Cooling It Down To Partying It Up

A relatively recent hypothesis for the neurotoxicity associated with MDMA is that it causes the brain to over-heat (see: 1, 2, 3). This would make the sorts of environments in which people take it particularly hazardous (hot raves, nightclubs, warm baths, and wild sex).

I really hope this is the core main reason for MDMA’s long-term deleterious effects.

Why?

Because then the damage would be completely preventable! In particular, I would point you to the athletic performance-enhancing technology developed at Stanford in 2012 that uses rapid thermal exchange devices (aka. “the cooling glove”*) in order to cool your blood and allow you to compete at a higher level. This is an extremely efficient method to keep the temperature of your whole body (including your brain!) within a healthy range.

Sadly, the device is likely to get banned for athletic purposes (it would be, some say, an unfair advantage if some teams have access to the cooling glove and others don’t). Sports are, of course, completely inconsequential, so the fact that the device is likely to get banned for this application shouldn’t matter. Yet it does, because as a result many people seem to be losing interest in this line of research.

Maybe, I would posit, the device could be resurrected as part of a modern harm-reduction strategy. Imagine night-clubs with a chill-out space stocked with dozens of cooling gloves. Party for 30 minutes, cool down for 10 minutes, repeat. If this could allow people to take MDMA once every month for the rest of their lives without enduring the brain damage that doing this usually causes… wouldn’t that be wonderful? I would expect it to also be highly beneficial for the benevolence of culture and the overall mental health of our society.

And this is all to say: Who would have known… that “being cool” was the key to partying for the rest of your life? Cool it down and party it up!


*For a skeptical take on the device, see: Better Than Steroids? The hype behind Stanford’s magic “cooling glove” for athletes. And a comeback article that extends its use to more serious applications: Cooling glove developed by Stanford researchers helps athletes and patients.

Cause X – What Will the New Shiny Effective Altruist Cause Be?

The Qualia Research Institute hosted an interesting event a couple of weeks ago. Here is how the event was advertised:

Description

Event NameQRI & Friends: “Cause X” – what will the new shiny EA cause be?
Time: Saturday, January 19, 2019 at 4 PM – 1 AM
Description: This event will consist of 4-minute presentations from attendees about what the “new EA cause area should be” (from 4pm to 6pm) followed by a casual and chill hangout for the rest of the evening.
There are 10 slots for the presentations, and we encourage you to sign up for one before they run out. If you want to give a presentation please fill out this form: [deleted link]
If you want to see people’s presentations please show up before 4:15pm (we will start the presentations at 4:30 sharp). Each participant will be given 4 minutes to present and 1 minute for Q&A. We will be strict on time. You should come prepared to defend your cause with logic, data, etc.
Everyone who sees the presentations will get to vote* at the end for the following three categories:
  1. Most likely to prevent as much suffering as possible with 1 million dollars of funding
  2. Most fun to think about
  3. Most likely to be the plan of a super-villain
There will be real prizes for each of these three categories!!!**
If you just want to come and hang out for the evening please show up from 6:30pm onwards. Vegetarian/vegan food and drinks will be served at around 7:30pm. Feel free to bring vegan/vegetarian food/drinks too.
As usual, feel free to invite people who are curious about consciousness and EA (but please let me know in advance so I can make a head-count for the event).

*Voting was carried out with Approval Voting (where every person can vote for as many presentations as they want and the ones with the highest number of votes win). This was chosen based on the assumption that some presentations might be similar, which would lead to an unfair penalty on similar presentations based on the spoiler effect. Additionally, voters who are undecided between more than one presentation can communicate their uncertainty via this type of voting rather than having that useful information be discarded.
**Prizes were announced the day of the event. For category (1) the prizes were “a fully-equipped first-aid kit plus a 16-bottle essential oils kit”. The winner of category (2) received a prize consisting of “a 3D Mirascope and an Ivy Cube“. And category (3) had as its prize an “Apollo Tools 39 piece general tool set (DT9706)“. These prizes were, of course, highly symbolic of their respective categories.

Winners

With the permission of the participants, here is what each of the winners presented:

For (1) two presenters tied in first place:

– Natália Mendonça presented about “Using smartphones to improve well-being measures in order to aid cause prioritization research” (link to presentation). She argued that the experience sampling paradigms that made waves in the 2000s and early 2010s happened at a time when relatively few people had smartphones. Since today smartphone adoption in developing countries has exploded we could use an experience sampling app to determine the major causes of suffering throughout the world in a way that wasn’t possible before. She specifically mentioned “comparing how bad different illnesses feel” in order to help us guide policy decision for cause prioritization.
– An anonymous attendee presented about “Psychedelic Drug Decriminalization“. Some of the core ideas involved taking a look at the effect sizes of the benefits of MDMA, LSD, psilocybin, etc. on various mental illnesses and comparing them against current alternatives. Also looking at the potential downsides they estimated that these only account for about 10% of the benefit, so cost-benefit wise it is very positive. They didn’t cover the entire presentation due to time – more details and a contact email can be found at https://enthea.net.

For (2) the winner was:

– Matthew Barnet who presented about “Timeloop Concept as Cause X” (link – slides don’t have much content; they were used just to keep the presentation on track). Matthew looked at the recent Qualia Computing article about the “Pseudo-Time Arrow” and wondered whether the importance of agents from an ethical point of view should be weighted at least in part based on their subjective time-structure. It’s true that 99% of experiences are experienced as having a linear causal time arrow, but this is not the case for the general space of possible experiences (e.g. including “moments of eternity”, “time loops”, “atemporal states”, etc. common on altered states of consciousness). He posited that perhaps time loop experiences have a much bigger moral importance because from the inside it feels like they never end. A discussion about infinite ethics and the quantification of consciousness ensued.

For (3) the winner was:

– Yev Barkalov, who proposed that rather than trying to endlessly battle in favor of digital privacy… how about we “just give up” and instead refocus the absence of digital privacy for social good. He mentioned China’s social credit score as a possible bad implementation of what he had in mind (“they have poisoned the well of the no-privacy camp by doing it so poorly”). Part of his argument was that technologies such as adblockers, crypto tokens, and the dark net further arms races in which advertisers, financial institutions, and governments become more clever at displaying ads, making you sign up for credit cards, and forcing citizens to abide by the law. Since arms races are dangerous and may lead to draconian systems while also being a waste of resources (due to their zero-sum nature), he suggested that we at least consider the alternative of seeing how a privacy-less world could work in practice. He posited that this could allow people to find quality collaborators more easily thanks to enhanced “people search” capabilities made available to the general population.

For completeness, the remaining presentations included:
Open Individualism as a new foundation for ethics
– Collective internet identities to replace countries
– The researching of possible Cause Xs as itself Cause X
– Automatic Truth Discovery neo-Wikipedia: like the current Wikipedia but with meta-analytic tools embedded into it, which provide confidence intervals for each claim based on the statistical robustness of the empirical findings that support it. And…
– A critique of utilitarianism that was more of a rant than a specific proposal (???)

Finally, I would like to add here some additional possible Causes X that I have thought about. These did not participate in the event because the organizers were not allowed to present (due to fairness and also because I didn’t want to “win a prize” that I bought myself):

  1. Subsidizing/sponsoring the use of HEPA filters in every house
  2. Distributing DMT vape pens that dispense in 4mg doses to deal with unexpected cluster headaches (this deserves an article of its own; cf. “Hell Must Be Destroyed“)
  3. Building a model that takes in genetic data and returns hedonic set point (and/or tells you which recreational drugs you are most likely to respond positively to).

In brief, (1) above might be a highly effective way of improving the health-span of a country’s population in a cost-effective fashion. As Robin Hanson has argued over the years, if we truly cared about the health of people, we would be spending more resources on the top 4 drivers of health (diet, exercise, sleep, and clean air) rather than on extravagant medical interventions designed to convince us that “an attempt was made.” Clean air, in particular, seems easy to influence at a rather minimal cost. HEPA filters capable of providing clean air to entire apartments (reducing by 10X the PM2.5 concentrations in the apartment) can cost as little as $70, with an upkeep of about $30 a year for renewing filters, and about $20 a year for electricity. Fermi calculation would indicate this would cut the average person’s daily PM2.5 exposure by half. I haven’t worked out the math concerning the amount of micromorts prevented per dollar this way, but the numbers seem extremely promising.

For (2) the rationale is that inhaling tiny doses of DMT aborts a cluster headache within about 3 seconds. Given the fact that about 0.1% of people will suffer from a cluster headache at least once in their lifetimes, and the fact that they are considered one of the most painful experiences possible, having a DMT vape pen within reach at all times as an insurance against spontaneous hellish levels of pain might be perfectly justified. A dedicated article about this specific topic will be posted soon.

And finally, (3) was recently argued in a Qualia Computing article: Triple S Genetic Counseling: Predicting Hedonic-Set Point with Commercial-Grade DNA Testing as an Effective Altruist Project. This may very well be a defensible Cause X on the basis that building such a model is already possible with the data available to commercial DNA testing companies like 23andMe, and that it might course-correct the reproductive strategy of millions of prospective parents within a few years, preventing untold amounts of suffering at a relatively small cost.

Triple S Genetic Counseling: Predicting Hedonic-Set Point with Commercial-Grade DNA Testing as an Effective Altruist Project

The term “Transhumanism” has many senses. It is a social movement, a philosophy, a set of technologies, and a conceptual rallying flag. David Pearce pins down the core sentiment behind the term like this:

If we get things right, the future of life in the universe can be wonderful beyond the bounds of human imagination: a “triple S” civilisation of superlongevity, superintelligence and superhappiness.

– David Pearce, in The 3 Supers

The concept of a “triple S” civilization is very widely applicable. For example, one can imagine future smart homes designed with it in mind. Such smart homes would have features to increase your longevity (HEPA filters, humidity control, mold detectors, etc.), increase your intelligence (adaptive noise-canceling, optimal lighting, smart foods), and happiness (mood-congruent lighting, music, aromas, etc.). Since there are trade-offs between these dimensions, one could specify how much one values each of them in advance, and the smart home would be tasked with maximizing a utility function based on a weighted average between the three S’s.

Likewise, one could apply the “triple S” concept to medical care, lifestyle choices, career development, governance, education, etc. In particular, one could argue that a key driver for the realization of a triple S civilization would be what I’d like to call “triple S genetic counseling.” In brief, this is counseling for prospective parents in order to minimize the risks of harming one’s children by being oblivious to the possible genetic risk for having a reduced longevity, intelligence, or happiness. Likewise, in the more forward-looking transhumanist side of the equation, triple S genetic counseling would allow parents to load the genetic dice in their kid’s favor in order to make them as happy, long-lived, and smart as possible.

Genetic counseling, as an industry, is indeed about to explode (cf. Nature’s recent article: Prospective parents should be prepared for a surge in genetic data). Predictably, there will be a significant fraction of society that will question the ethics of e.g. preimplantation genetic diagnosis for psychological traits. In practice, parents who are able to afford it will power ahead, for few prospective parents truly don’t care about the (probabilistic) well-being of their future offspring. My personal worry is not so much that this won’t happen, but that the emphasis will be narrow and misguided. In particular, both predicting health and intelligence based on sequenced genomes are very active areas of research. I worry that happiness will be (relatively) neglected. Hence the importance of emphasizing all three S’s.

In truth, I think that predicting the hedonic set-point of one’s potential future kids (i.e. the average level of genetically-determined happiness) is a relatively more important project than predicting IQ (cf. A genome-wide association study for extremely high intelligenceBGI). In addition, I anticipate that genetic-based models that predict a person’s hedonic set-point will be much more accurate than those that predict IQ. As it turns out, IQ is extremely polygenetic, with predictors diffused across the entire genome, and it is a very evolutionary recent axis of variance across the population. Predictors of hedonic-set point (such as the “pain-knob gene” SCN9A and it’s variants), on the other hand, are ancient and evolutionarily preserved across the phylogenetic tree. This makes baseline happiness a likely candidate for having a straight-forward universal physiological implementation throughout the human population. Hence my prediction that polygenetic scores of hedonic-set point will be much more precise than those for IQ (or even longevity).

Given all of the above, I would posit that a great place to start would be to develop a model that predicts hedonic set-point using all of the relevant SNPs offered by 23andMe*.  Not only would this be “low-hanging fruit” in the field of genetic counseling, it may also be a project that is way up there, close to the top of the “to do” list in Effective Altruism (cf. Cause X; Google Hedonics).

I thought about this because I saw that 23andMe reports on health predispositions based on single SNPs. From a utilitarian point of view, of particular interest are SNPs related to the SCN9A gene. For example, I found that 23andMe has the rs6746030 SNP, which some studies show can account for a percentage of the variance associated with pain in Parkinson’s and other degenerative diseases. The allele combination A/A is bad, making you more prone to experience pain intensely. This is just one SNP, though, and there ought to be a lot of other relevant SNPs, not only of the SCN9A gene but elsewhere too (e.g. involved in MAO enzymes, neuroplasticity, and pleasure centers innervation).

Concretely, the task would involve making two models and then combining them:

The first model uses people’s responses to 23andMe surveys to come up with a good estimate of a person’s hedonic set-point. Looking at some of the questions they ask, I would argue that there are more than enough dimensions to model how people vary in their hedonic set-point. They ask about things such as perception of pain, perception of spiciness, difficulty sleeping, stress levels, whether exercise is pleasant, etc. From a data science point of view, the challenge here is that number of responses provided by each participant is very variable; some power users respond to every question (and there are hundreds and hundreds), while most people respond to a few questions only, and a substantial minority respond to no questions at all. Most likely, the distribution of responses per participant follows a power law. So the model to build here has to be resilient against absent data. This is not an insurmountable problem, though, considering the existence of Bayesian Networks, PGMs, and statistical paradigms like Item Response Theory. For this reason, the model would need to both predict the most likely hedonic set-point of each participant, and provide confidence intervals specific to the participant based on the quality and relevance of the questions answered.

The second model would involve clustering and dimensionality reduction applied to the SNPs that are likely to be relevant for hedonic set-point. For example, one dimension would likely be a cluster of SNPs that are associated with “maximum intensity of pain”, another might be “how quickly pain subsides once it’s stimulated”, another “how much does pleasure counter-balance pain”, and so on. Each of these dimensions is likely to be determined by different neural circuits, and interact in non-linear ways, so they deserve their own separate dimension.

And finally, one would make a third model that combines the two models above, which predicts the hedonic set-point of a person derived from the first model using the genetic dimensions found by the second model. If you are an up-and-coming geneticist, I would like to nudge you in the direction of looking into this. As a side effect, you might as well get filthy rich in the process, as the genetic counseling field explodes in the next decade.


Bonus Content: What About Us?

Admittedly, many people will note that predicting a fraction of the variance of people’s hedonic set point with commercial DNA testing products will only really alleviate suffering in the medium to long term. The people who will benefit from this technology haven’t been born yet. In the meantime, what do we do about the people who currently have low hedonic set-points? Here is a creative, politically incorrect, and enticing idea:

Let’s predict which recreational drugs have the best cost-benefit profile for individuals based on their genetic makeup.

It is no secret that people react differently to drugs. 23andMe, among others, is currently doing research to predict your particular reaction to a drug based on your genetic makeup (cf. 23andMe can now tell you how you’ll react to 50+ common drugs). Unfortunately for people with anxiety, depression, chronic pain, and other hedonic tone illnesses, most psychiatric drugs are rather subtle and relatively ineffective. No wonder, compared to heroin, an SSRI is not likely to make you feel particularly great. As David Pearce argued in his essay Future Opioids, there is substantial evidence that many people who become addicts are driven to take recreational substances due to the fact that their endogenous opioid system is dysfunctional (e.g. they may have bad variants of opioid receptors, too many endorphin-degrading enzymes, etc.). The problem with giving people hard drugs is not that they don’t work in the short term; it is that they tend to backfire in the long-term and have cumulative negative health effects. As an aside, from the pharmaceutical angle, my main interest is the development of Anti-tolerance Drugs, which would allow hard drugs to work as mood-enhancers indefinitely.

This is not to say that there aren’t lucky people for whom the cost-benefit ratio of taking hard drugs is, in fact, rather beneficial. In what admittedly must have been a tongue-in-cheek marketing move, in the year 2010 the genetic interpretation company Knome (now part of Tute Genomics) studied Ozzy Osbourne‘s entire genome in order to determine how on earth he has been able to stay alive despite the gobs and gobs of drugs he’s taken throughout his life. Ozzy himself:

“I was curious, [g]iven the swimming pools of booze I’ve guzzled over the years—not to mention all of the cocaine, morphine, sleeping pills, cough syrup, LSD, Rohypnol…you name it—there’s really no plausible medical reason why I should still be alive. Maybe my DNA could say why.”

Ozzy Osbourne’s Genome (Scientific American, 2010)

Tentatively, Knome scientists said, Ozzy’s capacity to drink entire bottles of Whisky and Gin combined with bowlfuls of cocaine and multiple packs of cigarettes over the course of… breakfast… without ending up in the hospital may be due to novel mutations in his alcohol dehydrogenase gene (ADH4), as well as, potentially, the gene that codes for CLTCL1, a protein responsible for the intake of extra-cellular material into the cell’s inside. These are wild speculations, to be clear, but the general idea is brilliant.

Indeed, not everyone reacts in the same way to recreational drugs. A recent massive study on the health effects of alcohol funded by the Bill and Melinda Gates Foundation (cf. No amount of alcohol is good for your overall health) suggests that alcohol is bad for one’s health at every dosage. This goes against the common wisdom backed up with numerous studies that light-drinkers (~1 alcohol unit a day) live longer and healthier lives than teetotalers. The new study suggests that this is not a causal effect of alcohol. Rather, it so happens that a large fraction of teetotalers are precisely the kind of people who react very badly to alcohol as a matter of poor metabolism. Hence, teetotalers are not unhealthy because they avoid alcohol; they avoid alcohol because they are unhealthy, which explains their shorter life expectancy on average. That said, the study did show that 1 alcohol unit a day is, although damaging, very minimally so:

Anyhow, the world’s cultural fascination with alcohol is bizarre to me, considering the existence of drugs that have a much better hedonic and cost-benefit profile (cf. State-Space of Drug Effects). Perhaps finding out with genetic testing that you are likely to be an above-average alcohol metabolizer might be good to lessen your worry about having a couple of drinks now and then. But the much bigger opportunity here would be to allow you to find drugs that you are particularly compatible with. For example, a genetic test might determine based on a polygenetic score that you might benefit a whole lot from taking small amounts of e.g. Khat  (or some such obscure and relatively benign euphoriant). That is, that your genetic make-up is such that Khat will be motivation enhancing, empathy-increasing, good for your heart and lungs, reduce the rate of dopamine neuron death, etc. while at the same time producing little to no hangovers, no irritability, no sleep issues, or social dysfunction. Even though you may have thought that you are “not an uppers person”, perhaps that’s because, genetically, every other upper you have ever tried is objectively terrible for your health. But Khat wouldn’t be. Wouldn’t this information be useful? Indeed, I would posit, this might be a great step in the right direction in order to achieve the goal of  Wireheading Done Right.


*23andMe is here used as a shorthand for services in general like this (including Ancestry, Counsyl, Natera, etc.)

Featured image credit: source.

What is Love? Neural Annealing in the Presence of an Intentional Object

Excerpt from: The Neuroscience of Meditation: Four Models by Michael E. Johnson


Neural annealing: Annealing involves heating a metal above its recrystallization temperature, keeping it there for long enough for the microstructure of the metal to reach equilibrium, then slowly cooling it down, letting new patterns crystallize. This releases the internal stresses of the material, and is often used to restore ductility (plasticity and toughness) on metals that have been ‘cold-worked’ and have become very hard and brittle— in a sense, annealing is a ‘reset switch’ which allows metals to go back to a more pristine, natural state after being bent or stressed. I suspect this is a useful metaphor for brains, in that they can become hard and brittle over time with a build-up of internal stresses, and these stresses can be released by periodically entering high-energy states where a more natural neural microstructure can reemerge.

Furthermore, from what I gather from experienced meditators, successfully entering meditative flow may be one of the most reliable ways to reach these high-energy brain states. I.e., it’s very common for meditation to produce feelings of high intensity, at least in people able to actually enter meditative flow.* Meditation also produces more ‘pure’ or ‘neutral’ high-energy states, ones that are free of the intentional content usually associated with intense experiences which may distort or limit the scope of the annealing process. So we can think of intermediate-to-advanced (‘successful flow-state’) meditation as a reheating process, whereby the brain enters a more plastic and neutral state, releases pent-up structural stresses, and recrystallizes into a more balanced, neutral configuration as it cools. Iterated many times, this will drive an evolutionary process and will produce a very different brain, one which is more unified & anti-fragile, less distorted toward intentionality, and in general structurally optimized against stress.

An open question is how or why meditation produces high-energy brain states. There isn’t any consensus on this, but I’d offer with a nod to the predictive coding framework that bottom-up sense-data is generally excitatory, adding energy to the system, whereas top-down predictive Bayesian models are generally inhibitory, functioning as ‘energy sinks’. And so by ‘noting and knowing’ our sensations before our top-down models activate, in a sense we’re diverting the ‘energy’ of our sensations away from its usual counterbalancing force. If we do this long enough and skillfully enough, this energy can build up and lead to ‘entropic disintegration’, the prerequisite for annealing. (Thanks to Andrés for discussion here)

If this model is true, it feels very important for optimizing a meditation practice. E.g., we should try to figure out some rules of thumb for:

  • How to identify a high-energy brain state, in yourself and others, and how best to create them;
  • Things to do, and things not to do, during an annealing process (‘how to anneal the right things’);
  • Identifying tradeoffs in ‘cooling’ the brain quickly vs slowly.

Off the top of my head, I’d suggest that one of the worst things you could do after entering a high-energy brain state would be to fill your environment with distractions (e.g., watching TV, inane smalltalk, or other ‘low-quality patterns’). Likewise, it seems crucial to avoid socially toxic or otherwise highly stressful conditions. Most likely, going to sleep as soon as possible without breaking flow would be a good strategy to get the most out of a high-energy state. Avoiding strong negative emotions during such states seems important, as does managing your associations (psychedelics are another way to reach these high-energy states, and people have noticed there’s an ‘imprinting’ process where the things you think about and feel while high can leave durable imprints on how you feel after the trip). Finally, perhaps taking certain nootropics could help strengthen (or weaken) the magnitude of this annealing process.

Finally, to speculate a little about one of the deep mysteries of life, perhaps we can describe love as the result of a strong annealing process while under the influence of some pattern. I.e., evolution has primed us such that certain intentional objects (e.g. romantic partners) can trigger high-energy states where the brain smooths out its discontinuities/dissonances, such that given the presence of that pattern our brains are in harmony.[3] This is obviously a two-edged sword: on one hand it heals and renews our ‘cold-worked’ brain circuits and unifies our minds, but also makes us dependent: the felt-sense of this intentional object becomes the key which unlocks this state. (I believe we can also anneal to archetypes instead of specific people.)

Annealing can produce durable patterns, but isn’t permanent; over time, discontinuities creep back in as the system gets ‘cold-worked’. To stay in love over the long-term, a couple will need to re-anneal in the felt-presence of each other on a regular basis.[4] From my experience, some people have a natural psychological drive toward reflexive stability here: they see their partner as the source of goodness in their lives, so naturally they work hard to keep their mind aligned on valuing them. (It’s circular, but it works.) Whereas others are more self-reliant, exploratory, and restless, less prone toward these self-stable loops or annealing around external intentional objects in general. Whether or not, and within which precise contexts, someone’s annealing habits fall into this ‘reflexive stability attractor’ might explain much about e.g. attachment style, hedonic strategy, and aesthetic trajectory.

Links: Annealing (metallurgy)The entropic brain

[3] Anecdotally, the phenomenology of love-annealing is the object ‘feels beautiful from all angles’. This may imply that things (ideas, patterns, people) which are more internally coherent & invariant across contexts can produce stronger annealing effects — i.e. these things are more easy to fall deeply in love with given the same ‘annealing budget’, and this love is more durable.

[4] It’s important to note that both intense positive and intense negative experiences can push the brain into high-energy states; repeated annealing to negative emotions may serve many of the same functions as ‘positive annealing’, but also predispose brains to ‘sing in a minor key’ (see ‘kindling’).


Related Work: Algorithmic Reduction of Psychedelic States, Principia Qualia: Part II – Valence, and Ecstasy and Honesty


Image credit: Fabián Jiménez

The Phenomenal Character of LSD + MDMA (Candy-Flipping) According to Cognitive Scientist Steve Lehar

Excerpt from: The Grand Illusion: A Psychonautical Odyssey Into the Depths of Human Experience (pages 60-62) by Steve Lehar (emphasis and links are mine)


Ecstasy

About this time I had the good fortune of locating a supply of ecstasy. True to its name, ecstasy promotes a kind of euphoric jitteryness, in which it is just a thrill to be alive! Every fiber of your being is just quivering with energy. But ecstasy also has some interesting perceptual manifestations. In the first place there is a kind of jitteryness across the whole visual field. And this jitteryness is so pronounced that it can manifest itself in your eyeballs, that jitter back and forth at a blinding speed. If you relax, and just let the jitters take over, the oscillations of your eyes will blur the whole scene into a peculiar double image. But if you concentrate, and focus, the ocular jitter can be made to subside, and thus become less noticeable or bothersome. One of my friends got the ocular jitters so bad that he could not control them, and that prevented him from having a good time. That was the last time he took ecstasy. I however found it enchanting. And I analyzed that subtle jitteryness more carefully. It was not caused exclusively by jittering of the eyeball, but different objects in the perceived world also seemed to jitter endlessly between alternate states. In fact, all perceived objects jittered in this manner, creating a fuzzy blur between alternate states. This was interesting for a psychonaut! It seemed to me that I could see the mechanism of my visual brain sweeping out the image of my experience right before my eyes, like the flying spot of light that paints the television picture on the glowing phosphor screen. The refresh rate of my visual mechanism had slowed to such a point as to make this sweep visible to me. Very interesting indeed!

Candy-Flipping

Having access simultaneously to ecstasy and LSD, I tried my hand at the practice known in the drug literature as “candy flipping”, that is, taking ecstasy and LSD in combination. The combination is so unique and different from the experience of either drug in isolation, that it has earned its own unique name. Under LSD and ecstasy I could see the flickering blur of visual generation most clearly. And I saw peculiar ornamental artifacts on all perceived objects, like a Fourier representation with the higher harmonics chopped off. LSD by itself creates sharply detailed ornamental artifacts, like a transparent overlay of an ornamental lattice or filigree pattern superimposed on the visual scene, especially in darkness. Ecstasy smooths out those sharp edges and blurs them into a creamy smooth rolling experience. I would sometimes feel some part of my world suddenly bulging out to greater magnification, like a fish-eye lens distortion appearing randomly in space, stretching everything in that portion of space like a reflection in a funhouse mirror. But it was not an actual bulging that changed the shape of the visual world, but more of a seeming bulging, that was perceived in an invisible sense without actual distortion of the world. For example one time I was putting on my boots to go outside, and as I reached down to pull on a boot, I suddenly got the impression that my leg grew to ten times its normal length, but I could still reach my boot because my arms had also grown by the same proportion, as had the whole space in that part of the room. Nothing actually looked any different after this expansion, it was just my sense of the scale of the world that had undergone this transformation, and even as I contemplated this, and finished securing my boot, the world shrank down gradually back to its normal scale again and the distortion vanished.

I have theorized that the way that ecstasy achieved its creamy smoothness is by dithering or alternating so fast between perceptual alternatives as to blur them together, like a spinning propellor that appears as a semi-transparent disc. At this level of observation I was unable to get my co-trippers to see the features that I was seeing. I would ask them when they saw that line of trees, did they not see illusory projections, like a transparent overlay of vectors projecting up from the trees into the blue sky that I could see? They did not see these things. So don’t expect to see what I see when I take LSD and ecstasy. I report my observations as I experience them, but observation of the psychedelic experience is every bit as subjective and variable as any phenomenological observation of our own experience. What stands out for one observer might remain completely obscure to another.

But the features I observed in my psychedelic experience all pointed toward a single self-consistent explanation of the mechanism of experience. It appears that the spatial structure of visual experience is swept out by some kind of volumetric imaging mechanism with a periodic refresh scan, not unlike the principle of television imagery, but extended into three dimensions. This was interesting indeed!


Related Articles:

  • Quantifying Bliss – which proposes a model from first principles to explain the structural properties of an experience that makes it feel good, bad, mixed, or neutral (i.e. valence). It then derives from this model precise, empirically testable predictions for what really good experiences should look like. Specifically, MDMA euphoria is postulated to be the result of a high level of consonance between connectome-specific harmonic waves.
  • A Future for Neuroscience – which discusses the broad implications of a harmonic resonance theory of brain function for neuroscience, including new ways to conceptualize personality, and exotic states of consciousness.
  • The Pseudo-Time Arrow – which discusses a particular physicalist model to explain the experience of time by examining the patterns of *implicit causality* in networks of local binding (these terms are defined there). The bottom line being: each moment of experience contains time implicitly embedded in its geometric structure. Psychedelics, MDMA, and their combination would each have unique signature structural effects along the arrow of pseudo-time.

Taken together, these articles would provide an explanation for why MDMA has a uniquely euphoric effect. In particular, Lehar’s point that MDMA’s generalized jitteryness/dithering smooths out the sharp edges of an LSD experience would show up as the harmonization/regularization of the relationship between time-slices along the pseudo-time arrow of experience. The Symmetry Theory of Valence can then be applied in the resulting network of local binding after MDMA’s smoothing effect, leading to the peculiar insight that MDMA’s euphoric effects come from the symmetrification of experience along the axis of experiential time. The creaminess of experience produced by MDMDA that Lehar talks about feels very good precisely because it is the phenomenal character of a dissonance-free state of consciousness. Hence, the fundamental nature of pleasure is not behavioral reinforcement, the maximization of utility according to one’s utility function, or expected surprise minimization; pleasure is more fundamental and low-level than any of those properties. Pleasure, we predict, shall correspond to the degree and intensity of energized symmetries present in a bound moment of experience, and MDMA phenomenology is a clear example of what it looks like to optimize for this property.

Hell Must Be Destroyed

Singer called the movement that grew up around him “effective altruism”, and its rallying cry was that one ought to spend every ounce of one’s energy doing whatever most relieves human suffering, most likely either feeding the poor or curing various tropical diseases. Again, something his opponents rejected as impossible, unworkable, another example of liberal fanaticism. Really? Every ounce of your energy? Again, they could have just read their Bibles. Deuteronomy 6:5: “And you must love the Lord your God with all your heart, and with all your soul, and with all your strength.”
 
Then Singer changed his tune. In the 1970s, after the sky cracked and the world changed, he announced that charity was useless, that feeding the poor was useless, that curing tropical diseases was useless. There was only one cause to which a truly rational, truly good human being could devote his or her life.
 
Hell must be destroyed.
 
The idea of billions of human beings suffering unbearable pain for all eternity so outweighed our little earthly problems that the latter didn’t even register. He began meeting with his disciples in secret, teaching them hidden Names he said had been vouchsafed to him by angels. Thamiel put a price on his life – quite a high price actually. Heedless of his own safety, Singer traveled what remained of the civilized world, making converts wherever he went, telling them to be perfect as God was perfect, and every speech ended the same way. Hell must be destroyed.

An angel appears on Earth. This genderless being connected to God shows up on every screen on Earth at once and asks us if we are interested in drastically improving life on Earth. A large enough portion of those who hear the message (which gets a coverage of 80%+ of people worldwide) see into their souls and find the willingness to make life better, and then they see into their hearts and see the warmth of hope, and so they resolve to agree to do whatever is necessary to help the angel improve life on Earth. And thus the angel says “thanks to the collective desire to make it so, I shall change some things about how the planet is programed, and you will see a 99% reduction in suffering and a 20% increase in overall happiness.”
And so the angel gets to work.
A year passes, and nobody can really tell the difference from before. Most people’s day to day experience is perhaps even slightly more tedious and slightly more boring. What happened? After a few years it is clear that no major change has happened, and indeed affective psychologists report a mild but very generalized decrease in people’s engagement with their day to day activities and increases in feelings of being a bit disoriented. Did the angel scam us? Or did people fail to do their part? Or why are there no improvements? A large enough mass of people asked this question that the angel felt the need to provide an update. He comes back down and appears in all of the planet’s screens and says:
“Everything went according to plan. It is just that your society hasn’t reached the point of scientific development where you are able to measure the quality of experience of sentient beings. You aren’t quantifying pain very well.”
“Here is what I did. Above of all, I focused my energies on trying to prevent some of the worst experiences, which in aggregate happened to be an ethical catastrophe. I managed to reduce how bad these experiences were by about 99.99%.”
“I started by reducing how bad cluster headaches feel. They are now only about 44,000 dolors per second (d/s). They used to be around 450,000,000 d/s. You see, when most people get a fleeting headache, we are talking about headaches that range from 0.5 to 1d/s. You know, the type of headache that people are willing to wait out, and perhaps some people will ask for a little aspirin or some placebo of some sort and then get on with it. Most headaches are of this kind. But even if you bundle all of them together we are talking about a rounding error relative to the suffering caused by other types of headaches, the bad ones. Migraine, for example, tends to get to about 1,000 dolors per second, and sufferers have a hard time communicating the fact that it is not just a lot worse, it is a thousand times more painful than the “normal” ones. But even then that does not register relative to one of the really really bad ones, like cluster headaches, which as I said can spiral up to values close to a billion d/s. As it happens, on your planet there are simple chemical tricks to reduce that particular type of pain (e.g. LSD), so I just went ahead and got rid of the bulk of it very easily. It’s still super painful by human standards, but not by my standards, like it was before. To have a cluster headache now is just as “indescribably bad” as before, meaning it goes beyond people’s ability to imagine and make sense of. But that doesn’t challenge the fact that the 99.99% improvement I did is an ethical victory of civilizational magnitude.”
“Next I went on to reducing how bad it feels to have kidney stones, bone pain, and various kinds of particularly bad neuropathies in people with schizophrenia. By the time I had taken care of about the dozen or so worst kinds of pain, I had already overdelivered by an order of magnitude and was starting to run into diminishing returns. So I decided to go on to helping other planets in my quest to prevent as much suffering as possible.”
“I apologize I used about 0.13 hedons per second (h/s) from mundane experiences to implement one of those cosmic pain diminishing plans. In order to increase the amount of happiness in the world as I promised I made the experience of showering about 50% more enjoyable and the experience of listening to music about twice as good. As you can see, the bathing industry did take off, but not many thought much of it. And the musicians were able to tell that music was awesome again and wondered why, but most people seem to have attributed their increased musical enjoyment to what they imagined had been their own hidden musical talents all along.”
“Thank you, and keep enjoying your drastically improved planet.”

 

Thus, people realized that the world was indeed a lot better. Well, some did. And others complained, but it was ok.

Thanks to Michael Aaron Coleman and Jonathan Leighton for inspiring this piece. Michael suffers from cluster headaches and has described their phenomenology in gruesome detail. He says that in a 0 to 10 scale, cluster headaches are solid 10/10. But he also says you really need a different scale to make sense of this monster. He once used the phrase “minus one million hedonic tone”. He says that morphine makes the pain go from 10/10 to 9/10, if at all, maybe more like 9.5/10. Thankfully, LSD in small doses (~25 micrograms) makes it go to 1/10. DMT also works, but 5-MeO-DMT does not (and yet it still expands time, so not a good idea). Jonathan is the Executive Director of the Organization for the Prevention of Intense Suffering (OPIS). He works on identifying cases where intense suffering can be prevented on a massive scale and doing what has to be done. I recommend getting in touch with him if this is a particular interest of yours.

The Pseudo-Time Arrow: Explaining Phenomenal Time With Implicit Causal Structures In Networks Of Local Binding

At this point in the trip I became something that I can not put into words… I became atemporal. I existed without time… I existed through an infinite amount of time. This concept is impossible to comprehend without having actually perceived it. Even now in retrospect it is hard to comprehend it. But I do know that I lived an eternity that night… 

 

– G.T. Currie. “Impossible to Understand Reality: An Experience with LSD

Time distortion is an effect that makes the passage of time feel difficult to keep track of and wildly distorted.

 

PsychonautWiki

Introduction

What is time? When people ask this question it is often hard to tell what they are talking about. Indeed, without making explicit one’s background philosophical assumptions this question will usually suffer from a lot of ambiguity. Is one talking about the experience of time? Or is one talking about the physical nature of time? What sort of answer would satisfy the listener? Oftentimes this implicit ambiguity is a source of tremendous confusion. Time distortion experiences deepen the mystery; the existence of exotic ways of experiencing time challenges the view that we perceive the passage of physical time directly. How to disentangle this conundrum?

Modern physics has made enormous strides in pinning down what physical time is. As we will see, one can reduce time to causality networks, and causality to patterns of conditional statistical independence. Yet in the realm of experience the issue of time remains much more elusive.

In this article we provide a simple explanatory framework that accounts for both the experience of time and its relation to physical time. We then sketch out how this framework can be used to account for exotic experiences of time. We end with some thoughts pertaining the connection between the experience of time and valence (the pleasure-pain axis), which may explain why exotic experiences of the passage of time are frequently intensely emotional in nature.

To get there, let us first lay out some key definitions and background philosophical assumptions:

Key Terminology: Physical vs. Phenomenal Time

Physical Time: This is the physical property that corresponds to what a clock measures. In philosophy of time we can distinguish between eternalism and presentism. Eternalism postulate that time is a geometric feature of the universe, best exemplified with “block universe” metaphor (i.e. where time is another dimension alongside our three spatial dimensions). Presentism, instead, postulates that only the present moment is real; the past and the future are abstractions derived from the way we experience patterns in sequences of events. The present is gone, and the future has yet to come.

Now, it used to be thought that there was a universal metronome that dictated “what time it is” in the universe. With this view one could reasonably support presentism as a viable account of time. However, ever since Einstein’s theory of relativity was empirically demonstrated we now know that there is no absolute frame of reference. Based on the fundamental unity of space and time as presented by general relativity, and the absence of an absolute frame of reference, we find novel interesting arguments in favor of eternalism and against presentism (e.g. the Rietdijk–Putnam argument). On the other hand, presentists have rightly argued that the ephemeral nature of the present is self-revealing to any subject of experience. Indeed, how can we explain the feeling of the passage of time if reality is in fact a large geometric “static” structure? While this article does not need to take sides between eternalism and presentism, we will point out that the way we explain the experience of time will in turn diminish the power of presentist arguments based on the temporal character of our experience.

Phenomenal Time: This is the way in which the passing of time feels like. Even drug naïve individuals can relate to the fact that the passage of time feels different depending on one’s state of mind. The felt sense of time depends on one’s level of arousal (deeply asleep, dreaming, tired, relaxed, alert, wide awake, etc.) and hedonic tone (depressed, anxious, joyful, relaxed, etc.). Indeed, time hangs heavy when one is in pain, and seems to run through one’s fingers when one is having a great time. More generally, when taking into account altered states of consciousness (e.g. meditation, yoga, psychedelics) we see that there is a wider range of experiential phenomena than is usually assumed. Indeed, one can see that there are strange generalizations to phenomenal time. Examples of exotic phenomenal temporalities include: tachypsychia (aka. time dilation), time reversal, short-term memory tracers, looping, “moments of eternity“, temporal branching, temporal synchronicities, timelessness, and so on. We suggest that any full account of consciousness ought to be able to explain all of these variants of phenomenal time (among other key features of consciousness).

Key Background Assumptions

We shall work under three key assumptions. First, we have indirect realism about perception. Second, we have mereological nihilism in the context of consciousness, meaning that one’s stream of consciousness is composed of discrete “moments of experience”. And third, Qualia Formalism, a view that states that each moment of experience has a mathematical structure whose features are isomorphic to the features of the experience. Let us unpack these assumptions:

1. Indirect Realism About Perception

This view also goes by the name of representationalism or simulationism (not to be confused with the simulation hypothesis). In this account, perception as a concept is shown to be muddled and confused. We do not really perceive the world per se. Rather, our brains instantiate a world-simulation that tracks fitness-relevant features of our environment. Our sensory apparatus merely selects which specific world-simulation our brain instantiates. In turn, our world-simulations causally covaries with the input our senses receive and the motor responses it elicits. Furthermore, evolutionary selection pressures, in some cases, work against accurate representations of one’s environment (so long as these are not fitness-enhancing). Hence, we could say that our perception of the world is an adaptive illusion more than an accurate depiction of our surroundings.

A great expositor of this view is Steve Lehar. We recommend his book about how psychonautical experience make clear the fact that we inhabit (and in some sense are) a world-simulation created by our brain. Below you can find some pictures from his “Cartoon Epistemology“, which narrates a dialogue between a direct and an indirect realist about perception:

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Steve Lehar also points out that the very geometry of our world-simulation is that of a diorama. We evolved to believe that we can experience the world directly, and the geometry of our world-simulation is very well crafted to keep us under the influence of a sort of spell to makes us believe we are the little person watching the diorama. This world-simulation has a geometry that is capable of representing both nearby regions and far-away objects (and even points-at-infinity), and it represents the subject of experience with a self-model at its projective center.

We think that an account of how we experience time is possible under the assumption that experiential time is a structural feature of this world-simulation. In turn, we would argue that implicit direct realism about perception irrevocably confuses physical time and phenomenal time. For if one assumes that one somehow directly perceives the physical world, doesn’t that mean that one also perceives time? But in this case, what to make of exotic time experiences? With indirect realism we realize that we inhabit an inner world-simulation that causally co-varies with features of the environment and hence resolve to find the experience of time within the confines of one’s own skull.

2. Discrete Moments of Experience

A second key assumptions is that experiences are ontologically unitary rather than merely functionally unitary. The philosophy of mind involved in this key assumption is unfortunately rather complex and easy to misunderstand, but we can at least say the following. Intuitively, as long as one is awake an alert, it feels like one’s so-called “stream of consciousness” is an uninterrupted and continuous experience. Indeed, at the limit, some philosophers have even argued that one is a different person each day; subjects of experience are, as it were, delimited by periods of unconsciousness. We instead postulate that the continuity of experience from one moment to the next is an illusion caused be the way experience is constructed. In reality, our brains generate countless “moments of experience” every second, each with its own internal representation of the passage of time and the illusion of a continuous diachronic self.

Contrast this discretized view of experience with deflationary accounts of consciousness (which insist that there is no objective boundary that delimits a given moment of experience) and functionlist accounts of consciousness (which would postulate that experience is smeared across time over the span of hundreds of milliseconds).

The precise physical underpinnings of a moment of experience have yet to be discovered, but if monistic physicalism is to survive, it is likely that the (physical) temporal extension that a single moment of experience spans is incredibly thin (possibly no more than 10^-13 seconds). In this article we make no assumptions about the actual physical temporal extension of a moment of experience. All we need to say is that it is “short” (most likely under a millisecond).

It is worth noting that the existence of discrete moments of experience supports an Empty Individualist account of personal identity. That is, a person’s brain works as an experience machine that generates many conscious events every second, each with its own distinct coordinates in physical space-time and unique identity. We would also argue that this ontology may be compatible with Open Individualism, but the argument for this shall be left to a future article.

3. Qualia Formalism

This third key assumption states that the quality of all experiences can be modeled mathematically. More precisely, for any given moment of experience, there exists a mathematical object whose mathematical features are isomorphic the the features of the experience. At the Qualia Research Institute we take this view and run with it to see where it takes us. Which mathematical object can fully account for the myriad structural relationships between experiences is currently unknown. Yet, we think that we do not need to find the One True Mathematical Object in order to make progress in formalizing the structure of subjective experience. In this article we will simply invoke the mathematical object of directed graphs in order to encode the structure of local binding of a given experience. But first, what is “local binding”? I will borrow David Pearce’s explanation of the terms involved:

The “binding problem”, also called the “combination problem”, refers to the mystery of how the micro-experiences mediated by supposedly discrete and distributed neuronal edge-detectors, motion-detectors, shape-detectors, colour-detectors, etc., can be “bound” into unitary experiential objects (“local” binding) apprehended by a unitary experiential self (“global” binding). Neuroelectrode studies using awake, verbally competent human subjects confirm that neuronal micro-experiences exist. Classical neuroscience cannot explain how they could ever be phenomenally bound. As normally posed, the binding problem assumes rather than derives the emergence of classicality.

 

Non-Materialist Physicalism by David Pearce

In other words, “local binding” refers to the way in which the features of our experience seem to be connected and interwoven into complex phenomenal objects. We do not see a chair as merely a disparate set of colors, edges, textures, etc. Rather, we see it as an integrated whole with fine compositional structure. Its colors are “bound” to its edges which are “bound” to its immediate surrounding space and so forth.

A simple toy model for the structure of an experience can be made by saying that there are “simple qualia” such as color and edges, and “complex qualia” formed by the binding of simple qualia. In turn, we can represent an experience as a graph where each node is a simple quale and each edge is a local binding connection. The resulting globally connected graph corresponds to the “globally bound” experience. Each “moment of experience” is, thus, coarsely at any rate, a network.

While this toy model is almost certainly incomplete (indeed some features of experience may require much more sophisticated mathematical objects to be represented properly), it is fair to say that the rough outline of our experience can be represented with a network-like skeleton encoding the local binding connections. More so, as we will see, this model will suffice to account for many of the surprising features of phenomenal time (and its exotic variants).

Timeless Causality

While both physical and phenomenal time pose profound philosophical conundrums, it is important to denote that science has made a lot of progress providing formal accounts of physical time. Confusingly, even Einstein’s theory of general relativity is time-symmetric, meaning that the universe would behave the same whether time was moving forwards or backwards. Hence relativity does not provide, on its own, a direction to time. What does provide a direction to time are properties like the entropy gradient (i.e. the direction along which disorder is globally increasing) and, the focus of this article, causality as encoded in the network of statistical conditional independence. This is a mouthful, let us tackle it in more detail.

In Timeless Causality Yudkowsky argues one can tell the direction of causality, (and hence of the arrow of time) by examining how conditioning on events inform us about other events. We recommend reading the linked article for details (and for a formal account read SEP’s entry on the matter).

In the image above we have a schematic representation of two measurables (1 & 2) at several times (L, M, and R). The core idea is that we can determine the flow of causality by examining the patterns of statistical conditional independence, with questions like “if I’ve observed L1 and L2, do I gain information about M1 by learning about M2?” an so on*.

Along the same lines Wolfram has done research on how time may emerge in rule-based network modifications automata:

image-xlarge

Intriguingly, these models of time and causality are tenseless and hence eternalist. The whole universe works as a unified system in which time appears as an axis rather than a metaphysical universal metronome. But if eternalism is true, how come we can feel the passage of time? If moments of experience exist, how come we seem to experience movement and action? Shouldn’t we experience just a single static “image”, like seeing a single movie frame without being aware of the previous ones? We are now finally ready tackle these questions and explain how time may be encoded in the structure of one’s experience.

Pseudo-Time Arrow

pseudo_time_arrow_illustrated_1

Physical Time vs. Phenomenal Time (video source)

In the image above we contrast physical and phenomenal time explicitly. The top layer shows the physical state of a scene in which a ball is moving along a free-falling parabolic trajectory. In turn, a number of these states are aggregated by a process of layering (second row) into a unified “moment of experience”. As seen on the third row, each moment of experience represents the “present scene” as the composition of three slices of sensory input with a time-dependent dimming factor. Namely, the scene experienced is approximated with a weighted sum of three scenes with the most recent one being weighted the highest and the oldest the least.

In other words, at the coarsest level of organization time is encoded by layering the current input scene with faint after-images of very recent input scenes. In healthy people this process is rather subtle yet always present. Indeed, after-images are an omnipresent feature of sensory modalities (beyond sight).

A simple model to describe how after-images are layered on top of each other to generate a scene with temporal depth involves what we call “time-dependent qualia decay functions”. This function determines how quickly sensory (and internal) impressions fade over time. With e.g. psychedelics making this decay function significantly fatter (long-tailed) and stimulants making it slightly shorter (i.e. higher signal-to-noise ratio at the cost of reduced complex image formation).

With this layering process going on, and the Qualia Formalist model of experience as a network of local binding, we can further find a causal structure in experience akin to that in physical time (as explained in Timeless Causality):

Again, each node of the network represents a simple quale and each edge represents a local binding relationship between the nodes it connects. Then, we can describe the time-dependent qualia decay function as the probability that a node or an edge will vanish at each (physical) time step.

sober_pseudo_time_arrow_1

The rightmost nodes and edges are the most recent qualia triggered by sensory input. Notice how the nodes and edges vanish probabilistically with each time step, making the old layers sparsely populated.

With a sufficiently large network one would be able to decode the direction of causality (and hence of time) using the same principles of statistical conditional independence used to account for physical time. What we are proposing is that this underlies what time feels like.

Now that we understand what the pseudo-time arrow is, what can we do with it?

Explanatory Power: How the Pseudo-Time Arrow Explains Exotic Phenomenal Time

Let us use this explanatory framework on exotic experiences of time. That is, let us see how the network of local binding and its associated pseudo-time arrows can explain unusual experiences of time perception.

To start we should address the fact that tachypsychia (i.e. time dilation) could either mean (a) that “one experiences time passing at the same rate but that this rate moves at a different speed relative to the way clocks tick compared to typical perception” or, more intriguingly, (b) that “time itself feels slower, stretched, elongated, etc.”.

The former (a) is very easy to explain, while the latter requires more work. Namely, time dilation of the former variety can be explained by an accelerated or slowed down sensory sampling rate in such a way that the (physical) temporal interval between each layer is either longer or shorter than usual. In this case the structure of the network does not change; what is different is how it maps to physical time. If one were on a sensory deprivation chamber and this type of time dilation was going on one would not be able to say so since the quality of phenomenal time (as encoded in the network of local binding) remains the same as before. Perhaps compare how it feels like to see a movie in slow-motion relative to seeing it at its original speed while being perfectly sober. Since one is sober either way, what changes is how quickly the world seems to move, not how one feels inside.

The latter (b) is a lot more interesting. In particular, phenomenal time is often incredibly distorted when taking psychedelics in a way that is noticeable even in sensory deprivation chambers. In other words, it is the internal experience of the passage of time that changes rather than the layering rate relative to the external world. So how can we explain that kind of phenomenal time dilation?

Psychedelics

The most straightforward effect of psychedelics one can point out with regards to the structure of one’s experience is the fact that qualia seems to last for much longer than usual. This manifests as “tracers” in all sensory modalities. Using the vocabulary introduced above, we would say that psychedelics change the time-dependent qualia decay function by making it significantly “fatter”. While in sober conditions the positive after-image of a lamp will last between 0.2 and 1 second, on psychedelics it will last anywhere between 2 and 15 seconds. This results in a much more pronounced and perceptible change in the layering process of experience. Using Lehar’s diorama model of phenomenal space, we could represent various degrees of psychedelic intoxication with the following progression:

The first image is what one experiences while sober. The second is what one experiences if one takes, e.g. 10 micrograms of LSD (i.e. microdosing), where there is a very faint additional layer but is at times indistinguishable from sober states. The third, fourth, and fifth image represent what tracers may feel like on ~50, ~150, and ~300 micrograms of LSD, respectively. The last image is perhaps most reminiscent of DMT experiences, which provide a uniquely powerful and intense high-frequency layering at the onset of the trip.

In the graphical model of time we could say that the structure of the network changes by (1) a lower probability for each node to vanish in each (physical) time step, and (2) an even lower probability for each edge to vanish after each (physical) time step. The tracers experienced on psychedelics are more than just a layering process; the density of connections also increases. That is to say, while simple qualia lasts for longer, the connections between them are even longer-lasting. The inter-connectivity of experience is enhanced.

low_dose_lsd_pseudo_time_arrow

A low dose of a psychedelic will lead to a slow decay of simple qualia (colors, edges, etc.) and an even slower decay of connections (local binding), resulting in an elongated and densified pseudo-time arrow.

This explains why time seems to move much more slowly on psychedelics. Namely, each moment of experience has significantly more temporal depth than a corresponding sober state. To illustrate this point, here is a first-person account of this effect:

A high dose of LSD seems to distort time for me the worst… maybe in part because it simply lasts so long. At the end of an LSD trip when i’m thinking back on everything that happened my memories of the trip feel ancient.

When you’re experiencing the trip it’s possible to feel time slowing down, but more commonly for me I get this feeling when I think back on things i’ve done that day. Like “woah, remember when I was doing this. That feels like it was an eternity ago” when in reality it’s been an hour.

 

Shroomery user Subconscious in the tread “How long can a trip feel like?

On low doses of psychedelics, phenomenal time may seem to acquire a sort of high definition unusual for sober states. The incredible (and accurate) visual acuity of threshold DMT experiences is a testament to this effect, and it exemplifies what a densified pseudo-time arrow feels like:

SONY DSC

Just as small doses of DMT enhance the definition of spatial structures, so is the pseudo-time arrow made more regular and detailed, leading to a strange but compelling feeling of “HD vision”.

But this is not all. Psychedelics, in higher doses, can lead to much more savage and surrealistic changes to the pseudo-time arrow. Let us tackle a few of the more exotic variants with this explanatory framework:

Time Loops

This effect feels like being stuck in a perfectly-repeating sequence of events outside of the universe in some kind of Platonic closed timelike curve. People often accidentally induce this effect by conducting repetitive tasks or listening to repetitive sounds (which ultimately entrain this pattern). For most people this is a very unsettling experience since it produces a pronounce feeling of helplessness due to making you feel powerless about ever escaping the loop.

In terms of the causal network, this experience could be accounted for with a loop in the pseudo-time arrow of experience:

high_dose_lsd_infinite

High Dose LSD can lead to annealing and perfect “standing temporal waves” often described as “time looping” or “infinite time”

Moments of Eternity

Subjectively, so-called “Moments of Eternity” are extremely bizarre experiences that have the quality of being self-sustaining and unconditioned. It is often described in mystical terms, such as “it feels like one is connected to the eternal light of consciousness with no past and no future direction”. Whereas time loops lack some of the common features of phenomenal time such as a vanishing past, moments of eternity are even more alien as they also lack a general direction for the pseudo-time arrow.

high_dose_lsd_moment_of_eternity

High Dose LSD may also generate a pseudo-time arrow with a central source and sink to that connects all nodes.

Both time loops and moments of eternity arise from the confluence of a slower time-dependent qualia decay function and structural annealing (which is typical of feedback). As covered in previous posts, as depicted in numerous psychedelic replications, and as documented in PsychonautWiki, one of the core effects of psychedelics is to lower the symmetry detection threshold. Visually, this leads to the perception of wallpaper symmetry groups covering textures (e.g. grass, walls, etc.). But this effect is much more general than mere visual repetition; it generalizes to the pseudo-time arrow! The texture repetition via mirroring, gyrations, glides, etc. works indiscriminately across (phenomenal) time and space. As an example of this, consider the psychedelic replication gifs below and how the last one nearly achieves a standing-wave structure. On a sufficient dose, this can anneal into a space-time crystal, which may have “time looping” and/or “moment of eternity” features.

oscillation_1_5_5_75_5_1_10_0.05_signal_

Sober Input

Temporal Branching

As discussed in a previous post, a number of people report temporal branching on high doses of psychedelics. The reported experience can be described as simultaneously perceiving multiple possible outcomes of a given event, and its branching causal implications. If you flip a coin, you see it both coming up heads and tails in different timelines, and both of these timelines become superimposed in your perceptual field. This experience is particularly unsettling if one interprets it through the lens of direct realism about perception. Here one imagines that the timelines are real, and that one is truly caught between branches of the multiverse. Which one is really yours? Which one will you collapse into? Eventually one finds oneself in one or another timeline with the alternatives having been pruned. An indirect realist about perception has an easier time dealing with this experience as she can interpret it as the explicit rendering of one’s predictions about the future in such a way that they interfere with one’s incoming sensory stimuli. But just in case, in the linked post we developed an empirically testable predictions from the wild possibility (i.e. where you literally experience information from adjacent branches of the multiverse) and tested it using quantum random number generators (and, thankfully for our collective sanity, obtained null results).

high_dose_lsd_branching

High Dose LSD Pseudo-Time Arrow Branching, as described in trip reports where people seem to experience “multiple branches of the multiverse at once.”

Timelessness

Finally, in some situations people report the complete loss of a perceived time arrow but not due to time loops, moments of eternity, or branching, but rather, due to scrambling. This is less common on psychedelics than the previous kinds of exotic phenomenal time, but it still happens, and is often very disorienting and unpleasant (an “LSD experience failure mode” so to speak). It is likely that this also happens on anti-psychotics and quite possibly with some anti-depressants, which seem to destroy unpleasant states by scrambling the network of local binding (rather than annealing it, as with most euphoric drugs).

pseudo_time_arrow_loss

Loss of the Pseudo-Time Arrow (bad trips? highly scrambled states caused by anti-psychotics?)

In summary, this framework can tackle some of the weirdest and most exotic experiences of time. It renders subjective time legible to formal systems. And although it relies on an unrealistically simple formalism for the mathematical structure of consciousness, the traction we are getting is strong enough to make this approach a promising starting point for future developments in philosophy of time perception.

We will now conclude with a few final thoughts…

Hyperbolic Geometry

Intriguingly, with compounds such as DMT, the layering process is so fast that on doses above the threshold level one very quickly loses track of the individual layers. In turn, one’s mind attempts to bind together the incoming layers, which leads to attempts of stitching together multiple layers in a small (phenomenal) space. This confusion between layers compounded with a high density of edges is the way we explained the unusual geometric features of DMT hallucinations, such as the spatial hyperbolic symmetry groups expressed in its characteristic visual texture repetition (cf. eli5). One’s mind tries to deal with multiple copies of e.g. the wall in front, and the simplest way to do so is to stitch them together in a woven Chrysanthemum pattern with hyperbolic wrinkles.

Implementation Level of Abstraction

It is worth noting that this account of phenomenal time lives at the algorithmic layer of Marr’s levels of abstraction, and hence is an algorithmic reduction (cf. Algorithmic Reduction of Psychedelic States). A full account would also have to deal with how these algorithmic properties are implemented physically. The point being that a phenomenal binding plus causal network account of phenomenal time work as an explanation space whether the network itself is implemented with connectome-specific harmonic wavesserotonergic control-interruption, or something more exotic.

Time and Valence

Of special interest to us is the fact that both moments of eternity and time loops tend to be experienced with very intense emotions. One could imagine that finding oneself in such an altered state is itself bewildering and therefore stunning. But there are many profoundly altered states of consciousness that lack a corresponding emotional depth. Rather, we think that this falls out of the very nature of valence and the way it is related to the structure of one’s experience.

In particular, the symmetry theory of valence (STV) we are developing at the Qualia Research Institute posits that the pleasure-pain axis is a function of the symmetry (and anti-symmetry) of the mathematical object whose features are isomorphic to an experience’s phenomenology. In the case of the simplified toy model of consciousness based on the network of local binding connections, this symmetry may manifest in the form of regularity within and across layers. Both in time loops and moments of eternity we see a much more pronounced level of symmetry of this sort than in the sober pseudo-time arrow structure. Likewise, symmetry along the pseudo-time arrow may explain the high levels of positive valence associated with music, yoga, orgasm, and concentration meditation. Each of these activities would seem to lead to repeating standing waves along the pseudo-time arrow, and hence, highly valence states. Future work shall aim to test this correspondence empirically.

QRIalpha (1)

The Qualia Research Institute Logo (timeless, as you can see)


* As Yudkowsky puts it:

causeright_2

Suppose that we do know L1 and L2, but we do not know R1 and R2. Will learning M1 tell us anything about M2? […]

The answer, on the assumption that causality flows to the right, and on the other assumptions previously given, is no. “On each round, the past values of 1 and 2 probabilistically generate the future value of 1, and then separately probabilistically generate the future value of 2.” So once we have L1 and L2, they generate M1 independently of how they generate M2.

But if we did know R1 or R2, then, on the assumptions, learning M1 would give us information about M2. […]

Similarly, if we didn’t know L1 or L2, then M1 should give us information about M2, because from the effect M1 we can infer the state of its causes L1 and L2, and thence the effect of L1/L2 on M2.



Thanks to: Mike Johnson, David Pearce, Romeo Stevens, Justin Shovelain, Andrés Silva Ruiz, Liam Brereton, and Enrique Bojorquez for their thoughts about phenomenal time and its possible mathematical underpinnings.

Anti-Tolerance Drugs

It would indeed be extraordinary if – alone among the neurotransmitter systems of the brain – the endogenous opioid families were immune from dysfunction. Enkephalins are critical to “basal hedonic tone” i.e. whether we naturally feel happy or sad. Yet the therapeutic implications of a recognition that dysfunctional endogenous opioid systems underlie a spectrum of anxiety-disorders and depression are too radical – at present – for the medical establishment to contemplate. In consequence, the use of opioid-based pharmacotherapies for “psychological” pain is officially taboo. The unique efficacy of opioids in banishing mental distress is neglected. Their unrivalled efficacy in treating “physical” nociceptive pain is grudgingly accepted.

 

Future Opioids, by David Pearce

Albert Camus wrote that the only serious question is whether to kill yourself or not. Tom Robbins wrote that the only serious question is whether time has a beginning and an end. Camus clearly got up on the wrong side of bed, and Robbins must have forgotten to set the alarm. There is only one serious question. And that is: Who knows how to make love stay? [emphasis mine] Answer me that and I will tell you whether or not to kill yourself.

 

– Still Life with Woodpecker by Tom Robbins

As eloquently argued by David Pearce in Future Opioids, the problem with opioids and other euphoriant drugs is not that they make you feel good, but that the positive feelings are short lived. In their stead, tolerance, withdrawal, and dependence ultimately set in after repeated use. We take the position that these negatives are not a necessary outcome of feeling free from physical or psychological malaise, for the brain has clever negative feedback mechanisms that prevent us from wireheading chemically. Rather, we believe that tackling these negative feedback mechanisms directly might be they key that unlocks never-ending bliss. Note that even if excellent anti-tolerance drugs were to be developed and commercialized for therapeutic use, we would still need to find solutions to the problems posed by wireheading. Specifically, disabling the negative feedback mechanisms in place that prevent us from feeling well all the time still leaves unsolved the problem of avoiding getting stuck in counterproductive patterns of behavior and becoming at risk of turning into a pure replicator (for proposed solutions to these problems see: Wireheading Done Right). Still, we strongly believe that finding safe and effective anti-tolerance drugs is a step in the right direction in the battle against suffering throughout the living world.

We thus provide the following list of promising anti-tolerance drugs in the hopes of: (1) piquing the interest of budding psychopharmacologists who may be weighting-in on promising research leads, (2) show a proof of concept against the fake and fatalistic truism that “what goes up has to go down” (cf. The Hedonistic Imperative), and last but not least, (3) provide hope to people suffering from physical or psychological distress who would benefit from anti-tolerance drugs, such as those who experience treatment-resistant anxiety, depression, chronic pain, or chemical dependence.

It is worth noting that this list is just a draft, and we will continue to revise it as the science progresses. Please let us know in the comment section if you are aware of compounds not included in this list (of special interest are tier 1 and tier 2 compounds).

Tier System

The list is organized by tiers. Tier 1 includes compounds for which there is evidence that they can reverse tolerance. Tier 2 deals with compounds that seem to either block or attenuate the development of tolerance, meaning that co-administering them with a euphoric agonist reduces the speed at which this euphoriant creates tolerance. Tier 3 includes potentiators. That is, compounds that enhance the effects of other substances without at the same time increasing tolerance to the extent that would be expected given the intensity of the subjective effects. Tier 4 lists compounds that, while not exactly tolerance-related, are still worth mentioning by virtue of reducing the intensity of drug withdrawals. And finally, Tier 5 includes euphoriants that have a favorable pharmacological profile relative to their alternatives, although will still produce tolerance long-term. Typically, a substance belonging to Tier X will also belong to Tier X + 1 and above (except for Tier 5) but we omit repetitions to avoid redundancy (e.g. proglumide not only reverses tolerance, but prevents tolerance, is a potentiatior, and reduces withdrawals).

Opioid System

Tier 1

  1. Ibogaine (see: Low dose treatment)
  2. Proglumide
  3. Naltrexone (specifically in Ultra Low Doses)
  4. Ibudilast (AV-411)

Tier 2

  1. Agmatine (may also help with chronic pain on its own)
  2. Curcumin (found in Turmeric; only works in high-availability forms)
  3. Thymoquinone (found in Nigella Sativa/black seed oil)

Tier 3

  1. DXM (specially potentiates the analgesia, which may be of use for chronic pain sufferers)
  2. Hydroxyzine (beware of its effects on sufferers of Akathisia/Restless Legs Syndrome; also bad in the long term for one’s cognitive capacity)
  3. L-Tyrosine
  4. Magnesium (possibly tier 2 but only weakly so)

Tier 4

  1. L-Aspartic Acid
  2. Ashwagandha
  3. JDTic
  4. Gabapentin
  5. Clonidine

Tier 5

  1. Tianeptine (its effects on the delta opioid receptor attenuates its tolerance when used in therapeutic doses)
  2. Mitragynine (thanks to its partial agonism rather than full agonism it is less dangerous in high doses relative to alternatives; specifically, mitragyne does not have dangerous respiratory depression properties on its own, so switching heroin addicts to it would arguably save countless lives)

 

GABA System

Tier 1

  1. Flumazenil (note: very dose-dependent)

Tier 2

  1. Tranylcypromine
  2. Ginsenosides
  3. Homotaurine
  4. Fasoracetam

Tier 3

  1. Dihydromyricetin

See also.

Dopamine System

Insufficient datapoints for a tier system. Here are the few promising leads:

  1. D-serin
  2. D-cycloserine
  3. Sulbutamine
  4. Bromantane
  5. Memantine

See also.


Tanks to Adam Karlovsky for help compiling these lists.

Thoughts on the ‘Is-Ought Problem’ from a Qualia Realist Point of View

tl;dr If we construct a theory of meaning grounded in qualia and felt-sense, it is possible to congruently arrive at “should” statements on the basis of reason and “is” claims. Meaning grounded in qualia allows us to import the pleasure-pain axis and its phenomenal character to the same plane of discussion as factual and structural observations.

Introduction

The Is-Ought problem (also called “Hume’s guillotine”) is a classical philosophical conundrum. On the one hand people feel that our ethical obligations (at least the uncontroversial ones like “do not torture anyone for no reason”) are facts about reality in some important sense, but on the other hand, rigorously deriving such “moral facts” from facts about the universe appears to be a category error. Is there any physical fact that truly compels us to act in one way or another?

A friend recently asked about my thoughts on this question and I took the time to express them to the best of my knowledge.

Takeaways

I provide seven points of discussion that together can be used to make the case that “ought” judgements often, though not always, are on the same ontological footing as “is” claims. Namely, that they are references to the structure and quality of experience, whose ultimate nature is self-intimating (i.e. it reveals itself) and hence inaccessible to those who lack the physiological apparatus to instantiate it. In turn, we could say that within communities of beings who share the same self-intimating qualities of experience, the is/ought divide may not be completely unbridgeable.


Summaries of Question and Response

Summary of the question:

How does a “should” emerge at all? How can reason and/or principles and/or logic compel us to follow some moral code?

Summary of the response:

  1. If “ought” statements are to be part of our worldview, then they must refer to decisions about experiences: what kinds of experiences are better/worse, what experiences should or should not exist, etc.
  2. A shared sense of personal identity (e.g. Open Individualism – which posits that “we are all one consciousness”) allows us to make parallels between the quality of our experience and the experience of others. Hence if one grounds “oughts” on the self-intimating quality of one’s suffering, then we can also extrapolate that such “oughts” must exist in the experience of other sentient beings and that they are no less real “over there” simply because a different brain is generating them (general relativity shows that every “here and now” is equally real).
  3. Reduction cuts both ways: if the “fire in the equations of physics” can feel a certain way (e.g. bliss/pain) then objective causal descriptions of reality (about e.g. brain states) are implicitly referring to precisely that which has an “ought” quality. Thus physics may be inextricably connected with moral “oughts”.
  4. If one loses sight of the fact that one’s experience is the ultimate referent for meaning, it is possible to end up in nihilistic accounts of meaning (e.g. such as Quine’s Indeterminacy of translation and Dennett’s inclusion of qualia within that framework). But if one grounds meaning in qualia, then suddenly both causality and value are on the same ontological footing (cf. Valence Realism).
  5. To see clearly the nature of value it is best to examine it at its extremes (such as MDMA bliss vs. the pain of kidney stones). Having such experiences illuminates the “ought” aspect of consciousness, in contrast to the typical quasi-anhedonic “normal everyday states of consciousness” that most people (and philosophers!) tend to reason from. It would be interesting to see philosophers discuss e.g. the Is-Ought problem while on MDMA.
  6. Claims that “pleasure and pain, value and disvalue, good and bad, etc.” are an illusion by long-term meditators based on the experience of “dissolving value” in meditative states are no more valid than claims that pain is an illusion by someone doped on morphine. In brief: such claims are made in a state of consciousness that has lost touch with the actual quality of experience that gives (dis)value to consciousness.
  7. Admittedly the idea that one state of consciousness can even refer to (let alone make value judgements about) other states of consciousness is very problematic. In what sense does “reference” even make sense? Every moment of experience only has access to its own content. We posit that this problem is not ultimately unsolvable, and that human concepts are currently mere prototypes of a much better future set of varieties of consciousness optimized for truth-finding. As a thought experiment to illustrate this possible future, consider a full-spectrum superintelligence capable of instantiating arbitrary modes of experience and impartially comparing them side by side in order to build a total order of consciousness.

Full Question and Response

Question:

I realized I don’t share some fundamental assumptions that seemed common amongst the people here [referring to the Qualia Research Institute and friends].

The most basic way I know how to phrase it, is the notion that there’s some appeal to reason and/or principles and/or logic that compels us to follow some type of moral code.

A (possibly straw-man) instance is the notion I associate with effective altruism, namely, that one should choose a career based on its calculable contribution to human welfare. The assumption is that human welfare is what we “should” care about. Why should we? What’s compelling about trying to reconfigure ourselves from whatever we value at the moment to replacing that thing with human welfare (or anything else)? What makes us think we can even truly succeed in reconfiguring ourselves like this? The obvious pitfall seems to be we create some image of “goodness” that we try to live up to without ever being honest with ourselves and owning our authentic desires. IMO this issue is rampant in mainstream Christianity.

More generally, I don’t understand how a “should” emerges within moral philosophy at all. I understand how starting with a want, say happiness, and noting a general tendency, such as I become happy when I help others, that one could deduce that helping others often is likely to result in a happy life. I might even say “I should help others” to myself, knowing it’s a strategy to get what I want. That’s not the type of “should” I’m talking about. What I’m talking about is “should” at the most basic level of one’s value structure. I don’t understand how any amount of reasoning could tell us what our most basic values and desires “should” be.

I would like to read something rigorous on this issue. I appreciate any references, as well as any elucidating replies.

Response:

This is a very important topic. I think it is great that you raise this question, as it stands at the core of many debates and arguments about ethics and morality. I think that one can indeed make a really strong case for the view that “ought” is simply never logically implied by any accurate and objective description of the world (the famous is/ought Humean guillotine). I understand that an objective assessment of all that is will usually be cast as a network of causal and structural relationships. By starting out with a network of causal and structural relationships and using logical inferences to arrive at further high-level facts, one is ultimately bound to arrive at conclusions that themselves are just structural and causal relationships. So where does the “ought” fit in here? Is it really just a manner of speaking? A linguistic spandrel that emerges from evolutionary history? It could really seem like it, and I admit that I do not have a silver bullet argument against this view.

However, I do think that eventually we will arrive at a post-Galilean understanding of consciousness, and that this understanding will itself allow us to point out exactly where- if at all- ethical imperatives are located and how they emerge. For now all I have is a series of observations that I hope can help you develop an intuition for how we are thinking about it, and why our take is original and novel (and not simply a rehashing of previous arguments or appeals to nature/intuition/guilt).

So without further ado I would like to lay out the following points on the table:

  1. I am of the mind that if any kind of “ought” is present in reality it will involve decision-making about the quality of consciousness of subjects of experience. I do not think that it makes sense to talk about an ethical imperative that has anything to do with non-experiential properties of the universe precisely because there would be no one affected by it. If there is an argument for caring about things that have no impact on any state of consciousness, I have yet to encounter it. So I will assume that the question refers to whether certain states of consciousness ought to or ought not to exist (and how to make trade offs between them).
  2. I also think that personal identity is key for this discussion, but why this is the case will make sense in a moment. The short answer is that conscious value is self-intimating/self-revealing, and in order to pass judgement on something that you yourself (as a narrative being) will not get to experience you need some confidence (or reasonable cause) to believe that the same self-intimating quality of experience is present in other narrative orbits that will not interact with you. For the same reasons as (1) above, it makes no sense to care about philosophical zombies (no matter how much they scream at you), but the same is the case for “conscious value p. zombies” (where maybe they experience color qualia but do not experience hedonic tone i.e. they can’t suffer).
  3. A very important concept that comes up again and again in our research is the notion that “reduction cuts both ways”. We take dual aspect monism seriously, and in this view we would consider the mathematical description of an experience and its qualia two sides of the same coin. Now, many people come here and say “the moment you reduce an experience of bliss to a mathematical equation you have removed any fuzzy morality from it and arrived at a purely objective and factual account which does not support an ‘ought ontology'”. But doing this mental move requires you to take the mathematical account as a superior ontology to that of the self-intimating quality of experience. In our view, these are two sides of the same coin. If mystical experiences are just a bunch of chemicals, then a bunch of chemicals can also be a mystical experience. To reiterate: reduction cuts both ways, and this happens with the value of experience to the same extent as it happens with the qualia of e.g. red or cinnamon.
  4. Mike Johnson tends to bring up Wittgenstein and Quine to the “Is-Ought” problem because they are famous for ‘reducing language and meaning’ to games and networks of relationships. But here you should realize that you can apply the concept developed in (3) above just as well to this matter. In our view, a view of language that has “words and objects” at its foundation is not a complete ontology, and nor is one that merely introduces language games to dissolve the mystery of meaning. What’s missing here is “felt sense” – the raw way in which concepts feel and operate on each other whether or not they are verbalized. It is my view that here phenomenal binding becomes critical because a felt sense that corresponds to a word, concept, referent, etc. in itself encapsulates a large amount of information simultaneously, and contains many invariants across a set of possible mental transformations that define what it is and what it is not. More so, felt senses are computationally powerful (rather than merely epiphenomenal). Consider Daniel Tammet‘s mathematical feats achieved by experiencing numbers in complex synesthetic ways that interact with each other in ways that are isomorphic to multiplication, factorization, etc. More so, he does this at competitive speeds. Language, in a sense, could be thought of as the surface of felt sense. Daniel Dennett famously argued that you can “Quine Qualia” (meaning that you can explain it away with a groundless network of relationships and referents). We, on the opposite extreme, would bite the bullet of meaning and say that meaning itself is grounded in felt-sense and qualia. Thus, colors, aromas, emotions, and thoughts, rather than being ultimately semantically groundless as Dennett would have it, turn out to be the very foundation of meaning.
  5. In light of the above, let’s consider some experiences that embody the strongest degree of the felt sense of “ought to be” and “ought not to be” that we know of. On the negative side, we have things like cluster headaches and kidney stones. On the positive side we have things like Samadhi, MDMA, and 5-MEO-DMT states of consciousness. I am personally more certain that the “ought not to be” aspect of experience is more real than the “ought to be” aspect of it, which is why I have a tendency (though no strong commitment) towards negative utilitarianism. When you touch a hot stove you get this involuntary reaction and associated valence qualia of “reality needs you to recoil from this”, and in such cases one has degrees of freedom into which to back off. But when experiencing cluster headaches and kidney stones, this sensation- that self-intimating felt-sense of ‘this ought not to be’- is omnidirectional. The experience is one in which one feels like every direction is negative, and in turn, at its extremes, one feels spiritually violated (“a major ethical emergency” is how a sufferer of cluster headaches recently described it to me). This brings me to…
  6. The apparent illusory nature of value in light of meditative deconstruction of felt-senses. As you put it elsewhere: “Introspectively – Meditators with deep experience typically report all concepts are delusion. This is realized in a very direct experiential way.” Here I am ambivalent, though my default response is to make sense of the meditation-induced feeling that “value is illusory” as itself an operation on one’s conscious topology that makes the value quality of experience get diminished or plugged out. Meditation masters will say things like “if you observe the pain very carefully, if you slice it into 30 tiny fragments per second, you will realize that the suffering you experience from it is an illusory construction”. And this kind of language itself is, IMO, liable to give off the illusion that the pain was illusory to begin with. But here I disagree. We don’t say that people who take a strong opioid to reduce acute pain are “gaining insight into the fundamental nature of pain” and that’s “why they stop experiencing it”. Rather, we understand that the strong opioid changes the neurological conditions in such a way that the quality of the pain itself is modified, which results in a duller, “asymbolic“, non-propagating, well-confined discomfort. In other words, strong opioids reduce the value-quality of pain by locally changing the nature of pain rather than by bringing about a realization of its ultimate nature. The same with meditation. The strongest difference here, I think, would be that opioids are preventing the spatial propagation of pain “symmetry breaking structures” across one’s experience and thus “confine pain to a small spatial location”, whereas meditation does something different that is better described as confining the pain to a small temporal region. This is hard to explain in full, and it will require us to fully formalize how the subjective arrow of time is constructed and how pain qualia can make copies across it. [By noting the pain very quickly one is, I believe, preventing it from building up and then having “secondary pain” which emerges from the cymatic resonance of the various lingering echoes of pain across one’s entire “pseudo-time arrow of experience”.] Sorry if this sounds like word salad, I am happy to unpack these concepts if needed, while also admitting that we are in early stages of the theoretical and empirical development.
  7. Finally, I will concede that the common sense view of “reference” is very deluded on many levels. The very notion that we can refer to an experience with another experience, that we can encode the properties of a different moment of experience in one’s current moment of experience, that we can talk about the “real world” or its “objective ethical values” or “moral duty” is very far from sensical in the final analysis. Reference is very tricky, and I think that a full understanding of consciousness will do some severe violence to our common sense in this area. That, however, is different from the self-disclosing properties of experience such as red qualia and pain qualia. You can do away with all of common sense reference while retaining a grounded understanding that “the constituents of the world are qualia values and their local binding relationships”. In turn, I do think that we can aim to do a decently good job at re-building from the ground up a good approximation of our common sense understanding of the world using “meaning grounded in qualia”, and once we do that we will be in a solid foundation (as opposed to the, admittedly very messy, quasi-delusional character of thoughts as they exist today). Needless to say, this may also need us to change our state of consciousness. “Someday we will have thoughts like sunsets” – David Pearce.

 

The Qualia Explosion

Extract from “Humans and Intelligent Machines: Co-Evolution, Fusion or Replacement?” (talk) by David Pearce

Supersentience: Turing plus Shulgin?

Compared to the natural sciences (cf. the Standard Model in physics) or computing (cf. the Universal Turing Machine), the “science” of consciousness is pre-Galilean, perhaps even pre-Socratic. State-enforced censorship of the range of subjective properties of matter and energy in the guise of a prohibition on psychoactive experimentation is a powerful barrier to knowledge. The legal taboo on the empirical method in consciousness studies prevents experimental investigation of even the crude dimensions of the Hard Problem, let alone locating a solution-space where answers to our ignorance might conceivably be found.

Singularity theorists are undaunted by our ignorance of this fundamental feature of the natural world. Instead, the Singularitarians offer a narrative of runaway machine intelligence in which consciousness plays a supporting role ranging from the minimal and incidental to the completely non-existent. However, highlighting the Singularity movement’s background assumptions about the nature of mind and intelligence, not least the insignificance of the binding problem to AGI, reveals why FUSION and REPLACEMENT scenarios are unlikely – though a measure of “cyborgification” of sentient biological robots augmented with ultrasmart software seems plausible and perhaps inevitable.

If full-spectrum superintelligence does indeed entail navigation and mastery of the manifold state-spaces of consciousness, and ultimately a seamless integration of this knowledge with the structural understanding of the world yielded by the formal sciences, then where does this elusive synthesis leave the prospects of posthuman superintelligence? Will the global proscription of radically altered states last indefinitely?

Social prophecy is always a minefield. However, there is one solution to the indisputable psychological health risks posed to human minds by empirical research into the outlandish state-spaces of consciousness unlocked by ingesting the tryptaminesphenylethylaminesisoquinolines and other pharmacological tools of sentience investigation. This solution is to make “bad trips” physiologically impossible – whether for individual investigators or, in theory, for human society as a whole. Critics of mood-enrichment technologies sometimes contend that a world animated by information-sensitive gradients of bliss would be an intellectually stagnant society: crudely, a Brave New World. On the contrary, biotech-driven mastery of our reward circuitry promises a knowledge explosion in virtue of allowing a social, scientific and legal revolution: safe, full-spectrum biological superintelligence. For genetic recalibration of hedonic set-points – as distinct from creating uniform bliss – potentially leaves cognitive function and critical insight both sharp and intact; and offers a launchpad for consciousness research in mind-spaces alien to the drug-naive imagination. A future biology of invincible well-being would not merely immeasurably improve our subjective quality of life: empirically, pleasure is the engine of value-creation. In addition to enriching all our lives, radical mood-enrichment would permit safe, systematic and responsible scientific exploration of previously inaccessible state-spaces of consciousness. If we were blessed with a biology of invincible well-being, exotic state-spaces would all be saturated with a rich hedonic tone.

Until this hypothetical world-defining transition, pursuit of the rigorous first-person methodology and rational drug-design strategy pioneered by Alexander Shulgin in PiHKAL and TiHKAL remains confined to the scientific counterculture. Investigation is risky, mostly unlawful, and unsystematic. In mainstream society, academia and peer-reviewed scholarly journals alike, ordinary waking consciousness is assumed to define the gold standard in which knowledge-claims are expressed and appraised. Yet to borrow a homely-sounding quote from Einstein, “What does the fish know of the sea in which it swims?” Just as a dreamer can gain only limited insight into the nature of dreaming consciousness from within a dream, likewise the nature of “ordinary waking consciousness” can only be glimpsed from within its confines. In order to scientifically understand the realm of the subjective, we’ll need to gain access to all its manifestations, not just the impoverished subset of states of consciousness that tended to promote the inclusive fitness of human genes on the African savannah.

Why the Proportionality Thesis Implies an Organic Singularity

So if the preconditions for full-spectrum superintelligence, i.e. access to superhuman state-spaces of sentience, remain unlawful, where does this roadblock leave the prospects of runaway self-improvement to superintelligence? Could recursive genetic self-editing of our source code repair the gap? Or will traditional human personal genomes be policed by a dystopian Gene Enforcement Agency in a manner analogous to the coercive policing of traditional human minds by the Drug Enforcement Agency?

Even in an ideal regulatory regime, the process of genetic and/or pharmacological self-enhancement is intuitively too slow for a biological Intelligence Explosion to be a live option, especially when set against the exponential increase in digital computer processing power and inorganic AI touted by Singularitarians. Prophets of imminent human demise in the face of machine intelligence argue that there can’t be a Moore’s law for organic robots. Even the Flynn Effect, the three-points-per-decade increase in IQ scores recorded during the 20th century, is comparatively puny; and in any case, this narrowly-defined intelligence gain may now have halted in well-nourished Western populations.

However, writing off all scenarios of recursive human self-enhancement would be premature. Presumably, the smarter our nonbiological AI, the more readily AI-assisted humans will be able recursively to improve our own minds with user-friendly wetware-editing tools – not just editing our raw genetic source code, but also the multiple layers of transcription and feedback mechanisms woven into biological minds. Presumably, our ever-smarter minds will be able to devise progressively more sophisticated, and also progressively more user-friendly, wetware-editing tools. These wetware-editing tools can accelerate our own recursive self-improvement – and manage potential threats from nonfriendly AGI that might harm rather than help us, assuming that our earlier strictures against the possibility of digital software-based unitary minds were mistaken. MIRI rightly call attention to how small enhancements can yield immense cognitive dividends: the relatively short genetic distance between humans and chimpanzees suggests how relatively small enhancements can exert momentous effects on a mind’s general intelligence, thereby implying that AGIs might likewise become disproportionately powerful through a small number of tweaks and improvements. In the post-genomic era, presumably exactly the same holds true for AI-assisted humans and transhumans editing their own minds. What David Chalmers calls the proportionality thesis, i.e. increases in intelligence lead to proportionate increases in the capacity to design intelligent systems, will be vindicated as recursively self-improving organic robots modify their own source code and bootstrap our way to full-spectrum superintelligence: in essence, an organic Singularity. And in contrast to classical digital zombies, superficially small molecular differences in biological minds can result in profoundly different state-spaces of sentience. Compare the ostensibly trivial difference in gene expression profiles of neurons mediating phenomenal sight and phenomenal sound – and the radically different visual and auditory worlds they yield.

Compared to FUSION or REPLACEMENT scenarios, the AI-human CO-EVOLUTION conjecture is apt to sound tame. The likelihood our posthuman successors will also be our biological descendants suggests at most a radical conservativism. In reality, a post-Singularity future where today’s classical digital zombies were superseded merely by faster, more versatile classical digital zombies would be infinitely duller than a future of full-spectrum supersentience. For all insentient information processors are exactly the same inasmuch as the living dead are not subjects of experience. They’ll never even know what it’s like to be “all dark inside” – or the computational power of phenomenal object-binding that yields illumination. By contrast, posthuman superintelligence will not just be quantitatively greater but also qualitatively alien to archaic Darwinian minds. Cybernetically enhanced and genetically rewritten biological minds can abolish suffering throughout the living world and banish experience below “hedonic zero” in our forward light-cone, an ethical watershed without precedent. Post-Darwinian life can enjoy gradients of lifelong blissful supersentience with the intensity of a supernova compared to a glow-worm. A zombie, on the other hand, is just a zombie – even if it squawks like Einstein. Posthuman organic minds will dwell in state-spaces of experience for which archaic humans and classical digital computers alike have no language, no concepts, and no words to describe our ignorance. Most radically, hyperintelligent organic minds will explore state-spaces of consciousness that do not currently play any information-signalling role in living organisms, and are impenetrable to investigation by digital zombies. In short, biological intelligence is on the brink of a recursively self-amplifying Qualia Explosion – a phenomenon of which digital zombies are invincibly ignorant, and invincibly ignorant of their own ignorance. Humans too of course are mostly ignorant of what we’re lacking: the nature, scope and intensity of such posthuman superqualia are beyond the bounds of archaic human experience. Even so, enrichment of our reward pathways can ensure that full-spectrum biological superintelligence will be sublime.


Image Credit: MohammadReza DomiriGanji