Qualia Research Diary: Scents

[Epistemic Status: Diary Entries]

“Fake it until you deep fake it.”

― Joscha Bach

“Break often – not like porcelain, but like waves.”

― Scherezade Siobhan

“Ideology has two meanings- actually, most social terms have two meanings, one for the traumatized and one for the non-traumatized.”

― Michael Vassar

“You know the old adage about monkeys typing into infinity, and the question about whether they would eventually produce Hamlet? I think that maybe we are those monkeys, and we’re producing countless Hamlets every single day.”

― Jacob Stephen

“Reality is very weird, no doubt. At the same time, it is easy to get wrong ‘what kind of weird’ reality is.”

― Matthew Barnett

“It is not true that suffering ennobles the character; happiness does that sometimes, but suffering, for the most part, makes men petty and vindictive.”

― W. Somerset Maugham

December 13th 2019

In a different timeline, I open a high-class experimental qualia-focused restaurant. There is only one kind of meal every month, and it is a challenge to finish it. Only 10% of people manage to do so. On March of 2022, the menu consists of:

  1. A soup. A liter of (tap) water with a single mint leaf in it. Do not be deceived, this is not “spa water”. The amount of mint in it is exactly right below the perceptual threshold for the most discerning of tasters. Hence, you are guaranteed to (a) not be able to taste anything at all, while (b) fully knowing you are indeed drinking aromatic molecules from the mint leaf. Also, they give you a spoon and a straw. If you use the straw, you are “drinking your soup” while if you use the spoon you are “eating your soup”. Up to you. It’s a conceptual piece after all. Once -and only once- you finish it, they serve you the second course…
  2. There are aromas and flavors out there in the state-space of qualia-triggering molecules that cancel each other out perfectly. The second course consists of a series of small hors d’oeuvres that are completely tasteless. If you can taste anything- e.g. a hint of garlic, or orange- it means the chef didn’t prepare it well. The flavors need to be perfectly balanced for them to be entirely tasteless. And once you are done, they bring you…
  3. This thing they left on your table is akin to a wire puzzle, or one of those Hanayama pieces. They tell you that your third course consists of a tiny cookie hidden inside it. Average solving time: 25 minutes. 50% of people can’t solve it.
  4. You are given a miniature 3D printed sugar statue reconstruction of someone who shares your name (as close as possible). Before eating it, you have to scream “There can be only one!” and consume your namesake in a single bite.
  5. Trace minerals. They bring you this large metallic bowl with a tiny little bit of powder at the bottom; certainly no more than 50 or 60 milligrams of material. It contains half of your daily recommended dose of iron, manganese, copper, iodine, zinc, cobalt, fluoride and selenium. You can now finally know what these actually taste like. It turns out that the characteristic taste of your grandma’s famous tapioca dish was zinc. Moving on…
  6. Negative food. You donate 300ml of blood.
  7. Distilled saliva. You spit in a bowl a number of times. You are then given a little shot of perfectly tasteless and clean water. The water is chemically pure. However, it is the water in the saliva of the spit of another customer.
  8. Double blind taste experiment. You are given a dish. The waiters do not know what it is. You do not know what it is. You have to write a 100-word report of what you think about this dish. This is actual science; the data is used by a research lab at some undisclosed university. There is something very Buddhist about this course – how much does your top-down model of what you are eating modify your perception of it? What if you do not assume an “essence” behind it – block that specific energy sink from robbing you of the experience of raw low-level sensation?
  9. Sound control. Did you know that food tastes different in an airplane? Many factors contribute to this, but a major one is the constant background noise you can hear inside the aircraft. Turns out tastes change with specific sounds. The Qualia restaurant spent $500,000 dollars researching this (and publishing a number of peer-reviewed papers in the process). The output of that research is that you can now make chocolate taste like vanilla, and strawberry taste like melon – if only you play the proper sound at the right volume. And finally…
  10. Stroboscopic taste – you put on a mouthpiece that entrains half of your tongue to a 30Hz electric seizure vibration while the other half is entrained to 17Hz. As you eat the Ice-cream of Victory (flavored with passionfruit, peanut, and anise) you realize that the flavors combine with the stroboscopic stimulation to create the hallucination of an entire meal replete with much more complex flavors. The beat patterns are tasty.

If you finish the entire thing (which usually takes about 5 hours total) they take a photograph of you and “keep it to themselves”. No, there is no “victory board”. They just want a picture of you.

5/5 | Would recommend.

January 6th 2020

Favorite essential oils at the moment: Freesia, Violet, and Pear. It turns out Freesia was a predominant note in Dior “Addict 2“, a perfume I fell in love with when I was a teen. Violet is “ethereal” in that it feels strangely anesthetizing (the ketamine of smells). Pear is lovely.

High Entropy Alloys (HEAs) and Scents:

  1. Some scent combinations “collapse categories” (e.g. too many flowers combined blend into “generic flowery”).
  2. Others make unstable multi-phase blends (e.g. too many categories – spicy, citrus, minty, woody all at once).
  3. Violet + Pear create a scent HEA.

An interesting blend with “emergent” characteristics: Freesia, Pear, Violet, Sunflower, Azalea, and Patchouli. Very high valence mixture that has a novel feeling that does not seem to come from the ingredients. #HighEntropyAlloy #HighEntropyScent

January 8th 2020

Careful with raising the “scent entropy” too high!

In sound and sight, it seems that there is an inverted U curve relationship between stimuli entropy and the entropy of the experiential response. White noise may be- objectively- the way to cram in as much information as possible into a waveform. But perceptually, white noise is more like its own (neutral valence, indifferent) tone. Likewise visually, if you crowd your images way too much you can’t actually understand its meaning and true complexity. Perceptual complexity response is maximized in the middle, where you achieve “peak useful entropy”.

More so, extremely entropic stimuli can be used to “mask” any input by adding a dose of white noise or visual static. That’s how you can degrade the valence of something when you don’t know what kind of unpleasant input you will get in advance. White noise drowns out both construction sounds and baby screams. It’s a “universal diluter”, so to speak.

And so it seems that this is the case with smells too. If you combine any 40 (42?) scented molecules that are as different as possible, you get as a result a generic smell with neutral valence that is not distinctive at all. If you make a different 40-scent mixture with completely different molecules, it also smells the same! They call it white noise scent, or “Laurax”*.

In other words, the “high-entropy alloys” of smell may only really pay off in the range of 5 to 15 different molecules, where (perhaps) we maximize the experiential “character” of the resulting fragrance.

Now, of course commercial perfumes in practice do have dozens if not hundreds of aromachemicals. But their absolute “scent entropy” is probably not that high. Why? First, the entropy is reduced by the fact that most perfumes do concentrate on a few core notes; the many other notes are usually small additions and tweaks. And second, the perfumes are usually made with relatively few categories of smells blended together (musky, citrus, and flower could be one, or green, ozonic, and non-citrus fruity another, and so on). Additionally, to get true white noise smell you need to also add negatively valenced scents, which are rarely used in actual perfumes. I do wonder, though, if the perfume industry has a sense of the “scent entropy” of their various perfumes, and if having a measure of it would perhaps improve their ability to hone in on blends that have unique emergent characters without relying entirely on heuristics and trial and error. Or how about a portable “scent-entropy-o-meter”? I bet it would find some very useful applications.

[Good article about it: The “white noise” of smells; *I first learned about Laurax here: The whiff of white could hide strong odours: Complex mixtures of many odours tend to smell the same.].

January 10th 2020

Of all the industries, I get the impression that the perfume industry is ahead of the curve when it comes to incorporating hedonistic utilitarian notes into its embedded ideology.

January 11th 2020

Cilantro tasting like soap to 10% of the population is just the tip of the iceberg.


January 13th 2020

What are your favorite perfumes?
(and if it’s not impossible to describe – why do you like them so much?)

I’ll start:

Addict 2 by Dior
Eros pur femme by Versace
Light Blue by Dolce & Gabbana

Oh god, what kind of person have I become?

January 14th 2020

Scent combinations with unusual emergent characters that are “more than the sum of their parts” I have discovered so far:

  1. Violet + Pear
  2. Rose + Orange
  3. Honeydew Melon + Pomegranate
  4. Freesia + Golden Hydrangea

In each of these cases, combining in roughly equivalent intensities (i.e. 50-50 ‘equipotent’ mixtures) seems to give rise to qualities that are not present in either of the two scents. This is relatively rare, IMO. If you combine, e.g. lilac and jasmine, you just get something that smells like “lilac and jasmine”. But the four combinations above seem- to me- to give rise to new exotic qualia varieties.

An accord is more about getting rid of the individually distinguishable component scents. The end result, however, is one of a “generic” scent within a given category (or subcategory). For example “white flower accord” or “citrus accord” are common. And although you can distinguish between two citrus accords, they don’t really have unique character – at least not more than e.g. various kinds of brown noise have a unique character. The combinations I’m mentioning are not just ways of creating a category blend so that other elements of the perfume can be more noticeable. Rather, they are on their own uniquely characteristic, much like other pure essential oils.

If you mix a wide enough variety of flowers you inevitably get a flower accord. To get a new qualia type emergent you need something else. (I should add I’m new to the field and have a lot to learn).

I’m developing a way of explaining what a scent is like at a glance with relatively few parameters. One of them is category entropy, meaning how close a given category in the scent is to the maximally blended version of it (i.e. a fully generic “flowery” scent has maximum category entropy).

Then another parameter is the “global entropy” which describes how close the scent is to total white noise scent.

So we start by saying e.g. perfume X is “50% of the way to white noise scent and its distribution of core categories is 30% woody, 30% floral, 20% fruity, and 20% citrus”, then we zoom in to each category and describe its category entropy and salient notes: “the floral entropy is 40%, and the 60% remaining is shared in equal measure between rose and azalea” (repeat for each category).

Additionally, another important thing to add is if there are “note to note interactions”, which in my (limited) experience happens with some pairs. Maybe 10% of them, but I don’t know for sure. But you could describe them with lines between individual notes in a diagram. To round it all out, you also would point out the note accords that work as “phases” in the overall scent (drawing inspiration from high entropy alloys – an alloy that does not make a single crystal structure is called “multiphasic”). E.g. mango + patchouli + cinnamon + jasmine tends to produce two phases, a mango + cinnamon phase that toggles in your attention with the jasmine + patchouli phase. Finally, we would also note “valence inversion” effects that happen when there are combos of scents that when placed together give rise to a flipped valence (also a rare effect, IME).

For a slightly higher level of resolution, we would break down each category into subcategories and then describe the entropy of each. E.g. a floral perfume could be 80% of the way to maximum floral entropy in the “white flower” subcategory but only 10% of the way to maximum entropy in the “powdery flower” category.

This would allow us, I think, to put our finger on many scents that are hard to describe otherwise. Indeed, a lot of sophisticated perfumes, IMO, are playing a lot with different shades of high entropy, so talking about them in terms of notes like jasmine or amber is very misleading. It’s like calling a certain kind of brown noise “closest to a guitar sound” because one lacks words for describing noise profiles.

January 23rd 2020

Scent Factorization:

So we know that we can get “white noise smell” by combining 42 scents of completely different kinds at the same time. This maxes out the “scent entropy” (aka. “Laurax”).
If you combine 42 different flower scents, however, you get a maximally generic “flowery scent”. I call this “category collapse”.

Now some scents have what I call “special effects”, which are category-neutral qualities. An example is the ‘bitterness’ of grapefruit, which although is often associated with fruits, can occur in entirely different categories too.

So I thought: what if we try to combine scents from as many categories as possible that all share the same special effects? I call this “scent factorization”. Namely, you try to get “special effect + Laurax” by canceling out everything but the special effect.

I believe this actually works. Example:

A factorization of “bitter-sweetness” can be obtained by mixing:

Grapefruit + Geranium + Bergamot + Pomegranate + Cedar-wood

In this case you will see that geranium is almost like “the grapefruit of flowers” in that it is flowery in nature but still shares the same “bitter” quality as grapefruit (albeit at a different frequency – yes scent frequencies are a thing, but that’s a story for another time). Likewise, cedar-wood is the most grapefruit-like wood I’ve smelled.

Another interesting factorization is that of “creaminess”:

Coconut + Fig + Vanilla + Almond + Sandalwood

In this case, again, you’ll see that sandalwood is the most “creamy” of all woods (as far as I have tried), fig is the most creamy of all fruits, and so on.

But this is just the start. What other scent factorizations could we try? I’d say we could aim to have the special effects of “ozonic”, “green”, “ethereal”, “powdery”, “acrid”, “cloying”, and so on factorized. Each deserves to become its own perfume in my up and coming new line of high end perfumes called “The State-Space of Scents” (for the consciousness connoisseur).

February 2nd 2020

The Qualia Review – Episode 1: Women’s Perfumes (Part 1):

The Qualia Review – Episode 1: Women’s Perfumes (Part 2)

The Qualia Review is a tongue-in-cheek program where you will get non-expert opinions about the quality of experiences by people who really care about consciousness:

In each episode, Andrés Gómez Emilsson (qualiacomputing.com) reviews a particular qualia variety (i.e. category of experience) with a co-host (in this episode Victor Ochikubo).

In this first episode we review women’s perfumes. In particular, we review (from worst to best):

La Panthére by Cartiere (EDT)
By Invitation by Michael Bublé (EDP)
Guilty by Gucci (EDT)
Brit Rhythm by Burberry (EDT)
Jolie Fleur Bleue by Tory Burch (EDP)
Rose Goldea by Bvlgari (EDP)
Daisy Love by Marc Jacobs (EDT)
Valentino by Valentino (EDP)
Amazing Grace Ballet Rose by Philosophy (EDT)
Light Blue by Dolce & Gabbana (EDT)
Eros by Versace (EDT)

You will notice that this is unlike any other review of perfumes. This is because the review here provided addresses the following three aspects of scents:

  1. A qualia-focused account (i.e. entropy, categories, special effects, etc.)
  2. What kind of person would enjoy wearing this perfume (mood-congruence, personality, etc.)
  3. The social signaling that the perfume entails (sexual signaling, genetic fitness signaling, etc.)

In particular, (1) describes scents in terms of:

  • A) The global entropy (e.g. 40% of the way to white noise scent)
  • B) The within-category entropy (e.g. 70% of the way into ‘generic flowery’)
  • C) The individual notes that can be detected within each category (e.g. non-generic jasmine note being 30% of the flowery category)
  • D) Lines connecting notes that have non-linear interactions (e.g. pear & violet, rose & orange, pomegranate & honeydew make unique blends that have phenomenal properties unlike those of the individual ingredients)
  • E) Lines connecting notes that form separate “phases” across categories (e.g. with a mixture of mango, sandalwood, rose, lemon, and cinnamon you get three phases rather than a global consistent smell – mango + cinnamon, and lemon + sandalwood, with rose staying its own distinct scent)
  • F) Lines connecting “valence inversion” effects (some notes simply don’t seem to go together even though they are pleasant individually)
  • G) Special effects (e.g. “powdery”, “ethereal”, “acrid”, “creamy”, etc.)

Thus, we share an entirely new angle on how to describe the ineffable. Namely, the hard-to-put-your-finger-on elusive subjective quality of scents can finally be grounded in terms we can all understand (with a modicum of shared background assumptions).

Hope you enjoy! Happy scent qualia!

~Infinite Bliss~

February 5th 2020

Three scents that are surprisingly similar to strawberry (based on my personal experience with essential oils):

  1. Fig
  2. Freesia
  3. Peony

In fact, following the “scent factorization” concept – if you make a mixture of these three scents the resulting oil smells almost exactly like strawberry cake. Strange!

February 9th 2020

I love this video! The idea that the information content in a perfume could possibly fit so much phenomenal detail is enticing, albeit perhaps a bit optimistic.

In the interest of honesty, out of the 15 or so women’s perfumes I’ve experienced deeply so far, La Panthere by Cartier is the worst by quite a long shot.

I don’t mean this to troll! I am serious. I still don’t quite know why I feel it as so unpleasant. I think it has to do with its very high entropy quotient, and the fact that it centers around gardenia, which is my least favorite flower. It feels predatory – and perhaps the perfumist did succeed at telling a story. Too bad I aim to reprogram the biosphere so that predation is a long-forgotten nightmare of our ancestral Darwinian environment of adaptedness. So long! We should aim to transform scent exploration from its current state of commercialism mixed in with weapons of sexual conquest, and push it into new frontiers… the exploration of the state-space of consciousness, valence research, perhaps even energy parameter modulation! The future of scent qualia research is wide open.

The Qualia Review – Episode 2: Men’s Perfumes

The Qualia Review is a tongue-in-cheek program where you will get non-expert opinions about the quality of experiences by people who really care about consciousness:

In each episode, Andrés Gómez Emilsson (qualiacomputing.com) reviews a particular qualia variety (i.e. category of experience) with a co-host (in this episode Victor Ochikubo).

In this second episode we review men’s perfumes. In particular, we review (by order of appearance):

CK2 by Calvin Klein (EDT)
Pasha de Cartier Edition Noir by Cartier (EDT)
Virtu by Vince Camuto (EDT)
21 Le Fou by Dolce & Gabbana (EDT)
Le Male by Jean Paul Gaultier (EDT)
Scuderia Ferrari Light Essence Bright by Ferrari (EDT)
Jimmy Choo Man Blue by Jimmy Choo (EDT)
1 Million by Paco Rabanne (EDT)
Terre D’Hermes by Hermes (EDT)
Invictus by Paco Rabanne (EDT)
Bleu De Chanel by Chanel (EDP)

In this episode we also discuss the way in which an enriched conception of art could helps us reformulate the artistic potential of perfumes. We make allusions to the 8 models of art discussed in a previous video:

Harmonic Society: 8 Models of Art of a Scientific Paradigm of Aesthetic Qualia

See also:

Harmonic Society

Hope you enjoy! Happy scent qualia!

~Infinite Bliss~

February 10th 2020

Top 5 Male Perfumes:

  1. Bleu de Chanel (EDP)
  2. Scuderia Ferrari Light Essence Bright (EDT)
  3. Le Male by JPG (EDT)
  4. Nautica Voyage (EDT)
  5. 21 Le Fou by D&G (EDT)

It’s very sad that there is a huge paywall for scent qualia. It’s your birthright to know what they smell like!

February 11th 202084357695_2785896804835792_4296261472725499904_o

~120 essential oils and ~40 perfumes (ordered by categories and general character).

This is the dataset my brain has been training over to interpret the state-space of scent qualia for the last month and a half. This is still amateur level – but I can nonetheless confidently say that I now understand scent qualia at least 50% better than I did last year.

I would still appreciate specific suggestions for essential oils or perfumes to get that are very unusual or characteristic. I continue to be surprised by the uniqueness of oils, fragrances, and mixtures I haven’t tried before.

Also: drastic income inequality is a massive tragedy, no doubt. But why are people not talking about qualia inequality? I wish everyone was as qualia-rich as I am right now. I’m happy to share some scents with people who feel qualia-deprived; just come to the Bay and give me a call. 🙂

Ps. Peony is an incredibly versatile low-entropy flower scent with a creamy strawberry-like effect. I kept reading about how this or that perfume has peony in it, but it really took me owning an essential oil of it to grok the type of qualia peony is all about. Someday there will be a monument built to celebrate the qualia variety disclosed by peony formulas. I’m pretty sure of this.

February 14th 2020

People say “a blind buy” when they talk of buying a perfume they haven’t smelled. Shouldn’t it be more appropriate to say an “anosmic buy”?

February 18th 2020

In order to survive the apocalypse, having a “blue” fragrance on hand will become very useful. I suggest “Nautica Voyage“.

You can thank me later!

February 21st 2020

Sense of Smell is Linked to Sexual Orientation, Study Reveals

Very interesting! Two followup questions: (1) does it replicate on a larger sample size? and (2) is the baserate of different sexual orientations of anosmic people statistically different than those of the general population?

Gay men showed a strong preference for the body odour of other gay men in the scientific test of how the natural scent of someone’s body can contribute to the choice of a partner.


Although previous studies have shown that body odour plays a role in making heterosexual men or women attractive to members of the opposite sex, this is the first study that has investigated its role in sexual orientation. Charles Wysocki of the Monell Chemical Senses Centre in Philadelphia, a non-profit research institute, said the findings underline the importance of natural odours in determining a sexual partner whatever the sexual orientation of the person involved.


“Our findings support the contention that gender preference has a biological component that is reflected in both the production of different body odours and in the perception of and response to body odours,” Dr Wysocki said.

February 25th 2020

Review of Shalimar Eau de Parfum by Guerlain for women:


February 27th 2020

Jasmine, Tuberose, and Gardenia: the Dark Triad of White Flowers. Beware! They are treacherous, envious, and guileful. DO NOT TRUST. They will ruin your perfume with their high-entropy indolic ‘broad spectrum scent noise’. Deranged, distracting, and disingenuous. #FlowerProblems

March 12th 2020

Why you should not insufflate ketamine: (1) it can irreversibly damage your bladder and cause very serious untreatable chronic pain, (2) it can damage your liver, also very painful, but above all (3) it will slowly degrade your ability to experience scents! Not worth it IMO!

Cocaine is well known for causing anosmia in regular users. I suspect we are going to see a wave of anosmic people as ketamine becomes more popular. Don’t be a victim. “Remember kids, don’t insufflate drugs – either eat them or inject them” would be my DARE go-to phrase.

March 16th 2020

Running out of hand sanitizer but you are fab and have a perfume collection? Use some cheap perfume instead! It’s usually 70+% alcohol.


March 22nd 2020

There’s An Unexpected Loss Of Smell And Taste In Coronavirus Patients

Factoring in the loss of precious qualia would make this epidemic even worse. This year I’ve finally begun appreciating the state-space of scents. I’m heartbroken to learn about this effect. So much qualia in potentia that might be lost!

March 23rd 2020

We should emphasize the possibly of life-long loss of smell in order to get more young adults onboard with strict social distancing measures. A 20-something person might not fear a fever, but they may fear “having less sexy sex and enjoying food less for the rest of their lives”.

March 26th 2020EUF6KWvUEAIAbO5

Sense of smell over the years. People under 40: please do yourself a favor and get some nice scents so you enjoy them while you are still sensitive to them. It’s always a tragedy not to use a qualia variety and then lose it. #qualia #scent #aging #valence #bliss #WeAreTheQualia

March 29th 2020EUQLBqVUEAA3Nwh

This is the future – in 2010 I was saying that in the long run humanity will need to adopt entirely new and seemingly extreme measures against contagious diseases.

Nasal filters (aka. “nose condoms”) were one of the ideas I was considering at the time. Reality is now catching up with fiction.

Why adopt extreme measures? Because we haven’t seen anything yet. The possibility of rational virus design and the political will to invest in innovative weapons means that sooner or later we will encounter things with a case fatality rate > 80% and R0 > 4. Nothing short of large-scale contact network engineering and the widespread use of tech like nasal filters can really work against those long-tail risks.

Perhaps in the future going out without nasal filters will be considered as reckless as today it’s considered having unprotected sex with a random stranger. #NasalFilter #TheNewMask #PM2point5

April 8th 2020


Bright Neroli

Summer 2020 Unisex Perfume Recommendations:

1. Bright Neroli – Ferrari (amazing sharpness and cute Sicilian dry-down)

2. Monserrat – Bruno Fazzolari (incredible grapefruit punch and bitter-sweet resonance)

3. Born – Adidas (a cheap but highly rewarding lavender rhubarb scent).

April 21st 2020

Haven’t posted about scents in a while; I’m still actively researching this fascinating qualia variety (better do so while I still have scent qualia, which may of course go away if/when I acquire COVID-19).

I’ve developed a lot of new vocabulary to talk about scents. In particular, I like to break down a scent in terms of entropy (how close to ‘white noise scent’ it is), category distribution (% woody, citric, fruity, etc.), category-specific entropy (e.g. 70% of the way to ‘generic flowery’), specific notes (e.g. 10% rose), and of course, “special effects” (such as “creamy”, “powdery”, “bitter”, etc.).

A recent “special effect” I’ve explored is the rather peculiar feeling that the scent is “flammable”. For example, gasoline has it, and so does ethanol. It is similar to the feeling you get when you inhale nitrous oxide. A kind of fascinating gas-like intoxicated state that produces spatiotemporal confusion and a sense of resonance. Of the scents I currently have access to, 100% pure Neroli essential oil strongly triggers this particular special effect. Neroli has that strange “flammable” quality, perhaps an octave or two in pitch higher relative to gasoline. It’s equally enthralling as the smell of gasoline (for those who like it) but much more dinner-party-friendly.

Anyway, with this “flammable” special effect in mind, I’ve been exploring what can be added to it in order to create beautiful scents. Last night I found a combination that made me really happy. It consists of equal (intensity-adjusted) parts of:

  1. Neroli oil
  2. Orange essential oil
  3. Lime essential oil
  4. Pear essential oil

It is sweet, sour, and gasoline-like in an unexpectedly euphoric way. I highly recommend this quale. I very much like its vibe. Meet me there.

April 28th 2020



First I tried essential oils. Then I tried perfumes. Now I’m entering a third phase in my “scent literacy” journey: pure molecules.

I have 50 pure perfume ingredients in an air-tight container now. And I have been trying out a couple each day in a systematic way in order to map out the state-space of scents.
One core insight so far:

Essential oils are extremely rough approximations for “building blocks” of scents. Perfume notes are often described in terms of fruits, woods, flowers, animalic sources, etc. But “apple” is not a natural unit of scent qualia. Although there is a general “apple vibe”, in reality that vibe can come from any of 20 or so different molecules. Additionally, many molecules that have an apple vibe do not even appear in biological apples (and vice versa). I’ve so far tried two apple-vibe molecules:

  1. Alpha Damascone: The smell of a dried out green apple, slightly past its prime, unsweetened and with trace amounts of beeswax wrapper stuck to its skin.
  2. 5-octen-1-ol: The smell of extremely mild refrigerated apple sauce, slightly waxy, reminiscent of sandalwood, and at a slightly higher “phenomenal frequency” than damascone.

In other words, I’m learning that pure molecules are indeed more “simple” than essential oils by far. They feel very specific and low-dimensional rather than voluptuous and scenic. But despite their relative simplicity, they are still not “categorically pure”. A single molecule can smell woody, fruity, and camphorous all at the same time. Part of the story is likely that a single molecule can have a broad spectrum of receptor affinities. But even if only one scent receptor were to be activated, perhaps the resulting experience would also not be uni-categorical.

The fascinating implication here is that scents that feel very uni-categorical (e.g. pear essential oil being unequivocally “fruity” with no hint of floral or woody) are more likely to be compositions of many molecules!

Each uni-categorical accord is made by mixing many molecules that all share the same “main vibe” but have different “secondary traits”. This way the accord lets the secondary traits “cancel out in white noise scent” while the main vibe is additively compounded into a broad-spectrum power-punch of a single category, like fruity (reminiscent of “scent factorization”, which I’ve described in previous posts).

May 2nd 2020

You don’t need to be phenomenally rich in order to be phenomenally rich!

I’m an advocate of high-dose behavioral enrichment (I talk about it at 22:16):

May 3rd 2020

The Perfect Scent excerpt:

Ellena will dip a touche into a molecule called isobutyl phenylacetate, which smells vaguely chemical and nothing else, and another into a synthetic molecule whose common chemical name is ethyl vanillin. (A rich gourmandy vanilla molecule, its IUPAC name is 3-methoxy-4-hydroxy benzaldehyde, and it is the heart of Shalimar.) He puts the touches together and hands them to you. Chocolate appears in the air. “My métier is to find shortcuts to express as strongly as possible a smell. For chocolate, nature uses 800 molecules, minimum. I use two.” He hands you four touches, vanillin + natural essences of cinnamon, orange, and lime—each of these has the full olfactory range of the original material—and you smell an utterly realistic Coca-Cola. “With me,” says Ellena, “one plus one equals three. When I add two things, you get much more than two things.”


He will hand you a touche that he has sprayed with a molecule called nonenol cis-6, which by itself smells of honeydew melon or fresh water from a stream. He’ll then hand you a second touche with a natural lemon on it, direct you to hold them together now, and suddenly before you appears an olfactory hologram of an absolutely mesmerizing lemon sorbet.


The explicit point was not to create a thing but an illusion of that thing, an olfactory alchemy. The point of Nil was not to create a green mango but the illusion of a green mango.




Junior perfumers discover that Vetiver Huile Essentielle from Haiti smells like a Third World dirt floor and Vetiver Bourbon from Isle de la Réunion smells like a Third World dirt floor with cigar butts. (They hope to do something wonderful with the cigar butts.) They learn, as Ellena knew from decades of work, how to create the illusion of the scent of freesia with two simple molecules, both synthetics: ionone beta + linalool. And orange blossom: linalool + anthranylate de methyl, which by itself smells like aspirin. The classic Guerlain perfumes often used a molecule called styrex, which smells of olive oil pooled on a table in a chemical factory. Add phenylethylic alcohol and you get lilac. Add the smell of corpse (indoles), you get a much richer lilac. And you can give your lilac, freesia, and orange blossom a variety of metallic edges: Add allyl amyl glycolate, you get a cold metal freesia. Add amyl salycilate, and you get a freesia with the smell of a metal kitchen sink dusted with Ajax powder. Aldehyde C-12 lauric adds an iron with a bit of starch still on it.

May 8th 2020

Excerpt from Luca Turin and Tania Sanchez’s 2008 perfume guide:

Sports Fragrances:


The last decade has seen the unfortunate flourishing of a dismal genre, the fragrances for men and women who do not like fragrance and suspect that none of their friends do either. The result has been a slew of apologetic, bloodless, gray, whippet-like, shivering little things that are probably impossible, and certainly pointless, to tell apart. All fragrances whose name involves the words energy, blue, sport, turbo, fresh, or acier in any order or combination belong to this genre. This is stuff for the generic guy wishing to meet a generic girl to have generic offspring. It has nothing to do with any other pleasure than that of merging with the crowd. My fondest hope is everyone will stop buying them and the genre will perish. Just say no.


Lastly, and by way of contrast, remember that perfume is foremost a luxury, among the cheapest, comparable to a taxi ride or a glass of bubbly in its power to lift the mood without causing subsidence the morning after. Wear it for yourself.


– Luca Turin in PERFUMES: THE A-Z GUIDE (2008)

May 13th 2020

The perfume Tommy Girl just registered as an outlier to my nose. It registers as high in valence as Bleu de Chanel and Bright Neroli by Ferrari. Extraordinary perfume. 10/10 #ScentQualia

May 27th 2020

The Rainbow God Experience

One of the most interesting lines of evidence pointing in the direction of the Symmetry Theory of Valence is how in the neighborhood of the peak of high-energy neural annealing events one can often glimpse states of consciousness with a characteristic “full-spectrum of qualia” property.

This may happen nearing the peak of a strong LSD trip, during intense Jhanic concentration, Fire Kasina practice, or even just spontaneously (though extremely rarely).

At the actual peak of the annealing process you are likely to arrive at a “moment of eternity“- itself extremely high-valence- where the symmetry is so complete that it becomes impossible to distinguish between self and other, before and after, or even left and right (this is a phenomenal property of peak valence states, and not proof of Open Individualism and non-duality per se, even though most people tend to interpret such experiences that way).

The “Rainbow God” phenomena lives at the edge of such peak valence states.

Timothy Leary in “The Psychedelic Experience” says that as you approach the highest bardo you are given the choice between “tasting sugar” and “being the sugar”.

The former is close to the peak of the annealing process, where there is enough asymmetry in the state for you to be able to encode information and distinguish between past and future, self and other, etc. and thus able to experience a projective world-simulation and the illusion of a self that “experiences it”. At the top of the annealing process, however, the extreme symmetry does not allow you to do that. The valence is almost certainly higher, though the degree of consciousness is arguably lower. You are “the sugar” rather than “tasting the sugar” (i.e. you are luminosity rather than a constructed world-simulation “experiencing luminosity”).

Stunningly, this edge between perfect symmetry and its surroundings in configuration space often shows extreme levels of qualia diversity. This is an empirical observation you can verify for yourself (or you can trust me, find others who have experienced it, or derive it from first principles).

What is it like? At this boundary between quasi-perfect symmetry and perfect symmetry you experience rainbows with all the phenomenal colors in the CIELAB color space (and perhaps some other colors that you only see in heaven, like blue-yellow and red-green, which require enough energy to overcome the lateral-inhibition opponent process going on in the cortex at all other times). You experience a sense of “all possible temporalities”. A sense of “all possible scents”. And a sense of all possible spatial relationships at once.
If you get any closer to the peak of annealing, the rainbows collapse into luminosity, the scents into a sense of presence, the temporalities into a sense of eternal now, and the possible feelings of space into a projective-less “view from nowhere”. The combination of all qualia values of each qualia variety somehow, incredibly, seem to add to zero. But not any kind of zero. A special “Zero” perhaps equivalent to “no information but awake”. (Cf. David Pearce’s Zero Ontology for a possible grounding of this state in fundamental physics.)

Yes, this is very much a real state of consciousness. It is profound, and extremely important.

I call it the “Rainbow God” state of mind. I do not know how to reliably induce it, but I do know that it is likely to have extremely deep computational, ethical, and experiential properties capable of advancing our understanding of the nature of the state-space of consciousness. I just figured you should know this exists.

June 2nd 2020

Andreas Keller • Olfaction and Experiential Authenticity:scent_presentation

Really excellent presentation about the biological and physical underpinnings of scent. It’s a bit on the long end (50 minutes) but you can get 80% of it by just watching the first 12 minutes. It’s really good! So much information…

For instance: did you know there are about 400,000 scented flower species in the world? I struggle to come up with more than 30 flowers off the top of my head (up from 5 just less than a year ago). The remaining 399,970? Who knows what they smell like. We don’t have words for these smells… is it “rose” or “jasmine” smell? Good luck using that kind of ontology describing the space of possible flower smells.

Also: it turns out that volatile molecules don’t diffuse very effectively. So that’s why you get “whiffs” of scents – for the most part, in the wild, air is a very non-homogeneous gas, with all kinds of pockets with specific linear combinations of aromachemicals. Hence why holding two essential oils side by side doesn’t give rise to a proper mixture between them. You need to literally mix the oils and then smell the mixed result if you want to actually know what the combination is like. Otherwise you will get a whiff of one, a whiff of the other, etc. with a Poisson-like distribution. This also reminds me that: we have an olfactory bulb in each nostril! So if you apply one scent in one nostril and another scent in the other nostril, you will get a kind of “bi-scent rivalry” [binosmic?] similar to what you get when you see one image with the left eye and one image with the right eye (i.e. “binocular rivalry”).

I do think that “digital smell” is possible (unlike the presenter). But it will require us to describe each molecule in terms of their ADSR patterns for each of the basic scent qualities (that is, to describe how the sweetness develops across time – its attack, decay, sustain, and release – and do the same for each core qualia scent dimension). Without taking into account the ADSR envelope for each molecule, the mixtures will be uneven.

The lowest-hanging fruit would be to use a non-negative least squares regression that minimizes the error for the envelope of each of the core qualia scent dimensions. Hence, the molecular spectrum is not enough – the non-negative least squares requires pattern-matching across the entire temporal envelope of each dimension. IF we do this – then digital smells might be possible after all (IMO!).

June 3rd 2020

There are a TON of questions whose real answer is: “Bleu De Chanel”. Think about it.

That’s how VAST the multiverse is.

“Bleu De Chanel” spans eons and eons of subjective time – the grapefruit/incense/amber vibe ringing on and on throughout eternity. That’s how large it ALL is.


You can get a powerfully believable Smirnoff Lime impression with as little as a few drops of citral and aldehyde C-12 in an ethanol + water mixture. Amazing what passes as a “fine drink” these days.

“At least add some linalool to make it worth it” – would be my recommendation.


Note to self: by virtue of their sharp smell, aldehydes are powerful high-frequency psychoactives.

June 6th 2020

Note to self: Smelling a bunch of aldehydes over and over for several days in a row causes bad headaches. Use them only occasionally from now on.

June 13th 2020

I asked a DMT being about the nature of scent qualia. Its response: “One hint: are you sure it’s only one kind of qualia?”

An insight came like a lightning bolt. Yes! Two types:

  1. Aromachemicals that are “character impact”
  2. Flavor-like vibes

Totally different state-spaces!

Luca Turin, the quantum neurobiologist who has done research on the vibration theory of olfaction (showing “we can smell functional groups”) told me that if perfumes are tomato soups, the money is in “making the best cream” rather than in the “tomatoes”. Character impact!

Examples of character impact molecules:

  1. Beta-ionone
  2. Iso-E-Super
  3. Ambroxan
  4. Hedione
  5. Helional

Examples of flavor-like vibe molecules:

  1. Alpha-damascone (beautiful!)
  2. Aldehyde C-12
  3. Citral
  4. Cis-3-hexanyl-benxoate (yuk!)
  5. Verdalia

June 20th 2020


Magenta: The Non-Spectral Color

An important point of confusion about qualia to which I offer a clarification:

The qualia you experience as a result of light coming into your eyes can be logically and empirically dissociated from physical light. Color qualia, just as much as visual texture qualia, can be triggered by auditory stimuli in people with synesthesia, or people tripping. More so, you don’t even need light to ‘see’ in your dreams. Visual qualia is ultimately not intrinsically tied to physical light. Phenomenal light, as it were, is a particular spatial qualia that we use to ‘illuminate’ our inner world simulations. Yet this illumination is not based on photons.

Hence the mystery of magenta: phenomenal colors don’t always map on to frequencies of light. Even leaving aside the issue of metamerism, magenta itself is a ‘non-spectral color’ because you need to combine at minimum two frequencies of light to trigger that color qualia in your visual field (namely, a combination of the upper and lower frequencies you can detect).

Why do we experience color qualia from light, then? This is not out of logical necessity, but rather, because it happens to have the appropriate information processing properties for the mapping to be evolutionarily advantageous. The state-space of color and visual texture happen to have useful isomorphisms to the structure of visual data. But there is nothing to suggest they are the best at representing ‘projective data-structures’.

In fact, I strongly suspect that once we master free-wheeling hallucinations and qualia control techniques, we will discover new applications of exotic qualia varieties for information processing purposes. Such as, for instance, using complex synesthetic representations of natural numbers that make it easy to ‘feel’ whether a 10-digit number is prime or not.

Anyhow, this all informs the kind of answer I might give to the question “what is it like to be a bat?”. In particular, it compels me to say that for all we know echolocation information is represented with scent qualia. We simply don’t know enough about the information-theoretic properties of state-spaces of qualia varieties to make an educated guess for what kind of qualia is best at representing echolocation information.

And more so, even if you were to train a human to use echolocation from birth, there is no guarantee that the qualia varieties and the associated state-spaces their brain would recruit for that task would have anything to do with bat echolocation qualia. So the problem has more moving parts than is usually assumed.

June 28th 2020

“Son, there is something I’ve been meaning to tell you for a long time, but only now I’m brave enough to do so: I just don’t think aromatic Fougères are a good fit for you. Based on my experience, I think Chypres would fit you better. Or even some woody citruses. Not Fougères.”

July 16th 2020

I love smelling dirty every once in a while.Photo on 7-16-20 at 3.59 PM

July 19th 2020

If you have a prejudice against the smell of single molecules because they are “too simple” and you need some “entourage effect” balanced blend “only nature can provide”… try smelling Agrumen Aldehyde Light. A single molecule that smells like a full perfume!

Soapy lime herbal!

July 22nd 2020

Freesia is 90% linalool and 3% beta-ionol. I suppose that’s why my 50%/50% mixtures weren’t quite Freesia-like.

July 24th 2020

Vimalakīrti then asked the bodhisattvas from the Host of Fragrances [world], “How does Accumulation of Fragrances Tathāgata explain the Dharma?”


Those bodhisattvas said, “In our land the Tathāgata* explains [the Dharma] without words. He simply uses the host of fragrances to make the gods and humans enter into the practice of the Vinaya. The bodhisattvas each sit beneath fragrant trees, smelling such wondrous fragrances, from which they attain the ‘samādhi of the repository of all virtues.’ Those who attain this samādhi all become replete in the merits of the bodhisattva.”


– Chapter X – The Buddha Accumulation Of Fragrances

[*Tathāgata is an honorable name for the Buddha of a realm.]

July 30th 2020

Emergent scents – when you combine two or more aromachemical cocktails and you get as a result a scent that is different than the sum of its parts.

I have in the past found a number of essential oil combinations that do this (pear + violet, pomegranate + honeydew, lemon + lavender). But I figured that it’s much better to try to identify clear cases of this phenomenon by combining pure molecules.

So this little “research program” I have going on is to find pairs of aromachemicals and then mix them in many different ratios and smell the results (usually dissolved in ethanol at a concentration of ~20%). So far, it seems that about ~25% of pairs of molecules I’ve tried result in emergent scents. Here are some specific examples (please feel free to try at home and verify!!):

1) Humulene + d-limonene: Humulene smells herbal and earthy, d-limonene smells like orange or mandarin. When the ratio is ~4:1 I get an emergent scent that I can only describe as “classic chewing gum flavor”, completely distinct and phenomenally richer than the ingredients alone.

2) Linalool + beta-ionone: linalool smells like a very gasoline-like volatile version of a flower scent, beta-ionone is the classic “violet scent” molecule. When combined in 9:1 ratio I get an emergent scent that is like that of a citrus version of freesia or peony.

3) Humulene + vanillin: vanillin is the smell of vanilla, which is watery at the onset (attack and decay) and creamy on the second half (sustain and release). When combined in 1:1 ratio you get a completely new scent that feels close to a dried out old tobacco Cuban cigar blended with coffee liqueur.

That last one is also relatively close to the classic combination of vanilla + vetiver. Luca Turin told me that the perfume called Habanita is precisely playing with a vanilla/vetiver combo, which at first sniff comes across as a completely new and unrecognizable (yet very pleasant) scent. He said that a wonderful metaphor for this phenomenon is like the song Loro by Gismonti, where in the second half the piano and the flute play in such a synchronized fashion that you get the impression that there’s a new instrument involved. I’ve been smelling vanilla/vetiver while listening to this song. It’s quite beautiful.


Humulene combined with d-limonene create an emergent “missing fundamental” type olfactory illusion of classical chewing gum flavor. It only works when Humulene is between 70% and 90% of the mixture (before adding ethyl alcohol). Cleanest example of “emergent scent” I’ve found.

Humulene is a simple scent of the category “earthy”, roughly similar to a vetiver essential oil but “one octave higher”. It also has a very mild musky undertone.

D-limonene is an orange/lemon-like scent. Extremely common in perfumery. Chances are something you ate today has it.

July 31st 2020

The simplest example I can think of to illustrate what an “emergent scent” is comes from the auditory illusion called “the missing fundamental”.

If you play 200 hertz together with 300 hertz and 400 hertz you will hallucinate an emergent 100 hertz tone.

The 100 Hz tone is not there! But it is quite real in your experience.

Of course if you are very acquainted with this auditory effect, you might notice the fundamental (100hz) is a bit fainter than expected, and infer it’s an illusion. But it is nonetheless very much present in your experience.

Likewise, when you smell Humulene + Vanillin at a 1:1 ratio you will get a third smell that emerges as a sort of gestalt that “bridges together” the two underlying notes.

You can probably infer the input scent is made up of two notes if you are really experienced with this kind of phenomenon. But the third note, the gestalt, does not disappear when you have “reduced” it to the two underlying notes. It’s still there. Thus, really, the whole is greater than the sum of its parts.


Hear the effect yourself: Missing fundamentals. Periodicity and Pitch

August 1st 2020

I like my coffee how I like my perfumes: with the fewest chemicals needed to cause the desired effect.

As an aside, learning about emergent effects in low-entropy perfume recipes makes me think that there could probably be a job for “scent simplification”. Namely, take something like cacao, with hundreds of molecules contributing to its characteristic scent. The question is: what is the minimum viable number of aromachemicals you can use to replicate it (within a Just Noticeable Difference unit)?

I suspect most natural scents that come from a complex entourage effect have relatively minimalistic reconstructions. A question that also emerges is: what is the most complex scent? I.e. what is the smell whose minimum reconstruction has the maximum number of molecular diversity?

[It’s important to distinguish between molecular entropy and phenomenal entropy. A solution of Agrumen Aldehyde Light and ethanol has low molecular entropy but pretty high phenomenal entropy, whereas a “lime accord” made of tens of molecules could be high in molecular entropy yet low in phenomenal entropy because it smells very cleanly like a ‘single note’]


A master perfumer like Ellena has memorized hundreds, if not thousands, of recipes for manufacturing smells. Many complex natural scents can be conjured with only a few ingredients. The scent of freesia, he explained, is created by combining two simple molecules: beta-ionone and linalool, both synthetics. (To give freesia a cold, metallic edge, a touch of allyl amyl glycolate is added.) The smell of orange blossom is made by combining linalool and methyl anthranilate, which smells like Concord grapes.


In my presence, Ellena once dipped a touche into a molecule called isobutyl phenal acetate, which has a purely chemical smell, and another touche into vanillin, a synthetic version of vanilla. He placed the two paper strips together, waved them, and chocolate appeared in the air. “My métier is to find shortcuts to express as strongly as possible a smell,” he explained. “For chocolate, nature uses eight hundred molecules. I use two.” He handed me four touches—vanillin plus the natural essences of cinnamon, orange, and lime. The combined smell was a precise simulation of Coca-Cola. “With me, one plus one equals three,” Ellena said. “When I add two things, you get much more than two things.”


The Scent of the Nile: Jean-Claude Ellena creates a new perfume.
– By Chandler Burr

August 5th 2020

Imagine you have been a musician for your village all your life. You play drums and acoustic guitar and you have never heard modern music. One day you are gifted an iPod and you listen for the first time to the crazy sounds of psychedelic trance. For the first time in your life you experience the wonders of reverb, flanging, distortions, and FM-synthesis. Surely this gives you a sense that your conception of music only tapped into a tiny fraction of what had always been possible.

An analogy could be made with smells: having tried essential oils one gets the impression of understanding what is possible in the realm of scents. But one day you discover Galaxolide, hedione, and eso E super. Like reverb and FM-synthesis in sound, these compounds are capable of giving surreal, unexpected, and space-warping properties to scents (much like reverb in sound, they are character impact molecules, meaning that they modify the presentation of other scents more than contributing a ‘flavor’ of their own).

Galaxolide in particular is something you have probably smelled, either in perfumes or detergents, but it really only becomes clear just how insane of a substance it is when you smell it raw. I associate it with “DMT Realm Aesthetics” – like a smell coming from another planet where hyperdimensional experiences are common everyday events, and the world of the arts uses exotic phenomenal time routinely. It has a vibe I can only describe as “having already always been here yet just arrived”. It’s probably what traveling in time feels like when you are in a transcendent Bardo between lifetimes.


Pellwall describes galaxolide thus: “Galaxolide is an isochroman musk, that has an odour profile that is liked by most people and is similar to a macrocyclic musk. It is strong, clean smelling and a good fixative. It combines well with other musks and is often used in combinations.”

In wikipedia, they describe the scent as: “a synthetic musk with a clean sweet musky floral woody odor”.

I think the musk-like quality accounts for maybe 60% of its effect. But I swear there is something much more special about it than just a clean musk. It has a kind of time-dilation effect, and it seems to my nose as a “musk but high-dimensional”. Perhaps it’s musk + the harmonics of musk. So while other musks are just a single note, galaxolide is like the feeling of a musky accordion.


I’ll write about my setup for doing this kind of research, but suffice to say that it’s super cheap if you know what you are doing. Each experiment (i.e. a little bottle with a few ml of a new combination in precise proportions) costs me about ~30 cents to make, all things considered (the cost of the materials, the ethanol, the pipettes, the bottle).

I highly recommend just getting a 2ml sample vial. It can cost as little as $2.16 (plus shipment) here: Galaxolide.

Other stellar molecules to try out to expand your conception of what’s possible:

Linalool, dihydro linalool, alpha-damascone, damascenone, helional, C-16 aldehyde (strawberry), agrumen aldehyde light, farnesene, nerolione, and alpha-ionone. All of that can cost you as little as $30. Not a bad price for expanding your “sense of what’s possible”.


I so wish I had a “DMT-smell accord” to use as a note in perfume compositions.

There is this one here meant to evoke the hallucinogenic state, but reportedly it has nothing to do with the actual scent of DMT, which I find very disappointing. I will try to find the way to emulate the scent of it – I suspect that linalyl acetate and coranol could be part of the compounds making up that accord. I’ll let you know if I manage to make anything vaguely resemblant of that scent.375x500.59536

August 14th 2020

Lemon Lavender World

One of the first essential oil combinations I fixated upon was that of lemon plus lavender. You could say it is the “speedball” equivalent of essential oil combos, for it relaxes and excites at the same time. I figured that trying to “understand” the “lemon-lavender world” would be a good exercise in the quest of mapping out the state-space of scents.


Lemon Lavender experiments

I currently have six different lemon essential oils from different brands and places, and seven lavender essential oils. To my surprise, the variability is very substantial. The lemon essential oils range from extremely sour and astringent to sweet and waxy. The lavenders I have also have many different qualities: some are very oily and flavorful, while others are particularly camphorous. Which of the qualities are “essential” for lemon and lavender is surely a matter of convention, though I also think they point to roughly objective attractors – the citrus sharpness of lemon rings high and has a cascading sourness that can be used for waking up the senses, whereas lavender has a narcotic entrancing reverb effect. My quest to understand, and ultimately create, lemon lavender smells was not defined in terms of merely reconstructing the standard natural smells, but as an attempt at understanding how these two qualities interact at the phenomenal level.

The diversity of lemon and lavender oils means that the space of possible combinations is even larger. Of the 42 possible combinations of one lavender oil and one lemon oil I have some are far more blissful and rich than others. I picked a few of my favorite ones to use as “model lemon-lavenders” to try to emulate.

Starting in the spirit that in order to deeply understand a scent I have to be able to construct it from scratch- so that I understand how each piece contributes to the whole- I set myself the goal of creating both lemon and lavender accords and then exploring their combinations. All starting from raw aromachemical ingredients, of course:

Making a Lemon Accord

I have always wanted to know what makes citrus fruits smell the way they do. Empirically, both isomers of limonene are a key piece of the puzzle. For instance, both lemon and mandarin oil have upwards of 80% limonene. Alas, if you smell limonene alone, you will notice it is somewhat one-dimensional in character. It IS pointing in the direction of “citrus” quite clearly, but on its own is indisputably too simple to evoke a real lemon scent.

I had a false start: aldehydes. Aldehyde C-8 through C-15 are all “extremely high-pitch scents”. They give a sharp edge to perfumes like Chanel No. 5 and the like. But they are very hard to use – partly because they are extremely potent. So for a couple of days I worked with combinations of citral and aldehydes that had, though a somewhat citric quality, mostly headache-inducing effects. I ended this series of experiments when I got a headache that lasted 24 hours (this goes to show how far I am willing to go to understand that sweet, sweet lemon qualia).

Taking a step back, I decided to explore a different angle. Valencene (note the great name) is very similar to limonene, except slightly lower in pitch. When mixed in equal proportions with limonene one gets a richer, more believable citrus scent – both molecules seem to say the same thing but in a slightly different voice, which results in a kind of chorus effect (unlike merely doubling the volume of a single voice). Alas, at this point the scent is still a bit flat, and not particularly lemon-like relative to near-enemy citrus fruits like the good old orange, mandarin, or grapefruit.

I recall being very puzzled by the scent of lime, as it seems like a kind of “super lemon” when it comes to its high-pitched sour and astringent character. And no matter how much I tried mixing citrus-like aromachemicals, I found it hard to get any hint of lime in the results. That is until I discovered that lime oil has a great deal of alpha- and beta-pinene. These are molecules that are primarily found in trees (in pines!) and smell very woody. As it turns out, to turn a citrus smell into an outright lime scent you need to add woody molecules. In retrospect, this was always hidden in the name: Lemon + Pine = Lime. After having this insight, I realized that even lemon requires a bit of alpha- and beta-pinene to distinguish it from orange scent.

After a lot of trial and error, the most convincing minimalistic lemon scent I identified is (numbers represent parts):

3 D-Limonene
3 Valencene
1 Citral
2 Linalool
1 Alpha-Pinene
1 Beta-Pinene
1 Nerolione (optional; for a rindy effect)

Making a Lavender Accord

This turned out to be more difficult than making a lemon accord. I think this is not only me: I also own two “fragrance oils” (those products that are advertised in the same context as essential oils, yet in the fine print reveal they are not at all natural, and instead are synthetic reconstructions) of lavender, and neither of the two smell anything like lavender. So I wouldn’t be the first to fail.



Linalool is a key ingredient of lavender, making up about 30% to 50% of most lavender essential oils. This is a very powerful aromachemical that seems to work as a gasoline-like fuel amplifier and modifier for any other scent (“there is no boring ten-carbon alcohol” – Luca Turin). It is also one of the things that makes lavender so narcotic and entrancing. On its own it is already quite interesting. But it is only one of the voices in lavender.

Then you have linalyl acetate, which makes up between 0% and 30% of lavender oil, depending on the species, place of origin, and time of harvest. Linalyl acetate has a “dry” quality, which I associate with “salt” (in fact if you just add this to the lemon accord above you get a smell I would describe as “salted margarita cocktail”). Alpha and beta pinene also play a role in lavender.

Interestingly, a lot of lavender oils also have up to 10% of camphor, which contributes to its narcotic get-well-soon cozy quality. Alas, it is hard to work with this material, and it always smells too synthetic to me. I found that instead I could double-down on beta-pinene, which is more camphorous than alpha-pinene (which is more earthy), and does the job quite nicely.

Finally, centifoleather, farnesene, and various alcohols like coranol can give “flavor” to the accord. In the end, I’ve settled on a minimalistic (but I think effective) arrangement. It does not quite hit the flavor of lavender, but I think does a good job at evoking its “character impact”:

4 Linalool
1 Alpha-Pinene
4 Beta-Pinene
2 Linalyl Acetate
3 Farnesene

Putting It All Together

Ultimately, adding these two accords (and their variations) together does not always produce the best results, as some aromachemicals are repeated and the proportions that give rise to the desired interactions can be scrambled by the combination. This, by the way, is a general reason why synthetic combinations span a much larger space of possible scents. In brief, because to make reconstructions with natural oils you are constrained by non-negative least squares methods, and many combinations may simply be inaccessible that way.

Anyhow – with the combination, I found that adding some character impact molecules like abroxan and helional was important to create a “bridge” between the two phenomenal characters. Alpha-ionol also seems to do something good here that is hard to put your finger on. But I think it’s that it adds the right kind of waxy rindy effect (which it has some of) in a way that does not make the mixture feel “dry” (which more classically citrus waxy smells like nerolione inevitably do). So the end result has some of these three molecules.

I am happy to say that the best lemon lavender reconstruction so far is about as good as the median natural lemon lavender mixture. It is not as good as the best lemon lavender oil mixture, though, but it is a start. I still expect to perfect it quite a bit before unleashing it into the world.

Ladies and gentleman, I present to you Lemon Lavender World:

1 Citral
3 D-Limonene
3 Valencene
4 Linalool
1 Alpha-Pinene
4 Beta-Pinene
2 Linalyl Acetate
2 Helional
3 Farnesene
1 Ambroxan
2 Alpha-Ionol
80 Ethanol


Previous experiments
Marking the interesting ones to keep
Reference bottles of pure chemicals (and one chypre accord)

That Time Daniel Dennett Took 200 Micrograms of LSD (In Another Timeline)

[Epistemic status: fiction]

Andrew Zuckerman messaged me:

Daniel Dennett admits that he has never used psychedelics! What percentage of functionalists are psychedelic-naïve? What percentage of qualia formalists are psychedelic-naïve? In this 2019 quote, he talks about his drug experience and also alludes to meme hazards (though he may not use that term!):

Yes, you put it well. It’s risky to subject your brain and body to unusual substances and stimuli, but any new challenge may prove very enlightening–and possibly therapeutic. There is only a difference in degree between being bumped from depression by a gorgeous summer day and being cured of depression by ingesting a drug of one sort or another. I expect we’ll learn a great deal in the near future about the modulating power of psychedelics. I also expect that we’ll have some scientific martyrs along the way–people who bravely but rashly do things to themselves that disable their minds in very unfortunate ways. I know of a few such cases, and these have made me quite cautious about self-experimentation, since I’m quite content with the mind I have–though I wish I were a better mathematician. Aside from alcohol, caffeine, nicotine and cannabis (which has little effect on me, so I don’t bother with it), I have avoided the mind-changing options. No LSD, no psilocybin or mescaline, though I’ve often been offered them, and none of the “hard” drugs.


As a philosopher, I have always accepted the possibility that the Athenians were right: Socrates was quite capable of corrupting the minds of those with whom he had dialogue. I don’t think he did any clear lasting harm, but it is certainly possible for a philosopher to seriously confuse an interlocutor or reader—to the point of mental illness or suicide, or other destructive behavior. Ideas can be just as dangerous as drugs.


Dennett Explained by Brendan Fleig-Goldstein and Daniel A. Friedman (2019)

It would be quite fascinating to know what Dan would say about lived psychedelic states. With that in mind, here is an essay prompt originally conceived for GPT-3 to satisfy our curiosity:

And after seeing some surprising empirical results with his heterophenomenological methods when examining the experience of people on psychedelics, Daniel Dennett decided to experience it for himself by taking 200 micrograms of LSD. The first thing he said to himself as he felt the first indications of the come-up was…


Maggie and Anders

Maggie Wassinge and Anders Amelin (QRI Sweden volunteer coordinators and content contributors – see letters I & II, letters III, IV, V, & VI, and letters VII, VIII, & IX) decided to give it a go first. We shall then compare it with what GPT-3 can come up with at a later point.

In a way, what you are about to read can be thought of as Anders & Maggie’s simulation of a hyper-intelligent GPT-3-like system’s simulation of a hypothetical Daniel Dennett on LSD. So many layers, I know. But the results speak for themselves:

Dan says: Correlation is all that is needed. So what states a mind uses for modeling conditions of importance to it, is fundamentally arbitrary. Like with language. Words represent things to humans but there are many languages, and words do not resemble what they represent. They only correlate with what they represent, and the correlation needs to be learned. To do science about the mind, one does not need to attach any special weight to any conscious state of mind over any other. One person’s hope may be another person’s despair. These “qualia” are like internally projected hypo-languages which are different all over the map, if there were one. In fact there cannot be an interpersonal map of what things feel like personally. Only naïve people could hope for a fundamental linguistics of consciousness, as if these states were to constitute a universal language of some ground truth of the mind. Silly. Romantic. It’s all arbitrary. For the record, I never said subjective experiential states do not exist. People misrepresent me on that. What I am saying is that it will never be possible to scientifically map what the state that a word such as, for instance, “green”, translates to feels like by the brain of a given individual. My green could be your red.cielab-lch-color-tolerancing-methods

Just drop the whole idea of trying to map the state-space of qualia. That is my position. Or at least I know it is, logically. Right now I begin to notice how everything intensifies and becomes somehow more salient. More revealingly “real”. As I reflect on the notion of how “states” correlate, a humorous episode from my undergraduate student life so long ago, is brought to the surface. At Wesleyan it was, where I was taking a course in Art Appreciation. The lecturer was showing a slide of a still life. A bowl of fruit it was, conspicuously over-ripe. Pointing at one of the fruits, saying “Can anyone tell me what state this peach is in?” There was silence for about three seconds, then one student exclaimed: “Georgia”. Everyone laughed joyfully. Except me. I never quite liked puns. Too plebeian. Sense of humor is arbitrary. I believe that episode helped convince me that the mind is not mysterious after all. It is just a form of evolved spaghetti code finding arbitrary solutions to common problems. Much like adaptations of biochemistry in various species of life. The basic building blocks remain fixed as an operative system if you will, but what is constructed with it is arbitrary and only shaped by fitness proxies. Which are, again, nothing but correlations. I realized then that I’d be able to explain consciousness within a materialist paradigm without any mention of spirituality or new realms of physics. All talk of such is nonsense.Daniel_dennett_Oct2008

I have to say, however, that a remarkable transformation inside my mind is taking place as a result of this drug. I notice the way I now find puns quite funny. Fascinating. I also reflect on the fact that I find it fascinating that I find puns funny. It’s as if… I hesitate to think it even to myself, but there seems to be some extraordinarily strong illusion that “funny” and “fascinating” are in fact those very qualia states which… which cannot possibly be arbitrary. Although the reality of it has got to be that when I feel funniness or fascination, those are brain activity patterns unique to myself, not possible for me to relate to any other creature in the universe experiencing them the same way, or at least not to any non-human species. Not a single one would feel the same, I’m sure. Consider a raven, for example. It’s a bird that behaves socially intricately, makes plans for the next day, can grasp how tools are used, and excels at many other mental tasks even sometimes surpassing a chimpanzee. Yet a raven has a last common ancestor with humans more than three hundred million years ago. The separate genetic happenstances of evolution since then, coupled with the miniaturization pressure due to weight limitations on a flying creature, means that if I were to dissect and anatomically compare the brain of a raven and a human, I’d be at a total loss. Does the bird even have a cerebral cortex?03-brai-diagram

An out of character thing is happening to me. I begin to feel as if it were in fact likely that a raven does sense conscious states of “funny” and “fascinating”. I still have functioning logic that tells me it must be impossible. Certainly, it’s an intelligent creature. A raven is conscious, probably. Maybe the drug makes me exaggerate even that, but it ought to have a high likelihood of being the case. But the states of experience in a raven’s mind must be totally alien if it were possible to compare them side by side with those of a human, which of course it is not. The bird might as well come from another planet.Head_of_Raven

The psychedelic drug is having an emotional effect on me. It does not twist my logic, though. This makes for internal conflict. Oppositional suggestions spontaneously present themselves. Could there be at least some qualia properties which are universal? Or is every aspect arbitrary? If the states of the subjective are not epiphenomenal, there would be evolutionary selection pressures shaping them. Logically there should be differences in computational efficiency when the information encoded in qualia feeds back into actions carried out by the body that the mind controls. Or is it epiphenomenal after all? Well, there’s the hard problem. No use pondering that. It’s a drug effect. It’ll wear off. Funny thing though, I feel very, very happy. I’m wondering about valence. It now appeals strongly to take the cognitive leap that at least the positive/negative “axis” of experience may in fact be universal. A modifier of all conscious states, a kind of transform function. Even alien states could then have a “good or bad” quality to them. Not directly related to the cognitive power of intelligences, but used as an efficient guidance for agency by them all, from the humblest mite to the wisest philosopher. Nah. Romanticizing. Anthropomorphizing.

36766208_10160731731785637_6606215010454601728_oFurther into this “trip” now. Enjoying the ride. It’s not going to change my psyche permanently, so why not relax and let go? What if conscious mind states really do have different computational efficiency for various purposes? That would mean there is “ground truth” to be found about consciousness. But how does nature enable the process for “hitting” the efficient states? If that has been convergently perfected by evolution, conscious experience may be more universal than I used to take for granted. Without there being anything supernatural about it. Suppose the possibility space of all conscious states is very large, so that within it there is an ideally suited state for any mental task. No divine providence or intelligent design, just a law of large numbers.

The problem then is only a search algorithmic one, really. Suppose “fright” is a state ideally suited for avoiding danger. At least now, under the influence, fright strikes me as rather better for the purpose than attraction. Come to think of it, Toxoplasma Gondii has the ability to replace fright with attraction in mice with respect to cats. It works the same way in other mammals, too. Are things then not so arbitrarily organized in brains? Well, those are such basic states we’d share them with rodents presumably. Still can’t tell if fright feels like fear in a raven or octopus. But can it feel like attraction? Hmmm, these are just mind wanderings I go through while I wait for this drug to wear off. What’s the harm in it?

Suppose there is a most computationally efficient conscious state for a given mental task. I’d call that state the ground state of conscious intelligence with respect to that task. I’m thinking of it like mental physical chemistry. In that framework, a psychedelic drug would bring a mind to excited states. Those are states the mind has not practiced using for tasks it has learned to do before. The excited states can then be perceived as useless, for they perform worse at tasks one has previously become competent at while sober. Psychedelic states are excited with respect to previous mental tasks, but they would potentially be ground states for new tasks! It’s probably not initially evident exactly what those tasks are, but the great potential to in fact become more mentally able would be apparent to those who use psychedelics. Right now this stands out to me as absolutely crisp, clear and evident. And the sheer realness of the realization is earth-shaking. Too bad my career could not be improved by any new mental abilities.Touched_by_His_Noodly_Appendage_HD

Oh Spaghetti Monster, I’m really high now. I feel like the sober me is just so dull. Illusion, of course, but a wonderful one I’ll have to admit. My mind is taking off from the heavy drudgery of Earth and reaching into the heavens on the wings of Odin’s ravens, eternally open to new insights about life, the universe and everything. Seeking forever the question to the answer. I myself am the answer. Forty-two. I was born in nineteen forty two. The darkest year in human history. The year when Adolf Hitler looked unstoppable at destroying all human value in the entire world. Then I came into existence, and things started to improve.

It just struck me that a bird is a good example of embodied intelligence. Sensory input to the brain can produce lasting changes in the neural connectivity and so on, resulting in a saved mental map of that which precipitated the sensory input. Now, a bird has the advantage of flight. It can view things from the ground and from successively higher altitudes and remember the appearance of things on all these different scales. Plus it can move sideways large distances and find systematic changes over scales of horizontal navigation. Entire continents can be included in a bird’s area of potential interest. Continents and seasons. I’m curious if engineers will someday be able to copy the ability of birds into a flying robot. Maximizing computational efficiency. Human-level artificial intelligence I’m quite doubtful of, but maybe bird brains are within reach, though quite a challenge, too.

This GPT-3 system by OpenAI is pretty good for throwing up somewhat plausible suggestions for what someone might say in certain situations. Impressive for a purely lexical information processing system. It can be trained on pretty much any language. I wonder if it could become useful for formalizing those qualia ground states? The system itself is not an intelligence in the agency sense but it is a good predictor of states. Suppose it can model the way the mind of the bird cycles through all those mental maps the bird brain has in memory. Where the zooming in and out on different scales brings out different visual patterns. If aspects of patterns from one zoom level is combined with aspect from another zoom level, the result can be a smart conclusion about where and when to set off in what direction and with what aim. Then there can be combinations also with horizontally displaced maps and time-displaced maps. Essentially, to a computer scientist we are talking massively parallel processing through cycles of information compression and expansion with successive approximation combinations of pattern pieces from the various levels in rapid repetition until something leads to an action which becomes rewarded via a utility function maximization.


Axioms of Integrated Information Theory (IIT)

Thank goodness I’m keeping all this drugged handwaving to myself and not sharing it in the form of any trip report. I have a reputation for being down to Earth, and I wouldn’t want to spoil it. Flying with ravens, dear me. Privately it is quite fun right now, though. That cycling of mental maps, could it be compatible with the Integrated Information Theory? I don’t think Tononi’s people have gone into how an intelligent system would search qualia state-space and how it would find the task-specific ground states via successive approximations. Rapidly iterated cycling would bring in a dynamic aspect they haven’t gotten to, perhaps. I realize I haven’t read the latest from them. Was always a bit skeptical of the unwieldy mathematics they use. Back of the envelope here… if you replace the clunky “integration” with resonance, maybe there’s a continuum of amplitudes of consciousness intensity? Possibly with a threshold corresponding to IIT’s nonconscious feed-forward causation chains. The only thing straight from physics which would allow this, as far as I can tell from the basic mathematics of it, would be wave interference dynamics. If so, what property might valence correspond to? Indeed, be mappable to? For conscious minds, experiential valence is the closest one gets to updating on a utility function. Waves can interfere constructively and destructively. That gives us frequency-variable amplitude combinations, likely isomorphic with the experienced phenomenology and intensity of conscious states. Such as the enormous “realness” and “fantastic truth” I am now immersed in. Not sure if it’s even “I”. There is ego dissolution. It’s more like a free-floating cosmic revelation. Spectacular must be the mental task for which this state is the ground state!

Wave pattern variability is clearly not a bottleneck. Plotting graphs of frequencies and amplitudes for even simple interference patterns shows there’s a near-infinite space of distinct potential patterns to pick from. The operative system, that is evolution and development of nervous systems, must have been slow going to optimize by evolution via genetic selection early on in the history of life, but then it could go faster and faster. Let me see, humans acquired a huge redundancy of neocortex of the same type as animals use for avigation in spacetime locations. Hmmm…, that which the birds are so good at. Wonder if the same functionality in ravens also got increased in volume beyond what is needed for navigation? Opening up the possibility of using the brain to also “navigate” in social relational space or tool function space. Literally, these are “spaces” in the brain’s mental models.2000px-Migrationroutes.svg

Natural selection of genetics cannot have found the ground states for all the multiple tasks a human with our general intelligence is able to take on. Extra brain tissue is one thing it could produce, but the way that tissue gets efficiently used must be trained during life. Since the computational efficiency of the human brain is assessed to be near the theoretical maximum for the raw processing power it has available, inefficient information-encoding states really aren’t very likely to make up any major portion of our mental activity. Now, that’s a really strong constraint on mechanisms of consciousness there. If you don’t believe it was all magically designed by God, you’d have to find a plausible parsimonious mechanism for how the optimization takes place.

If valence is in the system as a basic property, then what can it be if it’s not amplitude? For things to work optimally, valence should in fact be orthogonal to amplitude. Let me see… What has a natural tendency to persist in evolving systems of wave interference? Playing around with some programs on my computer now… well, appears it’s consonance which continues and dissonance which dissipates. And noise which neutralizes. Hey, that’s even simple to remember: consonance continues, dissonance dissipates, noise neutralizes. Goodness, I feel like a hippie. Beads and Roman sandals won’t be seen. In Muskogee, Oklahoma, USA. Soon I’ll become convinced love’s got some cosmic ground state function, and that the multiverse is mind-like. Maybe it’s all in the vibes, actually. Spaghetti Monster, how silly that sounds. And at the same time, how true!


Artist: Matthew Smith

I’m now considering the brain to produce self-organizing ground state qualia selection via activity wave interference with dissonance gradient descent and consonance gradient ascent with ongoing information compression-expansion cycling and normalization via buildup of system fatigue. Wonder if it’s just me tripping, or if someone else might seriously be thinking along these lines. If so, what could make a catchy name for their model?

Maybe “Resonant State Selection Theory”? I only wish this could be true, for then it would be possible to unify empty individualism with open individualism in a framework of full empathic transparency. The major ground states for human intelligence could presumably be mapped pretty well with an impressive statistical analyzer like GPT-3. Mapping the universal ground truth of conscious intelligence, what a vision!

But, alas, the acid is beginning to wear off. Back to the good old opaque arbitrariness I’ve built my career on. No turning back now. I think it’s time for a cup of tea, and maybe a cracker to go with that.


Posthuman Art: Towards Full-Spectrum Positive Valence Amplification

Everyone says love hurts, but that is not true. Loneliness hurts. Rejection hurts. Losing someone hurts. Envy hurts. Everyone gets these things confused with love, but in reality love is the only thing in this world that covers up all pain and makes someone feel wonderful again. Love is the only thing in this world that does not hurt.


― Meša Selimović

Excerpt from the wonderful conversation between Lucas Perry, Sam Barker, and David Pearce posted on June 24 (2020) at the Future of Life Institute Podcast (where Mike Johnson and I have previously participated). [Emphasis mine].

Lucas Perry: For this first section, I’m basically interested in probing the releases that you already have done, Sam, and exploring them and your inspiration for the track titles and the soundscapes that you’ve produced. Some of the background and context for this is that much of this seems to be inspired by and related to David’s work, in particular the Hedonistic Imperative. I’m at first curious to know, Sam, how did you encounter David’s work, and what does it mean for you?

Sam Barker: David’s work was sort of arriving in the middle of a series of realizations, and kind of coming from a starting point of being quite disillusioned with music, and a little bit disenchanted with the vagueness, and the terminology, and the imprecision of the whole thing. I think part of me has always wanted to be some kind of scientist, but I’ve ended up at perhaps not the opposite end, but quite far away from it.

Lucas Perry: Could explain what you mean by vagueness and imprecision?

Sam Barker: I suppose the classical idea of what making music is about has a lot to do with the sort of western idea of individualism and about self-expression. I don’t know. There’s this romantic idea of artists having these frenzied creative bursts that give birth to the wonderful things, that it’s some kind of struggle. I just was feeling super disillusioned with all of that. Around that time, 2014 or 15, I was also reading a lot about social media, reading about behavioral science, trying to figure what was going on in this arena and how people are being pushed in different directions by this algorithmic system of information distribution. That kind of got me into this sort of behavioral science side of things, like the addictive part of the variable-ratio reward schedule with likes. It’s a free dopamine dispenser kind of thing. This was kind of getting me into reading about behavioral science and cognitive science. It was giving me a lot of clarity, but not much more sort of inspiration. It was basically like music.

Dance music especially is a sort of complex behavioral science. You do this and people do that. It’s all deeply ingrained. I sort of imagine the DJ as a sort Skinner box operator pulling puppet strings and making people behave in different ways. Music producers are kind of designing clever programs using punishment and reward, or suspense and release, and controlling people’s behavior. The whole thing felt super pushy and not a very inspiring conclusion. Looking at the problem from a cognitive science point of view is just the framework that helped me to understand what the problem was in the first place, so this kind of problem of being manipulative. Behavioral science is kind of saying what we can make people do. Cognitive psychology is sort of figuring out why people do that. That was my entry point into cognitive psychology, and that was kind of the basis for Debiasing.

There’s always been sort of a parallel for me between what I make and my state of mind. When I’m in a more positive state, I tend to make things I’m happier with, and so on. Getting to the bottom of what tricks were, I suppose, with dance music. I kind of understood implicitly, but I just wanted to figure out why things worked. I sort of came to the conclusion it was to do with a collection of biases we have, like the confirmation bias, and the illusion of truth effect, and the mere exposure effect. These things are like the guardians of four/four supremacy. Dance music can be pretty repetitive, and we describe it sometimes in really aggressive terminology. It’s a psychological kind of interaction.

Cognitive psychology was leading me to Kaplan’s law of the instrument. The law of the instrument says that if you give a small boy a hammer, he’ll find that everything he encounters requires pounding. I thought that was a good metaphor. The idea is that we get so used to using tools in a certain way that we lose sight of what it is we’re trying to do. We act in the way that the tool instructs us to do. I thought, what if you take away the hammer? That became a metaphor for me, in a sense, that David clarified in terms of pain reduction. We sort of put these painful elements into music in a way to give this kind of hedonic contrast, but we don’t really consider that that might not be necessary. What happens when we abolish these sort of negative elements? Are the results somehow released from this process? That was sort of the point, up until discovering the Hedonistic Imperative.

I think what I was needing at the time was a sort of framework, so I had the idea that music was decision making. To improve the results, you have to ask better questions, make better decisions. You can make some progress looking at the mechanics of that from a psychology point of view. What I was sort of lacking was a purpose to frame my decisions around. I sort of had the idea that music was a sort of a valence carrier, if you like, and that it could be tooled towards a sort of a greater purpose than just making people dance, which was for Debiasing the goal, really. It was to make people dance, but don’t use the sort of deeply ingrained cues that people used to, and see if that works.

What was interesting was how broadly it was accepted, this first EP. There were all kinds of DJs playing it in techno, ambient, electro, all sorts of different styles. It reached a lot of people. It was as if taking out the most functional element made it more functional and more broadly appealing. That was the entry point to utilitarianism. There was sort of an accidentally utilitarian act, in a way, to sort of try and maximize the pleasure and minimize the pain. I suppose after landing in utilitarianism and searching for some kind of a framework for a sense of purpose in my work, the Hedonistic Imperative was probably the most radical, optimistic take on the system. Firstly, it put me in a sort of mindset where it granted permission to explore sort of utopian ideals, because I think the idea of pleasure is a little bit frowned upon in the art world. I think the art world turns its nose up at such direct cause and effect. The idea that producers could be paradise engineers of sorts, or the precursors to paradise engineers, that we almost certainly would have a role in a kind of sensory utopia of the future.

There was this kind of permission granted. You can be optimistic. You can enter into your work with good intentions. It’s okay to see music as a tool to increase overall wellbeing, in a way. That was kind of the guiding idea for my work in the studio. I’m trying, these days, to put more things into the system to make decisions in a more conscious way, at least where it’s appropriate to. This sort of notion of reducing pain and increasing pleasure was the sort of question I would ask at any stage of decision making. Did this thing that I did serve those ends? If not, take a step back and try a different approach.

There’s something else to be said about the way you sort of explore this utopian world without really being bogged down. You handle the objections in such a confident way. I called it a zero gravity world of ideas. I wanted to bring that zero gravity feeling to my work, and to see that technology can solve any problem in this sphere. Anything’s possible. All the obstacles are just imagined, because we fabricate these worlds ourselves. These are things that were really instructive for me, as an artist.

Lucas Perry: That’s quite an interesting journey. From the lens of understanding cognitive psychology and human biases, was it that you were seeing those biases in dance music itself? If so, what were those biases in particular?

Sam Barker: On both sides, on the way it’s produced and in the way it’s received. There’s sort of an unspoken acceptance. You’re playing a set and you take a kick drum out. That signals to people to perhaps be alert. The lighting engineer, they’ll maybe raise the lights a little bit, and everybody knows that the music is going into sort of a breakdown, which is going to end in some sort of climax. Then, at that point, the kick drum comes back in. We all know this pattern. It’s really difficult to understand why that works without referring to things like cognitive psychology or behavioral science.

Lucas Perry: What does the act of debiasing the reception and production of music look like and do to the music and its reception?

Sam Barker: The first part that I could control was what I put into it. The experiment was whether a debiased piece of dance music could perform the same functionality, or whether it really relies on these deeply ingrained cues. Without wanting to sort of pat myself on the back, it kind of succeeded in its purpose. It was sort of proof that this was a worthy concept.

Lucas Perry: You used the phrase, earlier, four/four. For people who are not into dance music, that just means a kick on each beat, which is ubiquitous in much of house and techno music. You’ve removed that, for example, in your album Debiasing. What are other things that you changed from your end, in the production of Debiasing, to debias the music from normal dance music structure?

Sam Barker: It was informing the structure of what I was doing so much that I wasn’t so much on a grid where you have predictable things happening. It’s a very highly formulaic and structured thing, and that all keys into the expectation and this confirmation bias that people, I think, get some kind of kick from when the predictable happens. They say, yep. There you go. I knew that was going to happen. That’s a little dopamine rush, but I think it’s sort of a cheap trick. I guess I was trying to get the tricks out of it, in a way, so figuring out what they were, and trying to reduce or eliminate them was the process for Debiasing.

Lucas Perry: That’s quite interesting and meaningful, I think. Let’s just take trap music. I know exactly how trap music is going to go. It has this buildup and drop structure. It’s basically universal across all dance music. Progressive house in the 2010s was also exactly like this. What else? Dubstep, of course, same exact structure. Everything is totally predictable. I feel like I know exactly what’s going to happen, having listened to electronic music for over a decade.

Sam Barker: It works, I think. It’s a tried and tested formula, and it does the job, but when you’re trying to imagine states beyond just getting a little kick from knowing what was going to happen, that’s the place that I was trying to get to, really.

Lucas Perry: After the release of Debiasing in 2018, which was a successful attempt at serving this goal and mission, you then discovered the Hedonistic Imperative by David Pearce, and kind of leaned into consequentialism, it seems. Then, in 2019, you had two releases. You had BARKER 001 and you had Utility. Now, Utility is the album which most explicitly adopts David Pearce’s work, specifically in the Hedonistic Imperative. You mentioned electronic dance producers and artists in general can be sort of the first wave of, or can perhaps assist in paradise engineering, insofar as that will be possible in the near to short terms future, given advancements in technology. Is that sort of the explicit motivation and framing around those two releases of BARKER 001 and Utility?

Sam Barker: BARKER 001 was a few tracks that were taken out of the running for the album, because they didn’t sort of fit the concept. Really, I knew the last track was kind of alluding to the album. Otherwise, it was perhaps not sort of thematically linked. Hopefully, if people are interested in looking more into what’s behind the music, you can lead people into topics with the concept. With Utility, I didn’t want to just keep exploring cognitive biases and unpicking dance music structurally. It’s sort of a paradox, because I guess the Hedonistic Imperative argues that pleasure can exist without purpose, but I really was striving for some kind of purpose with the pleasure that I was getting from music. That sort of emerged from reading the Hedonistic Imperative, really, that you can apply music to this problem of raising the general level of happiness up a notch. I did sort of worry that by trying to please, it wouldn’t work, that it would be something that’s too sickly sweet. I mean, I’m pretty turned off by pop music, and there was this sort of risk that it would end up somewhere like that. That’s it, really. Just looking for a higher purpose with my work in music.

Lucas Perry: David, do you have any reactions?

David Pearce: Well, when I encountered Utility, yes, I was thrilled. As you know, essentially I’m a writer writing in quite heavy sub-academic prose. Sam’s work, I felt, helps give people a glimpse of our glorious future, paradise engineering. As you know, the reviews were extremely favorable. I’m not an expert critic or anything like that. I was just essentially happy and thrilled at the thought. It deserves to be mainstream. It’s really difficult, I think, to actually evoke the glorious future we are talking about. I mean, I can write prose, but in some sense music can evoke paradise better, at least for many people, than prose.

And it continues on. I highly recommend listening to the whole podcast: it is wonderfully edited and musical pieces referenced in the interview are brought up in real time for you to listen to. Barker also made a playlist of songs specifically for this podcast, which are played during the second half of the recording. It is delightful to listen to music that you know was produced with the explicit purpose of increasing your wellbeing. A wholesome message at last! Amazing art inspired by the ideology of Paradise Engineering, arriving near you… very soon.

As an aside, I think that shared visions of paradise are really essential for solving coordination problems. So…

Please join me in putting on Barker’s track Paradise Engineering, closing your eyes, and imagining- in detail- what the creation of an Institute for Paradise Engineering on a grand scale would look like. What would a positive Manhattan Project of Consciousness entail? What is the shortest path for us to create such a large-scale initiative?

By the way: the song is only 4 minutes long. So its duration is perfect for you to use as a guiding and grounding piece of media for a positive DMT trip. Press “play” immediately after you vaporize the DMT, sit back, relax, and try to render in your mind a posthuman paradise in which Full-Spectrum Supersentient Superintelligence has won and the threat of Pure Replicators has been averted. If you do this, please let me know what you experience as a result.

Ps. It’s worth noting that Barker’s conception of art is highly aligned with QRI’s view of what art could be like. See, in particular, models 4 through 8 in our article titled Harmonic Society.

Featured image by Michael Aaron Coleman


These are the answers to the most Frequently Asked Questions about the Qualia Research Institute. (See also: the glossary).

(Organizational) Questions About the Qualia Research Institute

  • What type of organization is QRI?

    • QRI is a nonprofit research group studying consciousness based in San Francisco, California. We are a registered 501(c)(3) organization.

  • What is the relationship between QRI, Qualia Computing, and Opentheory?

    • Qualia Computing and Opentheory are the personal blogs of QRI co-founders Andrés Gómez Emilsson and Michael Johnson, respectively. While QRI was in its early stages, all original QRI research was initially published on these two platforms. However, from August 2020 onward, this is shifting to a unified pipeline centered on QRI’s website.

  • Is QRI affiliated with an academic institution or university?

    • Although QRI does collaborate regularly with university researchers and laboratories, we are an independent research organization. Put simply, QRI is independent because we didn’t believe we could build the organization we wanted and needed to build within the very real constraints of academia. These constraints include institutional pressure to work on conventional projects, to optimize for publication metrics, and to clear various byzantine bureaucratic hurdles. It also includes professional and social pressure to maintain continuity with old research paradigms, to do research within an academic silo, and to pretend to be personally ignorant of altered states of consciousness. It’s not that good research cannot happen under these conditions, but we believe good consciousness research happens despite the conditions in academia, not because of them, and the best use of resources is to build something better outside of them.

  • How does QRI align with the values of EA?

    • Effective Altruism (EA) is a movement that uses evidence and reason to figure out how to do the most good. QRI believes this aesthetic is necessary and important for creating a good future. We also believe that if we want to do the most good, foundational research on the nature of the good is of critical importance. Two frames we offer are Qualia Formalism and Sentientism. Qualia Formalism is the claim that experience has a precise mathematical description, that a formal account of experience should be the goal of consciousness research. Sentientism is the claim that value and disvalue are entirely expressed in the nature and quality of conscious experiences. We believe EA is enriched by both Qualia Formalism and Sentientism.

  • What would QRI do with $10 billion?

    • Currently, QRI is a geographically distributed organization with access to commercial-grade neuroimaging equipment. The first thing we’d do with $10 billion is set up a physical headquarters for QRI and buy professional-grade neuroimaging devices (fMRI, MEG, PET, etc.) and neurostimulation equipment. We’d also hire teams of full-time physicists, mathematicians, electrical engineers, computer scientists, neuroscientists, chemists, philosophers, and artists. We’ve accomplished a great deal on a shoestring budget, but it would be hard to overestimate how significant being able to build deep technical teams and related infrastructure around core research threads would be for us (and, we believe, for the growing field of consciousness research). Scaling is always a process and we estimate our ‘room for funding’ over the next year is roughly ~$10 million. However, if we had sufficiently deep long-term commitments, we believe we could successfully scale both our organization and research paradigm into a first-principles approach for decisively diagnosing and curing most forms of mental illness. We would continue to run studies and experiments, collect interesting data about exotic and altered states of consciousness, pioneer new technologies that help eliminate involuntary suffering, and develop novel ways to enable conscious beings to safely explore the state-space of consciousness.

Questions About Our Research Approach

  • What differentiates QRI from other research groups studying consciousness?

    • The first major difference is that QRI breaks down “solving consciousness” into discrete subtasks; we’re clear about what we’re trying to do, which ontologies are relevant for this task, and what a proper solution will look like. This may sound like a small thing, but an enormous amount of energy is wasted in philosophy by not being clear about these things. This lets us “actually get to work.”

    • Second, our focus on valence is rare in the field of consciousness studies. A core bottleneck in understanding consciousness is determining what its ‘natural kinds’ are: terms which carve reality at the joints. We believe emotional valence (the pleasantness/unpleasantness of an experience) is one such natural kind, and this gives us a huge amount of information about phenomenology. It also offers a clean bridge for interfacing with (and improving upon) the best neuroscience.

    • Third, QRI takes exotic states of consciousness extremely seriously whereas most research groups do not. An analogy we make here is that ignoring exotic states of consciousness is similar to people before the scientific enlightenment thinking that they can understand the nature of energy, matter, and the physical world just by studying it at room temperature while completely ignoring extreme states such as what’s happening in the sun, black holes, plasma, or superfluid helium. QRI considers exotic states of consciousness as extremely important datapoints for reverse-engineering the underlying formalism for consciousness.

    • Lastly, we have a focus on precise, empirically testable predictions, which is rare in philosophy of mind. Any good theory of consciousness should also contribute to advancements in neuroscience. Likewise, any good theory of neuroscience should contribute to novel, bold, falsifiable predictions, and blueprints for useful things, such as new forms of therapy. Having such a full-stack approach to consciousness which does each of those two things is thus an important marker that “something interesting is going on here” and is simply very useful for testing and improving theory.

  • What methodologies are you using? How do you actually do research? 

    • QRI has three core areas of research: philosophy, neuroscience, and neurotechnology 

      • Philosophy: Our philosophy research is grounded in the eight problems of consciousness. This divide-and-conquer approach lets us explore each subproblem independently, while being confident that when all piecemeal solutions are added back together, they will constitute a full solution to consciousness.

      • Neuroscience: We’ve done original synthesis work on combining several cutting-edge theories of neuroscience (the free energy principle, the entropic brain, and connectome-specific harmonic waves) into a unified theory of Bayesian emotional updating; we’ve also built the world’s first first-principles method for quantifying emotional valence from fMRI. More generally, we focus on collecting high valence neuroimaging datasets and developing algorithms to analyze, quantify, and visualize them. We also do extensive psychophysics research, focusing on both the fine-grained cognitive-emotional effects of altered states, and how different types of sounds, pictures, body vibrations, and forms of stimulation correspond with low and high valence states of consciousness.

      • Neurotechnology: We engage in both experimentation-driven exploration, tracking the phenomenological effects of various interventions, as well as theory-driven development. In particular, we’re prototyping a line of neurofeedback tools to help treat mental health disorders.

  • What does QRI hope to do over the next 5 years? Next 20 years?

    • Over the next five years, we intend to further our neurotechnology to the point that we can treat PTSD (post-traumatic stress disorder), especially treatment-resistant PTSD. We intend to empirically verify or falsify the symmetry theory of valence. If it is falsified, we will search for a new theory that ties together all of the empirical evidence we have discovered. We aim to create an Effective Altruist cause area regarding the reduction of intense suffering as well as the study of very high valence states of consciousness.

    • Over the next 20 years, we intend to become a world-class research center where we can put the discipline of “paradise engineering” (as described by philosopher David Pearce) on firm academic grounds.

Questions About Our Mission

  • How can understanding the science of consciousness make the world a better place?

    • Understanding consciousness would improve the world in a tremendous number of ways. One obvious outcome would be the ability to better predict what types of beings are conscious—from locked-in patients to animals to pre-linguistic humans—and what their experiences might be like.

    • We also think it’s useful to break down the benefits of understanding consciousness in three ways: reducing the amount of extreme suffering in the world, increasing the baseline well-being of conscious beings, and achieving new heights for what conscious states are possible to experience.

    • Without a good theory of valence, many neurological disorders will remain completely intractable. Disorders such as fibromyalgia, complex regional pain syndrome (CRPS), migraines, and cluster headaches are all currently medical puzzles and yet have incredibly negative effects on people’s livelihoods. We think that a mathematical theory of valence will explain why these things feel so bad and what the shortest path for getting rid of them looks like. Besides valence-related disorders, nearly all mental health disorders, from clinical depression and PTSD to schizophrenia and anxiety disorders, will become better understood as we discover the structure of conscious experience.

    • We also believe that many (though not all) of the zero-sum games people play are the products of inner states of dissatisfaction and suffering. Broadly speaking, people who have a surplus of cognitive and emotional energy tend to play more positive sum games, are more interested in cooperation, and are very motivated to do so. We think that studying states such as those induced by MDMA that combine both high valence and a prosocial behavior mindset can radically alter the game theoretical landscape of the world for the better.

  • What is the end goal of QRI? What does QRI’s perfect world look like?

    • In QRI’s perfect future:

      • There is no involuntary suffering and all sentient beings are animated by gradients of bliss,

      • Research on qualia and consciousness is done at a very large scale for the purpose of mapping out the state-space of consciousness and understanding its computational and intrinsic properties (we think that we’ve barely scratched the surface of knowledge about consciousness),

      • We have figured out the game-theoretical subtleties in order to make that world dynamic yet stable: radically positive, without just making it fully homogeneous and stuck in a local maxima.

Questions About Getting Involved

  • How can I follow QRI’s work?

    • You can start by signing up for our newsletter! This is by far our most important communication channel. We also have a Facebook page, Twitter account, and Linkedin page. Lastly, we share some exclusive tidbits of ideas and thoughts with our supporters on Patreon.

  • How can I get involved with QRI?

    • The best ways to help QRI are to:

      • Donate to help support our work.

      • Read and engage with our research. We love critical responses to our ideas and encourage you to reach out if you have an interesting thought!

      • Spread the word to friends, potential donors, and people that you think would make great collaborators with QRI.

      • Check out our volunteer page to find more detailed ways that you can contribute to our mission, from independent research projects to QRI content creation.

Questions About Consciousness

  • What assumptions about consciousness does QRI have? What theory of consciousness does QRI support?

    • The most important assumption that QRI is committed to is Qualia Formalism, the hypothesis that the internal structure of our subjective experience can be represented precisely by mathematics. We are also Valence Realists: we believe valence (how good or bad an experience feels) is a real and well-defined property of conscious states. Besides these positions, we are fairly agnostic and everything else is an educated guess useful for pragmatic purposes.

  • What does QRI think of functionalism?

    • QRI thinks that functionalism takes many high-quality insights about how systems work and combines them in such a way that both creates confusion and denies the possibility of progress. In its raw, unvarnished form, functionalism is simply skepticism about the possibility of Qualia Formalism. It is simply a statement that “there is nothing here to be formalized; consciousness is like élan vital, confusion to be explained away.” It’s not actually a theory of consciousness; it’s an anti-theory. This is problematic in at least two ways:

      • 1. By assuming consciousness has formal structure, we’re able to make novel predictions that functionalism cannot (see e.g. QRI’s Symmetry Theory of Valence, and Quantifying Bliss). A few hundred years ago, there were many people who doubted that electromagnetism had a unified, elegant, formal structure, and this was a reasonable position at the time. However, in the age of the iPhone, skepticism that electricity is a “real thing” that can be formalized is no longer reasonable. Likewise, everything interesting and useful QRI builds using the foundation of Qualia Formalism stretches functionalism’s credibility thinner and thinner.

      • 2. Insofar as functionalism is skeptical about the formal existence of consciousness, it’s skeptical about the formal existence of suffering and all sentience-based morality. In other words, functionalism is a deeply amoral theory, which if taken seriously dissolves all sentience-based ethical claims. This is due to there being an infinite number of functional interpretations of a system: there’s no ground-truth fact of the matter about what algorithm a physical system is performing, about what information-processing it’s doing. And if there’s no ground-truth about which computations or functions are present, but consciousness arises from these computations or functions, then there’s no ground-truth about consciousness, or things associated with consciousness, like suffering. This is a strange and subtle point, but it’s very important. This point alone is not sufficient to reject functionalism: if the universe is amoral, we shouldn’t hold a false theory of consciousness in order to try to force reality into some ethical framework. But in debates about consciousness, functionalists should be up-front that functionalism and radical moral anti-realism is a package deal, that inherent in functionalism is the counter-intuitive claim that just as we can reinterpret which functions a physical system is instantiating, we can reinterpret what qualia it’s experiencing and whether it’s suffering.

    • For an extended argument, see Against Functionalism.

  • What does QRI think of panpsychism?

    • At QRI, we hold a position that is close to dual-aspect monism or neutral monism, which states that the universe is composed of one kind of thing that is neutral, and that both the mental and physical are two features of this same substance. One of the motivating factors for holding this view is that if there is deep structure in the physical, then there should be a corresponding deep structure to phenomenal experience. And we can tie this together with physicalism in the sense that the laws of physics ultimately describe fields of qualia. While there are some minor disagreements between dual-aspect monism and panpsychism, we believe that our position mostly fits well with a panpsychist view—that phenomenal properties are a fundamental feature of the world and aren’t spontaneously created only when a certain computation is being performed.

    • However, even with this view, there still are very important questions, such as: what makes a unified conscious experience? Where does one experience end and another begin? Without considering these problems in the light of Qualia Formalism, it is easy to tie animism into panpsychism and believe that inanimate objects like rocks, sculptures, and pieces of wood have spirits or complex subjective experiences. At QRI, we disagree with this and think that these types of objects might have extremely small pockets of unified conscious experience, but will mostly be masses of micro-qualia that are not phenomenally bound into some larger experience.

  • What does QRI think of IIT (Integrated Information Theory)?

    • QRI is very grateful for IIT because it is the first mainstream theory of consciousness that satisfies a Qualia Formalist account of experience. IIT says (and introduced the idea!) that for every conscious experience, there is a corresponding mathematical object such that the mathematical features of that object are isomorphic to the properties of the experience. QRI believes that without this idea, we cannot solve consciousness in a meaningful way, and we consider the work of Giulio Tononi to be one of our core research lineages. That said, we are not in complete agreement with the specific mathematical and ontological choices of IIT, and we think it may be trying to ‘have its cake and eat it too’ with regard to functionalism vs physicalism. For more, see Sections III-V of Principia Qualia.

    • We make no claim that some future version of IIT, particularly something more directly compatible with physics, couldn’t cleanly address our objections, and see a lot of plausible directions and promise in this space.

  • What does QRI think of the free energy principle and predictive coding?

    • On our research lineages page, we list the work of Karl Friston as one of QRI’s core research lineages. We consider the free energy principle (FEP), as well as related research such as predictive coding, active inference, the Bayesian brain, and cybernetic regulation, as an incredibly elegant and predictive story of how brains work. Friston’s idea also forms a key part of the foundation for QRI’s theory of brain self-organization and emotional updating, Neural Annealing.

    • However, we don’t think that the free energy principle is itself a theory of consciousness, as it suffers from many of the shortcomings of functionalism: we can tell the story about how the brain minimizes free energy, but we don’t have a way of pointing at the brain and saying *there* is the free energy! The FEP is an amazing logical model, but it’s not directly connected to any physical mechanism. It is a story that “this sort of abstract thing is going on in the brain” without a clear method of mapping this abstract story to reality.

    • Friston has supported this functionalist interpretation of his work, noting that he sees consciousness as a process of inference, not a thing. That said, we are very interested in his work on calculating the information geometry of Markov blankets, as this could provide a tacit foundation for a formalist account of qualia under the FEP. Regardless of this, though, we believe Friston’s work will play a significant role in a future science of mind.

  • What does QRI think of global workspace theory?

    • The global workspace theory (GWT) is a cluster of empirical observations that seem to be very important for understanding what systems in the brain contribute to a reportable experience at a given point in time. The global workspace theory is a very important clue for answering questions of what philosophers call Access Consciousness, or the aspects of our experience on which we can report.

    • However, QRI does not consider the global workspace theory to be a full theory of consciousness. Parts of the brain that are not immediately contributing to the global workspace may be composed of micro qualia, or tiny clusters of experience. They’re obviously impossible to report on, but they are still relevant to the study of consciousness. In other words, just because a part of your brain wasn’t included in the instantaneous global workspace, doesn’t mean that it can’t suffer or it can’t experience happiness. We value global workspace research because questions of Access Consciousness are still very critical for a full theory of consciousness.

  • What does QRI think of higher-order theories of consciousness?

    • QRI is generally opposed to theories of consciousness that equate consciousness with higher order reflective thought and cognition. Some of the most intense conscious experiences are pre-reflective or unreflective such as blind panic, religious ecstasy, experiences of 5-MeO-DMT, and cluster headaches. In these examples, there is not much reflectivity nor cognition going on, yet they are intensely conscious. Therefore, we largely reject any attempt to define consciousness with a higher-order theory.

  • What is the relationship between evolution and consciousness?

    • The relationship between evolution and consciousness is very intricate and subtle. An eliminativist approach arrives at the simple idea that information processing of a certain type is evolutionarily advantageous, and perhaps we can call this consciousness. However, with a Qualia Formalist approach, it seems instead that the very properties of the mathematical object isomorphic to consciousness can play key roles (either causal or in terms of information processing) that make it advantageous for organisms to recruit consciousness.

    • If you don’t realize that consciousness maps onto a mathematical object with properties, you may think that you understand why consciousness was recruited by natural selection, but your understanding of the topic would be incomplete. In other words, to have a full understanding of why evolution recruited consciousness, you need to understand what advantages the mathematical object has. One very important feature of consciousness is its capacity for binding. For example, the unitary nature of experience—the fact that we can experience a lot of qualia simultaneously—may be a key feature of consciousness that accelerates the process of finding solutions to constraint satisfaction problems. In turn, evolution would hence have a reason to recruit states of consciousness for computation. So rather than thinking of consciousness as identical with the computation that is going on in the brain, we can think of it as a resource with unique computational benefits that are powerful and dynamic enough to make organisms that use it more adaptable to their environments.

  • Does QRI think that animals are conscious?

    • QRI thinks there is a very high probability that every animal with a nervous system is conscious. We are agnostic about unified consciousness in insects, but we consider it very likely. We believe research on animal consciousness has relevance when it comes to treating animals ethically. Additionally, we do think that the ethical importance of consciousness has more to do with the pleasure-pain axis (valence), rather than cognitive ability. In that sense, the suffering of non-human animals may be just as morally relevant, if not more relevant than humans. The cortex seems to play a largely inhibitory role for emotions, such that the larger the cortex is, the better we’re able to manage and suppress our emotions. Consequently, animals whose cortices are less developed than ours may experience pleasure and pain in a more intense and uncontrollable way, like a pre-linguistic toddler.

  • Does QRI think that plants are conscious?

    • We think it’s very unlikely that plants are conscious. The main reason is that they lack an evolutionary reason to recruit consciousness. Large-scale phenomenally bound experience may be very energetically expensive, and plants don’t have much energy to spare. Additionally, plants have thick cellulose walls that separate individual cells, making it very unlikely that plants can solve the binding problem and therefore create unified moments of experience.

  • Why do some people seek out pain?

    • This is a very multifaceted question. As a whole, we postulate that in the vast majority of cases, when somebody may be nominally pursuing pain or suffering, they’re actually trying to reduce internal dissonance in pursuit of consonance or they’re failing to predict how pain will actually feel. For example, when a person hears very harsh music, or enjoys extremely spicy food, this can be explained in terms of either masking other unpleasant sensations or raising the energy parameter of experience, the latter of which can lead to neural annealing: a very pleasant experience that manifests as consonance in the moment.

  • I sometimes like being sad. Is QRI trying to take that away from me?

    • Before we try to ‘fix’ something, it’s important to understand what it’s trying to do for us. Sometimes suffering leads to growth; sometimes creating valuable things involves suffering. Sometimes, ‘being sad’ feels strangely good. Insofar as suffering is doing good things for us, or for the world, QRI advocates a light touch (see Chesterton’s fence). However, we also suggest two things:

      • 1. Most kinds of melancholic or mixed states of sadness usually are pursued for reasons that cash out as some sort of pleasure. Bittersweet experiences are far more preferable than intense agony or deep depression. If you enjoy sadness, it’s probably because there’s an aspect of your experience that is enjoyable. If it were possible to remove the sad part of your experience while maintaining the enjoyable part of it, you might be surprised to find that you prefer this modified experience more than the original one.

      • 2. There are kinds of sadness and suffering that are just bad, that degrade us as humans, and would be better to never feel. QRI doesn’t believe in forcibly taking away voluntary suffering, or pushing bliss on people. But we would like to live in a world where people can choose to avoid such negative states, and on the margin, we believe it would be better for humanity for more people to be joyful, filled with a deep sense of well-being.

  • If dissonance is so negative, why is dissonance so important in music?

    • When you listen to very consonant music or consonant tones, you will quickly adapt to these sounds and get bored of them. This has nothing to do with consonance itself being unpleasant and everything to do with learning in the brain. Whenever you experience the same stimuli repeatedly, most brains will trigger a boredom mechanism and add dissonance of its own in order to make you enjoy the stimuli less or simply inhibit it, not allowing you to experience it at all. Semantic satiation is a classic example of this where repeating the same word over and over will make it lose its meaning. For this reason, to trigger many high valence states of consciousness consecutively, you need contrast. In particular, music works with gradients of consonance and dissonance, and in most cases, moving towards consonance is what feels good rather than the absolute value of consonance. Music tends to feel the best when you mix a high absolute value of consonance together with a very strong sense of moving towards an even higher absolute value of consonance. Playing some levels of dissonance during a song will later enhance the enjoyment of the more consonant parts such as the chorus of songs, which are reported to be the most euphoric parts of song and typically are extremely consonant.

  • What is QRI’s perspective on AI and AI safety research?

    • QRI thinks that consciousness research is critical for addressing AI safety. Without a precise way of quantifying an action’s impact on conscious experiences, we won’t be able to guarantee that an AI system has been programmed to act benevolently. Also, certain types of physical systems that perform computational tasks may be experiencing negative valence without any outside observer being aware of it. We need a theory of what produces unpleasant experiences to avoid inadvertently creating superintelligences that suffer intensely in the process of solving important problems or accidentally inflict large-scale suffering.

    • Additionally, we think that a very large percentage of what will make powerful AI dangerous is that the humans programming these machines and using these machines may be reasoning from states of loneliness, resentment, envy, or anger. By discovering ways to help humans transition away from these states, we can reduce the risks of AI by creating humans that are more ethical and aligned with consciousness more broadly. In short: an antidote for nihilism could lead to a substantial reduction in existential risk.

    • One way to think about QRI and AI safety is that the world is building AI, but doesn’t really have a clear, positive vision of what to do with AI. Lacking this, the default objective becomes “take over the world.” We think a good theory of consciousness could and will offer new visions of what kind of futures are worth building—new Schelling points that humanity (and AI researchers) could self-organize around.

  • Can digital computers implementing AI algorithms be conscious?

    • QRI is agnostic about this question. We have reasons to believe that digital computers in their current form cannot solve the phenomenal binding problem. Most of the activity in digital computers can be explained in a stepwise fashion in terms of localized processing of bits of information. Because of this, we believe that current digital computers could be creating fragments of qualia, but are unlikely to be creating strongly globally bound experiences. So, we consider the consciousness of digital computers unlikely, although given our current uncertainty over the Binding Problem (or alternatively framed, the Boundary Problem), this assumption is lightly held. In the previous question, when we write that “certain types of physical systems that perform computational tasks may be experiencing negative valence”, we assume that these hypothetical computers have some type of unified conscious experience as a result of having solved the phenomenal binding problem. For more on this topic, see: “What’s Out There?

  • How much mainstream recognition has QRI’s work received, either for this line of research or others? Has it published in peer-reviewed journals, received any grants, or garnered positive reviews from other academics?

    • We are collaborating with researchers from Johns Hopkins University and Stanford University on several studies involving the analysis of neuroimaging data of high-valence states of consciousness. Additionally, we are currently preparing two publications for peer-reviewed journals on topics from our core research areas. Michael Johnson will be presenting at this year’s MCS seminar series, along with Karl Friston, Anil Seth, Selen Atasoy, Nao Tsuchiya, and others; Michael Johnson, Andrés Gómez Emilsson, and Quintin Frerichs have also given invited talks at various east-coast colleges (Harvard, MIT, Princeton, and Dartmouth).

    • Some well-known researchers and intellectuals that are familiar and think positively about our work include: Robin Carhart-Harris, Scott Alexander, David Pearce, Steven Lehar, Daniel Ingram, and more. Scott Alexander acknowledged that QRI put together the paradigms that contributed to Friston’s integrative model of how psychedelics work before his research was published. Our track record so far has been to foreshadow (by several years in advance) key discoveries later proposed and accepted in mainstream academia. Given our current research findings, we expect this trend to continue in the years to come.


  • How does QRI know what is best for other people/animals? What about cultural relativism?

    • We think that, to a large extent, people and animals work under the illusion that they are pursuing intentional objects, states of the external environment, or relationships that they may have with the external environment. However, when you examine these situations closely, you realize that what we actually pursue are states of high valence triggered by external circumstances. There may be evolutionary and cultural selection pressures that push us toward self-deception as to how we actually function. And we consider it negative to have these selection pressures makes us less self-aware because it often focuses our energy on unpleasant, destructive, or fruitless strategies. QRI hopes to support people in fostering more self-awareness, which can come through experiments with one’s own consciousness, like meditation, as well as through the deeper theoretical understanding of what it is that we actually want.

  • How central is David Pearce’s work to the work of the QRI?

    • We consider David Pearce to be one of our core lineages. We particularly value his contribution to valence realism, the insistence that states of consciousness come with an overall valence, and that this is very morally relevant. We also consider David Pearce to be very influential in philosophy of mind; Pearce, for instance, coined the phrase ‘tyranny of the intentional object’, the title of a core QRI piece of the same name. We have been inspired by Pearce’s descriptions for what any scientific theory of consciousness should be able to explain, as well as his particular emphasis on the binding problem. David’s vision of a world animated by ‘gradients of bliss’ has also been very generative as a normative thought experiment which integrates human and non-human well-being. We do not necessarily agree with all of David Pearce’s work, but we respect him as an insightful and vivid thinker who has been brave enough to actually take a swing at describing utopia and who we believe is far ahead of his time.

  • What does QRI think of negative utilitarianism?

    • There’s general agreement within QRI that intense suffering is an extreme moral priority, and we’ve done substantial work on finding simple ways of getting rid of extreme suffering (with our research inspiring at least one unaffiliated startup to date). However, we find it premature to strongly endorse any pre-packaged ethical theory, especially because none of them are based on any formalism, but rather an ungrounded concept of ‘utility’. The value of information here seems enormous, and we hope that we can get to a point where the ‘correct’ ethical theory may simply ‘pop out of the equations’ of reality. It’s also important to highlight the fact that common versions and academic formulations of utilitarianism seem to be blind to many subtleties concerning valence. For example, they do not distinguish between mixed states of consciousness where you have extreme pleasure combined with extreme suffering in such a way that you judge the experience to be neither entirely suffering nor entirely happiness and states of complete neutrality, such as extreme white noise. Because most formulations of utilitarianism do not distinguish between them, we are generally suspicious of the idea that philosophers of ethics have considered all of the relevant attributes of consciousness in order to make accurate judgments about morality.

  • What does QRI think of philosophy of mind departments?

    • We believe that the problems that philosophy of mind departments address tend to be very disconnected from what truly matters from an ethical, moral, and philosophical point of view. For example, there is little appreciation of the value of bringing mathematical formalisms into discussions about the mind, or what that might look like in practice. Likewise there is close to no interest in preventing extreme suffering nor understanding its nature. Additionally, there is usually a disregard for extreme states of positive valence, and strange or exotic experiences in general. It may be the case that there are worthwhile things happening in departments and classes creating and studying this literature, but we find them characterized by processes which are unlikely to produce progress on their nominal purpose, creating a science of mind.

    • In particular, in academic philosophy of mind, we’ve seen very little regard for producing empirically testable predictions. There are millions of pages written about philosophy of mind, but the number of pages that provide precise, empirically testable predictions is quite thin.

  • What therapies does QRI recommend for depression, anxiety, and chronic pain?

    • At QRI, we do not make specific recommendations to individuals, but rather point to areas of research that we consider to be extremely important, tractable, and neglected, such as anti-tolerance drugs, neural annealing techniques, frequency specific microcurrent for kidney stone pain, and N,N-DMT and other tryptamines for cluster headaches and migraines.

  • Why does QRI think it’s so important to focus on ending extreme suffering? 

    • QRI thinks ending extreme suffering is important, tractable, and neglected. It’s important because of the logarithmic scales of pleasure and pain—the fact that extreme suffering is far worse by orders of magnitude than what people intuitively believe. It’s tractable because there are many types of extreme suffering that have existing solutions that are fairly trivial or at least have a viable path for being solved with moderately funded research programs. And it’s neglected mostly because people are unaware of the existence of these states, though not necessarily because of their rarity. For example, 10% of the population experiences kidney stones at some point in their life, but for reasons having to do with trauma, PTSD, and the state-dependence of memory, even people who have suffered from kidney stones do not typically end up dedicating their time or resources toward eradicating them.

    • It’s also likely that if we can meaningfully improve the absolute worst experiences, much of the knowledge we’ll gain in that process will translate into other contexts. In particular, we should expect to figure out how to make moderately depressed people happier, fix more mild forms of pain, improve the human hedonic baseline, and safely reach extremely great peak states. Mood research is not a zero-sum game. It’s a web of synergies.

Many thanks to Andrew Zuckerman, Mackenzie Dion, and Mike Johnson for their collaboration in putting this together. Featured image is QRI’s logo – animated by Hunter Meyer.

The Manifesto of Tactilism

In the same genre as: The Qualia Manifesto, Rainbow God, The Super-Shulgin Academy, Perfumery as an Art Form, and Harmonic Society. [April 13 Note: I’m sharing this manifesto because of the extraordinary extent to which it values an often-disregarded qualia variety in a systematic and enthusiastic way. It is in no way in support of the politics or behaviors of its author.]

The Manifesto of Tactilism

by F.T. Marinetti
Milan, 11 January 1921.

Read at the Theatre de I’Oeuvre (Paris), the World Exposition of Modern Art (Geneva), and published inComoedia in January 1921

Futurism, founded by us in Milan in 1909, gave to the world a hatred of the Museum, the Academy and Sentimentalism; it gave the world Action-Art, the defence of youth against all senility, the glorification of illogical and mad innovative genius, the artistic sensibility of mechanisation, of speed, of the music hall, and of the simultaneous interpenetration of modern life, words in freedom, plastic dynamism, noise-intoners, synthetic theatre. Futurism today redoubles its creative effort.

Last summer, at Antignano, where the street named after Amerigo Vespucci, discoverer of America, curvingly coasts along the sea, I invented Tactilism. Red flags waved from the workshops taken over by the workers.

I was naked in the silky water that was torn by rocks, foamy scissors knives razors, among the iodine-filled mattresses of seaweed. I was nude in the sea of flexible steel, which had a fertile and virile breathing. I drank from the goblet of the sea filled to the rim with genius. The sun, with its long roasting flames, vulcanised my body and bolted the keel of my forehead rich with sails. A working-class boy, Who smelled of salt and hot stone, looked, smiling, at my first tactile board:

Having fun making little boats?!

I answered: “Yes, I’m building a craft that will take the human spirit to unknown waters.” Here are my reflections, the reflections of a swimmer: The unrefined and elemental majority of men came out of the Great War concerned only to conquer a greater material well-being. The minority, composed of artists and thinkers, sensitive and refined, instead displays the symptoms of a deep and mysterious ill that is probably a consequence of the great tragic exertion that the war imposed on humanity.

This illness displays, as symptoms, a sad listlessness, an excessively feminine neurasthenia, a hopeless pessimism, a feverish indecision of lost instincts, and an absolute lack of will.

The rough and elemental majority of men tumultuously hurls toward the revolutionary conquest of the Communist paradise and definitively storms the problem of happiness, convinced that it has solved it by satisfying all material needs and appetites.

The intellectual minority ironically scorns this breathless attempt, and no longer enjoying the ancient pleasures of Religion, of Art, of Love, which previously constituted its privilege and its shelter, brings life, which it no longer knows how to enjoy, to a cruel trial, and abandons itself to refined pessimism, sexual inversions, and to the artificial paradises of cocaine, opium, ether, etc. That majority and this minority both denounce Progress, Civilisation, the mechanical powers of Speed, of Comfort, of Hygiene, Futurism in short, as being responsible for their past, present, and future misfortunes.

Almost everyone proposes a return to a savage life, contemplative, slow, solitary, far from the hated cities.

As for us Futurists, we who bravely face the agonising drama of the post-war period, we are in favour of all the revolutionary attacks that the majority will attempt. But, to the minority of artists and thinkers, we yell at the top of our lungs: Life is always right!
The artificial paradises with which you attempt to murder her are useless. Stop dreaming of an absurd return to the savage life. Beware of condemning the superior powers of society and the marvels of speed. Heal, rather, the illness of the post-war period, giving humanity new and nutritious joys. Instead of destroying human throngs, it is necessary to perfect them. Intensify the communication and the fusion of human beings. Destroy the distances and the barriers that separate them in love and friendship. Give fullness and total beauty to these two essential manifestations of life: Love and Friendship.

In my careful and anti-traditional observations of all the erotic and sentimental phenomena that unite both sexes, and of the no-less-complex phenomena of friendship, I have understood that human beings speak to each other with their mouths and with their eyes, but do not manage a true sincerity because of the lack of sensitivity of the skin, which is still a mediocre conductor of thought.

While eyes and voices communicate their essences, the senses of touch of two individuals communicate almost nothing in their clashes, intertwining, or rubbing. Thus, the need to transform the handshake, the kiss, and the coupling into continuous transmissions of thought.

I started by submitting my sense of touch to an intensive treatment, pinpointing the confused phenomena of will and thought on various points on my body, and especially on the palms of my hands. This training is slow but easy, and all healthy bodies can, through this training, give surprising and exact results.

On the other hand, unhealthy sensibilities, which draw their excitability and their apparent perfection from the very weakness of the body, will achieve great tactile power less easily, without duration or confidence. I have created a first educational scale of touch, which is, at the same time, a scale of tactile values for Tactilism, or the Art of Touch.

First scale, level, with four different categories of touch.

First category: extremely confident touch, abstract, cold.

  • Sandpaper,
  • Silver-coated paper.


Second category: touch without heat, persuasive, reasoning.

  • Smooth silk,
  • Silk crepe.

Third category: exciting, lukewarm, nostalgic.

  • Velvet,
  • Wool from the Pyrenees,
  • Wool,
  • Silk-wool crepe.

Fourth category: almost irritating, hot, determined.

  • Granulous silk,
  • Plaited silk,
  • Spongy cloth.

Second scale, volumes

Fifth category: soft, hot, human.

  • Suede,
  • Horsehair or dog hair,
  • Human hair,
  • Marabou.

Sixth category: hot, sensual, spirited, affectionate.

  • Rough iron
  • Soft brush,
  • Sponge,
  • Wire brush,
  • Plush,
  • Human or peach fuzz,
  • Bird down.

Through this separation of tactile values, I have created:

1. Simple tactile boards that I will present to the public in our contactilations or conferences on the Art of touch.

I have arranged the previously catalogued tactile values in wise harmonic or antithetical combinations.

2. Abstract or suggestive tactile boards (hand journeys).

These tactile boards have arrangements of tactile values that allow hands to wander over them, following coloured trails and experiencing a succession of suggestive sensations, whose rhythm, in turn languid, cadenced, or tumultuous, is regulated by exact directions.

One of these abstract tactile boards made by me, and that has as a title Sudan-Paris, contains, in the part representing Sudan, rough, greasy coarse, prickly, burning tactile values (spongy material, sponge, sandpaper, wool, brush, wire brush); in the part representing The Sea, there are slippery, metallic, fresh tactile values (silver-coated paper); in the part representing Paris, there are soft, delicate, caressing tactile values, hot and cold at the same time (silk, velvet, feathers, down).

3. Tactile boards for the opposite sexes.

In these tactile boards, the arrangement of tactile values allows the hands of a man and a woman, tied together, to take a tactile journey together and evaluate it. These tactile boards are extremely varied, and the pleasure that they give is enriched by the harnessing of rival sensibilities, which will attempt to feel more acutely and better explain their rival sensations. These tactile boards are destined to replace the brutalising game of chess. [Emphasis mine]

4. Tactile pillows.

5. Tactile sofas.

6. Tactile beds.

7. Tactile shirts and dresses.

8. Tactile rooms.

In these tactile rooms, we will have floors and walls made of large tactile boards. Tactile values of mirrors, running water, rocks, metals, brushes, lightly electrified wires, marble, velvet, rugs that will give the bare feet of the male and female dancers varied pleasures.

9. Tactile streets.

10. Tactile theatres.

We will have theatres arranged for Tactilism. Seated spectators will rest their hands on long, running tactile ribbons that will produce tactile sensations with different rhythms. It will also be possible to place these ribbons on small rotating wheels, accompanying them with music and light.

11. Tactile boards for the improvisation of words in freedom.

The tactilist will express aloud the sensations that his hands’ journey transmits to him. His will be a free-word improvisation, that is, freed from all rhythm, prosody and syntax, an improvisation essential and synthetic and with as little of the human element
as possible. The improvising tactilist may be blindfolded, but it is preferable to wrap him in the light of a projector. The new initiates, who have not yet trained their tactile sensibilities, will be blindfolded. But, as for the true tactilists, the full light of a projector is preferable, since darkness has the drawback of concentrating sensitivity into an excessive abstraction.

The education of the sense of touch.

1. It will be necessary to keep the hands gloved for many days, during which the brain will attempt to condense in them the desire for varied tactile sensations.

2. To swim underwater, in the ocean, trying to distinguish tactilely the plaited currents and different temperatures.

3. Enumerate and recognise every evening, in absolute darkness, all of the objects in the bedroom. It was precisely with giving myself over to this exercise in the underground darkness of a trench in Gorizia, in 1917, that I made my first tactile experiments.

I never claimed to have invented the tactile sensibility, which has already manifested itself in genial forms in the Jongleuse and in the Hors~nature of Rachilde. Other writers and artists had premonitions of tactilism. Moreover, the plastic art of tactilism has been in existence for a long time. My great friend Boccioni, futurist painter and sculptor, felt as a tactilist when he created, in 1919, his plastic ensemble Fusion of a Head and a Window, with materials that are absolute contraries in tactile weight and value: iron, porcelain, and women’s hair.

The Tactilism created by me is clearly distinct from the plastic arts. It has nothing to do with, nothing to gain from, and everything to lose by association with painting or sculpture. It is necessary to avoid, as much as possible in the tactile boards, a variety in colour, which lends itself to plastic impressions. It will be difficult for painters and sculptors, who tend naturally to subordinate tactile values to visual values, to create significant tactile boards. Tactilism seems to me particularly suited to young poets, pianists, typists, and to all erotic, refined, and potent temperaments.

Tactilism, nevertheless, must avoid not only collaboration with plastic arts but also morbid erotomania. It must, simply, have as a goal tactile harmony, and it must indirectly collaborate in the perfecting of spiritual communication between human beings through the epidermis.

The identification of five senses is arbitrary, and one day we will certainly discover and catalogue numerous other senses. Tactilism will contribute to this discovery.

F. T. Marinetti, 1921

(source; also, here is my reading of the Manifesto; related: domestic cozy)

Qualia Production Presents: “The Seven Seals of Security” (and Other Communications from QRI Sweden)

By Maggie Wassinge and Anders Amelin (now QRI Sweden and HR helpers; see previous letters)


Jewelry by Anders and Maggie (see: Quantifying Bliss for the reference to “C, D, N”)

Hi everyone!

It’s Anders and Maggie in Stockholm, Sweden, here. Volunteers in human resource coordination for the QRI.

We would like to hereby announce our commitment to donate fifty thousand dollars to the Qualia Research Institute for research related to the mathematical modeling of phenomenological valence.

We are pretty much just your ordinary Swedish transhumanist couple. With a passion for finding out from first principles how things work. We whole-heartedly agree with Elon Musk that at the end of the day, excellence is the only passing grade. Over the last couple of years we have arrived at the solid conclusion that the biggest bonanza in effective altruism could only be realized by first of all solving valence. Symbolically, in comedy form, this is like first spending the necessary computational resources to arrive at the conciseness of 42 as “the answer”, before it can be determined what the right questions must then be. In our book it is with no doubt the Qualia Research Institute which corresponds to “Deep Thought” in what Elon Musk has called “the best philosophy book ever”: The Hitch-Hiker’s Guide to the Galaxy. Seriously here, it is advisable to balance this with a bit of David Pearce also, but indeed we do believe an encouraging “Don’t Panic” is in fact compatible with the laws of nature in this universe. Immense reward is there for those who roll up their sleeves and start working systematically from first principles.

But again, excellence is the only passing grade. The universe is no picnic. It is a field of seemingly infinite potentialities, all of which are open to exploration and exploitation. It is still unknown what the proto-states of sentience are intrinsically like, but it is clear that biological evolution works as an optimization engine for valence polarization. A “passing grade” for a long-term sustainable and prospering technological civilization must involve a universally global first-principles solution to the horrific downside of this: suffering. That solution must be combined with optimal development of the state space of positive valence and intelligence. It seems plausible that experienced negative valence is a computationally economic way for evolution to drive behavior when the implementation is in biochemistry. However, information processing can also be done non-consciously, and it stands to reason that all the informational saliency achieved via negative valence experience can instead be had via non-conscious processes which would be available to future suitably modified embodiments of intelligence.

The QRI is the only real player in this game so far, as our civilization takes its first baby steps towards maturity. In the domain of effective altruism, the Qualia Research Institute today corresponds to what bitcoin was when first launched. The difference is that the QRI doesn’t just promise to be a novel medium of exchange, but a novel competence about the first principles of well-being!

During the couple of years it took for us to come to the above conclusions, we set aside every penny we could spare. That became the fifty thousand we are now committing to the QRI. If enough others with the same visions were to do the same thing, soon enough it could begin adding up to real money. Money which at this foundational stage stands at quite a favorable exchange rate with respect to the ultimate currency of the universe: positive emotional valence.

Infinite bliss to everyone from a couple of Scandinavian old-timers!HEA-2020-01-19


High Entropy Alloy (Al + Ti + Cr + Mo + W) and Low-Entropy Non-Alloy (Ti) – made by Anders and Maggie. If non-materialist physicalist idealism (i.e. panpsychism that respects physics) is true, what do these bundles of baryonic matter feel like from the inside?

Letter IV: On Psychonautics

Psychedelic trippers put effort into trying to interpret what it all means ontologically. Plant spirits may be at work, or one taps into the collective unconscious or is simulated by some alien superintelligence.

The QRI could perhaps guide interested psychonauts in the direction of writing more scientifically productive reports.

A scientifically minded tripper needs to start with the realization that human beings are perfect psychonauts because our brains have an enormous excess capacity over what is minimally required to perform any one of the tasks that we do in everyday waking life. The highly unusual aspect of human brains is that they can produce general intelligence. This is rare in nature but when you have it, you assume it to be the normal state of affairs.

Trippers are often in disbelief over the ability of human brains to produce the fantastic content of psychedelic experiences. As if there is suddenly a superpower there which one never uses when sober. How can that be? It must be something supernatural going on, right? Actually, no. Not that we should rule out the “supernatural” a priori but it is not necessary.

The human mind uses a superpower all the time. One which is hidden in plain view, we might say. It is the superpower of selecting from a huge range of possibilities for what the mind could be doing, and homing in on exactly the one choice in every moment that is most appropriate right then and there. When those tight constraints are relaxed the human brain becomes a system which can explore far and wide in qualia state-space.

Intelligence is a phenomenon which uses multiple optimization points to converge on some invariance. At the theoretical efficiency maximum this takes surprisingly (to us) little raw processing power. A jumping spider does not display less strategic and tactical intelligence than a human does when hunting. The spider’s neural network is very much smaller than the human’s but the evolutionary fitness search available for evolving small, numerous and quickly reproducing creatures is much larger than for animals like us. For us it is not so much a question of evolution having optimized what every cell does, but one of having added more and more cells to increase overall performance.

The spider’s brain probably contains far less sub-optimal “spaghetti code” than the human’s. It is possible that the spider has access to exquisitely fine-tuned qualia for the crucial task of sneaking up on big, highly dangerous prey and bringing it down without botching the job. On the other hand, there might not be much opportunity for spiders to evolve general intelligence since they have already done away with everything that is “useless” for their sober everyday lives.


“Does my brain contain less spaghetti code than yours?”

A human brain is a mass of excitation-inhibition “spaghetti” which defies belief. An almost ultimate jack of all trades but master of none which cannot quite produce the hunting skills of the spider but can instead do a billion other things that the spider could not even in principle learn how to do.

It is the billion other things that we could do but don’t, which is the human superpower, not the few things that we actually do on a sober basis. This is a power which can be harnessed for psychonautics. You’ve got an inner-space warp drive in your head. Aptly named. 🖖

Letter V: Exciting Research Leads

Here are some suggestions for titles of essays and research papers the QRI could write if we had the resources.

  1. “Alloy, anneal, quench and temper: Forging a blade to cut mind at the joints”
  2. “Play me like a violin: A compressibility analysis of neuro-acoustic patterns captured during person to person interaction”
  3. “Leadership and consonance: Aggregate neuro-acoustic compressibility as a proxy for computational efficiency of human group intelligence”
  4. “Neural annealing through laughter: Neuro-acoustics of humor as a factor for healthy mental adjustment”
  5. “The tree of music: An annealable branching tuning-fork model for nervous systems”
  6. “Same but different: Suggesting a qualia analogue for the comparative planetology of Earth and Titan”
  7. “Music of life: Consonance, dissonance, noise and symmetry as explanatory elements for evolution from single cells to human minds”
  8. “Compartments of harmony bounded by dissonance: A neuro-acoustic model of domain specificity in cognition”

The Seven Seals of Security or Safety Through Uncertainty – Transhumanist Satire

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Letter VI: Earth as an Engine of Qualia Diversity

Handwaving Johnson & Gómez-Emilsson’s law about the surprisingly large size of qualia state space:

Presume that consciousness and matter are interconnected information structures. Can any useful parallels be drawn from the matter domain of outer space to the consciousness domain of inner space? Consider that planets, as a group, are subject to variation and (anthropic) selection. An interconnection point is provided by observation selection: Certain planetary properties far from the universe median are going to be found by intelligent conscious observers for their own planet of origin. A small subset of conscious observers are the ones who, like humans, have general intelligence and broad curiosity. Those observers are the few who observe more and more aspects of their own planet as well as adjacent space and the state space of matter at large, and ultimately perhaps also of consciousness at large. The evolutionary reproductive selection of such observers is not the default condition of all life but rather it is conditional upon even more unusual properties of their planet of origin than for the average life-bearing planet.

Conclusion: Earth is likely to be a highly unusual planet, and human consciousness is likely to be a highly unusual seat of experience. They are causally linked. A structural property they share could be a high level of diversity but never reaching cosmically global extremes on any single parameter. A Jill of all trades planet is married to a Jack of all trades mind.

While fairly good at impressively many trades, Jack and Jill are master and mistress of none. For a tentative and very loose analogy which may be better than nothing, let’s say planet Earth is like the human mind. The other planets in the Solar System are like altered human minds and some animal minds. Some basic properties like gravity, roundness and rotation are common to all the planets. Corresponding to suggested basic features of biologically evolved sentience, such as valence and some sensory modalities.

Then we follow Slartibartfast to the fjords of Norway. Here we see how Earth differs in diversity compared with the other “animals”. The planet’s surface is an energetic 3-phase regime. Solid crust, liquid water and solid water under highly dynamic conditions. Not widely separated like on Europa but forming extended areas of contact where unusual complexity emerges. It’s worth an award, really. (No, not Belgium…).

Human cognition is like Earth with its’ coasts and mountain ranges. A “just right” quantity and proportionality of ingredients is what allowed self-organization of Earth’s environmental complexity and its’ endurance over time via the mechanism of prolonged core solidification and plate tectonics. An unusual state of affairs in nature. It’s not unexpected in principle, only rare in actual existence. The same may go for evolution of the general cognition accessible to human minds.

A type of mind which is generally competent over multiple domains of agency cannot function as such if not many crucial parameters in its’ architecture fall within a tight range of “just right and not too much nor too little”. Or, in Swedish, “lagom”. If you loosen that constraint, such as by ingesting 5 grams of mushrooms blindfolded, your mind will clearly no longer function on your job or even in your body. But in exchange for giving up on that functionality as agent, you can max out on stuff like… well, it’s beyond words.

General intelligence is not compatible with an easy achievement of extreme states of consciousness, though as a less frequently added mental ingredient for a group intelligence (like human hunter-gatherers) extreme states can be hypothesized to enhance abilities of that group intelligence.

But what does the current human “master of none” in qualia rendering imply for the future of consciousness, and what about cosmic matter beyond the neighboring planets?

Beyond the Solar System we find many types of stars, black holes, dark matter and various ultra-thin, ultra-dense, ultra-cold, or ultra-hot configurations of matter in the wider domain of spacetime. Nature usually has not developed nonliving matter into configurations with even remotely as high a complexity as for living matter, simply because of no evolutionary selection pressures. Some nonbiological matter objects could be strong qualia generators just by chance, though. The Sun comes speculatively and punlessly to mind. Doing an IIT and a CDNS analysis on its’ surface magnetized plasma wave patterns may not be entirely far-fetched. But the big promise for expanding the diversity of actualized sentience comes through engineering. Jack and Jill is the couple who can pull that off, and their offspring can then grow up in that fabulous new landscape of experience. For they can become masters and mistresses. Dominatrices, even. The reason being that while the parents are tightly constrained experientially, the kids need not be.

For an efficiently organized advanced technological civilization, the constraints of being a highly general and resilient intelligence can be placed high up on the group level. Individual seats of experience with the sizes of today’s human or animal brains, say, can then be allowed to render experiential states more specialized to feel meaningful, enjoyable and worthwhile. (A dystopian version could instead generate unimaginable suffering, of course. Need to watch out…).

Earth is by far the most diverse planet in the Solar System, but it does not have the deepest ocean, the tallest mountain, the highest gravity, the hottest days, the most explosive volcanoes or the most intense thunderstorms. Human minds who have only experienced their evolved biologically functional mental states have not reached the consciousness state space equivalents of the extreme environments on the other planets. They have never snowboarded down the tellurobismutite condensate slopes on Maxwell Montes or been ejected on a ballistic trajectory by a sulfur dioxide plume from Tvashtar Patera. These things may be comparable to being a bat or taking psilocybin. As different from sober human experience as they are, they still merely hint at the range of possible experiences in the qualia state space opening up beyond. If all goes well, there will be psychonauts of the future who are children of Earth and able to engineer any form of matter and energy into conscious brain architectures. They would become what Max Tegmark has called “Life 3.0”.

Either that or, in a hopefully not terribly more likely scenario portrayed by imagined future historians, humanity stayed obsessed with the circulation of money to the detriment of all else.

This planet has – or rather had – a problem, which was this: most of the people living on it were unhappy for pretty much of the time. Many solutions were suggested for this problem, but most of these were largely concerned with the movement of small green pieces of paper, which was odd because on the whole it wasn’t the small green pieces of paper that were unhappy.” ― Douglas Adams, The Hitchhiker’s Guide to the Galaxy 🌎


Earth as an Engine of Qualia Diversity

Making Amazing Recreational Drug Cocktails


Imagine that you were tasked with creating a molecule to represent the spirit of California. I think that I would just glue together two MDMA molecules and call it a day.



It turns out Californidine is indeed a real molecule, named after the California Poppy. I am still wrapping my head around the fact that Californidine can be described as two MDMA molecules sharing the nitrogen atom and with the end of the carbon chain of each MDMA molecule bonded at the 2-position of the benzene ring of the other one (minus a hydrogen atom). Interestingly, this compound has no psychedelic or empathogenic action. At best, it can be described as a very mild and unreliable relaxing agent of “herbal strength” akin to the active ingredients of chamomile, valerian, or ashwagandha. So, joining two powerful heart-openers gives rise to a mild sleep-inducer? Perhaps this is a metaphor for something.


Californidine and MDMA

But that’s not what I want to talk to you about today. While gluing together psychoactive molecules may not have a (cartoonishly) desirable additive effect, doing so does express the spirit of what I want to propose today. And that is the impulse to use a creative and fun approach to drug design, letting your imagination run wild to avoid prematurely discarding one’s crazy ideas.

Notable Leads for Great Drug Combos

Over the last 10 years I’ve read many (many!) trip reports and have talked to hundreds of experienced psychonauts (see also: r/replications). It is largely thanks to a subset of these psychonauts, which for lack of a better term could be described as the subset of rational psychonauts, that I’ve been able to assemble empirically testable models for psychedelic phenomenology (some examples: Algorithmic Reduction of Psychedelic States, Hyperbolic Geometry of DMT Experiences, Quantifying Bliss, How to Secretly Communicate with People on LSD, etc.). Although my focus has largely been on the effects of individual drugs, I’ve become very cognizant of the fact that drug combinations can produce effects not accessible with individual substances. In other words, when it comes to mixing psychoactive substances, the sum is more often than not different from the sum of its parts. Some of these effects seem extremely significant both from a scientific and a philosophical point of view.

But first, an important disclaimer: mixing drugs is dangerous and you should never do it unless you really know what you are doing. The pile of celebrity deaths caused by multiple drug intoxication is only scratching the surface. Indeed, there are many combinations of drugs that are deadly even when the individual drugs taken on their own are relatively safe. For example, while 5-MeO-DMT is relatively safe when vaporized (save for egregiously negligent uses of the drug and the occasional drowning in one’s own vomit), taking 5-MeO-DMT orally in combination with an MAOI leads to extremely toxic reactions, such as severe hypertensive symptoms, overheating, and serotonin syndrome. Don’t do it. As a very rough guide for how mixtures of psychoactives behave, study the chart below.


Welcome to the practice of combining drugs. You may die. (source)

That said, just as drug combinations have a dangerous side, they also likely harbor hidden gems that are very safe, enjoyable, and mind-expanding in ways inaccessible via single drugs. As a general overview, some examples of the possible benefits of drug combinations include: (1) Enhanced euphoria, e.g. see speedball which is massively euphoric but also very dangerous, (2) reduced psychological discomfort (e.g. anxiolytics with psychedelics), (3) uniquely interesting effects, e.g. LSD + MDMA (see below), and (4) reduced physical side-effects and medical risks, e.g. calcium blockers to reduce MDMA neurotoxicity, 5HT2B antagonists to reduce cardiotoxicity of psychedelics, etc. as we’ll discuss. In addition, it is worth mentioning that from a therapeutic point of view, we also have the “more dakka effect“, where some conditions only respond to combining enough drugs (e.g. oncology). It’s possible chronic pain or severe depression may legitimately require multiple drugs to be adequately dealt with. Now let us examine in more detail some particularly interesting categories of drug combinations:

Psychedelics + Anxiolytics: According to many reports, phenibut in small doses seems to significantly reduce the anxiety that comes up on psychedelics. I am ambivalent about sharing this information given the fact that phenibut can become a huge problem for some people, but I think that on the whole it is wise for people to know that an over-the-counter “nootropic” can actually help avoid fear, discomfort, and panic attacks during a psychedelic experience.

Cannabis + Psychedelics: I generally find two kinds of psychedelic drug users. Those who cannot think of having a psychedelic trip without at some point smoking a joint, vaping, or eating a cannabis edible. And then those who would never dare to combine the two because they once had a terrifying experience with the combo. Interestingly, some of the people I’ve met over the years who seem to be able to easily handle massive doses of psychedelics (e.g. 500 micrograms of acid) respond terribly to weed, and especially badly if they are already tripping. Cannabis both modifies and potentiates psychedelic states of mind. It has a tendency to make the experience more conceptual rather than sensory or mystical. The combination also greatly increases the probability of getting stuck in time loops.

Empathogens + Psychedelics: One of the best descriptions of MDMA + LSD (also called candy-flipping) that I’ve found comes from Steven Lehar (emphasis added):

Under LSD and ecstasy I could see the flickering blur of visual generation most clearly. And I saw peculiar ornamental artifacts on all perceived objects, like a Fourier representation with the higher harmonics chopped off. LSD by itself creates sharply detailed ornamental artifactslike a transparent overlay of an ornamental lattice or filigree pattern superimposed on the visual scene, especially in darkness. Ecstasy smooths out those sharp edges and blurs them into a creamy smooth rolling experience. I would sometimes feel some part of my world suddenly bulging out to greater magnification, like a fish-eye lens distortion appearing randomly in space, stretching everything in that portion of space like a reflection in a funhouse mirror.

– Steven Lehar (The Phenomenal Character of LSD + MDMA)

Not everyone responds well to this combination, and given the nature of these substances, it seems likely that the dosages and the relative timing have a large influence on how the experience develops. I’ve heard three relatively “established” ways in which people use this combination. First, you have the school that says that you should take the MDMA at or slightly after the peak of the effects of LSD, that is 4-4:30h after taking it. The reasoning here is that you don’t want to be caught coming down from the MDMA while still having a long time to go on LSD since the acid could enhance the feelings of the comedown. The delayed gratification also pays-off by giving you several hours to face the problems you want to solve unaided and see how far you can get before the mood boost of MDMA gives you the determination to be contented with it.

The second school of thought about candy-flipping says that the biggest factor in how psychedelic experiences turn out is how they start. So what you want to do is take the MDMA 1 to 1:30 hours before the acid. This way, you only embark upon the inner journey when you are already in a really, really good chill state of mind. Some people report that the acid picks up the empathogenic quality of the state, amplifies it, and carries it on for much longer than if you had only taken MDMA alone.

There are many proponents and detractors to both of these schools. What I’ve seen more or less everyone agree on is to avoid taking substantial doses of LSD and MDMA (e.g. 200micrograms LSD + 120mg MDMA) at the same time. Apparently this is simply just too overwhelming and synergistic to be enjoyable, often causing a lot of nausea and palpitations.

The third school, however, is to take only a small dose of both at the same time. Say, 35micrograms LSD and 35mg MDMA. This apparently is an extremely positive combination. The experience is not mild due to the synergy, and it seems to provide an open, creative, level-headed mindset for many hours without much of a comedown or hangover. As with everything here, your mileage may vary.

Psychedelics + Dissociatives: Psychedelics and dissociatives have profound non-linear mixing effects. According to multiple sources, the right combination of LSD, Ketamine, and THC can give rise to a “free-wheeling hallucination“. This is a state of consciousness in which you gain a great degree of conscious control over the contents of the hallucinated world, so that you can project your will by saying “let there be a chair in front of me” and you will see it manifest in exquisite detail. You can rotate, translate, invert, fibrate, and project the chair in any way you want, as if you were now able to use your brain as a very general game engine of consciousness. That said, even when this doesn’t happen, the combination of psychedelics and dissociatives is ridiculously synergistic. People report getting stuck in extremely energetic time-loops akin to those caused by psychedelics and cannabis, but more powerful (cf. trip report of DMT + nitrous oxide). Steven Lehar calls the effect where the presence of a psychedelic changes the quality of a dissociative as “dissociative coloring”. I’ve been amazed at the fact that there is no mistaking when someone has previously experienced LSD and nitrous together. You don’t get reactions like “it didn’t do much for me”. This combo usually has a special place in the memory of a person who has experienced it. Eyes brighten, curiosity sparks. I’ve been asked on multiple occasions “what do you think is going on with the strange synergy between LSD and nitrous?” Now, 5-MeO-DMT and DMT are very different, and the LSD + nitrous state seems to have some resemblance with the 5-MeO-DMT state. They share that strange feeling of becoming a kind of saturated resonance box. The feeling is one of becoming a vessel full of coordinated and coherent vibrations that unearth and dissolve internal boundaries and blockages. The process inherently blocks your ability to conceptualize in a dualistic way. The cognitive content of the state is better captured by a huge blinking sign that reads “THIS, THIS, THIS” on repeat rather than the more usual “that thing over there connected to this over here, modulated by what happens there” kind of cognitive state we are more familiar with. DMT on its own is very different than this, in that the mental formations and patterns of binding that emerge are extremely specific, detailed, and irreducibly complex. Not so on the upper ranges of the dissociative and psychedelic cocktail, where the resonance is profound and the asymmetries needed to store complex information are constantly smoothed out by the ongoing full-body bath of reverb. (cf. Neural Annealing).

Dissociatives + Empathogens: According to several trip reports and credible personal communications, taking ketamine while on MDMA can bring back “the magic” that one only ever experienced with MDMA the first few times using it. Also MDMA and nitrous have profound research-worthy synergy.

Potentiation: Shulgin reported that substances that don’t feel psychedelically active on their own may nonetheless potentiate the effects of other psychedelics. For instance:

(with 160 mg of MDPR followed at 2h by 100μg LSD) This proved to be almost too intoxicating, and a problem arose that had to have a solution. The entire research group was here, and all were following this same regimen. Two hours into the second half of the experiment a telephone call came that reminded me of a promise I had made to perform in a social afternoon with the viola in a string quartet. Why did I answer the phone? My entire experience was, over the course of about 20 minutes, pushed down to a fragile threshold, and I drove about 10 minutes to attend a swank afternoon event and played an early Beethoven and a middle Mozart with an untouched glass of expensive Merlot in front of me. I could always blame the booze. I declined the magnificent food spread, split, and returned to my own party. Safely home, and given 20 more minutes, I was back into a rolling +++ and I now know that the mind has a remarkable ability to control the particular place the psyche is in. 

(Entry on MDPR, from PIHKAL)

More common than the above, ayahuasca is intrinsically a drug combo primarily of the potentiation kind. As mentioned before, cannabis not only alters but also potentiates the effects of psychedelics. It is worth mentioning there is a community of people who believe that noopept (a cholinergic nootropic, see below) can potentiate MDMA. While there is some evidence that MDMA is itself mildly cholinergic– and thus provides a sense of mental clarity in addition to the loved-up feeling- too much cholinergic action tends to make people feel rigid, robotic, and hyper-cerebral. I am therefore personally skeptical of the benefits of combining something like noopept with MDMA, as the potentiation of some of its qualities may come at the cost of reduced emotional sensitivity. Why trade a feeling of renewed innocence and receptivity with calculating prowess? I doubt this is the best use of a roll.

Anti-tolerance Drugs: This is a category of combinations with tremendous potential to relieve suffering, to the extent that I think of it as a humanitarian tragedy that there are no concerted research efforts currently in this direction. Sufferers of chronic pain and treatment-resistance depression could make use of drugs that help them keep the tolerance to the drugs they depend upon for having a livable life under control. I know this has a lot of the ring of turtles all the way down (“when are you going to get the anti-tolerance drugs for anti-tolerance drugs? And then the anti-tolerance for anti-tolerance for…”) but I am sincere when I say that looking here may pay off in spades. Already we see ibogaine doing other-worldly magnificent things to cure addiction and reverse tolerance. Who knows what a large targeted research program with this focus may discover. Some examples of anti-tolerance drugs include proglumide, ibogaine, and black seed oil for opioids, and flumazenil for benzodiazepines.

Prevent Physical Side Effects: Epidemiological data suggests that chronic or heavy use of 5HT2B agonists may lead to heart valve disease (cf. Fen-Phen), which does not bode well for the long-term (as opposed to acute) safety of many psychedelic compounds. Now, neuroscientist Thomas Ray believes that 5HT2B may be necessary for some of the characteristic psychedelic action of entheogens, so blocking it altogether may come at the cost of eliminating the reason why the drug is interesting. That said, we do know that 5-MeO-DMT is profoundly psychedelic and yet has negligible 5HT2B activity. It would be very useful to know what happens when one combines psychedelics with heavy 5HT2B affinity, like 2C-B and DOB, with 5HT2B antagonists (usually prescription medicines). Would blocking 5HT2B agonism avoid cardiotoxicity? And what would the drug feel like then? Another interesting lead is the affinity of compounds like 2C-E and 2C-T-2 to the 5HT3 receptor, which is predominantly in the gut and modulates feelings like nausea. Additionally, since 5HT3 antagonists are antiemetic it really stands to reason that taking one before e.g. tripping on shrooms may give you a much less, ahem, visceral experience. Finally, I would like to explore the implications of the fact that of all of the compounds in Ray’s study the only one with significant affinity for calcium channels is MDMA. Would this be related to its neurotoxicity? And would taking a calcium channel blocker prevent it? It might still be wise regardless simply as a way to lessen the cardiac load of the compound.

Nootropic Stacks (cf. the Qualia Pill):  Many people who explore nootropics make “stacks”. That is, rather than taking only piracetam, they might take a combination of piracetam, aniracetam, pramiracetam, coluracetam, and l-tyrosine. I suspect that this is popular because most nootropics are pretty mild and often hard to notice, and people want to be able to feel the effects. I generally do not think this is sensible, though, as we don’t understand these substances well enough. More so, branded “nootropic stacks” can have upwards of 30 different psychoactive substances crammed together in half a dozen pills you are supposed to take daily. While I do think there are likely gems to be found in the vast combinatorial space of cognition-boosting chemicals, I simply do not see any way in which the current major brands of nootropic stacks could have done the type of research needed to find them. I therefore do not personally recommend you go out and try such combos, at least not until we know a lot more about how to do combinations properly. If you want to try nootropic stacks, I’d recommend you start with small doses of two or three well-researched nootropics at most and do your own research thoroughly before settling on a particular combination.


LSD + DMT Visual Replication

Psychedelics and Psychedelics: A classic psychedelic combo that I’ve heard a lot about is LSD + DMT. The state that emerges from this combination is apparently unique, though if you take enough DMT the LSD fades into the background. Apparently psychedelics tend to have a characteristic spectral effect on your brain’s harmonics (see: Connectome-Specific Harmonic Waves on LSD), which manifests in the form of experiencing “vibes of different frequencies” specific to the drug you are taking. The case of LSD and DMT is very interesting, since their characteristic frequencies are sufficiently far apart (to put a number on it, LSD may be in the vicinity of 18Hz while DMT may be close to 30Hz) that they can be separated easily. You thus get a spectral effect of two peaks interfering with one another, oftentimes creating a powerful 3D grid of Moiré patterns, like a super-charged version of the “regular” DMT Chrysanthemum. As a method for spectral analysis, studying the beat patterns of psychedelic drug combos could go a long way in formulating a systematic characterization of their phenomenology. Speculatively, this may even allow us to come up with specific psychedelic drug cocktails that produce maximally consonant harmonious effects.

Idiosyncratic Responses

A final thought to add to this section concerns the fact that people respond differently to drugs. One can reason that if drug A affects 20% of people in a different way while drug B affects 10% of people in a different way, that A + B would lead to 4 different kinds of responses. More so, the more drugs you pile on top of each other, the more specific and individualized the response would be. I think that this is likely true in the general case, but I would argue that it is not universally true. A useful analogy here is with the way people respond to the scent of different molecules: you may lack the gene that encodes the receptor for a particular molecule, but perfumes usually have 30 or more scent-contributing molecules, so the experience of a perfume may be more similar between people than their experience of individual molecules. At the extreme, we have the phenomenon of “white noise scent” where once you mix 40+ molecules in equal (intensity-adjusted) proportions that span scent-space, it all starts smelling the same. The notion of “scent entropy” can be imported to drugs as well: I would expect a kind of inverted U-curve for “how idiosyncratic” the responses to drug combinations are as a function of the total entropy of the combo.

Drug Cocktails From First Principles

The way we aim to understand psychoactive substances at the Qualia Research Institute is in terms of the way they modify the neuroacoustic profile of the brain. And while this is what I see as the most promising approach moving forward, I believe that there is nonetheless a lot of low-hanging fruit at the receptor level of analysis.

The first time I’d thought of trying to emulate the effects of a drug using a cocktail of other drugs came up years ago when I found out that MDMA is likely neurotoxic. At the time I thought perhaps it was just a matter of getting the right dopaminergic, serotonergic, and oxytocinergic activity going for you to replicate the MDMA high. It’s a good thought, and some people have taken it to heart, such as the creators of “Poly”, an MDMA-like cocktail (cf. Kisspeptine). But as we’ll see, MDMA is more complex than that, and we may need to consider far more variables to make a “credible MDMA substitute”.

Looking beyond drug combos of only two or three drugs, and with a nod to concepts from the field of high-entropy alloys (HEAs), we could start thinking about the secret gems to be found in the vast combinatorial space of “high-entropy drug combos”. But what kind of principles could we use to safely combine 5+ drugs? The full story will probably be much, much more complicated than the following approach, but it is still nonetheless worth exploring as a first pass. Namely, to break down each drug in terms of their receptor affinity profile and then use those affinities additively to create arbitrary “synthetic” receptor affinity profiles. There are many reasons why this might not work: receptor affinity may not work linearly or have a clear rule-based behavior. For instance, it is still unclear if a single drug that has affinity for key serotonin receptors (say 5HT2A, 5HT2B, and 5HT7) in addition to working as an NMDR antagonist would produce the same feeling of “synergistic action” as there is between psychedelics and dissociatives. More so, there could be additional intra-cellular signaling specific to each molecule, so that two molecules that work as agonists with the exact same 5HT2B affinity may have different downstream effects inside the neuron, and then those intracellular effects might have phenomenological properties of their own. But leaving all of those caveats and unknowns aside for a moment, what would it look like to create drug cocktails with this method?


True for both people and drugs!

After giving it some thought I realized that the problem can be reduced to a non-negative least squares (NNLS) optimization (non-negative because, as they say: “you can always take more drugs, but you cannot take less drugs”). It turns out there are already open source implementations of algorithms that solve this optimization problem (for both R and Python)*. So I downloaded the data from the famous Thomas Ray study of psychedelic receptor affinity and played with the data and the non-negative least squares method in a Jupyter notebook for a bit. The first thing I tried was to create a compound like 2C-B but better. Under dubious- but not entirely random- assumptions, I set the desired receptor affinity to be that of 2C-B but with the following modifications: to have the 5HT2B affinity be as low as possible in order to minimize cardiotoxicity concerns, and borrow from MDMA’s unique profile the hypothesis that the Imidazoline receptor is related to heart-opening effects. Additionally, I modified the receptor profile so that the drug would give you more focus than 2C-B by having a higher affinity for the dopamine receptors. To top it off, I racked up the desired receptor affinity for 5HT7, as it has been implicated in providing the more utterly mind-blowing power of psychedelics. I entered these modifications into the NNLS optimizer and the output I got was**:

0.48*2C-B + 0.337*5-MeO-DMT + 0.116*MDMA + 0.043*cis-2a + 0.016*6-F-DMT + 0.005*Mescaline

I see, so since 2C-B is still the backbone of the desired affinity pattern, it appears in high proportion in the mixture as a kind of “base” on top of which the modifications are made. It makes sense that 5-MeO-DMT would come next as it is pretty selective for 5HT7 (remember, the most literally mind-blowing chemical), and MDMA would follow due to the desire for Imidazoline affinity. That by the way, is also probably partly why the formula contains a pinch of Mescaline, to round up that Imidazoline for good measure. I then decided to relax the 5HT7 requirement and instead increase the 5HT6 and 5HT5A, and got the following formula:

0.038*Lisuride + 0.273*2C-B + 0.056*DMT +0.079*Mescaline + 0.15*MDMA + 0.377*RR-2b + 0.018*Ibogaine

And this now looks pretty different. After playing like this for a while, it occurred to me to use this technique to basically try to reconstruct a drug using a non-negative linear combination of the remaining drugs available. Imagine for example that you are stuck in quarantine at your house and you don’t have any 2C-B to kill time (I know! Very relatable isn’t it?), but you do somehow happen to have an assortment of hundreds of other unscheduled random research chemicals. Could you combine them in such a way that you approximate the effects of 2C-B? Well, let’s see.

Here are the “drug reconstructions” the method derives (again, please, don’t try this at home):

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I am pleasantly surprised to see the formulas actually do seem pretty intuitive to me. Take for example the DIPT reconstruction. The top two ingredients are 5-MeO-DIPT and DPT, which are the two closest structural analogues of DIPT in the dataset. Or take the one for DOB: this is the amphetamine version of 2C-B, so it makes sense that both an amphetamine psychedelic (Aleph-2) and 2C-B would make up the top two ingredients. Or consider 5-MeO-DMT, with its most prominent ingredient being 5-MeO-TMT, which is one carbon atom away in terms of structure. Or see how Mescaline’s heart-opening effects are well represented by its reconstruction with MDMA and MDA, while TMA contributes the receptor affinity characteristic of the trimethoxy class of functional groups, along with another Mescaline-like phenethylamine, 4C-T-2. Alas, here is where an imperfect understanding of drug interactions could come and bite us in the ass: if 4C-T-2 is anything like 2C-T-2, it might have some MAOI action, which could be potentially very dangerous to combine with compounds like MDMA. Needless to say, before you go out and try these crazy drug cocktails, we first need a thorough understanding of each drug well beyond just its affinity to “only” 30 or so receptors.

Now, not every reconstruction makes sense to me, and really only a few substances have what I would call a descent mean squared error. See the receptor affinity tables below for examples of both successful and unsuccessful reconstructions (only non-zero entries shown):

DOB and 2C-T-2 have some of the lowest errors in the sample, meaning that their reconstructions are pretty good, while Ibogaine and MDMA have two of the worst error rates, and their reconstructions are still obviously pretty far from the goal. Naturally, if we were ever to test this method in the lab (with e.g. a drug discrimination paradigm) we would probably start with the most accurate reconstructions first. For instance, train rats to distinguish between 2C-B and DOB, and see if administering the (2C-B-containing) “DOB reconstruction” makes the rats think they got DOB rather than 2C-B.

Master Druggist (Synapse? Dendrite?)

I would like to conclude this essay with an interesting speculation: what if we developed drug combos like we develop perfumes? It is my appreciation that it takes a very high level of intelligence, domain expertise, and psychological robustness to be able to contribute usefully to the field of psychonautics. Sasha Shulgin spent over 30 years taking hundreds of completely new drugs, and I would very much trust his judgement about what makes a great psychedelic drug combo than I would trust a random BlueLight or Erowid user. (As an aside: Shulgin was extremely cautious in his approach, but he certainly wasn’t doing some of the low-hanging fruit on safety, such as wearing a heart monitor or measuring his blood pressure when taking a new drug, for starters. Future systematic psychonautic work should also record as much biometric data as is feasible). You wouldn’t put on a perfume made by someone who has only ever worn Axe, would you? Training a “Nose” takes up to 7 years, and it involves becoming deeply familiar with the scent of a long list of molecules, accords, and perfumes. Likewise, I’d expect that in order to be qualified to find extremely good drug combinations, one would first need to become familiar with the effect of many different individual drugs, “natural drug accords” (e.g. peyote), and designed drug cocktails. Only once you have an intuitive sense of how e.g. the sigma receptor interacts with the 5HT1A receptor would I trust your judgement about adding a pinch of agmatine to your already convoluted mixture of 20 psychoactive substances. A Super-Shulgin Academy could train people to be professional drug cocktail makers (if perfumers are called “Noses” would we call Super-Shulgin certified cocktail makers “Dendrites”?). As discussed above, this assumes that we can do this safely, which I suspect will be possible once we map out the space of dangerous combinations and receptors we shouldn’t mess with to avoid side effects like cardiotoxicity (e.g. 5HT2B, 5HT3A, calcium channels, etc.).

You come to the master cocktail designer with a general concept for a new recreational drug, and they would come up with activity profiles that best evoke those feelings. The Dendrite would select from hundreds or thousands*** of pure chemicals and accords to create your unique cocktail. As is the case with Noses in the perfume industry, a Dendrite would tend to have a set of about one to two hundred “frequently used” compounds, and a dozen or so “signature” ones they’re deeply familiar with and that usually reveal who the Druggist is, if found in large proportions in the end product. Of course there would be “house favorites” (e.g. the classic “ambroxan bomb” of Dior fragrances for men) and chemical fads (e.g. the wide adoption of Iso E Super in 90s perfumes). Every year would come with a new season of amazing, safe, and uniquely interesting recreational drug cocktails.

In perfumery you find both natural and synthetic “accords”: “Violet reconstructions” attempt to emulate the smell of violet but in a much more long-lasting, storable, and versatile way. Good Dendrites would not only use “natural accords” such as “peyote” or “marijuana plant” but would also make their own, aided with computer models and datasets of trip reports along with their own first person experiences. In both perfumery and professional drug cocktail making we would study accords packed with combos of qualia-triggering chemicals, and a Dendrite could be known not only for making good final products, but for making excellent accords with predictable and desirable effects.

To finalize the analogy (and this article) we could also discuss the way in which perfumes feel “broad spectrum” thanks to being constructed by combining “top, heart, and base notes”. Roughly speaking, top notes tend to “feel higher frequency” (such as citric scents) while base notes tend to “feel low frequency” (such as woody scents), not unlike how a symphony will tend to combine sounds across the spectrum. The most interesting, voluptuous, and commercially viable combos would also probably have a broad spectrum of activity. They would be anxiolytic, exciting, relaxing, trippy, and empathogenic to various degrees all at once. They would combine fast, slow, and spiritual euphoria in a single power punch of qualia cornucopia. As such, each drug cocktail made this way would entail an entire worldview – a whole realm currently hidden in the vast state-space of consciousness.

* For an intuition: recall from linear algebra that a basis of n linearly independent vectors span an n-dimensional vector space. When the vector that you are trying to reconstruct is not in the span of your basis, the best you can do is to project your vector to the nearest hyperplane of the spanning space. Adding the constraint that you can only make non-negative linear combinations with your basis vectors, you find that the span will look like an ‘inverted pyramid’, and the least-squares solution will be the point of that inverted pyramid that is closest to your desired vector. This is why most of the reconstructions only use a subset of the available drugs in the dataset. In most cases, the desired vector (i.e. affinity profile in this case) will be outside of the inverted pyramid of the non-negative span, and the closest hyperplane will be a linear combination of only a subset of the building blocks- those which span that particular hyperplane. I.e. the solution is the projection to the nearest hyperplane segment covering the non-negative span. This is what the NNLS method is doing under the hood.

** Note: It’s important to point out that these are not dosages. The coefficients provided by the non-negative least squares method apply to the normalized affinity “npKi“, which is the receptor affinity normalized by the highest affinity among the receptors. The coefficients will be correlated with “proportion of a standard active dose” but there will be an error caused by the pretty tricky confounder that molecules vary in their “breadth of affinity”. Additionally: the psychoactivity of each receptor is not the same, we are not considering saturation effects, the difference between partial and full agonists is not taken into account, downstream effects are ignored, etc. etc. Needless to say, there is still quite some work to be done to transform these coefficients into meaningful dosages.

*** List of Psychoactive Drugs a professional Dendrite would be expected to be familiar with:

L-Tyrosine, L-DOPA, Apomorphine, Flumazenil, CPZ, BPAP, PPAP, Cabergoline, DAR-0100, Lisuride, Pergolide, Pramipexole, Rotigotine, Biopterin, PLP, Aminepetine, PCP, Marijuana, Dextromethorphan, Isoflavones, Citicoline, Metadoxine, Arecoline, Niacinamide, Paraxanthine, a-GPC, Acetylcarnitine, AR-R17779, GTS-21, Ispronidine, PHA-543,613, SSR-180,711, WAY-317,538, Hopantenic Acid, IDRA-21, Propentofylline, PRL-8-53, Trytophan, Picamilon, Betahistine, A-349,821, Cipoxifan, Creatine, Mildronate, Pregnenolone, Nisoxetine, Orexin, CP-39,332, Esreboxetine, Daledalin, AM-1248, Phenoxybenzamine, Symbescaline, Phentolamine, Isomescaline, Tolazoline, a-Methylfentanyl, Ketamine, Dichlorpane, 3-meo-pcp, Hex-en, Paraflourofentanyl, 3-Methylfentanyl, Metofoline, Buscaline, O-DT, Nortilidine, Thiobuscaline, Dizocilpine, Rolicyclidine, Phenescaline, Tenocyclidine, Methoxyketamine, pFPP, 5-me-MDA, 4-MAR, 1,4-Butanediol, 2-Methyl-2-Butynol, GHV, GVL, Mebroqualone, Benzylbutylbarbituates, Phenmetrazine, 3-Fluorophenmetrazine, Crack, Cocaine, Coca, Kava, Phenylacetylindoles, Benzoylindoles, Napthoylindoles, Adamantoyindoles, Pineapple Sage, Kokum, Brahmi, Artic Weed, Skullcap, Salvia Splendens, Coriander, Rhodiola Rosea, Velvet Bean, Bitter Orange, St. John’s Worth, Grape Seed Extract, Tulsi, Blessed Thistle, 3-Desoxy-MDA, Skatole, Isoindole, Indole, Benztropine, Diphenhydramine, Niaprazin, Doxylamine, Alaproclate, Zopiclone, Ifoxetine, Methylmethaqualone, Panuramine, Meta-Tyramine, Para-Tyramine, 2M2B, Pirandamine, SB-649,915, Epinephrine, Mepyramine, Octopamin, Delucemine, Oxidopamine, β-Methylphenethylamine, Mesembrine, Psuedoephedrine, Etolorex, Cathine, Cathinone, Ethcathinone, Norfenfluramine, Fenfluramine, Phentermine, Metaescaline, n-Ethylbuphedrone, Naphyrone, Pyrovalerone, Isopropylamphertamine, Clobenzorex, Pholedrine, Chlorphentermine, Xylopropamine, DON, DOPR, TMA, Methyl-BOB, Tetramethoxyamphetamine, 4-MTA, Bromatane, Hydroxyzine, BNC-210, CL-218,872, L-838,417, SL-651,498, S32212, 6-CAT, TAP, ETAI, IMP, Lorxaserin, Cisapride, Tegaserod, AS-19, E-55888, LP-12, LP-44, LP-211, Etoperidone, Lorpiprazole, Lubazodone, Mepiperazole, 5-TASB, TB, 3-TE, 4-TE, 2-TIM, 3-TIM, 4-TIM, 3-TM, 4-TM, TMA, TMA-2, TMA-3, TMA-4, TMA-5, TMA-6, 3-TME, 4-TME, 5-TME, 2T-MMDA-3a, 4T-MMDA-2, TMPEA, 2-TOET, 5-TOET, 2-TOM, 5-TOM, TOMSO, TP, TRIS, 3-TSB, 4-TSB, 3-T-TRIS, 4-T-TRIS, 44-BMAR, 3-MOMC, Prolintane, SDB-001, AB-FUBINACA, Dichloromethylphenidate, AB-PINACA, MN-24, 5F-MN25, A-836,339, ADBICA, 5F-NNEI, RCS-4, RCS-8, MPHP, 6-APDB, 4-HMP, EDMA, a-PBP, Methylhexamine, a-PPP, 4-FMD, EIDA, Phenylphrine, UWA-101, MPBP, RH-34, F-2, F-22, MR-2096, Adrenochrome, AET, Carbogen, DOB, DOM, Desmorphine, Ethylcathinone, Ehylene, GHV, Hypocretin, mCPP, MDPR, Methaqualone, TFMPP, CPP, MeoPP, A2, Salvinorin A, Scoplamine, TMA-2, BDO, 2c-B-FLY, 4-Flouromethcathinone, 4-HO-MPT, U4EA, 4-MTA, Phenylpiracetam, Aniracetam, Coluracetam, Pramiracetam, Melatonin, NRG-3, Theobromine, A834-735, Oxytocin, NZT-48, Heroine, 3-HO-PCP, MAOIs, 4-MeO-PCP, 3c-P, 5-IAI, Atropine, 5-IT, Bufotenin, 5-MAPB, 4-Aco-MiPT, 6-MAPB, ALD-52, AMMI, MET, D2PM, DET, CBD, CBN, LY-2183240, SF-SDB-005, AM-404, EG-018, DXM, FDU-PB22, AL-LAD, 3-MeOMC, 2-MeO-Diphenidine, 4-MPD, bk-MDMA, 4-MeO-a-PVP, GHB, 4-MeO-PBP, MBDB, 4-MeO-PV9, Fentanyl, 4F-PV8, a-PBT, BDB, a-PVT, 2-FMA, Dibutylone, 5-Meo-DiPT, Diclofensine, Methcathinone, DL-4662, MDEA, MDPPP, Methylone, Butylone, NEB, Phenibut, PV-8, GABA, 25B-NBF, Etaqualone, 5-API, Ethylone, Pentadrone, 4F-PVP, 25C-NBF, BZ-6378, C30-NBOMe, RH-34, MDAT, MDMA, MDMAI, Dimethocaine, Synthacaine, 3β-FBT, 5-MeO-BFE, 3,4-DMMC, AM-1248, MTTA, AM-2233, URB-597, AM-694, AM-087, BAY-38-7271, AB-005, A-796260, URB-754, 2-DPMP, a-PVP, 25N-NBOMe, 5-MeO-NiPT, Dexmethylphenidate, Buphedrone, RTI-111, Pentylone, 25I-NBF, Flourotropacocaine, Flourococaine, Cocaethylene, 25D-NBOMe, 25E-NBOMe, DMT, 5-Meo-DMT, 2C-I, 2C-E, 25I-NBOMe, 25I-NBOH, 25C-NBOMe, MXE, MDA, MDE, Mescaline, Ibogaine, Bromo-DragonFLY, Salvinorum, RU-28306, 2NE1, Psilocybin, HOT-7, JWH-018, JWH-250, 5-Meo-EiPT, AM-2201, 5-APDI, BZP, BZ, 4-MEC, MDPV, Bakers Ammonia, THC, THCv, Chloral, Chlorabutynol, MT-45, 5-Methyl-Ethylone, Methylphenidate, Ethylphenidate, 6-APB, 5-APB, Muscimol, 5-MeO-MALT, AKB48, 3,4-CTMP, PB-22, Diphenidine, UR-144, Flubromazepam, HU-210, MPA, XLR-11, MN-18, Naltrexone, STS-135, Gabapentin, 5-MAPB, Nitrous, Etizolam, Mephedrone, Pyrazolam, Methedrone, AH-7921, Phenazepam, AMT, OxyNEO, DPT, 5-MeO-AET, 4-Aco-DMT, EAM-2201, 5-MeO-DALT, 5-MeO-AMT, Acefentanyl, Ehylphenidate, 4-HO-MiPT, THJ-2201, 5-APDB, 5-EAPB, 4-HO-DPT, DOC, bk-2c-B, Escaline, THJ-018, 4-HO-MET, 2-AI, 2-MeO-Ketamine, Methoxphenidine, Ketamine, 2c-EF, Methamphetamine, Dextroamphetamine, Nitracaine, DALT, IAP, 4-fa, 2-Me-DMT, 4-fcocaine, Isopropyl Nitrate, 5-MeO-TMT, Piracetam, Amatadine, Choline, Memantine, 5-HTP, Camfetamine, Methallyescaline, LSZ, LSA, NBOMe-Mescaline, Loperamide, LSB, 25P-NBOMe, 25G-NBOMe, 3-MeO-PCE, MAM-2201, PCP, MPTP, MDAI, DOI, BB-22, EA-3167, BDF, L-Theanine, Dimethylone, Hydrocodone, Codeine, Morphine, Dilaudid, Oxycontin, Alpralozam, Diazepam, Fentanyl, Soma, Suboxone, Marinol, Seroquell, Trazodone, Lithium Bicarbonate, Abilify, Methadone, Amitriptyline, Strattera, Chloral Hydrate, Bromazepam, Buperonorphrine, Bupropion, Chlordiazepoxide, Clonidine,Clonazepam, Cyclobenzaprine, Dramamine, Benadryl, Ethchlorvynol, Fluoxetine, Tianeptine, Amineptine, Flurazepam, Metaxalone, Mirtazapine, Nalaxone, Nimetazepam, Oxymorphone, Paroxetine, Zopidone, Pregabalin, Promethazine, Risperadone, Selegiline, Sertraline, Sumatripan, Tiagabine, Propofol, Propanolol, Tiletamine, Zolpidem, Lotus, Aloe, Datura, Calendula, Chacruna, Galangal, Chaliponga, Chamomile, Damiana, Fever Few, Nightshade, Ginseng, Foxglove, Lavender, Henbane, Mugwort, Hemlock, Monkshood, Dream Herb, Capsaicin, Amanita, Hawaiian Baby Woodrose, Ergot, Hops, Imphepho, Indian Warrior, Kanna, Dagga, Kratom, Mandrake, Valerian, Nicotiana Tobacum, Nicotiana Rustica, Mimosa Hostilis, Morning Glory, Nutmeg, Opium Lettuce, Poppy, Sinicuichi, Syrian Rue, Tree Tobacco, Wormwood, Yohimbe, Yopo, Khat, Peyote, Cannabis, Catnip, Phalaris, San Pedro, Soma (ancient), Chacruna, Acacia, Ephedra, Mulungu, Mullet Fish, Siganus Spinus, Fugu, Sting-ray Venom, Bufo Alvarius, Epipedobates Tricolor, Waxy Monkey Frog, Salamandra Salamandra, Cobra & Scorpion Venom, Reindeer Urine, Glomeris Marginata, Sergeant Major, Grouper, Bluefish, Brass Beam, Flathead Mullet, Golden Goatfish, Rabbit Fish, Goat Fish, Adrafinil, DHEA, Dilantin, DMAE, Fipexide, Gerovital, Ginko, Black seed oil, HGH, Hydeigine, Meclofenoxate, Modafinil, Oxiracetam, Phenyton, Vasopressin, Vinopocetine, Bee Venom, Monkey Frog, UCM-707, AM-1172, VDM-11, VDM-13, OMDM1, OMDM2, LY-2318912, O-2093, OL-135, URB-597, URB-532, AEM, AL, ALEPH, ALEPH-2, ALEPH-4, ALEPH-6, ALEPH-7, ARIANDE, ASB, B, BEATRICE, BIS-TOM, BOB, BOH, BOHD, BOM, 4-Br-3,5-DMA, 3-Br-4,5-MDA, 2C-B, 3C-BZ, 2C-C, 2C-D, 3C-E, 2C-F, 2C-G, 2C-G-3, 2C-G-4, 2C-G-5, 2C-G-N, 2C-H, 2C-N, 2C-O-4, 2C-P, CPM, 2C-SE, 2C-T, 2C-T-4, 2C-T-2, 2C-T-7, Ψ-2C-T-4, 2C-T-8, 2C-T-9, 2C-T-13, 2C-T-15, 2C-T-17, 2C-T-21, 4-D, β-D, DESOXY, 2,4-DMA, 2,5-DMA, 3,4-DMA, DMCPA, DMMDA, DMMDA-2, DMPEA, DOAM, DOBU, DOEF, DOET, Ψ-DOM, DON, DOPR, E, EEE, EEM, EME, EMM, ETHYL-J, ETHYL-K, FLEA, G-3, G-4, G-5, GANESHA, G-N, HOT-2, HOT-17, IDNNA, IM, IP, IRIS, J, LOPHOPHINE, M, 4-MA, MADAM-6, MAL, MDAL, MDBU, MDBZ, MDCPM, MDDM, MDHOET, MDIP, MDMC, MDMEO, MDMEOET, MDMP, MDOH, MDPEA, MDPH, MDPL, MDPR, ME, MEDA, MEE, MEM, MEPEA, META-DOB, META-DOT, METHYL-DMA, METHYL-DOB, METHYL-J, METHYL-K, METHYL-MA, METHYL-MMDA-2, MMDA, MMDA-2, MMDA-3a, MMDA-3b, MP, MME, MPM, ORTHO-DOT, P, PE, PEA, PROPYNYL, SB, TA, 3-TASB, 4-TASB, Tropane, Vomeronasal Organ, Tropine, Hyosyamin, Dihydrokavain, Hyoscine, Myrcene, Ecgonine, 7-OH-DPAT, Benzoylecgonine, Sunifiram, Hydroxytropacocaine, Estrogen, Methylegonine Cinnamate, Estradiol, Catuabines, Estratetraenol, Phenyltropane, Androstenone, Civetone, Adrostenol, 5F-PB-22, Androstadienone, CBG, THCa, CBC, CBDa, Anandamide, 2-AG, CBL, CBDv, CBCv, CBGv, CBGm, Ibogaine, Noribogaine, Tabernanthine, Coronaridine, Ibogamine, Vaocangine, 18-MC, 5-MeO-Alkyltryptamine, β-Carboline, Tryptoline, Pinoline, Harmane, Harmaline, Harmine, Harmalol, Harmalan, Harmanamide, Acetylnorhormine, Bufotenin Oxide, DMT-N-Oxide, 5-MeO-Tryptamine, 5-OH-DMT, 5-MeO-DMT-Oxide, 3,4-Dimethoxyphenylamine, 6-MeO-Harman, Anethole, Safrole, Estragole, Monolignol, Pukateine, Glaucine, THP, Nantenine, Thujone, Lagochilin, Nicotine, Carbachol, Methacholine, ME-18-MC, 18-MAC, Tryptamine, β-Methyl-Phenethylamine, NMT, Voacanga Africana, Vachellia Farnesiana, Duboisia Hopwood, Acacia Victoriae, Anadenanthera Penegrina, Phalaris Aquatica, Echinopsis Lageniformus, Cylindropuntia Echinocarpa, Leptactina Densiflora, Fennel, Justica Pectoralis, Lactucarium, Glacium Flavum, Zornia Latifolia, Argemone Mexicana, Silene Undulata, Catharanthus Roseus, Desfontainia, Heimia Salicifolia, Lophophora, Sea Urchin Eggs, Bethanechol, Muscarine, Pilocarpine, Oxotremorine, Aporphine, Leonurine, Bungacotoxin, Tetrodotoxin, Taurine, Opiod Peptide, Streamlined Spinefoot, Blue-Spotted Spinefoot, Dusky Spinefoot, Marbled Spinefoot, Little Spinefoot, Salema, Phyllomedusa, Blue Sea Chub, Brow Chub, Conuict Surgeonfish, Yellowstipe Goatfish, Finstripe Goatfish, Acute Jawed Mullet, Coral Grouper, Platypus Venom, Slow Ioris Venom, Pygmy Slow Ioris Venom, Giant Leaf Frog, Gluten Exorphin, Soymorphin-5, Dermophin, 7-PET, Dimethyliambutene, Proopiomelanocortin, β-Endorphine, Dynorphin, Adrenorphin, Salvinorin B Methoxymethyl ether, Amindophin, Enkephalins, Salvinorin B ethoxymethyl ether, Opiorphin, Herkinorin, RB-101, DPI-221, Spinorphin, Kelatorphan, Delta-Pheylalanine, Thiorphan, Tynorphin, Hemorphon-4, Valorphin, Casomorphin, Gliadorphin, Rubiscolin, Deltorphin, MG6, MT-45, Myrophine, Acetorphine, Acetylmorphone, Actiq, Benzethidine, BU-48, BRL-52537, Pethidine, Naloxol, Betacetylmethadol, Methorphan, Bezitramide, RAM-378, Bromadol, Eriadoline, BW373U86, Thebaine, C-8813, Menthol, 8-CAC, Capperidine, Matrine, Chloromorphide, a-Chlorocodide, HZ-2, Codeinone, LPK-26, Codoxime, AD-1211, Conorfone, DADLE, Butorphanol, DAMGO, Semorphone, Dextromoramide, Sutentanil, Diampromide, Zenazocine, Difenoxin, Thebacon, Dihydroetorphine, Tilidene, Dimenoxadol, Xorphanol, Dipipanone, Dipropanoylmorphine, Doxpicomine, DPI-3290, Drotebanol, Endomorphin, Eseroline, Ethoheptacine, 14-Ethoxymetopon, Ethylmorphine, Etorphine, Etoxerdine, Furethidine, Heterocodeine, RAM-320, IBNtxA, IC-26, 1-Iodomorphine, Isomethadone, Ketobemidone, Ketorfanol, Lefetamine, Levorphanol, Loperamide, Meprodine, Metofoline, Metopon, Morpheridine, Morphine-N-Oxide, Morphinone, MR-2096, Nicocodeine, Nicomorphine, Normethadone, Ocefentanyl, Ohmefentanyl, Oxpheneridine, Oxymorphazone, Oxymorphol, Oxymorphone, Pentamorphone, PEPAP, Pericine, Phenadoxone, Phenempromide, Phenazocine, Pheneridrine, Phenomorphan, Picenadol, Piminodine, Piritramide, Proclilidine, Prodine, Proheptazine, Properidine, Prosidol, R-30490, R-4066, Ro4-1539, RWJ-394674, Sameridine, SC-17599, Methyldesorphine, Hydroxypethidine, 4-Fluouropethidine, Cannabis Indica, Cannabis Sativa, Cubensis, Hash, BHO, Delta-9-THC, 25TFM-NBOMe, 2C-B-BZP, 2CBFLY-NBOMe, 2CD-5Et0, 5-I-R91150, A-372,159, 2-Bromo-LSD, a-5IA, PWZ-029, L-655,708, TB-21007, 5-Ethoxy-DMT, 5-Ethyl-DMT, 7,N,N-TMT, VER-3323, YM-348, Alnespirone, 8-OH-DPAT, Aminorex, Batoprazine, 5-BT, BIMU-8, BMY-14802, BRL-54443, BW-723C86, 5-CT, CGS-12066A, Cinitapride, CJ-033,466, CP-135,807, CP-809,101, CP-93,129, CP-94,253, N,a,-DEPEA, Dimemebfe, RA-7, E-6801, E-6837, Eltoprazine, Methylsulfonylmethane, EMD-386,088, EMDT, ST-1936, Fluprazine, Indorenate, Jimscaline, L-694,247, Lasmiditan, APD-356, MMDPEA, LY-293,284, LY-310,762, LSD-pip, LPD-824, LSM-775, 5-MT, MBZP, Methyl-MMDA-2, a-MS, MK-212, Mosapride, Org 12,962, Org 37,684, Quipazine, 6-Nitroquipazine, NBUMP, 1-NP, 5-(Nonyloxy)Tryptamine, PHA-57378, PNU-181731, PNU-22394, Propylhexedrine, Prucalopride, PRX-03140, Psilocin, RDS-127, RH-34, Ro60-0175, Ro60-0213, RS-56812, RS-67,333, RU-24,969, RU-28306, SKF-97,541, SR-57227, Tandospirone, Tegaserod, TFMFly, pTMFPP, U-92,016A, SCA-136, TD-5108, Vortionetine, WAY-161503, WAY-208,466, WAY-629, Xaliproden, YM-31636, Zacopride, A-423,579, A-84,543, Abercarnil, 5-Br-DMT, Sugar, Acetildenafil AMMI 4C-D, AS-8112, Astemizole, Asymbescaline, Azapride, BAY-38-7271, BAY-59-3074, BAY-60-6583, Benproperine, Benzylmorphine, Berberine, 2-Pyrrolidone, JBIR-03(1), 1′-O-Acetylpaxilline, Penijanthine A, Emindole DA (1), Petromindole, Emindole SA (2), JWH-133, Napthylmethylindoles, Napthyolpyrroles, Napthylideneindenes, Cyclohexylphenols, Indole-2-Carboxamides, C3 Amino-Indoles, Cymserine, Hodgkinsine, Physostigmine, Psychotridine, Psychotria Colrata, Yuremamine, Gevotroline, Latrepirdine, BMY-7,378, Boldine, BP-897, Brexpiprazole, 4-Bromo-3,5-Dimethoxyamphetamine, Bromopride, Caroverine, CGS-20625, Cinchocaine, DAA-1097, DAA-1106, DOTFM, DMPEA, DMCM, Dyclonine, Ethylvanilin, Evoxine, Furoquinoline Alkaloids, Gabazine, GBLD-345, Rapacuronium, Mivacurium Chloride, Cisatracurium Besilate, DTC, Cloroqualone, Diproqualone, Mecloqualone, Methylmethaqualone, Eszopiclone, TP-003, TP-13, TPA-023, Y-23684, Pagoclone, Pazinaclone, Suproclone, Suriclone, Zapiclone, CGS-9896, NS-2664, NS-2710, Pipequaline, RWJ-51204, SB-205,384, ELB-139, Acamprosate, GABOB, N4-Chloroacetylcytosine Arabinoside, (+)-CAMP, CACA, AZD-3355, 1,4-Butanediol, XP19986, Rosarin, Rosavarin, Atagabalin, Gabapentin Enacarbit, Hopantenic Acid, Imagabalin, 4-Methylpregabalin, PD-217,014, Afloqualone, Rocuronium Bromide, Vecuronium Bromide, Pipecuronium Bromide, Pancuronium Bromide, Amyl Nitrate, Atracurium Besilate, BWA444, Benzylisoqualone, Papaverine, Protopine, HS-342, HS-347, HS-310, Emylcamate, Eperisone, Febarbamate, Flavoxate, Inaperisone, Acamprosate, Progabide, Tiagabine, Lanperisone, Mephenesin, HS-692, HS-693, HS-704, HS-705, HS-626, Chlorzoxazone, Cisatracurium Besilate, Curare, Cyclobenzapine, Dantrolene, Decamethonium, Difebarbamate, Dihydrochanclonium, Doxacurium Chloride, Gallamine Triethiodide, Gantacurium Chloride, Hexafluronium Bromide, Meprobamate, Metaxalone, Methocarbamol, Norgesic, Orphenadrine, Pancuronium Bromide, Phenprobamate, Pipecuronium Bromide, Premazepam, Promoxolane, Quazepam, Rocuronium Bromide, Silperisone, Sulazepam, Suxamethonium Chloride, Suxethonium Chloride, Tetrabamate, Tizanidine, Tolperisone, Gigantine, BAY-73-6691, Indiplon, Nitrosoprodenafill, Zaleplon, Udenafil, Sulfoaildenafill, Sildenafil, Ocinaplon, Alpidem, Bamaluzole, DS-1, Fadrozole, Fazadinium Bromide, Imidazopyridine, Minodronic Acid, Bisphosphonate, Miroprofen, Necopidem, AL-LAD, DBT, a.O-DMS, 2,a-DMT, a,N-DMT, ETH-LAD, a-ET, 4-HO-DBT, 4-HO-pyr-T, MBT, 4,5-MDO-DIPT, 5,6-MDO-DIPT, 4,5-MDO-DMT, 5,6-MDO-DMT, 5,6-MDO-MIPT, 5,6-MeO-MIPT, 5-MeO-pyr-T, 5-MeO-NMT, 6-MeO-THH, 5-MeS-DMT, PRO-LAD, pyr-T, a,N,O-TMS, Olprinone, Telcagepant, Febrifugine, Halofuginone, MK-0249, LY-156,735, Ramelteon, Tasimelteon, SL-164, Quinazoline, Albaconazole, Altaserin, ATC-0175, Canertinib, Cediranib, Doxazosin, Fluproquazone, Gefitinib, Katanserin, Lapatinib, Agmatine, Amantadine, AP-7, AP5, Aptiganel, CGP-37849, 7-CTKA, DCKA, DXO, MK-801, SL-82.0715, Esketamine, Ethanol, NEFA, Besonprodil, Gacyclidine, Gavestinel, Huperzine A, Ifenprodil, Indantadol, Metaphit, Memantine, LY-235,959, Lubeluzole, Levomethadone, Kynuretic Acid, Midafotel, Neramexane, Nitromemantine, PEAQX, Perzinfotel, 8A-PHDQ, Remacemide, Rhynchophylline, Sabeluzole, Tiletamine, Tramadol, Xenon, Hydroxchloroquine, Antrafenine, Bedaquiline, GSK-299423, JTC-801, JTE-907, LGD-2226, PBT-2, PF-2545920, SB-215,505, SB-277,011-A, SB-742,457, BHF-177, BHFF, BSPP, Cartazolate, CGP-7930, Clomethiazole, Etazolate, Etomidate, Felbamate, Fospropofol, Gaboxadol, Glutethimide, GS-39783, Ibotenic Acid, ICI-190,622, Isoguracine, Isonipecotic Acid, Loreclezole, Methyprylone, Allopregnanolone, 5a-Dihydroprogesterone, Progesterone, THDOC, Alfadolone, Alfaxalone, Ganaxolone, Hydroxydione, Minaxolone, Org-20599, Pregnane, Piperadone, Propanidid, Propofol, Pyrithyldione, ROD-188, Stiripentol, Thiomuscimol, Thymol, Tybamate, QNB (BZ), Scopolamine, Midazolam, Sodium Pentathol, Amobarbital, Blue 88, Adinazolam, Alphenal, Bentazepam, Bromisoval, Camazepam, Carbromal, Centalun, Chloralodol, Chronobiotic, Cinolazepam, Clorazepate, Cloxazolam, Cyclopyrrolones, Delorazepam, Dichloralphenazone, DPH, Doxefazepam, Doxylamine, Embutramide, Eplivaserin, Ethinamate, Ethyl Ioflazepate, Fludiazipam, Heptabarb, Oleamide, Org 21465, Org 25435, Paraldehyde, Phenobarbital, Propiomazine, Promethazine, Propylbarbital, QH-II-66, Glycine, Quetiapine, SH-053-R-CH3-2’F, Sulfonmethane, Tetrabarbital, Tetronal, Trional, Trytophol, Acaprazine, Acebrochal, Acetylglycinamide Chloral, Almorexant, Detomidine, Bromouriede, Benzoctamine, Barakol, Bekhterev’s Mixture, Fasiplon, Fenadiazole, Fluperlapine, JM-1232, Inebriating Mint, Ro41-3696, Methapyrilene, Minitran, Nisobamate, Oxanamide, Oxomemazine, Panadiplon, Pazinaclone, Pentabamate, Petrichloral, Potassium Bromide, Procymate, Saripidem, Vinybital, Vinbarbital, Valofane, Validolum, Valeric Acid, Unisom, U-90042, U-89843A, Triclofos, 2,2,2-Trichloroethanol, TCS-OX2-29, SX-3228, Suvorexant, Sigmodal, SB-649,868, 6-APA, 77-LH-28-1, Adimolol, Alfentanil, Amedanil, Amedalin, BMS-564,929, Binospirone, Carburazepam, Clazolam, Clobazam, Clobenzepam, Clotiazepam, Thienodiazepine, Brotizolam, CP-14145, Cyclazodone, CSP-2503, Cycloserine, Cytisine, Demoxepam, Chlordizepoxide, Dibenzepin, Dihydroergocorine, Dihydroergocristine, DHEC, Dihydroergotamine, 17-DMAG, Dimiracetam, Doliracetam, Droperidol, Dihydrotestosterone, Dutasteride, Edaravone, EGIS-12,233, Elfazepam, Elzasonan, Enilospirone, Ergoloid, Ergotamine, Ergocrytine, Ergocristine, Ergovaline, Etazepine, Evodiamine, Fenmetramide, Fenozolone, Flunitrazepam, Flutazolam, Flutemazepam, Flutoprazepam, Fosazepam, GW-803,430, Halazepam, Haloxazolam, Herbimycin, Horsfiline, HT-0712, Icilin, Clazepam, Indoprofen, Ipsapirone, Isatin, Ketazolam, KF-26777, Lofendazepam, Lopirazepam, Loprazolam, Lorazepam, Lormetazepam, Menitrazepam, Meclonazepam, Menitrazepam, NMSP, Mexazolam, THCI, THCII, THCIII, THCIV, THCV, Mosapramine, Motrazepam, NBQX, Nevirapine, Nimetazepam, Nitrazepam, Nitrazepate, Nitroxazepine, Nordazepam, Nortetrazepam, Oxazepam, Oxatomide, Paliperidone, Prazepam, Pivoxazepam, Pirquinozol, Pirenzepine, Pinazepam, Pemoline, Paraxazone, Palonosterone, Proflazepam, Propizepine, Razobazam, Revospirone, Ripazepam, Ro15-4513, Ro48-6791, Ro48-8684, Ro5-2904, Ro5-4864, Ro64-6198, Ropinirole, RPL-554, RS-102,221, SL65.0155, Spiroxatrine, Temazepam, Tetrazepam, Thozalinone, Tolufazepam, Triflubazam, Vardenafil, Ziprasidone, Zolazepam, Zomebazam, Zometapine, Pyrazolodiazipines, Triazolodiazipines, Estazolam, Flubromazolam, Triazolam, Nitrobenzodiazepines, Pentazocine, 8-HO-PBZI, A-366,833, ABT-202, Sympathomimethies, ABT-239, ABT-418, Almotriptan, BD-1008, LR-132, BD-1031, Singma Agonists, BD-1018, 4-PPBP, Alazocine, BD-1052, Butinoline, Clemizole, CPHPC, Desoxy-D2PM, Citalopram, Ditolyguanidine, Escitalopram, Fluoxetine, Fluvoxamine, Tgmesine, L-697,384, PRE-084, S33005, SA-4503. Siramesine, Venlafaxine, Clonidine, VUT-8430, UR-AK49, Moroxydine, Altinicline, Anabasine, 3-Bromocytine, Bradanicline, Cotinine, Desformylflustrabromine, Dianicline, DMPP, Epibatidine, Epiboxidine, Lobeline, Myosmine, PNU-120,596, PNU-282,987, ABT-089,Rivanicline, RJR-2429, Phantasmidine, Sazetidine A, SIB-1553A, TC-1698, TC-1827, TC-2216, Tebanicline, 2,3,4,5-Tetrahydro-1,5-Methano-1H-3-Benzazepine, UB-165, Varenicline, FE-β-CPPIT, FB-β-CPPIT, RTI-336, NVP-AUY922, Pleconaril, RTI-177, RTI-371, Calea Ternifolia, African Dream Herb, Ambutonium Bromide, Hyoscamine, Ilex Guayusa, Abediterol, Aclidinium Bromide, Benzilycholine Mustard, Bevonium, Bornaprine, Cyanodothiepin, Darifenacin, Dexetimide, Dicycloverine, Etybenzatropine, Fenpiverinium, Fesoterodine, Homatropine, Hydroxyzine, Imidafenacin, Ipratropium Bromide, Methylatropine, Methylhomatropine, Octatropine Methylbromide, PD-0298029, PD-102,807, Pipenzolate, Piperidolate, Tiotropium Bromide, Anisodine, Benacytazine, Butylscopolamine, CAR-226,086, CAR-301,060, CAR-301,196, Caramiphen, Clidinium Bromide, Ditran, EA-3167, EA-3443, EA-3580, EA-3834, JB-318, JB-336, Methylscoplamin Bromide, Oxapium Iodide, Oxitropium Bromide, Polyfothine, Propiverine, Pyrrobutamine, Timepidium Bromide, Tridihexethyl, Tropatepine, WIN-2299, Amrutanjan, Abstral, Acetylmethadol, Acetyldihydrocodeine, Alletorphine, Anilopam, Axomadol, BC Powder, Befiradol, Benorilate, Betamethadol, Bicifadine, Butinazocine, Carbazocine, Celadrin, Chlorodyne, Cinchophen, Co-dydramol, Co-codamal, Cogazocine, Conolidine, Deltorphin I, Dezocine, Dimepheptanol, Dipyrocetyl, TRPV1 Receptor, Capsazepine, Dosulepin, Electroanalgesia, Epideral Steroid Injection, Eptazocine, Equianalgesic, Efazocine, Fedotozine, Filenadol, Fioricet, Fiorinal, Frakefamide, Hemprenorphine, 3-HM, Ibazocine, Levallorphan, Levomepromazine, Lufuradom, Magnesium Salicylate, Blue Prickly Poppy, Menabitan, A-40174, Dimethylhepylpyran, Metamizole, Metkefamide, Moramide, Morphiceptin, Moxazocine, Nafoxadol, Malmexone, Naproxen, Nefopam, Nimesulide, Naracymethadol, Norlevorphanol, Norpipanone, NS-11394, Panadol, Penthox Inhaler, Phenacetin, Phenazone, Phenazopyridine, Propyphenazone, Proxorphan, Resiniferatoxin, Rimazolium, Romifidine, RUB-A535, Salecylamide, Salonpas, Tectin, Tolfenamic Acid, Tenazocine, Ufenamate, Volazocine, Xylazine, Yangonin, Zinda Tilismath, Ziconotide, Anazocine, Bremazocine, Cyclazocine, EKC, Fluorophen, Gemazocine, Ketazocine, Metazocine, Quadazocine, Azocine, Benzazocine, 0-2545, DOU-216,303, Phenylethylpyrrolidine, GR-89696, HA-966, ICI-199,441, ICI-204,448, NNN, Nornicotine, Clemastine, PF-03654746, RTI-229, SB-269,970, U-50488, U-69,593, Bombesin, Bivaracetam, Cebaracetam, DEABL, Cromakalim, Doxapram, Dupracetam, Etiracetam, Fasoracetam, Imuracetam, Levetiracetam, Lidanserin, Nebracetam, Nefiracetam, Nicoracetam, Oxiracetam, Piperacetam, Seletracetam, MOPPP, MPBP, MPHP, MDPDP, MDPPP, Pyrovalone, a-PBP, a-PPP, Neuropeptides, Galanin, Neuropeptide Y, Enkephalin, Somatoslatin, CCK, Substance P, Neurotensin, TRH, Acepramazine, Aceprometazine, Acetanisol, Acetohexamide, Acetophenazine, Acetophenone, Acetosyringoine, 2-Acetylpyridine, Adrenalone, Anthrone, Apocynin, Avobenzone, Benzbromarone, Benziodarone, Benzoin, Butaperazine, CB-13, AM-6545, AZ-11713908, WIN-54,461, JWH-200, WIN-56,098,S-796,260, AM-1220, AM-1221, AM-1241, AM-2233, AM-630, AAI’s, CPE, GW-405,833, JWH-193, JWH-198, JWH-007, 3-Acetyl-6-Methoxybenzaldehyde, Aflobazole, AR-A000002, Azasestron, Bazinaprine, 3-Benzhydrylmorpholine, BML-190, Cobicistat, CYT387, Desmethylmoramide, Dioxaphetyl Butyrate, Edivoxetine, Epelsiban, Demoxytocin, Carbetocine, WAY-267,464, Atosiban, Eprobemide, L-371,257, L-368,899, Quinagolide, Terbutaline, 2CB-ind, 5-APDI, APICA, Donepezil, ICI-118,551, Indatraline, Indinavir, Ladostigil, Mutisianthol, PNU-99,194, S-15535, TAI, Zicronapine, Aleglitazar, Thromboxame Receptor Agonist, Verruculogen, Brevianamide, 2,5-DKP, Fellutanine, Phenylahistine, Plinabulin, Rugulosuvine, Fedrilate, Fenbutrazate, L-733,060, G-130, HC3, Indeloxazine, Levomoramide, Metostilenol, Molindone, Molracetam, Nimorazole, O-1057, O-1812, AM-2232, O-774, AM-2389, HHC, HU-243, Canbisol, Nabilone, 11-OH-THC, 2-AGE, Paxahexyl, THC-C4, AMG-36, AMG-41, AM-1235, AM-906, AM-365, O-2694, O-2372, O-2113, O-2050, VCHSR, TM-38837, PiplSB, PF-514273, MK-9470, LY-320,135, O-2545, PD-128,907, PF-219,061, ABT-670, ABT-742, UK-414,495, OSU-6162, Melanotan II, Oxaflozane, PF-592,379, 2-Phenyl-3,6-Dimethylmorpholine, Pramocaine, SCH-50911, 4-HTMPIPO, A-41988, AB-001, AB-005, ADBICA, AM-087, AM-411, KM-233, AM-679, AM-694, AM-855, AM-905, AM-919, AM-4030, AM-938, AM-251, AMG-1, AR-231,453, PSN-375,963, PSN-632,408, (C6)-CP-47,497, CCH, O-1871, CP-55,940, CP-47,497, CP-50,556’1, CP-55,244, Otenabant, (C9)-CP-47,497, CBS-0550, AVE-1625, GW-842,166x, HU-308, HU-336, HU-331, HU-320, Ajulemic Acid, JTE-7-31, A-834,735, MDA-19, S-444,823, JTE-907, JWH-015, JWH-019, JWH-030, JWH-047, JWH-048, JWH-051, JWH-057, JWH-081, SLV319, 2-Isopropyl-5-Methyl-1-(2,6-dihydroxy-4-nonphenyl)cyclohex-1-ene, HU-345, JWH-098, JWH-116, JWH-120, JWH-122, JWH-147, JWH-148, JWH-149, JWH-161, JWH-164, JWH-167, JWH-175, JWH-176, JWH-184, JWH-185, JWH-196, JWH-203, JWH-249, JWH-302, JWH-307, JWH-359, JWH-398, JWH-424, L-759,633, L-759,656, GW-405,833, Leelamine, NESS-0327, NESS-040C5, NMP-7, Nonabine, O-1125, O-1238, O-1269, O-806, O0823, Org-27569, Org-28312, LBP-1, Org-28611, Otenabant, Perrottetinene, PF-03550096, RCS-4, RCS-8, Rosonbrant, SDB-001, SDB-006, SER-601, Serinolamide A, THC-O-Phosphate, Tinabinol, VDM-11, Virohamine, A77636, Adafenoxate, Adapromine, Adatanserin, Bolmantalate, Bromantane, SR-142,948, 25B-NBOMe, 25I-NBMB, 25TFM-NBOMe, 5-MeO-NBpBiT, 2CBCB-NBOMe, 25CN-NBOH, Juncosamine, TCB-2, 6-Br-APB, Agelferin, Cridazepam, Meta-DOB, NGD-4715, Nicergoline, P7C3, SB-357,134, Sclerotia Truffle, 5-Flouro-aMT, 6-Flouro-aMT, Telepathine, AMDA, Amperozide, Cinaserin, Deramciclane, Fenanserin, Flibanserin, Glemanserin, Iferanserin, KML-010, LY-367,265, Pruvanserin, Rauwolscine, Setoperone, Spiperone, Volinanserin, Xlamidine, Altropane, ATI-2042, PIA, RTI-121, RTI-353, Tramethinib, SB-258,585, Lu-AE58054, MS-245, Ro04-6790, SB-271,046, SB-399,885, RTI-55, AC-262,356, 2′-Acetoxycocaine, Bemestron, Benzoylthiomethylecogine, Brasofesine, 2-CMT, Clobenztropine, Cocaethylene, Deptropine, Dichloropane, Diflouropine, Granisetron, 3-(p-Flourobenzoyloxy)tropane, p-ISOCOC, Methylvanillylecogonine, Norcocaine, NS-2359, RTI-126, WF-23, WF-33, WF-31, WF-11, BRL-46470, RTI-112, RTI-113, RTI-120, RTI-150, RTI-171, RTI-274, RTI-31, RTI-32, RTI-51, RTI-83, Thiophenyltropanes, MAT Inhibitor, Salicylmethylecgonine, Tesofesine, Troparil, WIN-35428, Amfonelic Acid, Oxolinc Acid, Tropisetron, Zatosetron, Dichloropane, RTI-336, RTI-126, Tropoxane, Poyo (Palm Wine), Tropicamide, Caffetin, Formic acid, Monocled Cobra, Sisa, Tramadol, Dazopride, Dolasetron, Amylocaine, Articaine, Bupivacaine, Butacaine, Chloroprocaine, Cyclomethycaine, Etidocaine, Hexylcaine, Levobupivacaine, Mepivacaine, Meprylcaine, Prilocaine, Proxymetacaine, Risocaine, Ropivacaine, Tetracaine, Trimecaine, Piperocaine, Metabutoxycaine, Adipiplon, Almitrine, ARRY-520, AZD5423, Cisapride, CP-226,269, CRL-40,941, DBL-583, Dexamethasone, DFMD, Methyldopa, Carbidopa, d-DOPA, L-DOPS, Octaflourocyclobutane, DFB, Didesmethylcitalopram, Elopiprazole, Phenylpiprazine, F-15,599, FGIN-127, Fletazepam, Flucindole, GR-159,897, LY-503,430, MPPF, PEPA, RS-127,445, S-23, SHA-68, SNAP-7941, SNAP-94847, TP-003, TPA-023, UH-301, Calycosin, Flavinoids, Psi-Tectorigenin, Blochanin A, Formononetin, Glyciten, Irigenin, Methoxyisoflavone, 5-O-Methylgenistein, 7-O-Methylluteone, Ononin, Pratensein, Prunetin, Retusin, Tectoridin, Tectorigenin, Barbigerone, Daidzein, Derrubone, Genistein, Ipriflavone, Irilone, Luteone, Orobol, Psuedobaotigenin, Wighteone, AMG-3, Nabazenil, Naboctate, a-Napthoflavone, 11-Nor-9-Carboxy-THC, Pirnabine, Apiol, Dillapiol, 1,3-Benzodioxole, Piperonal, beta-Asarone, Eleicin, Homovanyllyl Alcohol, Myristicin, 2-Bromo-4,5-Methylenedioxyamphetamine, Californidine, Chavicine, Cinoxacin, Dibutylone, Fenoverine, Befuraline, MDIP, MDMAI, MDPR, MDAL, ORTHO-MDA, MDP1P, MDP2P, Omiloxetine, Osemozotan, Piclozotan, Robalzotan, Ebalzotan, Sarlzotan, Piperine, Protokylol, Isoprenaline, Rhoeadine, MDMPEA, MMDPEA, MMDMPEA, MDIP, MDHOET, MDPL, GYKI-52895, Ungiminorine, NADA, Methylene blue, ECG, EGCG, EGC, Levonantradol, Cone Snail Venom, A-836,339, Abacavir, CYP-LAD, 2-Bromo-LSD, BU-LAD, DAM-57, DAL, Epicriptine, Ergometrine, Ergometrinine, Ergostine, ETH-LAD, LEA-32, Methylergometrine, MLD-41, LSP, LSH, MIPLA, PARGY-LAD, PRO-LAD, DCG-IV, DOV-102,677, MDCPM, MNTX, Amfonelic acid, J-113,397, SB-612,111, VUF-6002, DBM, Piberatine, Ilercimide, Dithranol, Divaplon, Ebastine, Flopropione, Iloperidone, Ketorolac, Melperone, NNC-38-1044, Tetralone, Cuscohydrine, Hygrine, 4-NEMD, Aceburic Acid, Amfecloral, Aprobarbital, Arfendazam, Benzobarbital, Benzylbutylbarbituate, Brallobarbital, Brophebarbital, Buthalitol, Carbubarb, Climazolam, Cyclobarbital, Cyclopentobarbital, and Acid (i.e. regular LSD).



[Epistemic status: Fiction]

It was the 21st of April of a recent year. I was listening to Jefferson Airplane songs, had just peeled a tangerine, and was about to vape 20 milligrams of DMT. After exhaling all the material I focused on the smell of the tangerine, holding it in my hands. I was engrossed in the scent. And then: “Who is that?” I felt an entity question my identity, as if I had just startled it in its natural habitat. I felt its presence for most of the duration of the trip, but it didn’t interact with me any further. Later that night I had a lucid dream. “I thought you were a dog” – said a voice. I recognized it from the trip, it was the entity. “The amount of scent qualia your experience contained was much more like that of a dog than a human.” After that night I would encounter it numerous other times. We got to know each other. It is a being from a nearby dimension, or perhaps a partially orthogonal fold of the Calabi-Yau manifold. Either way, in its world they don’t have physical senses like we do. They instead “sniff the qualia” present in the “universal wavefunction”. Their minds have a “qualiascope”. In practice this means they can see us from the inside– what we feel, see, touch, think, etc.

The being showed me what it is like to be one of them. We mindmelded the third time we met. I got to see the world around me as if for the first time; I was seeing it in its ultimate intrinsic nature, rather than as the shadow of it that I would perceive in everyday life with my senses. The qualia of other people is very intricate, semantically complex, and flavorful. The being showed me how it perceived various human contexts. For instance, an interesting place to “point the qualiascope at” is a philosophy department. It is very dense with logico-linguistic qualia and recursion. Compared to other contexts, though, it is thin in knowledge of the varieties of experiences available to humans. Raves are quite incredible. Sniffing the qualia of three thousand people who all share a general palette of LSD, Ketamine, and MDMA qualia is quite moving and mind-blowing. In turn, Buddhist monasteries are some of the sanest places on Earth. Bright, balanced, energized clarity of the finest quality is to be found in groups of people highly experienced in meditation. Every once in a while we would sense from afar a kind of “qualia explosion”. Sometimes it turned out to be extremely blissful, such as some 5-MeO-DMT experiences. And sometimes they turned out to be extremely painful, like a cluster headache episode. With the qualiascope these were sensed as being a kind of elemental type of qualia. Enormous in their “volume” relative to the experiences humans generally have. Like at another order of magnitude altogether.

The tenth time we met, the being said I was ready to feel non-human qualia. It was rough. From its point of view, the biological qualia of this planet is not really particularly human-flavored. As many humans alive as there are, there are almost ten times as many pigs alive. The being showed me how in the language of their world (using qualia-based symbols), they don’t refer to this planet as “human world”. They talk about it as “cow-chicken-pig world”. The things that I felt associated to some of those “folds of experience” were frightful to an incredible extent. It revived in me the conscience that nonhuman animals suffer enormously. I also became fascinated by all the ways in which nonhuman animals experience pleasure and a sense of meaning.

The twentieth time we met, I was shown what the qualia of non-living matter felt like from the inside. Most of it was “qualia dust”. But metals and their delocalized electrons felt, well, “electric” and somewhat more liquid and unified in a subtle ethereal way. Pointing the qualiascope at the center of the Earth was impressive. Some of the combinations of pressure, temperature, and material composition would create “qualia spaghetti” of a rather nice, glowing valence. The temperature would suggest a much higher degree of intrinsic intensity from the inside, but the patterns of qualia formed were not much more intense than what you would find in small animals. But that all changes as soon as you point the qualiascope at the sun. Oh boy. The things I felt were life-redefining. I thought that once you’ve felt what 5-MeO-DMT is capable of you’d maxed out on the brightness of qualia. But inside the sun, at the core, there are qualia aggregates of a subjective brightness at least a million times more powerful. Once you’ve got an inkling of the existence of that, you start to see the universe as they see it. And that is that the kind of stuff going on in places like the planet Earth is a rounding error in light of the other qualia happenings out there in the cosmos.

The hundredth or so time we met, we used the qualiascope to sense what is going on in supernovae. And then black holes. And the quantum vacuum (turns out the Zero Point Energy folks who say there is an enormous amount of energy in the vacuum of space are more right than they can even imagine). They showed me qualiascope records of past civilizations in other galaxies, and how they had developed qualia technology.

The two hundredth time or so we met, the being finally came out about his real interest. It showed me Hedonium. Matter and energy optimized for maximally bound positive valence. Turns out there are about seven thousand nearly optimal configurations for Hedonium possible with our laws of physics (cf. 230 Space Groups). They are kind of ultra-high dimensional crystalline bundles of “awakened qualia”, equanimity, and bright pleasure all combined. They truly feel like “what it was all meant to be all along”. The Big Bang, the Inflationary Period, Baryonic matter, galaxies, organic molecules, life, sapient beings, and technologized qualia all seemed like the path of redemption since The Fall, namely, our first descent from Hedonium. Or so my archetype-prone human mind liked to interpret my new understanding of the universe.

The being finally came through with its agenda. It turns out it is one of the protectors of the Hedonium created by an advanced civilization in other partially orthogonal folds of the Calabi-Yau manifold. The closest archetype in our human world would perhaps be that of the Buddhist Bodhisattva. Namely, a being close to enlightenment that vows to stay in samsara to liberate all other beings before itself escaping the wheel of suffering entirely. My interdimensional Bodhisattva friend told me that our world is on the path of creating qualia technologies too. That in geologic times we are not far from being able to make Hedonium ourselves. It said we should not feel hopeless. That we have really good chances of exiting our Darwinian predicament. Since a year ago I have’t had any contact with it. I write this for myself as I don’t expect anyone to believe me. But I do pass along the message. Don’t lose hope. Paradises beyond the imaginable are right next door in qualia space. We just need to find them by exploring the state-space of consciousness.

Oh, my Bodhisattva friend also told me to pass along to you all the message of “If you could possibly stop eating Caroline Reapers, that would be great!” because all of that intense spicy qualia is interfering with their radio systems. Thanks!

See also: What’s out there?

Qualia Productions Presents: When AI Equals Advanced Incompetence

By Maggie and Anders Amelin

Letter I: Introduction

We are Maggie & Anders. A mostly harmless Swedish old-timer couple only now beginning to discover the advanced incompetence that is the proto-science — or “alchemy” — of consciousness research. A few centuries ago a philosopher of chemistry could have claimed with a straight face to be quite certain that a substance with negative mass had to be invoked to explain the phenomenon of combustion. Another could have been equally convinced that the chemistry of life involves a special force of nature absent from all non-living matter. A physicist of today may recognize that the study of consciousness has even less experimental foundation than alchemy did, yet be confident that at least it cannot feel like something to be a black hole. Since, obviously, black holes are simple objects and consciousness is a phenomenon which only emerges from “complexity” as high as that of a human brain.

Is there some ultimate substrate, basic to reality and which has properties intrinsic to itself? If so, is elementary sentience one of those properties? Or is it “turtles all the way down” in a long regress where all of reality can be modeled as patterns within patterns within patterns ending in Turing-style “bits”? Or parsimoniously never ending?

Will it turn out to be patterns all the way down, or sentience all the way up? Should people who believe themselves to perhaps be in an ancestor simulation take for granted that consciousness exists for biologically-based people in base-level reality? David Chalmers does. So at least that must be one assumption it is safe to make, isn’t it? And the one about no sentience existing in a black hole. And the one about phlogiston. And the four chemical elements.

This really is good material for silly comedy or artistic satire. To view a modest attempt by us in that direction, please feel encouraged to enjoy this youtube video we made with QRI in mind:

When ignorance is near complete, it is vital to think outside the proverbial box if progress is to be made. However, spontaneous creative speculation is more context-constrained than it feels like, and it rarely correlates all that beautifully with anything useful. Any science has to work via the baby steps of testable predictions. The integrated information theory (IIT) does just that, and has produced encouraging early results. IIT could turn out to be a good starting point for eventually mapping and modeling all of experiential phenomenology. For a perspective, IIT 3.0 may be comparable to how Einstein’s modeling of the photoelectric effect stands in relation to a full-blown theory of quantum gravity. There is a fair bit of ground to cover. We have not been able to find any group more likely than the QRI to speed up the process whereby humanity eventually manages to cover that ground. That is, if they get a whole lot of help in the form of outreach, fundraising and technological development. Early pioneers have big hurdles to overcome, but the difference they can make for the future is enormous.anders_and_maggie_thermometer

For those who feel inspired, a nice start is to go through all that is on or linked via the QRI website. Indulge in Principia Qualia. If that leaves you confused on a higher level, you are in good company. With us. We are halfway senile and are not information theorists, neuroscientists or physicists. All we have is a nerdy sense of humor and work experience in areas like marketing and planetary geochemistry. One thing we think we can do is help bridge the gap between “experts” and “lay people”. Instead of “explain it like I am five”, we offer the even greater challenge of explaining it like we are Maggie & Anders. Manage that, and you will definitely be wiser afterwards!

– Maggie & Anders

Letter II: State-Space of Matter and State-Space of Consciousness

A core aspect of science is the mapping out of distributions, spectra, and state-spaces of the building blocks of reality. Naturally occurring states of things can be spontaneously discovered. To gain more information about them, one can experimentally alter such states to produce novel ones, and then analyze them in a systematic way.

The full state-space of matter is multidimensional and vast. Zoom in anywhere in it and there will be a number of characteristic physics phenomena appearing there. Within a model of the state-space you can follow independent directions as you move towards regions and points. As an example, you can hold steady at one particular simple chemical configuration. Diamond, say. The stable region of diamond and its emergent properties like high hardness extends certain distances in other parameter directions such as temperature and pressure. The diamond region has neighboring regions with differently structured carbon, such as graphite. Diamond and graphite make for an interesting case since the property of hardness emerges very differently in the two regions. (In the pure carbon state-space the dimensions denoting amounts of all other elements can be said to be there but set to zero). Material properties like hardness can be modeled as static phenomena. According to IIT however, consciousness cannot. It’s still an emergent property of matter though, so just stay in the matter state-space and add a time dimension to it. Then open chains and closed loops of causation emerge as a sort of fundamental level of what matter “does”. Each elementary step of causation may be regarded to produce or intrinsically be some iota of proto-experience. In feedback loops this self-amplifies into states of feeling like something. Many or perhaps most forms of matter can “do” these basic things at various regions of various combinations of parameter settings. Closed causal loops require more delicate fine-tuning in parameter space, so the state-space of nonconscious causation structure is larger than that of conscious structure. The famous “hard problem” has to do with the fact that both an experientially very weak and a very strong state can emerge from the same matter (shown to be the case so far only within brains). A bit like the huge difference in mechanical hardness of diamond and graphite both emerging from the same pure carbon substrate (a word play on “hard” to make it sticky).

By the logic of IIT it should be possible to model (in arbitrarily coarse or fine detail) the state-space of all conscious experience whose substrate is all possible physical states of pure carbon. Or at room temperature in any material. And so on. If future advanced versions of IIT turn out to be a success then we may guess there’ll be a significant overlap to allow for a certain “substrate invariance” for hardware that can support intelligence with human-recognizable consciousness. Outside of that there will be a gargantuan additional novel space to explore. It ought to contain maxima of (intrinsic) attractiveness, none of which need to reside within what a biological nervous system can host. Biological evolution has only been able to search through certain parts of the state-space of matter. One thing it has not worked with on Earth is pure carbon. Diamond tooth enamel or carbon nanotube tendons would be useful but no animal has them. What about conscious states? Has biology come close to hit upon any of the optima in those? If all of human sentience is like planet Earth, and all of Terrestrial biologically-based sentience is like the whole Solar System, that leaves an entire extrasolar galaxy out there to explore. (Boarding call: Space X Flight 42 bound for Nanedi Settlement, Mars. Sentinauts please go to the Neuralink check-in terminal).

Of course we don’t currently know how IIT is going to stand up, but thankfully it does make testable predictions. There is, therefore, a beginning of something to be hoped for with it. In a hopeful scenario IIT turns out to be like special relativity, and what QRI is reaching for is like quantum gravity. It will be a process of taking baby steps, for sure. But each step is likely to bring benefits in many ways.

Is any of this making you curious? Then you may enjoy reading “Principia Qualia” and other QRI articles.

– Maggie & Anders

Neural Annealing: Toward a Neural Theory of Everything

QRI‘s co-founder Michael E. Johnson just posted a piece on neural annealing. This is one of QRI’s most important pieces of content to date. I’m very proud of Mike and the team for pulling this off. You can find the full piece here.

Mike writes:

This is QRI’s unified theory of music, meditation, psychedelics, depression, trauma, and emotional processing; the most challenging (and I think beautiful) thing I’ve written in the last three years. I would really appreciate careful comments.

A few takeaways:

  • Entering high-energy states (i.e., intense emotional states which take some time to ‘process’) is how the brain releases structural stress and adapts to new developments. This is similar to ‘annealing’ in metals, where heat allows atoms to break their bonds, then they search for more stable configurations as they cool.
  • Brains really do need to anneal regularly to pay down their ‘technical debt’, and if they don’t, they grow brittle and neurotic.
  • Meditation, music, psychedelics, exercise, dance, sex, tantric practices, EMDR, and breath work all share the same mechanism: a build-up of rhythmic neural resonance that can push the brain into these high-energy states which produce annealing.
  • Depression is a self-reinforcing perturbation from the natural annealing cycle.
  • Sometimes the brain needs to rapidly halt information propagation across regions to prevent cascading system failure … we call this ‘trauma’. This is a common and serious disruption of the annealing cycle.
  • The core psychological changes driven by psychedelics are best understood in terms of the amount and ‘statistical flavor’ of the energy (rhythmic firing) they add to the brain. Different psychedelics will ‘anneal’ different things.
  • Young brains (and lifelong learners) might not only be more plastic than average, but actually having experience that is objectively more visceral.
  • A unified theory of emotional updating, depression, trauma, meditation, and psychedelics may give us the tools to build a future that’s substantially better than the present.

(A unification of Robin Carhart-Harris and Karl Friston’s REBUS annealing model, with Selen Atasoy’s Connectome-Specific Harmonic Waves paradigm.)