity (e.g. 5HT2B, 5HT3A, calcium channels, etc.).

You come to the master cocktail designer with a general concept for a new recreational drug, and they would come up with activity profiles that best evoke those feelings. The Dendrite would select from hundreds or thousands*** of pure chemicals and accords to create your unique cocktail. As is the case with Noses in the perfume industry, a Dendrite would tend to have a set of about one to two hundred “frequently used” compounds, and a dozen or so “signature” ones they’re deeply familiar with and that usually reveal who the Druggist is, if found in large proportions in the end product. Of course there would be “house favorites” (e.g. the classic “ambroxan bomb” of Dior fragrances for men) and chemical fads (e.g. the wide adoption of Iso E Super in 90s perfumes). Every year would come with a new season of amazing, safe, and uniquely interesting recreational drug cocktails.

In perfumery you find both natural and synthetic “accords”: “Violet reconstructions” attempt to emulate the smell of violet but in a much more long-lasting, storable, and versatile way. Good Dendrites would not only use “natural accords” such as “peyote” or “marijuana plant” but would also make their own, aided with computer models and datasets of trip reports along with their own first person experiences. In both perfumery and professional drug cocktail making we would study accords packed with combos of qualia-triggering chemicals, and a Dendrite could be known not only for making good final products, but for making excellent accords with predictable and desirable effects.

To finalize the analogy (and this article) we could also discuss the way in which perfumes feel “broad spectrum” thanks to being constructed by combining “top, heart, and base notes”. Roughly speaking, top notes tend to “feel higher frequency” (such as citric scents) while base notes tend to “feel low frequency” (such as woody scents), not unlike how a symphony will tend to combine sounds across the spectrum. The most interesting, voluptuous, and commercially viable combos would also probably have a broad spectrum of activity. They would be anxiolytic, exciting, relaxing, trippy, and empathogenic to various degrees all at once. They would combine fast, slow, and spiritual euphoria in a single power punch of qualia cornucopia. As such, each drug cocktail made this way would entail an entire worldview – a whole realm currently hidden in the vast state-space of consciousness.

* For an intuition: recall from linear algebra that a basis of n linearly independent vectors span an n-dimensional vector space. When the vector that you are trying to reconstruct is not in the span of your basis, the best you can do is to project your vector to the nearest hyperplane of the spanning space. Adding the constraint that you can only make non-negative linear combinations with your basis vectors, you find that the span will look like an ‘inverted pyramid’, and the least-squares solution will be the point of that inverted pyramid that is closest to your desired vector. This is why most of the reconstructions only use a subset of the available drugs in the dataset. In most cases, the desired vector (i.e. affinity profile in this case) will be outside of the inverted pyramid of the non-negative span, and the closest hyperplane will be a linear combination of only a subset of the building blocks- those which span that particular hyperplane. I.e. the solution is the projection to the nearest hyperplane segment covering the non-negative span. This is what the NNLS method is doing under the hood.

** Note: It’s important to point out that these are not dosages. The coefficients provided by the non-negative least squares method apply to the normalized affinity “npKi“, which is the receptor affinity normalized by the highest affinity among the receptors. The coefficients will be correlated with “proportion of a standard active dose” but there will be an error caused by the pretty tricky confounder that molecules vary in their “breadth of affinity”. Additionally: the psychoactivity of each receptor is not the same, we are not considering saturation effects, the difference between partial and full agonists is not taken into account, downstream effects are ignored, etc. etc. Needless to say, there is still quite some work to be done to transform these coefficients into meaningful dosages.

*** List of Psychoactive Drugs a professional Dendrite would be expected to be familiar with:

L-Tyrosine, L-DOPA, Apomorphine, Flumazenil, CPZ, BPAP, PPAP, Cabergoline, DAR-0100, Lisuride, Pergolide, Pramipexole, Rotigotine, Biopterin, PLP, Aminepetine, PCP, Marijuana, Dextromethorphan, Isoflavones, Citicoline, Metadoxine, Arecoline, Niacinamide, Paraxanthine, a-GPC, Acetylcarnitine, AR-R17779, GTS-21, Ispronidine, PHA-543,613, SSR-180,711, WAY-317,538, Hopantenic Acid, IDRA-21, Propentofylline, PRL-8-53, Trytophan, Picamilon, Betahistine, A-349,821, Cipoxifan, Creatine, Mildronate, Pregnenolone, Nisoxetine, Orexin, CP-39,332, Esreboxetine, Daledalin, AM-1248, Phenoxybenzamine, Symbescaline, Phentolamine, Isomescaline, Tolazoline, a-Methylfentanyl, Ketamine, Dichlorpane, 3-meo-pcp, Hex-en, Paraflourofentanyl, 3-Methylfentanyl, Metofoline, Buscaline, O-DT, Nortilidine, Thiobuscaline, Dizocilpine, Rolicyclidine, Phenescaline, Tenocyclidine, Methoxyketamine, pFPP, 5-me-MDA, 4-MAR, 1,4-Butanediol, 2-Methyl-2-Butynol, GHV, GVL, Mebroqualone, Benzylbutylbarbituates, Phenmetrazine, 3-Fluorophenmetrazine, Crack, Cocaine, Coca, Kava, Phenylacetylindoles, Benzoylindoles, Napthoylindoles, Adamantoyindoles, Pineapple Sage, Kokum, Brahmi, Artic Weed, Skullcap, Salvia Splendens, Coriander, Rhodiola Rosea, Velvet Bean, Bitter Orange, St. John’s Worth, Grape Seed Extract, Tulsi, Blessed Thistle, 3-Desoxy-MDA, Skatole, Isoindole, Indole, Benztropine, Diphenhydramine, Niaprazin, Doxylamine, Alaproclate, Zopiclone, Ifoxetine, Methylmethaqualone, Panuramine, Meta-Tyramine, Para-Tyramine, 2M2B, Pirandamine, SB-649,915, Epinephrine, Mepyramine, Octopamin, Delucemine, Oxidopamine, β-Methylphenethylamine, Mesembrine, Psuedoephedrine, Etolorex, Cathine, Cathinone, Ethcathinone, Norfenfluramine, Fenfluramine, Phentermine, Metaescaline, n-Ethylbuphedrone, Naphyrone, Pyrovalerone, Isopropylamphertamine, Clobenzorex, Pholedrine, Chlorphentermine, Xylopropamine, DON, DOPR, TMA, Methyl-BOB, Tetramethoxyamphetamine, 4-MTA, Bromatane, Hydroxyzine, BNC-210, CL-218,872, L-838,417, SL-651,498, S32212, 6-CAT, TAP, ETAI, IMP, Lorxaserin, Cisapride, Tegaserod, AS-19, E-55888, LP-12, LP-44, LP-211, Etoperidone, Lorpiprazole, Lubazodone, Mepiperazole, 5-TASB, TB, 3-TE, 4-TE, 2-TIM, 3-TIM, 4-TIM, 3-TM, 4-TM, TMA, TMA-2, TMA-3, TMA-4, TMA-5, TMA-6, 3-TME, 4-TME, 5-TME, 2T-MMDA-3a, 4T-MMDA-2, TMPEA, 2-TOET, 5-TOET, 2-TOM, 5-TOM, TOMSO, TP, TRIS, 3-TSB, 4-TSB, 3-T-TRIS, 4-T-TRIS, 44-BMAR, 3-MOMC, Prolintane, SDB-001, AB-FUBINACA, Dichloromethylphenidate, AB-PINACA, MN-24, 5F-MN25, A-836,339, ADBICA, 5F-NNEI, RCS-4, RCS-8, MPHP, 6-APDB, 4-HMP, EDMA, a-PBP, Methylhexamine, a-PPP, 4-FMD, EIDA, Phenylphrine, UWA-101, MPBP, RH-34, F-2, F-22, MR-2096, Adrenochrome, AET, Carbogen, DOB, DOM, Desmorphine, Ethylcathinone, Ehylene, GHV, Hypocretin, mCPP, MDPR, Methaqualone, TFMPP, CPP, MeoPP, A2, Salvinorin A, Scoplamine, TMA-2, BDO, 2c-B-FLY, 4-Flouromethcathinone, 4-HO-MPT, U4EA, 4-MTA, Phenylpiracetam, Aniracetam, Coluracetam, Pramiracetam, Melatonin, NRG-3, Theobromine, A834-735, Oxytocin, NZT-48, Heroine, 3-HO-PCP, MAOIs, 4-MeO-PCP, 3c-P, 5-IAI, Atropine, 5-IT, Bufotenin, 5-MAPB, 4-Aco-MiPT, 6-MAPB, ALD-52, AMMI, MET, D2PM, DET, CBD, CBN, LY-2183240, SF-SDB-005, AM-404, EG-018, DXM, FDU-PB22, AL-LAD, 3-MeOMC, 2-MeO-Diphenidine, 4-MPD, bk-MDMA, 4-MeO-a-PVP, GHB, 4-MeO-PBP, MBDB, 4-MeO-PV9, Fentanyl, 4F-PV8, a-PBT, BDB, a-PVT, 2-FMA, Dibutylone, 5-Meo-DiPT, Diclofensine, Methcathinone, DL-4662, MDEA, MDPPP, Methylone, Butylone, NEB, Phenibut, PV-8, GABA, 25B-NBF, Etaqualone, 5-API, Ethylone, Pentadrone, 4F-PVP, 25C-NBF, BZ-6378, C30-NBOMe, RH-34, MDAT, MDMA, MDMAI, Dimethocaine, Synthacaine, 3β-FBT, 5-MeO-BFE, 3,4-DMMC, AM-1248, MTTA, AM-2233, URB-597, AM-694, AM-087, BAY-38-7271, AB-005, A-796260, URB-754, 2-DPMP, a-PVP, 25N-NBOMe, 5-MeO-NiPT, Dexmethylphenidate, Buphedrone, RTI-111, Pentylone, 25I-NBF, Flourotropacocaine, Flourococaine, Cocaethylene, 25D-NBOMe, 25E-NBOMe, DMT, 5-Meo-DMT, 2C-I, 2C-E, 25I-NBOMe, 25I-NBOH, 25C-NBOMe, MXE, MDA, MDE, Mescaline, Ibogaine, Bromo-DragonFLY, Salvinorum, RU-28306, 2NE1, Psilocybin, HOT-7, JWH-018, JWH-250, 5-Meo-EiPT, AM-2201, 5-APDI, BZP, BZ, 4-MEC, MDPV, Bakers Ammonia, THC, THCv, Chloral, Chlorabutynol, MT-45, 5-Methyl-Ethylone, Methylphenidate, Ethylphenidate, 6-APB, 5-APB, Muscimol, 5-MeO-MALT, AKB48, 3,4-CTMP, PB-22, Diphenidine, UR-144, Flubromazepam, HU-210, MPA, XLR-11, MN-18, Naltrexone, STS-135, Gabapentin, 5-MAPB, Nitrous, Etizolam, Mephedrone, Pyrazolam, Methedrone, AH-7921, Phenazepam, AMT, OxyNEO, DPT, 5-MeO-AET, 4-Aco-DMT, EAM-2201, 5-MeO-DALT, 5-MeO-AMT, Acefentanyl, Ehylphenidate, 4-HO-MiPT, THJ-2201, 5-APDB, 5-EAPB, 4-HO-DPT, DOC, bk-2c-B, Escaline, THJ-018, 4-HO-MET, 2-AI, 2-MeO-Ketamine, Methoxphenidine, Ketamine, 2c-EF, Methamphetamine, Dextroamphetamine, Nitracaine, DALT, IAP, 4-fa, 2-Me-DMT, 4-fcocaine, Isopropyl Nitrate, 5-MeO-TMT, Piracetam, Amatadine, Choline, Memantine, 5-HTP, Camfetamine, Methallyescaline, LSZ, LSA, NBOMe-Mescaline, Loperamide, LSB, 25P-NBOMe, 25G-NBOMe, 3-MeO-PCE, MAM-2201, PCP, MPTP, MDAI, DOI, BB-22, EA-3167, BDF, L-Theanine, Dimethylone, Hydrocodone, Codeine, Morphine, Dilaudid, Oxycontin, Alpralozam, Diazepam, Fentanyl, Soma, Suboxone, Marinol, Seroquell, Trazodone, Lithium Bicarbonate, Abilify, Methadone, Amitriptyline, Strattera, Chloral Hydrate, Bromazepam, Buperonorphrine, Bupropion, Chlordiazepoxide, Clonidine,Clonazepam, Cyclobenzaprine, Dramamine, Benadryl, Ethchlorvynol, Fluoxetine, Tianeptine, Amineptine, Flurazepam, Metaxalone, Mirtazapine, Nalaxone, Nimetazepam, Oxymorphone, Paroxetine, Zopidone, Pregabalin, Promethazine, Risperadone, Selegiline, Sertraline, Sumatripan, Tiagabine, Propofol, Propanolol, Tiletamine, Zolpidem, Lotus, Aloe, Datura, Calendula, Chacruna, Galangal, Chaliponga, Chamomile, Damiana, Fever Few, Nightshade, Ginseng, Foxglove, Lavender, Henbane, Mugwort, Hemlock, Monkshood, Dream Herb, Capsaicin, Amanita, Hawaiian Baby Woodrose, Ergot, Hops, Imphepho, Indian Warrior, Kanna, Dagga, Kratom, Mandrake, Valerian, Nicotiana Tobacum, Nicotiana Rustica, Mimosa Hostilis, Morning Glory, Nutmeg, Opium Lettuce, Poppy, Sinicuichi, Syrian Rue, Tree Tobacco, Wormwood, Yohimbe, Yopo, Khat, Peyote, Cannabis, Catnip, Phalaris, San Pedro, Soma (ancient), Chacruna, Acacia, Ephedra, Mulungu, Mullet Fish, Siganus Spinus, Fugu, Sting-ray Venom, Bufo Alvarius, Epipedobates Tricolor, Waxy Monkey Frog, Salamandra Salamandra, Cobra & Scorpion Venom, Reindeer Urine, Glomeris Marginata, Sergeant Major, Grouper, Bluefish, Brass Beam, Flathead Mullet, Golden Goatfish, Rabbit Fish, Goat Fish, Adrafinil, DHEA, Dilantin, DMAE, Fipexide, Gerovital, Ginko, Black seed oil, HGH, Hydeigine, Meclofenoxate, Modafinil, Oxiracetam, Phenyton, Vasopressin, Vinopocetine, Bee Venom, Monkey Frog, UCM-707, AM-1172, VDM-11, VDM-13, OMDM1, OMDM2, LY-2318912, O-2093, OL-135, URB-597, URB-532, AEM, AL, ALEPH, ALEPH-2, ALEPH-4, ALEPH-6, ALEPH-7, ARIANDE, ASB, B, BEATRICE, BIS-TOM, BOB, BOH, BOHD, BOM, 4-Br-3,5-DMA, 3-Br-4,5-MDA, 2C-B, 3C-BZ, 2C-C, 2C-D, 3C-E, 2C-F, 2C-G, 2C-G-3, 2C-G-4, 2C-G-5, 2C-G-N, 2C-H, 2C-N, 2C-O-4, 2C-P, CPM, 2C-SE, 2C-T, 2C-T-4, 2C-T-2, 2C-T-7, Ψ-2C-T-4, 2C-T-8, 2C-T-9, 2C-T-13, 2C-T-15, 2C-T-17, 2C-T-21, 4-D, β-D, DESOXY, 2,4-DMA, 2,5-DMA, 3,4-DMA, DMCPA, DMMDA, DMMDA-2, DMPEA, DOAM, DOBU, DOEF, DOET, Ψ-DOM, DON, DOPR, E, EEE, EEM, EME, EMM, ETHYL-J, ETHYL-K, FLEA, G-3, G-4, G-5, GANESHA, G-N, HOT-2, HOT-17, IDNNA, IM, IP, IRIS, J, LOPHOPHINE, M, 4-MA, MADAM-6, MAL, MDAL, MDBU, MDBZ, MDCPM, MDDM, MDHOET, MDIP, MDMC, MDMEO, MDMEOET, MDMP, MDOH, MDPEA, MDPH, MDPL, MDPR, ME, MEDA, MEE, MEM, MEPEA, META-DOB, META-DOT, METHYL-DMA, METHYL-DOB, METHYL-J, METHYL-K, METHYL-MA, METHYL-MMDA-2, MMDA, MMDA-2, MMDA-3a, MMDA-3b, MP, MME, MPM, ORTHO-DOT, P, PE, PEA, PROPYNYL, SB, TA, 3-TASB, 4-TASB, Tropane, Vomeronasal Organ, Tropine, Hyosyamin, Dihydrokavain, Hyoscine, Myrcene, Ecgonine, 7-OH-DPAT, Benzoylecgonine, Sunifiram, Hydroxytropacocaine, Estrogen, Methylegonine Cinnamate, Estradiol, Catuabines, Estratetraenol, Phenyltropane, Androstenone, Civetone, Adrostenol, 5F-PB-22, Androstadienone, CBG, THCa, CBC, CBDa, Anandamide, 2-AG, CBL, CBDv, CBCv, CBGv, CBGm, Ibogaine, Noribogaine, Tabernanthine, Coronaridine, Ibogamine, Vaocangine, 18-MC, 5-MeO-Alkyltryptamine, β-Carboline, Tryptoline, Pinoline, Harmane, Harmaline, Harmine, Harmalol, Harmalan, Harmanamide, Acetylnorhormine, Bufotenin Oxide, DMT-N-Oxide, 5-MeO-Tryptamine, 5-OH-DMT, 5-MeO-DMT-Oxide, 3,4-Dimethoxyphenylamine, 6-MeO-Harman, Anethole, Safrole, Estragole, Monolignol, Pukateine, Glaucine, THP, Nantenine, Thujone, Lagochilin, Nicotine, Carbachol, Methacholine, ME-18-MC, 18-MAC, Tryptamine, β-Methyl-Phenethylamine, NMT, Voacanga Africana, Vachellia Farnesiana, Duboisia Hopwood, Acacia Victoriae, Anadenanthera Penegrina, Phalaris Aquatica, Echinopsis Lageniformus, Cylindropuntia Echinocarpa, Leptactina Densiflora, Fennel, Justica Pectoralis, Lactucarium, Glacium Flavum, Zornia Latifolia, Argemone Mexicana, Silene Undulata, Catharanthus Roseus, Desfontainia, Heimia Salicifolia, Lophophora, Sea Urchin Eggs, Bethanechol, Muscarine, Pilocarpine, Oxotremorine, Aporphine, Leonurine, Bungacotoxin, Tetrodotoxin, Taurine, Opiod Peptide, Streamlined Spinefoot, Blue-Spotted Spinefoot, Dusky Spinefoot, Marbled Spinefoot, Little Spinefoot, Salema, Phyllomedusa, Blue Sea Chub, Brow Chub, Conuict Surgeonfish, Yellowstipe Goatfish, Finstripe Goatfish, Acute Jawed Mullet, Coral Grouper, Platypus Venom, Slow Ioris Venom, Pygmy Slow Ioris Venom, Giant Leaf Frog, Gluten Exorphin, Soymorphin-5, Dermophin, 7-PET, Dimethyliambutene, Proopiomelanocortin, β-Endorphine, Dynorphin, Adrenorphin, Salvinorin B Methoxymethyl ether, Amindophin, Enkephalins, Salvinorin B ethoxymethyl ether, Opiorphin, Herkinorin, RB-101, DPI-221, Spinorphin, Kelatorphan, Delta-Pheylalanine, Thiorphan, Tynorphin, Hemorphon-4, Valorphin, Casomorphin, Gliadorphin, Rubiscolin, Deltorphin, MG6, MT-45, Myrophine, Acetorphine, Acetylmorphone, Actiq, Benzethidine, BU-48, BRL-52537, Pethidine, Naloxol, Betacetylmethadol, Methorphan, Bezitramide, RAM-378, Bromadol, Eriadoline, BW373U86, Thebaine, C-8813, Menthol, 8-CAC, Capperidine, Matrine, Chloromorphide, a-Chlorocodide, HZ-2, Codeinone, LPK-26, Codoxime, AD-1211, Conorfone, DADLE, Butorphanol, DAMGO, Semorphone, Dextromoramide, Sutentanil, Diampromide, Zenazocine, Difenoxin, Thebacon, Dihydroetorphine, Tilidene, Dimenoxadol, Xorphanol, Dipipanone, Dipropanoylmorphine, Doxpicomine, DPI-3290, Drotebanol, Endomorphin, Eseroline, Ethoheptacine, 14-Ethoxymetopon, Ethylmorphine, Etorphine, Etoxerdine, Furethidine, Heterocodeine, RAM-320, IBNtxA, IC-26, 1-Iodomorphine, Isomethadone, Ketobemidone, Ketorfanol, Lefetamine, Levorphanol, Loperamide, Meprodine, Metofoline, Metopon, Morpheridine, Morphine-N-Oxide, Morphinone, MR-2096, Nicocodeine, Nicomorphine, Normethadone, Ocefentanyl, Ohmefentanyl, Oxpheneridine, Oxymorphazone, Oxymorphol, Oxymorphone, Pentamorphone, PEPAP, Pericine, Phenadoxone, Phenempromide, Phenazocine, Pheneridrine, Phenomorphan, Picenadol, Piminodine, Piritramide, Proclilidine, Prodine, Proheptazine, Properidine, Prosidol, R-30490, R-4066, Ro4-1539, RWJ-394674, Sameridine, SC-17599, Methyldesorphine, Hydroxypethidine, 4-Fluouropethidine, Cannabis Indica, Cannabis Sativa, Cubensis, Hash, BHO, Delta-9-THC, 25TFM-NBOMe, 2C-B-BZP, 2CBFLY-NBOMe, 2CD-5Et0, 5-I-R91150, A-372,159, 2-Bromo-LSD, a-5IA, PWZ-029, L-655,708, TB-21007, 5-Ethoxy-DMT, 5-Ethyl-DMT, 7,N,N-TMT, VER-3323, YM-348, Alnespirone, 8-OH-DPAT, Aminorex, Batoprazine, 5-BT, BIMU-8, BMY-14802, BRL-54443, BW-723C86, 5-CT, CGS-12066A, Cinitapride, CJ-033,466, CP-135,807, CP-809,101, CP-93,129, CP-94,253, N,a,-DEPEA, Dimemebfe, RA-7, E-6801, E-6837, Eltoprazine, Methylsulfonylmethane, EMD-386,088, EMDT, ST-1936, Fluprazine, Indorenate, Jimscaline, L-694,247, Lasmiditan, APD-356, MMDPEA, LY-293,284, LY-310,762, LSD-pip, LPD-824, LSM-775, 5-MT, MBZP, Methyl-MMDA-2, a-MS, MK-212, Mosapride, Org 12,962, Org 37,684, Quipazine, 6-Nitroquipazine, NBUMP, 1-NP, 5-(Nonyloxy)Tryptamine, PHA-57378, PNU-181731, PNU-22394, Propylhexedrine, Prucalopride, PRX-03140, Psilocin, RDS-127, RH-34, Ro60-0175, Ro60-0213, RS-56812, RS-67,333, RU-24,969, RU-28306, SKF-97,541, SR-57227, Tandospirone, Tegaserod, TFMFly, pTMFPP, U-92,016A, SCA-136, TD-5108, Vortionetine, WAY-161503, WAY-208,466, WAY-629, Xaliproden, YM-31636, Zacopride, A-423,579, A-84,543, Abercarnil, 5-Br-DMT, Sugar, Acetildenafil AMMI 4C-D, AS-8112, Astemizole, Asymbescaline, Azapride, BAY-38-7271, BAY-59-3074, BAY-60-6583, Benproperine, Benzylmorphine, Berberine, 2-Pyrrolidone, JBIR-03(1), 1′-O-Acetylpaxilline, Penijanthine A, Emindole DA (1), Petromindole, Emindole SA (2), JWH-133, Napthylmethylindoles, Napthyolpyrroles, Napthylideneindenes, Cyclohexylphenols, Indole-2-Carboxamides, C3 Amino-Indoles, Cymserine, Hodgkinsine, Physostigmine, Psychotridine, Psychotria Colrata, Yuremamine, Gevotroline, Latrepirdine, BMY-7,378, Boldine, BP-897, Brexpiprazole, 4-Bromo-3,5-Dimethoxyamphetamine, Bromopride, Caroverine, CGS-20625, Cinchocaine, DAA-1097, DAA-1106, DOTFM, DMPEA, DMCM, Dyclonine, Ethylvanilin, Evoxine, Furoquinoline Alkaloids, Gabazine, GBLD-345, Rapacuronium, Mivacurium Chloride, Cisatracurium Besilate, DTC, Cloroqualone, Diproqualone, Mecloqualone, Methylmethaqualone, Eszopiclone, TP-003, TP-13, TPA-023, Y-23684, Pagoclone, Pazinaclone, Suproclone, Suriclone, Zapiclone, CGS-9896, NS-2664, NS-2710, Pipequaline, RWJ-51204, SB-205,384, ELB-139, Acamprosate, GABOB, N4-Chloroacetylcytosine Arabinoside, (+)-CAMP, CACA, AZD-3355, 1,4-Butanediol, XP19986, Rosarin, Rosavarin, Atagabalin, Gabapentin Enacarbit, Hopantenic Acid, Imagabalin, 4-Methylpregabalin, PD-217,014, Afloqualone, Rocuronium Bromide, Vecuronium Bromide, Pipecuronium Bromide, Pancuronium Bromide, Amyl Nitrate, Atracurium Besilate, BWA444, Benzylisoqualone, Papaverine, Protopine, HS-342, HS-347, HS-310, Emylcamate, Eperisone, Febarbamate, Flavoxate, Inaperisone, Acamprosate, Progabide, Tiagabine, Lanperisone, Mephenesin, HS-692, HS-693, HS-704, HS-705, HS-626, Chlorzoxazone, Cisatracurium Besilate, Curare, Cyclobenzapine, Dantrolene, Decamethonium, Difebarbamate, Dihydrochanclonium, Doxacurium Chloride, Gallamine Triethiodide, Gantacurium Chloride, Hexafluronium Bromide, Meprobamate, Metaxalone, Methocarbamol, Norgesic, Orphenadrine, Pancuronium Bromide, Phenprobamate, Pipecuronium Bromide, Premazepam, Promoxolane, Quazepam, Rocuronium Bromide, Silperisone, Sulazepam, Suxamethonium Chloride, Suxethonium Chloride, Tetrabamate, Tizanidine, Tolperisone, Gigantine, BAY-73-6691, Indiplon, Nitrosoprodenafill, Zaleplon, Udenafil, Sulfoaildenafill, Sildenafil, Ocinaplon, Alpidem, Bamaluzole, DS-1, Fadrozole, Fazadinium Bromide, Imidazopyridine, Minodronic Acid, Bisphosphonate, Miroprofen, Necopidem, AL-LAD, DBT, a.O-DMS, 2,a-DMT, a,N-DMT, ETH-LAD, a-ET, 4-HO-DBT, 4-HO-pyr-T, MBT, 4,5-MDO-DIPT, 5,6-MDO-DIPT, 4,5-MDO-DMT, 5,6-MDO-DMT, 5,6-MDO-MIPT, 5,6-MeO-MIPT, 5-MeO-pyr-T, 5-MeO-NMT, 6-MeO-THH, 5-MeS-DMT, PRO-LAD, pyr-T, a,N,O-TMS, Olprinone, Telcagepant, Febrifugine, Halofuginone, MK-0249, LY-156,735, Ramelteon, Tasimelteon, SL-164, Quinazoline, Albaconazole, Altaserin, ATC-0175, Canertinib, Cediranib, Doxazosin, Fluproquazone, Gefitinib, Katanserin, Lapatinib, Agmatine, Amantadine, AP-7, AP5, Aptiganel, CGP-37849, 7-CTKA, DCKA, DXO, MK-801, SL-82.0715, Esketamine, Ethanol, NEFA, Besonprodil, Gacyclidine, Gavestinel, Huperzine A, Ifenprodil, Indantadol, Metaphit, Memantine, LY-235,959, Lubeluzole, Levomethadone, Kynuretic Acid, Midafotel, Neramexane, Nitromemantine, PEAQX, Perzinfotel, 8A-PHDQ, Remacemide, Rhynchophylline, Sabeluzole, Tiletamine, Tramadol, Xenon, Hydroxchloroquine, Antrafenine, Bedaquiline, GSK-299423, JTC-801, JTE-907, LGD-2226, PBT-2, PF-2545920, SB-215,505, SB-277,011-A, SB-742,457, BHF-177, BHFF, BSPP, Cartazolate, CGP-7930, Clomethiazole, Etazolate, Etomidate, Felbamate, Fospropofol, Gaboxadol, Glutethimide, GS-39783, Ibotenic Acid, ICI-190,622, Isoguracine, Isonipecotic Acid, Loreclezole, Methyprylone, Allopregnanolone, 5a-Dihydroprogesterone, Progesterone, THDOC, Alfadolone, Alfaxalone, Ganaxolone, Hydroxydione, Minaxolone, Org-20599, Pregnane, Piperadone, Propanidid, Propofol, Pyrithyldione, ROD-188, Stiripentol, Thiomuscimol, Thymol, Tybamate, QNB (BZ), Scopolamine, Midazolam, Sodium Pentathol, Amobarbital, Blue 88, Adinazolam, Alphenal, Bentazepam, Bromisoval, Camazepam, Carbromal, Centalun, Chloralodol, Chronobiotic, Cinolazepam, Clorazepate, Cloxazolam, Cyclopyrrolones, Delorazepam, Dichloralphenazone, DPH, Doxefazepam, Doxylamine, Embutramide, Eplivaserin, Ethinamate, Ethyl Ioflazepate, Fludiazipam, Heptabarb, Oleamide, Org 21465, Org 25435, Paraldehyde, Phenobarbital, Propiomazine, Promethazine, Propylbarbital, QH-II-66, Glycine, Quetiapine, SH-053-R-CH3-2’F, Sulfonmethane, Tetrabarbital, Tetronal, Trional, Trytophol, Acaprazine, Acebrochal, Acetylglycinamide Chloral, Almorexant, Detomidine, Bromouriede, Benzoctamine, Barakol, Bekhterev’s Mixture, Fasiplon, Fenadiazole, Fluperlapine, JM-1232, Inebriating Mint, Ro41-3696, Methapyrilene, Minitran, Nisobamate, Oxanamide, Oxomemazine, Panadiplon, Pazinaclone, Pentabamate, Petrichloral, Potassium Bromide, Procymate, Saripidem, Vinybital, Vinbarbital, Valofane, Validolum, Valeric Acid, Unisom, U-90042, U-89843A, Triclofos, 2,2,2-Trichloroethanol, TCS-OX2-29, SX-3228, Suvorexant, Sigmodal, SB-649,868, 6-APA, 77-LH-28-1, Adimolol, Alfentanil, Amedanil, Amedalin, BMS-564,929, Binospirone, Carburazepam, Clazolam, Clobazam, Clobenzepam, Clotiazepam, Thienodiazepine, Brotizolam, CP-14145, Cyclazodone, CSP-2503, Cycloserine, Cytisine, Demoxepam, Chlordizepoxide, Dibenzepin, Dihydroergocorine, Dihydroergocristine, DHEC, Dihydroergotamine, 17-DMAG, Dimiracetam, Doliracetam, Droperidol, Dihydrotestosterone, Dutasteride, Edaravone, EGIS-12,233, Elfazepam, Elzasonan, Enilospirone, Ergoloid, Ergotamine, Ergocrytine, Ergocristine, Ergovaline, Etazepine, Evodiamine, Fenmetramide, Fenozolone, Flunitrazepam, Flutazolam, Flutemazepam, Flutoprazepam, Fosazepam, GW-803,430, Halazepam, Haloxazolam, Herbimycin, Horsfiline, HT-0712, Icilin, Clazepam, Indoprofen, Ipsapirone, Isatin, Ketazolam, KF-26777, Lofendazepam, Lopirazepam, Loprazolam, Lorazepam, Lormetazepam, Menitrazepam, Meclonazepam, Menitrazepam, NMSP, Mexazolam, THCI, THCII, THCIII, THCIV, THCV, Mosapramine, Motrazepam, NBQX, Nevirapine, Nimetazepam, Nitrazepam, Nitrazepate, Nitroxazepine, Nordazepam, Nortetrazepam, Oxazepam, Oxatomide, Paliperidone, Prazepam, Pivoxazepam, Pirquinozol, Pirenzepine, Pinazepam, Pemoline, Paraxazone, Palonosterone, Proflazepam, Propizepine, Razobazam, Revospirone, Ripazepam, Ro15-4513, Ro48-6791, Ro48-8684, Ro5-2904, Ro5-4864, Ro64-6198, Ropinirole, RPL-554, RS-102,221, SL65.0155, Spiroxatrine, Temazepam, Tetrazepam, Thozalinone, Tolufazepam, Triflubazam, Vardenafil, Ziprasidone, Zolazepam, Zomebazam, Zometapine, Pyrazolodiazipines, Triazolodiazipines, Estazolam, Flubromazolam, Triazolam, Nitrobenzodiazepines, Pentazocine, 8-HO-PBZI, A-366,833, ABT-202, Sympathomimethies, ABT-239, ABT-418, Almotriptan, BD-1008, LR-132, BD-1031, Singma Agonists, BD-1018, 4-PPBP, Alazocine, BD-1052, Butinoline, Clemizole, CPHPC, Desoxy-D2PM, Citalopram, Ditolyguanidine, Escitalopram, Fluoxetine, Fluvoxamine, Tgmesine, L-697,384, PRE-084, S33005, SA-4503. Siramesine, Venlafaxine, Clonidine, VUT-8430, UR-AK49, Moroxydine, Altinicline, Anabasine, 3-Bromocytine, Bradanicline, Cotinine, Desformylflustrabromine, Dianicline, DMPP, Epibatidine, Epiboxidine, Lobeline, Myosmine, PNU-120,596, PNU-282,987, ABT-089,Rivanicline, RJR-2429, Phantasmidine, Sazetidine A, SIB-1553A, TC-1698, TC-1827, TC-2216, Tebanicline, 2,3,4,5-Tetrahydro-1,5-Methano-1H-3-Benzazepine, UB-165, Varenicline, FE-β-CPPIT, FB-β-CPPIT, RTI-336, NVP-AUY922, Pleconaril, RTI-177, RTI-371, Calea Ternifolia, African Dream Herb, Ambutonium Bromide, Hyoscamine, Ilex Guayusa, Abediterol, Aclidinium Bromide, Benzilycholine Mustard, Bevonium, Bornaprine, Cyanodothiepin, Darifenacin, Dexetimide, Dicycloverine, Etybenzatropine, Fenpiverinium, Fesoterodine, Homatropine, Hydroxyzine, Imidafenacin, Ipratropium Bromide, Methylatropine, Methylhomatropine, Octatropine Methylbromide, PD-0298029, PD-102,807, Pipenzolate, Piperidolate, Tiotropium Bromide, Anisodine, Benacytazine, Butylscopolamine, CAR-226,086, CAR-301,060, CAR-301,196, Caramiphen, Clidinium Bromide, Ditran, EA-3167, EA-3443, EA-3580, EA-3834, JB-318, JB-336, Methylscoplamin Bromide, Oxapium Iodide, Oxitropium Bromide, Polyfothine, Propiverine, Pyrrobutamine, Timepidium Bromide, Tridihexethyl, Tropatepine, WIN-2299, Amrutanjan, Abstral, Acetylmethadol, Acetyldihydrocodeine, Alletorphine, Anilopam, Axomadol, BC Powder, Befiradol, Benorilate, Betamethadol, Bicifadine, Butinazocine, Carbazocine, Celadrin, Chlorodyne, Cinchophen, Co-dydramol, Co-codamal, Cogazocine, Conolidine, Deltorphin I, Dezocine, Dimepheptanol, Dipyrocetyl, TRPV1 Receptor, Capsazepine, Dosulepin, Electroanalgesia, Epideral Steroid Injection, Eptazocine, Equianalgesic, Efazocine, Fedotozine, Filenadol, Fioricet, Fiorinal, Frakefamide, Hemprenorphine, 3-HM, Ibazocine, Levallorphan, Levomepromazine, Lufuradom, Magnesium Salicylate, Blue Prickly Poppy, Menabitan, A-40174, Dimethylhepylpyran, Metamizole, Metkefamide, Moramide, Morphiceptin, Moxazocine, Nafoxadol, Malmexone, Naproxen, Nefopam, Nimesulide, Naracymethadol, Norlevorphanol, Norpipanone, NS-11394, Panadol, Penthox Inhaler, Phenacetin, Phenazone, Phenazopyridine, Propyphenazone, Proxorphan, Resiniferatoxin, Rimazolium, Romifidine, RUB-A535, Salecylamide, Salonpas, Tectin, Tolfenamic Acid, Tenazocine, Ufenamate, Volazocine, Xylazine, Yangonin, Zinda Tilismath, Ziconotide, Anazocine, Bremazocine, Cyclazocine, EKC, Fluorophen, Gemazocine, Ketazocine, Metazocine, Quadazocine, Azocine, Benzazocine, 0-2545, DOU-216,303, Phenylethylpyrrolidine, GR-89696, HA-966, ICI-199,441, ICI-204,448, NNN, Nornicotine, Clemastine, PF-03654746, RTI-229, SB-269,970, U-50488, U-69,593, Bombesin, Bivaracetam, Cebaracetam, DEABL, Cromakalim, Doxapram, Dupracetam, Etiracetam, Fasoracetam, Imuracetam, Levetiracetam, Lidanserin, Nebracetam, Nefiracetam, Nicoracetam, Oxiracetam, Piperacetam, Seletracetam, MOPPP, MPBP, MPHP, MDPDP, MDPPP, Pyrovalone, a-PBP, a-PPP, Neuropeptides, Galanin, Neuropeptide Y, Enkephalin, Somatoslatin, CCK, Substance P, Neurotensin, TRH, Acepramazine, Aceprometazine, Acetanisol, Acetohexamide, Acetophenazine, Acetophenone, Acetosyringoine, 2-Acetylpyridine, Adrenalone, Anthrone, Apocynin, Avobenzone, Benzbromarone, Benziodarone, Benzoin, Butaperazine, CB-13, AM-6545, AZ-11713908, WIN-54,461, JWH-200, WIN-56,098,S-796,260, AM-1220, AM-1221, AM-1241, AM-2233, AM-630, AAI’s, CPE, GW-405,833, JWH-193, JWH-198, JWH-007, 3-Acetyl-6-Methoxybenzaldehyde, Aflobazole, AR-A000002, Azasestron, Bazinaprine, 3-Benzhydrylmorpholine, BML-190, Cobicistat, CYT387, Desmethylmoramide, Dioxaphetyl Butyrate, Edivoxetine, Epelsiban, Demoxytocin, Carbetocine, WAY-267,464, Atosiban, Eprobemide, L-371,257, L-368,899, Quinagolide, Terbutaline, 2CB-ind, 5-APDI, APICA, Donepezil, ICI-118,551, Indatraline, Indinavir, Ladostigil, Mutisianthol, PNU-99,194, S-15535, TAI, Zicronapine, Aleglitazar, Thromboxame Receptor Agonist, Verruculogen, Brevianamide, 2,5-DKP, Fellutanine, Phenylahistine, Plinabulin, Rugulosuvine, Fedrilate, Fenbutrazate, L-733,060, G-130, HC3, Indeloxazine, Levomoramide, Metostilenol, Molindone, Molracetam, Nimorazole, O-1057, O-1812, AM-2232, O-774, AM-2389, HHC, HU-243, Canbisol, Nabilone, 11-OH-THC, 2-AGE, Paxahexyl, THC-C4, AMG-36, AMG-41, AM-1235, AM-906, AM-365, O-2694, O-2372, O-2113, O-2050, VCHSR, TM-38837, PiplSB, PF-514273, MK-9470, LY-320,135, O-2545, PD-128,907, PF-219,061, ABT-670, ABT-742, UK-414,495, OSU-6162, Melanotan II, Oxaflozane, PF-592,379, 2-Phenyl-3,6-Dimethylmorpholine, Pramocaine, SCH-50911, 4-HTMPIPO, A-41988, AB-001, AB-005, ADBICA, AM-087, AM-411, KM-233, AM-679, AM-694, AM-855, AM-905, AM-919, AM-4030, AM-938, AM-251, AMG-1, AR-231,453, PSN-375,963, PSN-632,408, (C6)-CP-47,497, CCH, O-1871, CP-55,940, CP-47,497, CP-50,556’1, CP-55,244, Otenabant, (C9)-CP-47,497, CBS-0550, AVE-1625, GW-842,166x, HU-308, HU-336, HU-331, HU-320, Ajulemic Acid, JTE-7-31, A-834,735, MDA-19, S-444,823, JTE-907, JWH-015, JWH-019, JWH-030, JWH-047, JWH-048, JWH-051, JWH-057, JWH-081, SLV319, 2-Isopropyl-5-Methyl-1-(2,6-dihydroxy-4-nonphenyl)cyclohex-1-ene, HU-345, JWH-098, JWH-116, JWH-120, JWH-122, JWH-147, JWH-148, JWH-149, JWH-161, JWH-164, JWH-167, JWH-175, JWH-176, JWH-184, JWH-185, JWH-196, JWH-203, JWH-249, JWH-302, JWH-307, JWH-359, JWH-398, JWH-424, L-759,633, L-759,656, GW-405,833, Leelamine, NESS-0327, NESS-040C5, NMP-7, Nonabine, O-1125, O-1238, O-1269, O-806, O0823, Org-27569, Org-28312, LBP-1, Org-28611, Otenabant, Perrottetinene, PF-03550096, RCS-4, RCS-8, Rosonbrant, SDB-001, SDB-006, SER-601, Serinolamide A, THC-O-Phosphate, Tinabinol, VDM-11, Virohamine, A77636, Adafenoxate, Adapromine, Adatanserin, Bolmantalate, Bromantane, SR-142,948, 25B-NBOMe, 25I-NBMB, 25TFM-NBOMe, 5-MeO-NBpBiT, 2CBCB-NBOMe, 25CN-NBOH, Juncosamine, TCB-2, 6-Br-APB, Agelferin, Cridazepam, Meta-DOB, NGD-4715, Nicergoline, P7C3, SB-357,134, Sclerotia Truffle, 5-Flouro-aMT, 6-Flouro-aMT, Telepathine, AMDA, Amperozide, Cinaserin, Deramciclane, Fenanserin, Flibanserin, Glemanserin, Iferanserin, KML-010, LY-367,265, Pruvanserin, Rauwolscine, Setoperone, Spiperone, Volinanserin, Xlamidine, Altropane, ATI-2042, PIA, RTI-121, RTI-353, Tramethinib, SB-258,585, Lu-AE58054, MS-245, Ro04-6790, SB-271,046, SB-399,885, RTI-55, AC-262,356, 2′-Acetoxycocaine, Bemestron, Benzoylthiomethylecogine, Brasofesine, 2-CMT, Clobenztropine, Cocaethylene, Deptropine, Dichloropane, Diflouropine, Granisetron, 3-(p-Flourobenzoyloxy)tropane, p-ISOCOC, Methylvanillylecogonine, Norcocaine, NS-2359, RTI-126, WF-23, WF-33, WF-31, WF-11, BRL-46470, RTI-112, RTI-113, RTI-120, RTI-150, RTI-171, RTI-274, RTI-31, RTI-32, RTI-51, RTI-83, Thiophenyltropanes, MAT Inhibitor, Salicylmethylecgonine, Tesofesine, Troparil, WIN-35428, Amfonelic Acid, Oxolinc Acid, Tropisetron, Zatosetron, Dichloropane, RTI-336, RTI-126, Tropoxane, Poyo (Palm Wine), Tropicamide, Caffetin, Formic acid, Monocled Cobra, Sisa, Tramadol, Dazopride, Dolasetron, Amylocaine, Articaine, Bupivacaine, Butacaine, Chloroprocaine, Cyclomethycaine, Etidocaine, Hexylcaine, Levobupivacaine, Mepivacaine, Meprylcaine, Prilocaine, Proxymetacaine, Risocaine, Ropivacaine, Tetracaine, Trimecaine, Piperocaine, Metabutoxycaine, Adipiplon, Almitrine, ARRY-520, AZD5423, Cisapride, CP-226,269, CRL-40,941, DBL-583, Dexamethasone, DFMD, Methyldopa, Carbidopa, d-DOPA, L-DOPS, Octaflourocyclobutane, DFB, Didesmethylcitalopram, Elopiprazole, Phenylpiprazine, F-15,599, FGIN-127, Fletazepam, Flucindole, GR-159,897, LY-503,430, MPPF, PEPA, RS-127,445, S-23, SHA-68, SNAP-7941, SNAP-94847, TP-003, TPA-023, UH-301, Calycosin, Flavinoids, Psi-Tectorigenin, Blochanin A, Formononetin, Glyciten, Irigenin, Methoxyisoflavone, 5-O-Methylgenistein, 7-O-Methylluteone, Ononin, Pratensein, Prunetin, Retusin, Tectoridin, Tectorigenin, Barbigerone, Daidzein, Derrubone, Genistein, Ipriflavone, Irilone, Luteone, Orobol, Psuedobaotigenin, Wighteone, AMG-3, Nabazenil, Naboctate, a-Napthoflavone, 11-Nor-9-Carboxy-THC, Pirnabine, Apiol, Dillapiol, 1,3-Benzodioxole, Piperonal, beta-Asarone, Eleicin, Homovanyllyl Alcohol, Myristicin, 2-Bromo-4,5-Methylenedioxyamphetamine, Californidine, Chavicine, Cinoxacin, Dibutylone, Fenoverine, Befuraline, MDIP, MDMAI, MDPR, MDAL, ORTHO-MDA, MDP1P, MDP2P, Omiloxetine, Osemozotan, Piclozotan, Robalzotan, Ebalzotan, Sarlzotan, Piperine, Protokylol, Isoprenaline, Rhoeadine, MDMPEA, MMDPEA, MMDMPEA, MDIP, MDHOET, MDPL, GYKI-52895, Ungiminorine, NADA, Methylene blue, ECG, EGCG, EGC, Levonantradol, Cone Snail Venom, A-836,339, Abacavir, CYP-LAD, 2-Bromo-LSD, BU-LAD, DAM-57, DAL, Epicriptine, Ergometrine, Ergometrinine, Ergostine, ETH-LAD, LEA-32, Methylergometrine, MLD-41, LSP, LSH, MIPLA, PARGY-LAD, PRO-LAD, DCG-IV, DOV-102,677, MDCPM, MNTX, Amfonelic acid, J-113,397, SB-612,111, VUF-6002, DBM, Piberatine, Ilercimide, Dithranol, Divaplon, Ebastine, Flopropione, Iloperidone, Ketorolac, Melperone, NNC-38-1044, Tetralone, Cuscohydrine, Hygrine, 4-NEMD, Aceburic Acid, Amfecloral, Aprobarbital, Arfendazam, Benzobarbital, Benzylbutylbarbituate, Brallobarbital, Brophebarbital, Buthalitol, Carbubarb, Climazolam, Cyclobarbital, Cyclopentobarbital, and Acid (i.e. regular LSD).



[Epistemic status: Fiction]

It was the 21st of April of a recent year. I was listening to Jefferson Airplane songs, had just peeled a tangerine, and was about to vape 20 milligrams of DMT. After exhaling all the material I focused on the smell of the tangerine, holding it in my hands. I was engrossed in the scent. And then: “Who is that?” I felt an entity question my identity, as if I had just startled it in its natural habitat. I felt its presence for most of the duration of the trip, but it didn’t interact with me any further. Later that night I had a lucid dream. “I thought you were a dog” – said a voice. I recognized it from the trip, it was the entity. “The amount of scent qualia your experience contained was much more like that of a dog than a human.” After that night I would encounter it numerous other times. We got to know each other. It is a being from a nearby dimension, or perhaps a partially orthogonal fold of the Calabi-Yau manifold. Either way, in its world they don’t have physical senses like we do. They instead “sniff the qualia” present in the “universal wavefunction”. Their minds have a “qualiascope”. In practice this means they can see us from the inside– what we feel, see, touch, think, etc.

The being showed me what it is like to be one of them. We mindmelded the third time we met. I got to see the world around me as if for the first time; I was seeing it in its ultimate intrinsic nature, rather than as the shadow of it that I would perceive in everyday life with my senses. The qualia of other people is very intricate, semantically complex, and flavorful. The being showed me how it perceived various human contexts. For instance, an interesting place to “point the qualiascope at” is a philosophy department. It is very dense with logico-linguistic qualia and recursion. Compared to other contexts, though, it is thin in knowledge of the varieties of experiences available to humans. Raves are quite incredible. Sniffing the qualia of three thousand people who all share a general palette of LSD, Ketamine, and MDMA qualia is quite moving and mind-blowing. In turn, Buddhist monasteries are some of the sanest places on Earth. Bright, balanced, energized clarity of the finest quality is to be found in groups of people highly experienced in meditation. Every once in a while we would sense from afar a kind of “qualia explosion”. Sometimes it turned out to be extremely blissful, such as some 5-MeO-DMT experiences. And sometimes they turned out to be extremely painful, like a cluster headache episode. With the qualiascope these were sensed as being a kind of elemental type of qualia. Enormous in their “volume” relative to the experiences humans generally have. Like at another order of magnitude altogether.

The tenth time we met, the being said I was ready to feel non-human qualia. It was rough. From its point of view, the biological qualia of this planet is not really particularly human-flavored. As many humans alive as there are, there are almost ten times as many pigs alive. The being showed me how in the language of their world (using qualia-based symbols), they don’t refer to this planet as “human world”. They talk about it as “cow-chicken-pig world”. The things that I felt associated to some of those “folds of experience” were frightful to an incredible extent. It revived in me the conscience that nonhuman animals suffer enormously. I also became fascinated by all the ways in which nonhuman animals experience pleasure and a sense of meaning.

The twentieth time we met, I was shown what the qualia of non-living matter felt like from the inside. Most of it was “qualia dust”. But metals and their delocalized electrons felt, well, “electric” and somewhat more liquid and unified in a subtle ethereal way. Pointing the qualiascope at the center of the Earth was impressive. Some of the combinations of pressure, temperature, and material composition would create “qualia spaghetti” of a rather nice, glowing valence. The temperature would suggest a much higher degree of intrinsic intensity from the inside, but the patterns of qualia formed were not much more intense than what you would find in small animals. But that all changes as soon as you point the qualiascope at the sun. Oh boy. The things I felt were life-redefining. I thought that once you’ve felt what 5-MeO-DMT is capable of you’d maxed out on the brightness of qualia. But inside the sun, at the core, there are qualia aggregates of a subjective brightness at least a million times more powerful. Once you’ve got an inkling of the existence of that, you start to see the universe as they see it. And that is that the kind of stuff going on in places like the planet Earth is a rounding error in light of the other qualia happenings out there in the cosmos.

The hundredth or so time we met, we used the qualiascope to sense what is going on in supernovae. And then black holes. And the quantum vacuum (turns out the Zero Point Energy folks who say there is an enormous amount of energy in the vacuum of space are more right than they can even imagine). They showed me qualiascope records of past civilizations in other galaxies, and how they had developed qualia technology.

The two hundredth time or so we met, the being finally came out about his real interest. It showed me Hedonium. Matter and energy optimized for maximally bound positive valence. Turns out there are about seven thousand nearly optimal configurations for Hedonium possible with our laws of physics (cf. 230 Space Groups). They are kind of ultra-high dimensional crystalline bundles of “awakened qualia”, equanimity, and bright pleasure all combined. They truly feel like “what it was all meant to be all along”. The Big Bang, the Inflationary Period, Baryonic matter, galaxies, organic molecules, life, sapient beings, and technologized qualia all seemed like the path of redemption since The Fall, namely, our first descent from Hedonium. Or so my archetype-prone human mind liked to interpret my new understanding of the universe.

The being finally came through with its agenda. It turns out it is one of the protectors of the Hedonium created by an advanced civilization in other partially orthogonal folds of the Calabi-Yau manifold. The closest archetype in our human world would perhaps be that of the Buddhist Bodhisattva. Namely, a being close to enlightenment that vows to stay in samsara to liberate all other beings before itself escaping the wheel of suffering entirely. My interdimensional Bodhisattva friend told me that our world is on the path of creating qualia technologies too. That in geologic times we are not far from being able to make Hedonium ourselves. It said we should not feel hopeless. That we have really good chances of exiting our Darwinian predicament. Since a year ago I have’t had any contact with it. I write this for myself as I don’t expect anyone to believe me. But I do pass along the message. Don’t lose hope. Paradises beyond the imaginable are right next door in qualia space. We just need to find them by exploring the state-space of consciousness.

Oh, my Bodhisattva friend also told me to pass along to you all the message of “If you could possibly stop eating Caroline Reapers, that would be great!” because all of that intense spicy qualia is interfering with their radio systems. Thanks!

See also: What’s out there?

Qualia Productions Presents: When AI Equals Advanced Incompetence

By Maggie and Anders Amelin

Letter I: Introduction

We are Maggie & Anders. A mostly harmless Swedish old-timer couple only now beginning to discover the advanced incompetence that is the proto-science — or “alchemy” — of consciousness research. A few centuries ago a philosopher of chemistry could have claimed with a straight face to be quite certain that a substance with negative mass had to be invoked to explain the phenomenon of combustion. Another could have been equally convinced that the chemistry of life involves a special force of nature absent from all non-living matter. A physicist of today may recognize that the study of consciousness has even less experimental foundation than alchemy did, yet be confident that at least it cannot feel like something to be a black hole. Since, obviously, black holes are simple objects and consciousness is a phenomenon which only emerges from “complexity” as high as that of a human brain.

Is there some ultimate substrate, basic to reality and which has properties intrinsic to itself? If so, is elementary sentience one of those properties? Or is it “turtles all the way down” in a long regress where all of reality can be modeled as patterns within patterns within patterns ending in Turing-style “bits”? Or parsimoniously never ending?

Will it turn out to be patterns all the way down, or sentience all the way up? Should people who believe themselves to perhaps be in an ancestor simulation take for granted that consciousness exists for biologically-based people in base-level reality? David Chalmers does. So at least that must be one assumption it is safe to make, isn’t it? And the one about no sentience existing in a black hole. And the one about phlogiston. And the four chemical elements.

This really is good material for silly comedy or artistic satire. To view a modest attempt by us in that direction, please feel encouraged to enjoy this youtube video we made with QRI in mind:

When ignorance is near complete, it is vital to think outside the proverbial box if progress is to be made. However, spontaneous creative speculation is more context-constrained than it feels like, and it rarely correlates all that beautifully with anything useful. Any science has to work via the baby steps of testable predictions. The integrated information theory (IIT) does just that, and has produced encouraging early results. IIT could turn out to be a good starting point for eventually mapping and modeling all of experiential phenomenology. For a perspective, IIT 3.0 may be comparable to how Einstein’s modeling of the photoelectric effect stands in relation to a full-blown theory of quantum gravity. There is a fair bit of ground to cover. We have not been able to find any group more likely than the QRI to speed up the process whereby humanity eventually manages to cover that ground. That is, if they get a whole lot of help in the form of outreach, fundraising and technological development. Early pioneers have big hurdles to overcome, but the difference they can make for the future is enormous.anders_and_maggie_thermometer

For those who feel inspired, a nice start is to go through all that is on or linked via the QRI website. Indulge in Principia Qualia. If that leaves you confused on a higher level, you are in good company. With us. We are halfway senile and are not information theorists, neuroscientists or physicists. All we have is a nerdy sense of humor and work experience in areas like marketing and planetary geochemistry. One thing we think we can do is help bridge the gap between “experts” and “lay people”. Instead of “explain it like I am five”, we offer the even greater challenge of explaining it like we are Maggie & Anders. Manage that, and you will definitely be wiser afterwards!

– Maggie & Anders

Letter II: State-Space of Matter and State-Space of Consciousness

A core aspect of science is the mapping out of distributions, spectra, and state-spaces of the building blocks of reality. Naturally occurring states of things can be spontaneously discovered. To gain more information about them, one can experimentally alter such states to produce novel ones, and then analyze them in a systematic way.

The full state-space of matter is multidimensional and vast. Zoom in anywhere in it and there will be a number of characteristic physics phenomena appearing there. Within a model of the state-space you can follow independent directions as you move towards regions and points. As an example, you can hold steady at one particular simple chemical configuration. Diamond, say. The stable region of diamond and its emergent properties like high hardness extends certain distances in other parameter directions such as temperature and pressure. The diamond region has neighboring regions with differently structured carbon, such as graphite. Diamond and graphite make for an interesting case since the property of hardness emerges very differently in the two regions. (In the pure carbon state-space the dimensions denoting amounts of all other elements can be said to be there but set to zero). Material properties like hardness can be modeled as static phenomena. According to IIT however, consciousness cannot. It’s still an emergent property of matter though, so just stay in the matter state-space and add a time dimension to it. Then open chains and closed loops of causation emerge as a sort of fundamental level of what matter “does”. Each elementary step of causation may be regarded to produce or intrinsically be some iota of proto-experience. In feedback loops this self-amplifies into states of feeling like something. Many or perhaps most forms of matter can “do” these basic things at various regions of various combinations of parameter settings. Closed causal loops require more delicate fine-tuning in parameter space, so the state-space of nonconscious causation structure is larger than that of conscious structure. The famous “hard problem” has to do with the fact that both an experientially very weak and a very strong state can emerge from the same matter (shown to be the case so far only within brains). A bit like the huge difference in mechanical hardness of diamond and graphite both emerging from the same pure carbon substrate (a word play on “hard” to make it sticky).

By the logic of IIT it should be possible to model (in arbitrarily coarse or fine detail) the state-space of all conscious experience whose substrate is all possible physical states of pure carbon. Or at room temperature in any material. And so on. If future advanced versions of IIT turn out to be a success then we may guess there’ll be a significant overlap to allow for a certain “substrate invariance” for hardware that can support intelligence with human-recognizable consciousness. Outside of that there will be a gargantuan additional novel space to explore. It ought to contain maxima of (intrinsic) attractiveness, none of which need to reside within what a biological nervous system can host. Biological evolution has only been able to search through certain parts of the state-space of matter. One thing it has not worked with on Earth is pure carbon. Diamond tooth enamel or carbon nanotube tendons would be useful but no animal has them. What about conscious states? Has biology come close to hit upon any of the optima in those? If all of human sentience is like planet Earth, and all of Terrestrial biologically-based sentience is like the whole Solar System, that leaves an entire extrasolar galaxy out there to explore. (Boarding call: Space X Flight 42 bound for Nanedi Settlement, Mars. Sentinauts please go to the Neuralink check-in terminal).

Of course we don’t currently know how IIT is going to stand up, but thankfully it does make testable predictions. There is, therefore, a beginning of something to be hoped for with it. In a hopeful scenario IIT turns out to be like special relativity, and what QRI is reaching for is like quantum gravity. It will be a process of taking baby steps, for sure. But each step is likely to bring benefits in many ways.

Is any of this making you curious? Then you may enjoy reading “Principia Qualia” and other QRI articles.

– Maggie & Anders

Neural Annealing: Toward a Neural Theory of Everything

QRI‘s co-founder Michael E. Johnson just posted a piece on neural annealing. This is one of QRI’s most important pieces of content to date. I’m very proud of Mike and the team for pulling this off. You can find the full piece here.

Mike writes:

This is QRI’s unified theory of music, meditation, psychedelics, depression, trauma, and emotional processing; the most challenging (and I think beautiful) thing I’ve written in the last three years. I would really appreciate careful comments.

A few takeaways:

  • Entering high-energy states (i.e., intense emotional states which take some time to ‘process’) is how the brain releases structural stress and adapts to new developments. This is similar to ‘annealing’ in metals, where heat allows atoms to break their bonds, then they search for more stable configurations as they cool.
  • Brains really do need to anneal regularly to pay down their ‘technical debt’, and if they don’t, they grow brittle and neurotic.
  • Meditation, music, psychedelics, exercise, dance, sex, tantric practices, EMDR, and breath work all share the same mechanism: a build-up of rhythmic neural resonance that can push the brain into these high-energy states which produce annealing.
  • Depression is a self-reinforcing perturbation from the natural annealing cycle.
  • Sometimes the brain needs to rapidly halt information propagation across regions to prevent cascading system failure … we call this ‘trauma’. This is a common and serious disruption of the annealing cycle.
  • The core psychological changes driven by psychedelics are best understood in terms of the amount and ‘statistical flavor’ of the energy (rhythmic firing) they add to the brain. Different psychedelics will ‘anneal’ different things.
  • Young brains (and lifelong learners) might not only be more plastic than average, but actually having experience that is objectively more visceral.
  • A unified theory of emotional updating, depression, trauma, meditation, and psychedelics may give us the tools to build a future that’s substantially better than the present.

(A unification of Robin Carhart-Harris and Karl Friston’s REBUS annealing model, with Selen Atasoy’s Connectome-Specific Harmonic Waves paradigm.)

Is the Orthogonality Thesis Defensible if We Assume Both Valence Realism and Open Individualism?

Ari Astra asks: Is the Orthogonality Thesis Defensible if We Assume Both “Valence Realism” and Open Individualism?

Ari’s own response: I suppose it’s contingent on whether or not digital zombies are capable of general intelligence, which is an open question. However, phenomenally bound subjective world simulations seem like an uncharacteristic extravagance on the part of evolution if non-sphexish p-zombie general intelligence is possible.

Of course, it may be possible, but just not reachable through Darwinian selection. But the fact that a search process as huge as evolution couldn’t find it and instead developed profoundly sophisticated phenomenally bound subjectivity is (possibly strong) evidence against the proposition that zombie AGI is possible (or likely to be stumbled on by accident).

If we do need phenomenally bound subjectivity for non-sphexish intelligence and minds ultimately care about qualia valence – and confusedly think that they care about other things only when they’re below a certain intelligence (or thoughtfulness) level – then it seems to follow that smarter than human AGIs will converge on valence optimization.

If OI is also true, then smarter than human AGIs will likely converge on this as well – since it’s within the reach of smart humans – and this will plausibly lead to AGIs adopting sentience in general as their target for valence optimization.

Friendliness may be built into the nature of all sufficiently smart and thoughtful general intelligence.

If we’re not drug-naive and we’ve conducted the phenomenological experiment of chemically blowing open the reducing valves that keep “mind at large” out and that filteratively shape hominid consciousness, we know by direct acquaintance that it’s possible to hack our way to more expansive awareness.

We shouldn’t discount the possibility that AGI will do the same simply because the idea is weirdly genre bending. Whatever narrow experience of “self” AGI starts with in the beginning, it may quickly expand out of.

Michael E. Johnson‘s response: The orthogonality thesis seems sound from ‘far mode’ but always breaks down in ‘near mode’. One way it breaks down is in implementation: the way you build an AGI system will definitely influence what it tends to ‘want’. Orthogonality is a leaky abstraction in this case.

Another way it breaks down is that the nature and structure of the universe instantiates various Schelling points. As you note, if Valence Realism is true, then there exists a pretty big Schelling point around optimizing that. Any arbitrary AGI would be much more likely to optimize for (and coordinate around) optimizing for positive qualia than, say, paperclips. I think this may be what your question gets at.

Coordination is also a huge question. You may have read this already, but worth pointing to: A new theory of Open Individualism.

To collect some threads- I’d suggest that much of the future will be determined by the coordination capacity and game-theoretical equilibriums between (1) different theories of identity, and (2) different metaphysics.

What does ‘metaphysics’ mean here? I use ‘metaphysics’ as shorthand for ‘the ontology people believe is ‘real’. What they believe we should look at when determining moral action.’

The cleanest typology for metaphysics I can offer is: some theories focus on computations as the thing that’s ‘real’, the thing that ethically matters – we should pay attention to what the *bits* are doing. Others focus on physical states – we should pay attention to what the *atoms* are doing. I’m on team atoms, as I note here: Against Functionalism.

My suggested takeaway: an open individualist who assumes computationalism is true (team bits) will have a hard time coordinating with an open individualist who assumes physicalism is true (team atoms) — they’re essentially running incompatible versions of OI and will compete for resources. As a first approximation, instead of three theories of personal identity – Closed Individualism, Empty Individualism, Open Individualism – we’d have six. CI-bits, CI-atoms, EI-bits, EI-atoms, OI-bits, OI-atoms. Whether the future is positive will be substantially determined by how widely and deeply we can build positive-sum moral trades between these six frames.

Maybe there’s further structure, if we add the dimension of ‘yes/no’ on Valence Realism. But maybe not– my intuition is that ‘team bits’ trends toward not being valence realists, whereas ‘team atoms’ tends toward it. So we’d still have these core six.

(I believe OI-atoms or EI-atoms is the ‘most true’ theory of personal identity, and that upon reflection and under consistency constraints agents will converge to these theories at the limit, but I expect all six theories to be well-represented by various agents and pseudo-agents in our current and foreseeable technological society.)

Psychotic Depression

Excerpt from Infinite Jest by David Foster Wallace (pgs. 692-698)

And re Ennet House resident Kate Gompert and this depression issue:

Some psychiatric patients — plus a certain percentage of people who’ve gotten so dependent on chemicals for feelings of well-being that when the chemicals have to be abandoned they undergo a loss-trauma that reaches way down deep into the soul’s core systems — these persons know firsthand that there’s more than one kind of so-called ‘depression’. One kind is low-grade and sometimes gets called anhedonia[280] or simple melancholy. It’s a kind of spiritual torpor in which one loses the ability to feel pleasure or attachment to things formerly important. The avid bowler drops out of his league and stays home at night staring dully at kick-boxing youtube videos cartridges. The gourmand is off his feed. The sensualist finds his beloved Unit all of a sudden to be so much feelingless gristle, just hanging there. The devoted wife and mother finds the thought of her family about as moving, all of a sudden, as a theorem of Euclid. It’s a kind of emotional novocaine, this form of depression, and while it’s not overly painful its deadness is disconcerting and… well, depressing. Kate Gompert’s always thought of this anhedonic state as a kind of radical abstracting of everything, a hollowing out of stuff that used to have affective content. Terms that undepressed toss around and take for granted as full and fleshy — happiness, joie de vivre, preference, love — are stripped to their skeletons and reduced to abstract ideas. They have, as it were, denotation but not connotation. The anhedonic can still speak about happiness and meaning et al., but she has become incapable of feeling anything in them, of understanding anything about them, of hoping anything about them, or of believing them to exist as anything more than concepts. Everything becomes an outline of the thing. Objects become schemata. The world becomes a map of the world. An anhedonic can navigate, but has no location. I.e. the anhedonic becomes, in the lingo of Boston AA, Unable To Identify.

It’s worth nothing that, among younger E.T.A.s, the standard take on Dr. J. O. Incandenza’s suicide attributes his putting his head in the microwave to this kind of anhedonia. This is maybe because anhedonia’s often associated with the crises that afflict extremely goal-oriented people who reach a certain age having achieved all or more than all than they’d hoped for. The what-does-it-all-mean-type crisis of middle-aged Americans. In fact this is in fact not what killed Incandenza at all. In fact the presumption that he’d achieved all his goals and found that the achievement didn’t confer meaning or joy on his existence says more about the students at E.T.A. than it says about Orin’s and Hal’s father: still under the influence of the deLint-like carrot-and-stick philosophies of their hometown coaches rather than the more paradoxical Schtitt/Incandenza/Lyle school, younger athletes who can’t help gauging their whole worth by their place in an ordinal ranking use the idea that achieving their goals and finding the gnawing sense of worthlessness still there in their own gut as a kind of psychic bogey, something that they can use to justify stopping on their way down to dawn drills to smell flowers along the E.T.A. paths. The idea that achievement doesn’t automatically confer interior worth is, to them, still, at this age, an abstraction, rather like the prospect of their own death — ‘Caius Is Mortal’ and so on. Deep down, they all still view the competitive carrot as the grail. They’re mostly going through the motions when they invoke anhedonia. They’re mostly small children, keep in mind. Listen to any sort of sub-16 exchange you hear in the bathroom or food line: ‘Hey, there, how are you?’ ‘Number eight this week, is how I am.’ They all still worship the carrot. With the possible exception of the tormented LaMount Chu, they all still subscribe to the delusive idea that the continent’s second-ranked fourteen-year-old feels exactly twice as worthwhile as the continent’s #4.

Deluded or not, it’s still a lucky way to live. Even though it’s temporary. It may well be that the lower-ranked little kids at E.T.A. are proportionally happier than the higher-ranked kids, since we (who are mostly not small children) know it’s more invigorating to want than to have, it seems. Though maybe this is just the inverse of the same delusion.

Hal Incandenza, though he has no idea yet of why his father really put his head in a specially-dickied microwave in the Year of the Trial-Size Dove Bar, is pretty sure that it wasn’t because of standard U.S. anhedonia. Hal himself hadn’t had a bona fide intensity-of-interior-life-type emotion since he was tiny; he finds terms like joie and value to be like so many variables in rarified equations, and he can manipulate them well enough to satisfy everyone but himself that he’s in there, inside his own hull, as a human being — but in fact he’s far more robotic than John Wayne. One of his troubles with his Moms is the fact that Avril Incandenza believes she knows him inside and out as a human being, and an internally worthy one at that, when in fact inside Hal there’s pretty much nothing at all, he knows. His Moms Avril hears her own echoes inside him and thinks what she hears is him, and this makes Hal feel the one thing he feels to the limit, lately: he is lonely.

It’s of some interest that the lively arts of the millennial U.S.A. treat anhedonia and internal emptiness as hip and cool. It’s maybe the vestiges of the Romantic glorification of Weltschmerz, which means world-weariness or hip ennui. Maybe it’s the fact that most of the arts here are produced by world-weary and sophisticated older people and then consumed by younger people who not only consume art but study it for clues on how to be cool, hip — and keep in mind that, for kids and younger people, to be hip and cool is the same as to be admired and accepted and included and so Unalone. Forget so-called peer-pressure. It’s more like peer-hunger. No? We enter a spiritual puberty where we snap to the fact that the great transcendent horror is loneliness, excluded encagement in the self. Once we’ve hit this age, we will now give or take anything, wear any mask, to fit, be part-of, not be Alone, we young. The U.S. arts are our guide to inclusion. A how-to. We are shown how to fashion masks of ennui and jaded irony at a young age where the face is fictile enough to assume the shape of whatever it wears. And then it stuck there, the weary cynicism that saves us from gooey sentiment and unsophisticated naïvité. Sentiment equals naïvité on this continent (at least since the Reconfiguration). One of the things sophisticated viewers have always liked about the J. O. Incandenza’s The American Century as Seen Through a Brick is its unsubtle thesis that naïvité is the last true terrible sin in the theology of millennial America. And since sin is the sort of thing that can be talked about only figuratively, it’s natural that Himself’s dark little cartridge was mostly about a myth, viz. that queerly persistent U.S. myth that cynicism and naïvité are mutually exclusive. Hal, who’s empty but not dumb, theorizes privately that what passes for hip cynical transcendence of sentiment is really some kind of fear of being really human, since to be really human (at least as he conceptualizes it) is probably to be unavoidably sentimental and naïve and goo-prone and generally pathetic, is to be in some basic interior way forever infantile, some sort of not-quite-right-looking infant dragging itself anaclitically around the map, with big wet eyes and froggy-soft skin, huge skull, gooey drool. One of the really American things about Hal, probably, is the way he despises what it is he’s really lonely for: this hideous internal self, incontinent of sentiment and need, that pulses and writhes just under the hip empty mask, anhedonia.[281]

The American Century as Seen Through a Brick‘s main and famous key-image is of a piano-string vibrating — a high D, it looks like — vibrating and making a very sweet unadorned solo sound indeed, and then a little thumb comes into the frame, a blunt moist pale and yet dingy thumb, with disreputable stuff crusted in one of the nail-corners, small and unlined, clearly an infantile thumb, and as it touches the paino string the high sweet sound immediately dies. And the silence that follows is excruciating. Later in the film, after much mordant and didactic panoramic brick-following, we’re back at the piano-string, and the thumb is removed, and the high sweet sound recommences, extremely pure and solo, and yet now somehow, as the volume increases, now with something rotten about it underneath, there’s something sick-sweet and overripe and potentially putrid about the one clear high D as its volume increases and increases, the sound getting purer and louder and more dysphoric until after a surprisingly few seconds we find ourselves right in the middle of the pure undampered sound longing and even maybe praying for the return of the natal thumb, to shut it up.

Hal isn’t old enough yet to know that this is because numb emptiness isn’t the worst kind of depression. That dead-eyed anhedonia is but a remora on the ventral flank of the true predator, the Great White Shark of pain. Authorities term this condition clinical depression or involutional depression or unipolar dysphoria. Instead of just an incapacity for feeling, a deadening of the soul, the predator-grade depression Kate Gompert always feels as she Withdraws from secret marijuana is itself a feeling. It goes by many names — anguish, despair, torment, or q.v. Burton’s melancholia or Yevtuschenko’s more authoritative psychotic depression — but Kate Gompert, down in the trenches with the thing itself, knows it simply as It.

It is a level of psychic pain wholly incompatible with human life as we know it. It is a sense of radical and thoroughgoing evil not just as a feature but as the essence of conscious existence. It is a sense of poisoning that pervades the self at the self’s most elementary levels. It is a nausea of the cells and soul. It is an unnumb intuition in which the world is fully rich and animate and un-map-like and also thoroughly painful and malignant and antagonistic to the self, which depressed self It billows on and coagulates around and wraps in Its black folds and absorbs into Itself, so that an almost mystical unity is achieved with a world every constituent of which means painful harm to the self. Its emotional character, the feeling Gompert describes It as, is probably mostly indescribable except as a sort of double bind in which any/all of the alternatives we associate with human agency — sitting or standing, doing or resting, speaking or keeping silent, living or dying — are not just unpleasant but literally horrible.

It is also lonely on a level that cannot be conveyed. There is no way Kate Gompert could ever even begin to make someone else understand what clinical depression feels like, not even another person who is herself clinically depressed, because a person in such a state is incapable of empathy with any other living thing. This anhedonic Inability To Identify is also an integral part of It. If a person in physical pain has a hard time attending to anything except that pain[282], a clinically depressed person cannot even perceive any other person or thing as independent of the universal pain that is digesting her cell by cell. Everything is part of the problem, and there is no solution. It is a hell for one.

The authoritative term psychotic depression makes Kate Gompert feel especially lonely. Specifically the psychotic part. Think of it this way. Two people are screaming in pain. One of them is being tortured with electric current. The other is not. The screamer who’s being tortured with electric current is not psychotic: her screams are circumstantially appropriate. The screaming person who’s not being tortured, however, is psychotic, since the outside parties making the diagnoses can see no electrodes or measurable amperage. One of the least pleasant things about being psychotically depressed on a ward full of psychotically depressed patients is coming to see that none of them is really psychotic, that their screams are entirely appropriate to certain circumstances part of whose special charm is that they are undetectable by any outside party. Thus the loneliness: it’s a closed circuit: the current is both applied and received from within.

The so-called ‘psychotically depressed’ person who tries to kill herself doesn’t do so out of quote ‘hopelessness’ or any abstract conviction that life’s assets and debits do not square. And surely not because death seems suddenly appealing. The person in whom Its invisible agony reaches a certain unendurable level will kill herself the same way a trapped person will eventually jump from the window of a burning high-rise. Make no mistake about people who leap from burning windows. Their terror of falling from a great height is still just as great as it would be for you or me standing speculatively at the same window just checking out the view; i.e. the fear of falling remains constant. The variable here is the other terror, the fire’s flames: when the flames get close enough, falling to death becomes the slightly less terrible of the two terrors. It’s not desiring the fall; it’s terror of the flames. And yet nobody down on the sidewalk, looking up and yelling ‘Don’t!’ and ‘Hang on!’, can understand the jump. Not really. You’d have to personally be trapped and felt flames to really understand a terror way beyond falling.

But and so the idea of a person in the grip of It being bound by a ‘Suicide Contract’ some well-meaning Substance-abuse halfway house makes her sign is simply absurd. Because such a contract will constrain such a person only until the exact psychic circumstances that made the contract necessary in the first place assert themselves, invisibly and indescribably. That the well-meaning halfway-house Staff does not understand Its overriding terror will only make the depressed resident feel more alone.

One fellow psychotically depressed patient Kate Gompert came to know at Newton-Wellesley Hospital in Newton two years ago was a man in his fifties. He was a civil engineer whose hobby was model trains — like from Lionel Trains Inc., etc. — for which he erected incredibly intricate systems of switching and track that filled his basement recreation room. His wife brought photographs of the trains and network of trellis and track into the locked ward, to help remind him. The man said he had been suffering from psychotic depression for seventeen straight years, and Kate Gompert had had no reason to disbelieve him. He was stocky and swart with thinning hair and hands that he held very still in his lap as he sat. Twenty years ago he had slipped on a patch of 3-In-1-brand oil from his model-train tracks and bonked his head on the cement floor of his basement rec room in Wellesley Hills, and when he woke up in the E.R. he was depressed beyond all human endurance, and stayed that way. He’d never once tried suicide, though he confessed that he yearned for unconsciousness without end. His wife was very devoted and loving. She went to Catholic Mass every day. She was very devout. The psychotically depressed man, too, went to daily Mass when he was not institutionalized. He prayed for relief. He still had his job and his hobby. He went to work regularly, taking medical leaves only when the invisible torment got too bad for him to trust himself, or when there was some radical new treatment the psychiatrists wanted him to try. They’d tried Tricyclics, M.A.O.I.s, insulin-comas, Selective-Serotonin-Reuptake Inhibitors[283], the new and side-effect-laden Quadracyclics. They’d scanned his lobes and affective matrices for lesions and scars. Nothing worked. Not even high-amperage E.C.T. relieved It. This happens sometimes. Some cases of depression are beyond human aid. The man’s case gave Kate Gompert the howling fantods. The idea of this man going to work and to Mass and building miniaturized railroad networks day after day after day while feeling anything like what Kate Gompert felt in that ward was simply beyond her ability to imagine. The rationo-spiritual part of her knew this man and his wife must be possessed of a courage way off any sort of known courage-chart. But in her toxified soul Kate Gompert felt only a paralyzing horror at the idea of the squat dead-eyed man laying toy track slowly and carefully in the silence of his wood-panelled rec room, the silence total except for the sounds of the track being oiled and snapped together and laid into place, the man’s head full of poison and worms and every cell in his body screaming for relief from flames no one else could help with or even feel.

The permanently psychotically depressed man was finally transferred to a place on Long Island to be evaluated for a radical new type of psychosurgery where they supposedly went in and yanked out your whole limbic system, which is the part of the brain that causes all sentiment and feeling. The man’s fondest dream was anhedonia, complete psychic numbing. I.e. death in life. The prospect of radical psychosurgery was the dangled carrot that Kate guessed still gave the man’s life enough meaning for him to hang onto the windowsill by his fingernails, which were probably black and gnarled from the flames. That and his wife: he seemed genuinely to love his wife, and she him. He went to bed every night at home holding her, weeping for it to be over, while she prayed or did that devout thing with beads.

The couple had gotten Kate Gompert’s mother’s address and had sent Kate an Xmas card the last two years, Mr. and Mrs. Ernest Feaster of Wellesley Hills MA, stating that she was in her prayers and wishing her all available joy. Kate Gompert doesn’t know whether Mr. Ernest’s limbic system got yanked out or not. Whether he achieved anhedonia. The Xmas cards had had excruciating little watercolor pictures of locomotives on them. She could barely stand to think about them, even at the best of times, which the present was not.

[280] Anhedonia was apparently coined by Ribot, a Continental Frenchman, who in his 19th-century Psychologie des Sentiments says he means it to denote the psychoequivalent of analgesia, which is the neurologic supression of pain.

[281] This had been one of Hal’s deepest and most pregnant abstractions, one he’d come up with once while getting secretly high in the Pump Room. That we’re all lonely for something we don’t know we’re lonely for. How else to explain the curious feeling that he goes around feeling like he misses somebody he’s never even met? Without the universalizing abstraction, the feeling would make no sense.

[282] (the big reason why people in pain are so self-absorbed and unpleasant to be around)

[283] S.S.R.I.s, of which Zoloft and the ill-fated Prozac were the ancestors.

See also:

  • Wireheading Done Right – which steel-mans the case for philosophical and practical hedonism by outlining how to change our reward circuitry in such a way that (1) we never need to feel bad, (2) we move between different varieties of bliss depending on their functional properties, and (3) avoid becoming a pure replicator.
  • Tyranny of the Intentional Object – the stories we tell ourselves to explain every sense of pleasure and every sense of pain we feel are all, for the most part, deeply psychotic. That is, in so far as we attribute their valence to external triggers –  in truth, every feeling’s valence is the result of the fine-grained structure of the qualia that implements it. You don’t scream at a bullet ant’s sting. You scream at the deep scintillating patterns of qualia shaped by dissonance, shearing, pinching, tearing, etc. (all symmetry breaking effects) that result from the sting.
  • Logarithmic Scales of Pleasure and Pain – I like that David Foster Wallace makes a distinction between run-of-the-mill anhedonia and the Great White Shark of clinical depression. More broadly, we ought to realize that bad experiences of pain and suffering are not just a fraction worse than the rest, but they can indeed be orders of magnitude worse. On the flip-side, this is also true for positive experiences, with illustrative examples such as Buddhist Jhanas, temporal lobe epilepsy, and the lucky 5-MeO-DMT-induced state of supreme bliss.

Also relevant: David Pearce‘s Abolitionist Bioethics, Mike Johnson‘s A Future for Neuroscience, and Romeo Stevens‘ post about Core Transformation.

Finally, see Scott Alexander‘s book review of Infinite Jest.

Two Recent Presentations: (1) Hyperbolic Geometry of DMT Experiences, and (2) Harmonic Society

Here are two recent talks I gave. The first one is a talk about the Hyperbolic Geometry of DMT Experiences I gave at the Harvard Science of Psychedelics Club in mid-September (2019). And the second talk is about QRI‘s models of art, which took place in June (2019) at a QRI party in the Bay Area.

The Hyperbolic Geometry of DMT Experiences (@Harvard Science of Psychedelics Club)


Andrés Gómez Emilsson from the Qualia Research Institute presents about the Hyperbolic Geometry of DMT Experiences.

At a high-level, this video presents an algorithmic reduction of DMT phenomenology which imports concepts from hyperbolic geometry and dynamic systems theory in order to explain the “weirder than weird” hallucinations one can have on this drug. Andrés describes what different levels of DMT intoxication feel like in light of a model in which experience has both variable geometric curvature and information content. The benefit of this model cashes out in a novel approach to design DMT experiences in order to maximize specific desired benefits.

See original article: The Hyperbolic Geometry of DMT Experiences: Symmetries, Sheets, and Saddled Scenes

And the Explain Like I’m 5 version: ELI5 “The Hyperbolic Geometry of DMT Experiences”

Presentation outline:

  • Thermometers of Experience
  • The Leaf Metaphor
  • Introduction to Hyperbolic Geometry
  • DMT Levels
  • Level 1: Threshold (& Symmetry Hotel)
  • Level 2: Chrysanthemum
  • Level 3: Magic Eye (& Crystal Worlds)
  • Level 4: Waiting Room
  • Level 5: Breakthrough
  • Level 6: Amnesia
  • Energy – Complexity Landscape
  • Dynamic Systems
  • Fixed Point
  • Limit Cycles
  • Chaos
  • Noise Driven Structures
  • Turbulence
  • Conclusion
  • Super-Shulgin Academy
  • Atman Retreat
  • Wrap-Up

About the speaker: Andrés studied Symbolic Systems at Stanford (and has a masters in Computational Psychology, also from Stanford). He has professional experience in data science engineering, machine learning, and affective science. His research at the Qualia Research Institute ranges from algorithm design, to psychedelic theory, to neurotechnology development, to mapping and studying the computational properties of consciousness. Andrés blogs at

The Qualia Research Institute (QRI) is a non-profit based in the Bay Area close to San Francisco which seeks to discover the computational properties of experience. QRI has a “full-stack approach” to the science of consciousness which incorporates philosophy of mind, neuroscience, and neurotechnology. For more information see:

The Harvard Science of Psychedelics Club hosts events on psychedelic research, meditation, neuroscience, students sharing their own experiences, and much more.


– Wallpaper group 632 rotating along each symmetry element – Nick Xu

– Many of the images are by Paul Nylander:

– The Hyperbolic Honeycomb images and 3D prints are by Henry Segerman, who also has an awesome Youtube channel where he shows 3D printed math. We used his design to print the Honeycombs we were passing around during the lecture:

– Space-Time Dynamics in Video Feedback: Jim Crutchfield, Entropy Productions, Santa Cruz (1984):

Many thanks to Andrew Zuckerman and Kenneth Shinozuka for helping organize this event. And thanks to David Pearce, Michael Johnson, Romeo Stevens, Quintin Frerichs, the anonymous trippers, and many others for making this work real.

And here are the slides:


Dynamic Systems animations:

Harmonic Society: 8 Models of Art for a Scientific Paradigm of Aesthetic Qualia


Andrés Gómez Emilsson from the Qualia Research Institute gives a presentation about how art works according to modern neuroscience and philosophy of mind.

The video discusses eight different models of art: models 1 through 4 have been discussed in academic literature and the current intellectual zeitgeist, while models 5 through 8 are new, original, and the direct result of recent insights about consciousness as uncovered by modern neuroscience, philosophy of mind, and the work of the Qualia Research Institute.


We start by assuming that there are real stakes in art. This motivates the analysis of this subject matter, and it focuses where we place our gaze. We examine a total of eight models for “what art might be about”, divided into two groups. The first group of four are some of the most compelling contemporary models, which derive their strength from fields such as philosophy of language, economics, evolutionary psychology, and anthropology. These models are: (1) art as a word only definable in a family resemblance way with no necessary or sufficient features, (2) art as social signaling of desirable genetic characteristics, (3) art as Schelling point creation, and (4) art as the cultivation of sacred experiences. These four models, however enlightening, nonetheless only account for what David Marr might describe as the computational level of abstraction while leaving the algorithmic and implementation levels of abstraction unexamined. They explain what art is about in terms of why it exists and what its coarse effects are, but not the nature of its internal representations or its implementation. Hence we propose a second group of four models in order to get a “full-stack” view of art. These models are: (5) art as a tool for exploring the state-space of consciousness, (6) art as a method for changing the energy parameter of experience, (7) art as activities that induce neural annealing (which implements novel valence modulation, i.e. surprising pain/pleasure effects), and (8) art as an early prototype of a future affective language that will allow diverse states of consciousness to make sense of each other. These frameworks address how art interfaces with consciousness and how its key valuable features might be implemented neurologically. We conclude with a brief look at how embracing these new paradigms could, in principle, lead to the creation of a society free from suffering and interpersonal misunderstanding. Such a society, aka. Harmonic Society, would be designed with the effect of guaranteeing positive valence interactions using principles from a post-Galilean science of consciousness.


The 8 models of art are:

1. Art as family resemblance (Semantic Deflation)

2. Art as Signaling (Cool Kid Theory)

3. Art as Schelling-point creation (a few Hipster-theoretical considerations)

4. Art as cultivating sacred experiences (self-transcendence and highest values)

5. Art as exploring the state-space of consciousness (ϡ☀♘🏳️‍🌈♬♠ヅ)

6. Art as something that messes with the energy parameter of your mind (ꙮ)

7. Art as puzzling valence effects (emotional salience and annealing as key ingredients)

8. Art as a system of affective communication: a protolanguage to communicate information about worthwhile qualia (which culminates in Harmonic Society).

The presentation is based on an essay published in the Berlin-based art magazine Art Against Art (see: Issue #6).

Article is posted online here: Models 1 & 2, 3 & 4, 5 & 6, 7 & 8.

See more about the Qualia Research Institute at:

Andrés blogs at Qualia Computing: Top 10 Qualia Computing Articles

Infinite bliss!!!

And here are the slides:

State of the Qualia, Fall 2019

Qualia Research Institute’s inaugural newsletter.

What is QRI trying to do?

Our long-term vision is to end suffering. To destroy hell, and to build tools for exploring all the bright futures which come after. To take the Buddha’s vision of 2600 years ago, update it with advanced theory and technology, and make it real for all creatures.

Our medium-term goal is to build a ‘full-stack’ approach to the mind and brain, centered around emotional valence. Critically, better philosophy should lead to better neuroscience, and better neuroscience should lead to better neurotechnology. We’re skeptical of any philosophical approaches that don’t try to “pay rent” by building empirically useful things.

Our short-term deliverables are to refine our tools for evaluating EEG readings of emotionally-intense states (e.g. 5-MeO-DMT), build a hardware platform for non-invasive precision brain stimulation, and release an updated version of our full-stack theory of brain dynamics (‘neural annealing’).

We think we’re on track for all of these goals. On one level this is a huge claim- but as Archimedes said, “Give me a place to stand, and a lever long enough, and I will move the world.” We think we have that lever, and we’re building a place to stand.

Progress to date

Philosophy: over the course of the last few years, we’ve imported and integrated many key insights from our research lineages – in aggregate we believe these form the world’s best map of how to not get confused in navigating the formalization of consciousness. Our paradigm (laid out in Principia Qualia) builds on top of these lineages, and our core philosophical result is the Symmetry Theory of Valence (STV), an information-theoretic approach towards understanding how pleasant an experience is. (STV is important because it’s such a crisp and theoretically significant hypothesis: if it’s right, and we can prove it, the world will shift overnight.) We’ve also done significant philosophical research on the phenomenological nature of time, DMT states, and the logarithmic nature of pain and pleasure, to pick a few topics. Read more.

Neuroscience: Over the past two years we’ve put together a substantial push into neuroscience, which is showing increasing traction. Scott Alexander recently noticed how we actually beat Robin Carhart-Harris and Karl Friston (the world’s most-influential neuroscientist!) to the punch with an annealing model for psychedelics; this also forms the basis for (we believe) the world’s best neuroscience paradigm for explaining the mechanisms and effects of meditation and was mentioned in Tim Ferriss’s newsletter. We’re also a center of gravity (along with Selen Atasoy, its creator) for phenomenological interpretation of the Connectome-Specific Harmonic Wave (CSHW) paradigm.

Organization: This year saw QRI run a successful summer internship program in San Francisco with 3 superstar interns, Andrew and Kenneth from Harvard and Quintin from Washington University. More recently, we spent a month in Boston on a ‘work sprint’, and ended up giving 3 talks at Harvard and 1 at MIT, with plans to do more at various Ivies this fall. One of the most fun outputs of this summer was Zuck’s QRI explainer video (4.5 minutes).

I’m ridiculously proud of everything we’ve accomplished — a few years ago, QRI was mostly a promissory note that a formalist approach to consciousness could produce something interesting. Today, I can say with a straight face that QRI is one of the premier consciousness research centers in the world, releasing top-tier cross-disciplinary research every few months.

What’s next

Our current push is centered on empirically validating the Symmetry Theory of Valence (STV) and integrating it with our neuroscience stack. This involves releasing an updated version of our ‘neural annealing’ neuroscience paradigm, building a hardware platform for patterned stimulation, and refining our “CDNS” algorithm to work with EEG, with an eye toward using 5-MeO-DMT EEG data to evaluate STV. It looks like 2020 will be a breakout year for us.

What we need

Frankly speaking, we need your support. Building things is hard, and what we’re doing has never been done before. Our core bottlenecks are moneypeople, and executive function.

Money: so far, QRI has been mostly self-funded from the co-founders’ personal savings. I’m proud of everyone’s commitment, but this is unsustainable, especially as we attempt more ambitious projects. At this point, we have enough results to make a firm case that supporting QRI is likely to produce an awesome amount of value for the world, potentially literally the most leveraged philanthropic effort existing today. Frankly speaking the future we’re building won’t get built if we don’t secure funding, and I ask for your help and generosity. You can donate here. (Thank you to our key supporters this year! Your efforts allowed us to onboard three amazing interns and will support building things this Fall.)

People: high-quality organizations are incredibly hungry for high-quality people. QRI is no exception. If you think you have something to offer, please get in touch about collaboration, volunteering, research, and so on. Importantly, we don’t just need researchers: we’re hungry for operations people, and looking for help with getting on podcasts (speaking with Sam Harris and Joe Rogan would both be big wins!), organizing or getting speaking engagements (especially in the Bay), and even small, fun projects like making a series of QRI meme t-shirts.

Executive function: there’s a natural tension between research and organization-building. Paul Graham talks about this in Maker’s Schedule, Manager’s Schedule; research needs big uninterrupted chunks of time, whereas management and outreach involves lots of small tasks. Speaking personally, I struggle with keeping up with all our inquiries while also doing ‘deep work’. I would offer three thoughts to potential volunteers:

  1. Please have patience if we don’t get back to you right away. We’re juggling as best we can!
  2. When possible, we absolutely love it when people can figure out their own way to help — I can think of few things more pleasant to see in my inbox than someone sharing a “by the way, I made this” link to e.g. a nice HTML version of Principia Qualia, an explainer video for various QRI concepts, a deep review of our experimental method, etc.
  3. One of the highest leverage ways to help is to build infrastructure for us. E.g., if you’re familiar with the main themes of our work and want to be a volunteer coordinator for us, that would be an amazing force-multiplier.

I am incredibly proud of what we’ve done so far, and incredibly excited about the future. We will need your help to build it.

All the best,

Michael Edward Johnson

Executive Director, Qualia Research Institute