Modern Accounts of Psychedelic Action

Excerpts from Unifying Theories of Psychedelic Drug Effects (2018) by Link Swanson (these are just key quotes; the full paper is worth reading)

Abstract

How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data. Next, I review late 19th-century and early 20th-century theories—model psychoses theory, filtration theory, and psychoanalytic theory—and highlight their shared features. I then briefly review recent findings on the neuropharmacology and neurophysiology of psychedelic drugs in humans. Finally, I describe recent theories of psychedelic drug effects which leverage 21st-century cognitive neuroscience frameworks—entropic brain theory, integrated information theory, and predictive processing—and point out key shared features that link back to earlier theories. I identify an abstract principle which cuts across many theories past and present: psychedelic drugs perturb universal brain processes that normally serve to constrain neural systems central to perception, emotion, cognition, and sense of self. I conclude that making an explicit effort to investigate the principles and mechanisms of psychedelic drug effects is a uniquely powerful way to iteratively develop and test unifying theories of brain function.


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Subjective rating scale items selected after psilocybin (blue) and placebo (red) (n = 15) (Muthukumaraswamy et al., 2013). “Items were completed using a visual analog scale format, with a bottom anchor of ‘no, not more than usually’ and a top anchor of ‘yes, much more than usually’ for every item, with the exception of ‘I felt entirely normal,’ which had bottom and top anchors of ‘No, I experienced a different state altogether’ and ‘Yes, I felt just as I normally do,’ respectively. Shown are the mean ratings for 15 participants plus the positive SEMs. All items marked with an asterisk were scored significantly higher after psilocybin than placebo infusion at a Bonferroni-corrected significance level of p < 0.0022 (0.5/23 items)” (Muthukumaraswamy et al., 2013, p. 15176).


Neuropharmacology and Neurophysiological Correlates of Psychedelic Drug Effects

Klee recognized that his above hypotheses, inspired by psychoanalytic theory and LSD effects, required neurophysiological evidence. “As far as I am aware, however, adequate neurophysiological evidence is lacking … The long awaited millennium in which biochemical, physiological, and psychological processes can be freely correlated still seems a great distance off” (Klee, 1963, p. 466, 473). What clues have recent investigations uncovered?

A psychedelic drug molecule impacts a neuron by binding to and altering the conformation of receptors on the surface of the neuron (Nichols, 2016). The receptor interaction most implicated in producing classic psychedelic drug effects is agonist or partial agonist activity at serotonin (5-HT) receptor type 2A (5-HT2A) (Nichols, 2016). A molecule’s propensity for 5-HT2A affinity and agonist activity predicts its potential for (and potency of) subjective psychedelic effects (Glennon et al., 1984McKenna et al., 1990Halberstadt, 2015Nichols, 2016Rickli et al., 2016). When a psychedelic drug’s 5-HT2A agonist activity is intentionally blocked using 5-HT2A antagonist drugs (e.g., ketanserin), the subjective effects are blocked or attenuated in humans under psilocybin (Vollenweider et al., 1998Kometer et al., 2013), LSD (Kraehenmann et al., 2017a,bPreller et al., 2017), and ayahuasca (Valle et al., 2016). Importantly, while the above evidence makes it clear that 5-HT2A activation is a necessary (if not sufficient) mediator of the hallmark subjective effects of classic psychedelic drugs, this does not entail that 5-HT2A activation is the sole neurochemical cause of all subjective effects. For example, 5-HT2A activation might trigger neurochemical modulations ‘downstream’ (e.g., changes in glutamate transmission) which could also play causal roles in producing psychedelic effects (Nichols, 2016). Moreover, most psychedelic drug molecules activate other receptors in addition to 5-HT2A (e.g., 5-HT1A, 5-HT2C, dopamine, sigma, etc.) and these activations may importantly contribute to the overall profile of subjective effects even if 5-HT2A activation is required for their effects to occur (Ray, 20102016).

How does psychedelic drug-induced 5-HT2A receptor agonism change the behavior of the host neuron? Generally, 5-HT2A activation has a depolarizing effect on the neuron, making it more excitable (more likely to fire) (Andrade, 2011Nichols, 2016). Importantly, this does not necessarily entail that 5-HT2Aactivation will have an overall excitatory effect throughout the brain, particularly if the excitation occurs in inhibitory neurons (Andrade, 2011). This important consideration (captured by the adage ‘one neuron’s excitation is another neuron’s inhibition’) should be kept in mind when tracing causal links in the pharmaco-neurophysiology of psychedelic drug effects.

In mammalian brains, neurons tend to ‘fire together’ in synchronized rhythms known as temporal oscillations (brain waves). MEG and EEG equipment measure the electromagnetic disturbances produced by the temporal oscillations of large neural populations and these measurements can be quantified according to their amplitude (power) and frequency (timing) (Buzsáki and Draguhn, 2004). Specific combinations of frequency and amplitude can be correlated with distinct brain states, including waking ‘resting’ state, various attentional tasks, anesthesia, REM sleep, and deep sleep (Tononi and Koch, 2008Atasoy et al., 2017a). In what ways do temporal oscillations change under psychedelic drugs? MEG and EEG studies consistently show reductions in oscillatory power across a broad frequency range under ayahuasca (Riba et al., 20022004Schenberg et al., 2015Valle et al., 2016), psilocybin (Muthukumaraswamy et al., 2013Kometer et al., 2015Schartner et al., 2017), and LSD (Carhart-Harris et al., 2016cSchartner et al., 2017). Reductions in the power of alpha-band oscillations, localized mainly to parietal and occipital cortex, have been correlated with intensity of subjective visual effects—e.g., ‘I saw geometric patterns’ or ‘My imagination was extremely vivid’—under psilocybin (Kometer et al., 2013Muthukumaraswamy et al., 2013Schartner et al., 2017) and ayahuasca (Riba et al., 2004Valle et al., 2016). Under LSD, reductions in alpha power still correlated with intensity of subjective visual effects but associated alpha reductions were more widely distributed throughout the brain (Carhart-Harris et al., 2016c). Furthermore, ego-dissolution effects and mystical-type experiences (e.g., ‘I experienced a disintegration of my “self” or “ego”’ or ‘The experience had a supernatural quality’) have been correlated with reductions in alpha power localized to anterior and posterior cingulate cortices and the parahippocampal regions under psilocybin (Muthukumaraswamy et al., 2013Kometer et al., 2015) and throughout the brain under LSD (Carhart-Harris et al., 2016c).

The concept of functional connectivity rests upon fMRI brain imaging observations that reveal temporal correlations of activity occurring in spatially remote regions of the brain which form highly structured patterns (brain networks) (Buckner et al., 2013). Imaging of brains during perceptual or cognitive task performance reveals patterns of functional connectivity known as functional networks; e.g., control network, dorsal attention network, ventral attention network, visual network, auditory network, and so on. Imaging brains in taskless resting conditions reveals resting-state functional connectivity (RSFC) and structured patterns of RSFC known as resting state networks (RSNs; Deco et al., 2011). One particular RSN, the default mode network (DMN; Buckner et al., 2008), increases activity in the absence of tasks and decreases activity during task performance (Fox and Raichle, 2007). DMN activity is strong during internally directed cognition and a variety of other ‘metacognitive’ functions (Buckner et al., 2008). DMN activation in normal waking states exhibits ‘inverse coupling’ or anticorrelation with the activation of task-positive functional networks, meaning that DMN and functional networks are often mutually exclusive; one deactivates as the other activates and vice versa (Fox and Raichle, 2007).

In what ways does brain network connectivity change under psychedelic drugs? First, functional connectivity between key ‘hub’ areas—mPFC and PCC—is reduced. Second, the ‘strength’ or oscillatory power of the DMN is weakened and its intrinsic functional connectivity becomes disintegrated as its component nodes become decoupled under psilocybin (Carhart-Harris et al., 20122013), ayahuasca (Palhano-Fontes et al., 2015), and LSD (Carhart-Harris et al., 2016cSpeth et al., 2016). Third, brain networks that normally show anticorrelation become active simultaneously under psychedelic drugs. This situation, which can be described as increased between-network functional connectivity, occurs under psilocybin (Carhart-Harris et al., 20122013Roseman et al., 2014Tagliazucchi et al., 2014), ayahuasca (Palhano-Fontes et al., 2015) and especially LSD (Carhart-Harris et al., 2016cTagliazucchi et al., 2016). Fourth and finally, the overall repertoire of explored functional connectivity motifs is substantially expanded and its informational dynamics become more diverse and entropic compared with normal waking states (Tagliazucchi et al., 20142016Alonso et al., 2015Lebedev et al., 2016Viol et al., 2016Atasoy et al., 2017bSchartner et al., 2017). Notably, the magnitude of occurrence of the above four neurodynamical themes correlates with subjective intensity of psychedelic effects during the drug session. Furthermore, visual cortex is activated during eyes-closed psychedelic visual imagery (de Araujo et al., 2012Carhart-Harris et al., 2016c) and under LSD “the early visual system behaves ‘as if’ it were receiving spatially localized visual information” as V1-V3 RSFC is activated in a retinotopic fashion (Roseman et al., 2016, p. 3036).

Taken together, the recently discovered neurophysiological correlates of subjective psychedelic effects present an important puzzle for 21st-century neuroscience. A key clue is that 5-HT2A receptor agonism leads to desynchronization of oscillatory activity, disintegration of intrinsic integrity in the DMN and related brain networks, and an overall brain dynamic characterized by increased between-network global functional connectivity, expanded signal diversity, and a larger repertoire of structured neurophysiological activation patterns. Crucially, these characteristic traits of psychedelic brain activity have been correlated with the phenomenological dynamics and intensity of subjective psychedelic effects.


21st-Century Theories of Psychedelic Drug Effects

Entropic Brain Theory

Entropic Brain Theory (EBT; Carhart-Harris et al., 2014) links the phenomenology and neurophysiology of psychedelic effects by characterizing both in terms of the quantitative notions of entropy and uncertainty. Entropy is a quantitative index of a system’s (physical) disorder or randomness which can simultaneously describe its (informational) uncertainty. EBT “proposes that the quality of any conscious state depends on the system’s entropy measured via key parameters of brain function” (Carhart-Harris et al., 2014, p. 1). Their hypothesis states that hallmark psychedelic effects (e.g., perceptual destabilization, cognitive flexibility, ego dissolution) can be mapped directly onto elevated levels of entropy/uncertainty measured in brain activity, e.g., widened repertoire of functional connectivity patterns, reduced anticorrelation of brain networks, and desynchronization of RSN activity. More specifically, EBT characterizes the difference between psychedelic states and normal waking states in terms of how the underlying brain dynamics are positioned on a scale between the two extremes of order and disorder—a concept known as ‘self-organized criticality’ (Beggs and Plenz, 2003). A system with high order (low entropy) exhibits dynamics that resemble ‘petrification’ and are relatively inflexible but more stable, while a system with low order (high entropy) exhibits dynamics that resemble ‘formlessness’ and are more flexible but less stable. The notion of ‘criticality’ describes the transition zone in which the brain remains poised between order and disorder. Physical systems at criticality exhibit increased transient ‘metastable’ states, increased sensitivity to perturbation, and increased propensity for cascading ‘avalanches’ of metastable activity. Importantly, EBT points out that these characteristics are consistent with psychedelic phenomenology, e.g., hypersensitivity to external stimuli, broadened range of experiences, or rapidly shifting perceptual and mental contents. Furthermore, EBT uses the notion of criticality to characterize the difference between psychedelic states and normal waking states as it “describes cognition in adult modern humans as ‘near critical’ but ‘sub-critical’—meaning that its dynamics are poised in a position between the two extremes of formlessness and petrification where there is an optimal balance between order and flexibility” (Carhart-Harris et al., 2014, p. 12). EBT hypothesizes that psychedelic drugs interfere with ‘entropy-suppression’ brain mechanisms which normally sustain sub-critical brain dynamics, thus bringing the brain “closer to criticality in the psychedelic state” (Carhart-Harris et al., 2014, p. 12).


Integrated Information Theory

Integrated Information Theory (IIT) is a general theoretical framework which describes the relationship between consciousness and its physical substrates (Oizumi et al., 2014Tononi, 20042008). While EBT is already loosely consistent with the core principles of IIT, Gallimore (2015) demonstrates how EBT’s hypotheses can be operationalized using the technical concepts of the IIT framework. Using EBT and recent neuroimaging data as a foundation, Gallimore develops an IIT-based model of psychedelic effects. Consistent with EBT, this IIT-based model describes the brain’s continual challenge of minimizing entropy while retaining flexibility. Gallimore formally restates this problem using IIT parameters: brains attempt to optimize the give-and-take dynamic between cause-effect information and cognitive flexibility. In IIT, a (neural) system generates cause-effect information when the mechanisms which make up its current state constrain the set of states which could casually precede or follow the current state. In other words, each mechanistic state of the brain: (1) limits the set of past states which could have causally given rise to it, and (2) limits the set of future states which can causally follow from it. Thus, each current state of the mechanisms within a neural system (or subsystem) has an associated cause-effect repertoire which specifies a certain amount of cause-effect information as a function of how stringently it constrains the unconstrained state repertoire of all possible system states. Increasing the entropy within a cause-effect repertoire will in effect constrain the system less stringently as the causal possibilities are expanded in both temporal directions as the system moves closer to its unconstrained repertoire of all possible states. Moreover, increasing the entropy within a cause-effect repertoire equivalently increases the uncertainty associated with its past (and future) causal interactions. Using this IIT-based framework, Gallimore (2015)argues that, compared with normal waking states, psychedelic brain states exhibit higher entropy, higher cognitive flexibility, but lower cause-effect information.


Predictive Processing

The first modern brain imaging measurements in humans under psilocybin yielded somewhat unexpected results: reductions in oscillatory power (MEG) and cerebral blood flow (fMRI) correlated with the intensity of subjective psychedelic effects (Carhart-Harris et al., 2012Muthukumaraswamy et al., 2013). In their discussion, the authors suggest that their findings, although surprising through the lens of commonly held beliefs about how brain activity maps to subjective phenomenology, may actually be consistent with a theory of brain function known as the free energy principle (FEP; Friston, 2010).

In one model of global brain function based on the free-energy principle (Friston, 2010), activity in deep-layer projection neurons encodes top-down inferences about the world. Speculatively, if deep-layer pyramidal cells were to become hyperexcitable during the psychedelic state, information processing would be biased in the direction of inference—such that implicit models of the world become spontaneously manifest—intruding into consciousness without prior invitation from sensory data. This could explain many of the subjective effects of psychedelics (Muthukumaraswamy et al., 2013, p. 15181).

What is FEP? “In this view, the brain is an inference machine that actively predicts and explains its sensations. Central to this hypothesis is a probabilistic model that can generate predictions, against which sensory samples are tested to update beliefs about their causes” (Friston, 2010). FEP is a formulation of a broader conceptual framework emerging in cognitive neuroscience known as predictive processing (PP; Clark, 2013)10. PP has links to bayesian brain hypothesis (Knill and Pouget, 2004), predictive coding (Rao and Ballard, 1999), and earlier theories of perception and cognition (MacKay, 1956Neisser, 1967Gregory, 1968) dating back to Helmholtz (1925) who was inspired by Kant (1996; see Swanson, 2016). At the turn of the 21st century, the ideas of Helmholtz catalyzed innovations in machine learning (Dayan et al., 1995), new understandings of cortical organization (Mumford, 1992Friston, 2005), and theories of how perception works (Kersten and Yuille, 2003Lee and Mumford, 2003).


Conclusion

The four key features identified in filtration and psychoanalytic accounts from the late 19th and early 20th century continue to operate in 21st-century cognitive neuroscience: (1) psychedelic drugs produce their characteristic diversity of effects because they perturb adaptive mechanisms which normally constrain perception, emotion, cognition, and self-reference, (2) these adaptive mechanisms can develop pathologies rooted in either too much or too little constraint (3) psychedelic effects appear to share elements with psychotic symptoms because both involve weakened constraints (4) psychedelic drugs are therapeutically useful precisely because they offer a way to temporarily inhibit these adaptive constraints. It is on these four points that EBT, IIT, and PP seem consistent with each other and with earlier filtration and psychoanalytic accounts. EBT and IIT describe psychedelic brain dynamics and link them to phenomenological dynamics, while PP describes informational principles and plausible neural information exchanges which might underlie the larger-scale dynamics described by EBT and IIT. Certain descriptions of neural entropy-suppression mechanisms (EBT), cause-effect information constraints (IIT), or prediction-error minimization strategies (PP, FEP) are loosely consistent with Freud’s ego and Huxley’s cerebral reducing valve.


Qualia Computing comment: As you can see above, 21st century theories of psychedelic action have a lot of interesting commonalities. A one-line summary of what they all agree on could be: Psychedelics increase the available state-space of consciousness by removing constraints that are normally imposed by standard brain functioning. That said, they do not make specific predictions about valence. That is, they leave the question of “which alien states of consciousness will feel good and which ones will feel bad” completely unaddressed. In the following posts about the presentations of members of the Qualia Research Institute at The Science of Consciousness 2018 you will see how, unlike other modern accounts, our Qualia Formalist approach to consciousness can elucidate this matter.

What If God Were a Closed Individualist Presentist Hedonistic Utilitarian With an Information-Theoretic Identity of Indiscernibles Ontology?

Extract from “Unsong” (chapter 18):

There’s an old Jewish childrens’ song called Had Gadya. It starts:

A little goat, a little goat
My father bought for two silver coins,
A little goat, a little goat

Then came the cat that ate the goat
My father bought for two silver coins
A little goat, a little goat

Then came that dog that bit the cat…

And so on. A stick hits the dog, a fire burns the stick, water quenches the fire, an ox drinks the water, a butcher slaughters the ox, the Angel of Death takes the butcher, and finally God destroys the Angel of Death. Throughout all of these verses, it is emphasized that it is indeed a little goat, and the father did indeed buy it for two silver coins.

[…]

As far as I know, no one has previously linked this song to the Lurianic Kabbalah. So I will say it: the deepest meaning of Had Gadya is a description of how and why God created the world. As an encore, it also resolves the philosophical problem of evil.

The most prominent Biblical reference to a goat is the scapegoating ritual. Once a year, the High Priest of Israel would get rid of the sins of the Jewish people by mystically transferring all of them onto a goat, then yelling at the goat until it ran off somewhere, presumably taking all the sin with it.

The thing is, at that point the goat contained an entire nation-year worth of sin. That goat was super evil. As a result, many religious and mystical traditions have associated unholy forces with goats ever since, from the goat demon Baphomet to the classical rather goat-like appearance of Satan.

So the goat represents evil. I’ll go along with everyone else saying the father represents God here. So God buys evil with two silver coins. What’s up?

The most famous question in theology is “Why did God create a universe filled with so much that is evil?” The classical answers tend to be kind of weaselly, and center around something like free will or necessary principles or mysterious ways. Something along the lines of “Even though God’s omnipotent, creating a universe without evil just isn’t possible.”

But here we have God buying evil with two silver coins. Buying to me represents an intentional action. Let’s go further – buying represents a sacrifice. Buying is when you sacrifice something dear to you to get something you want even more. Evil isn’t something God couldn’t figure out how to avoid, it’s something He covets.

What did God sacrifice for the sake of evil? Two silver coins. We immediately notice the number “two”. Two is not typically associated with God. God is One. Two is right out. The kabbalists identify the worst demon, the nadir of all demons, as Thamiel, whose name means “duality in God”. Two is dissonance, divorce, division, dilemmas, distance, discrimination, diabolism.

This, then, was God’s sacrifice. In order to create evil, He took up duality.

“Why would God want to create evil? God is pure Good!”

Exactly. The creation of anything at all other than God requires evil. God is perfect. Everything else is imperfect. Imperfection contains evil by definition. Two scoops of evil is the first ingredient in the recipe for creating universes. Finitude is evil. Form is evil. Without evil all you have is God, who, as the kabbalists tell us, is pure Nothing. If you want something, evil is part of the deal.

Now count the number of creatures in the song. God, angel, butcher, ox, water, fire, stick, dog, cat, goat. Ten steps from God to goat. This is the same description of the ten sephirot we’ve found elsewhere, the ten levels by which God’s ineffability connects to the sinful material world without destroying it. This is not a coincidence because nothing is ever a coincidence. Had Gadya isn’t just a silly children’s song about the stages of advancement of the human soul, the appropriate rituals for celebrating Passover in the Temple, the ancient Sumerian pantheon, and the historical conquests of King Tiglath-Pileser III. It’s also a blueprint for the creation of the universe. Just like everything else.


(see also: ANSWER TO JOB)

Everything in a Nutshell

David Pearce at Quora in response to the question: “What are your philosophical positions in one paragraph?“:

“Everyone takes the limits of his own vision for the limits of the world.”
(Schopenhauer)

All that matters is the pleasure-pain axis. Pain and pleasure disclose the world’s inbuilt metric of (dis)value. Our overriding ethical obligation is to minimise suffering. After we have reprogrammed the biosphere to wipe out experience below “hedonic zero”, we should build a “triple S” civilisation based on gradients of superhuman bliss. The nature of ultimate reality baffles me. But intelligent moral agents will need to understand the multiverse if we are to grasp the nature and scope of our wider cosmological responsibilities. My working assumption is non-materialist physicalism. Formally, the world is completely described by the equation(s) of physics, presumably a relativistic analogue of the universal Schrödinger equation. Tentatively, I’m a wavefunction monist who believes we are patterns of qualia in a high-dimensional complex Hilbert space. Experience discloses the intrinsic nature of the physical: the “fire” in the equations. The solutions to the equations of QFT or its generalisation yield the values of qualia. What makes biological minds distinctive, in my view, isn’t subjective experience per se, but rather non-psychotic binding. Phenomenal binding is what consciousness is evolutionarily “for”. Without the superposition principle of QM, our minds wouldn’t be able to simulate fitness-relevant patterns in the local environment. When awake, we are quantum minds running subjectively classical world-simulations. I am an inferential realist about perception. Metaphysically, I explore a zero ontology: the total information content of reality must be zero on pain of a miraculous creation of information ex nihilo. Epistemologically, I incline to a radical scepticism that would be sterile to articulate. Alas, the history of philosophy twinned with the principle of mediocrity suggests I burble as much nonsense as everyone else.


Image credit: Joseph Matthias Young

Would Maximally Efficient Work Be Fun?

Excerpt from Superintelligence: Paths, Dangers, Strategies (2014) by Nick Bostrom (pg. 207-210).

Would Maximally Efficient Work Be Fun?

One important variable in assessing the desirability of a hypothetical condition like this* is the hedonic state of the average emulation**. Would a typical emulation worker be suffering or would he be enjoying the experience of working hard on the task at hand?

We must resist the temptation to project our own sentiments onto the imaginary emulation worker. The question is not whether you would feel happy if you had to work constantly and never again spend time with your loved ones–a terrible fate, most would agree.

It is moderately more relevant to consider the current human average hedonic experience during working hours. Worldwide studies asking respondents how happy they are find that most rate themselves as “quite happy” or “very happy” (averaging 3.1 on a scale from 1 to 4)***. Studies on average affect, asking respondents how frequently they have recently experienced various positive or negative affective states, tend to get a similar result (producing a net affect of about 0.52 on a scale from -1 to 1). There is a modest positive effect of a country’s per capita income on average subjective well-being.**** However, it is hazardous to extrapolate from these findings to the hedonic state of future emulation workers. One reason that could be given for this is that their condition would be so different: on the one hand, they might be working much harder; on the other hand, they might be free from diseases, aches, hunger, noxious odors, and so forth. Yet such considerations largely miss the mark. The much more important consideration here is that hedonic tone would be easy to adjust through the digital equivalent of drugs or neurosurgery. This means that it would be a mistake to infer the hedonic state of future emulations from the external conditions of their lives by imagining how we ourselves and other people like us would feel in those circumstances. Hedonic state would be a matter of choice. In the model we are currently considering, the choice would be made by capital-owners seeking to maximize returns on their investment in emulation-workers. Consequently, this question of how happy emulations would feel boils down to the question of which hedonic states would be most productive (in the various jobs that emulations would be employed to do). [Emphasis mine]

Here, again, one might seek to draw an inference from observations about human happiness. If it is the case, across most times, places, and occupations, that people are typically at least moderately happy, this would create some presumption in favor of the same holding in a post-transition scenario like the one we are considering. To be clear, the argument in this case would not be that human minds have a predisposition towards happiness so they would probably find satisfaction under these novel conditions; but rather that a certain average level of happiness has proved adaptive for human minds in the past so maybe a similar level of happiness will prove adaptive from human-like minds in the future. Yet this formulations also reveals the weakness of the inference: to wit, that the mental dispositions that were adaptive for hunter-gatherer hominids roaming the African savanna may not necessarily be adaptive for modified emulations living in post-transition virtual realities. We can certainly hope that the future emulation-workers would be as happy as, or happier than, typical workers were in human history; but we have yet to see any compelling reason for supposing it would be so (in the laissez-faire multipolar scenario currently under examination).

Consider the possibility that the reason happiness is prevalent among humans (to whatever limited extent it is prevalent) is that cheerful mood served a signaling function in the environment of evolutionary adaptedness. Conveying the impression to other members of the social group of being in flourishing condition–in good health, in good standing with one’s peers, and in confident expectation of continued good fortune–may have boosted an individual’s popularity. A bias toward cheerfulness could thus have been selected for, with the result that human neurochemistry is now biased toward positive affect compared to what would have been maximally efficient according to simpler materialistic criteria. If this were the case, then the future of joie de vivre might depend on cheer retaining its social signaling function unaltered in the post-transition world: an issue to which we will return shortly. 

What if glad souls dissipate more energy than glum ones? Perhaps the joyful are more prone to creative leaps and flights of fancy–behaviors that future employers might disprize in most of their workers. Perhaps a sullen or anxious fixation on simply getting on with the job without making mistakes will be the productivity-maximizing attitude in most lines of work. The claim here is not that this is so, but that we do not know that it is not so. Yet we should consider just how bad it could be if some such pessimistic hypothesis about a future Malthusian state turned out to be true: not only because of the opportunity cost of having failed to create something better–which would be enormous–but also because the state could be bad in itself, possibly far worse that the original Malthusian state.

We seldom put forth full effort. When we do, it is sometimes painful. Imagine running on a treadmill at a steep incline–heart pounding, muscles aching, lungs gasping for air. A glance at the timer: your next break, which will will also be your death, is due in 49 years, 3 months, 20 days, 4 hours, 56 minutes, and 12 seconds. You wish you had not been born.

Again the claim is not that this is how it would be, but that we do not know that it is not. One could certainly make a more optimistic case. For example, there is no obvious reason that emulations would need to suffer bodily injury and sickness: the elimination of physical wretchedness would be a great improvement over the present state of affairs. Furthermore, since such stuff as virtual reality is made of can be fairly cheap, emulations may work in sumptuous surroundings–in splendid mountaintop palaces, on terraces set in a budding spring forest, or on the beaches of azure lagoon–with just the right illumination, temperature, scenery and décor; free from annoying fumes, noises, drafts, and buzzing insects; dressed in comfortable clothing, feeling clean and focused, and well nourished. More significantly, if–as seems perfectly possible–the optimum human mental state for productivity in most jobs is one of joyful eagerness, then the era of the emulation economy could be quite paradisiacal.

There would, in any case, be a great option value in arranging matters in such a manner that somebody or something could intervene to set things right if the default trajectory should happen to veer toward dystopia. It could also be desirable to have some sort of escape hatch that would permit bailout into death and oblivion if the quality of life were to sink permanently below the level at which annihilation becomes preferable to continued existence.

Unconscious outsourcers?

In the long run, as the emulation era gives way to an artificial intelligence era (or if machine intelligence is attained directly via AI without a preceding whole brain emulation stage) pain and pleasure might possibility disappear entirely in a multipolar outcome, since a hedonic reward mechanism may not be the most effective motivation system for a complex artificial agent (one that, unlike the human mind, is not burdened with the legacy of animal wetware). Perhaps a more advanced motivation system would be based on an explicit representation of a utility function or some other architecture that has not exact functional analogs to pleasure and pain.

A related but slightly more radical multipolar outcome–one that could involve the elimination of almost all value from the future–is that the universal proletariat would not even be conscious. This possibility is most salient with respect to AI, which might be structured very differently than human intelligence. But even if machine intelligence were initially achieved through whole brain emulation, resulting in conscious digital minds, the competitive forces unleashed in a post-transition economy could easily lead to the emergence of progressively less neuromorphic forms of machine intelligence, either because synthetic AI is created de novo or because the emulations would, through successive modifications and enhancements, increasingly depart their original human form.


* Scenarios where sentient emulations are being used to do maximally efficient work.

** Footnote: “An ethical evaluation might take into account many other factors as well. Even if all the workers were constantly well pleased with their condition, the outcome might still be deeply morally objectionable on other grounds–though which other grounds is a matter of dispute between rival moral theories. But any plausible assessment would consider subjective well-being to be one important factor. See also Bostrom and Yudkowsky (2015).”

*** World Values Survey (2008).

**** Helliwell and Sachs (2012).

Qualia Manifesto

by Ken Mogi (published in 1998)

0. Summary

It is the greatest intellectual challenge for humanity at present to elucidate the first principles behind the fact that there is such a thing as a subjective experience. The hallmark of our subjective experiences is qualia. It is the challenge to find the natural law behind the neural generation of qualia which constitute the percepts in our mind, or to go beyond the metaphor of a “correspondence” between physical and mental processes. This challenge is necessary to go beyond the present paradigm of natural sciences which is based on the so-called objective point of view of description. In order to pin down the origin of qualia, we need to incorporate the subjective point of view in a non-trivial manner.

The clarification of the nature of the way how qualia in our mind are invoked by the physical processes in the brain and how the “subjectivity” structure which supports qualia is originated is an essential step in making compatible the subjective and objective points of view.

The elucidation of the origin of qualia rich subjectivity is important not only as an activity in the natural sciences, but also as a foundation and the ultimate justification of the whole world of the liberal arts. Bridging the gap between the two cultures (C.P.Snow) is made possible only through a clear understanding of the origin of qualia and subjectivity.

Qualia symbolize the essential intellectual challenge for the humanity in the future. The impact of its elucidation will not be limited to the natural sciences. The liberal arts, religion, and the very concept of what a man is will be reassessed from the very foundations.

1. History of the Mind-Brain Problem

The strong AI position held by Marvin Minsky and others was an attempt to simulate some aspects of human intelligence from an objective point of view. It had little to say about the essential problems of the mind, namely the qualia rich subjectivity.

In an effort to fill the gap left by the objective natural sciences, such movements as the “new science” and the “new age” came into the scene. These activities, however, were not particularly keen on taking seriously the consistency with the objective sciences. Even if we are to find new paradigms in search of the theory of mind, the consistency with the objective sciences should be maintained. Theses “alternative movements” tended instead to the over-emphasis of the subjective. These activities did not therefore lead to a real breakthrough in the science of the mind. These activities proved to be a stud.

The concept of information due to Claude Shannon is based on a statistical picture, and as he himself declared in his historic paper, has nothing to do with the semantics of information. Despite this, the Shannonian concept of information has been applied to “understand” the information processing in the brain. For example, it is an experimentally accepted fact that there is a correspondence between certain features of external objects and the spatio-temporal firing pattern of a group of neurons in our brain. This selectivity of neural activities is called “response selectivity” and is an important analytical concept in neuropsychology. However, it is wrong to think that the nature of our qualia rich perception can be explained away by the fact that there are activities of neurons in the brain characterized by certain response selectivities. We should instead start from the “interaction picture” rather than the “statistical picture”.

We cannot elucidate the neural correlates of qualia starting from the concept of response selectivity. We should instead start from Mach’s principle in perception.

Qualia is deeply related to the semantic aspects of information. The Shannonian concept of information has little to do with qualia.

2. Qualia and Subjectivity

In view of the neurophysiological data, it is reasonable to assume that qualia in our mind are caused by the collection of action potentials on the cellular membrane of the neuron in our brain.

“I” feel the qualia in “my” mind. This “I” and “my” structure (subjectivity) is maintained also by the neural firings in my brain. The problems of qualia and subjectivity are deeply related.

Qualia and subjectivity in general cannot be explained away by a simple extension of physicalism. From the point of view of the objective sciences, it is necessary and sufficient to describe the temporal evolution of a system. However, the principle of correspondence of qualia to physical states should be constructed on top of the conventional type of natural laws that describe the temporal evolution of the system. This particular natural law should be of a different character from the conventional ones.

Even if we obtain an ultimate physical theory of everything, it only gives a complete description of the temporal evolution of a physical system;even then the origin of qualia from physical processes such as brain activities would remain unsolved.

Causality plays an essential role when we consider the way the perceptual space-time structure in which qualia are embedded arises from the space-time structure of the neural firing in the brain. In particular, in the Principle of Interaction Simultaneity plays an essential role in the origin of the subjective time.

The “subjectivity” that we discuss here has relatively little to do with the “subjectivity” in the context of the theory of measurement in quantum mechanics. It is our view that the introduction of the concept of subjectivity in quantum mechanics did a tremendous disservice. It confused rather than enriched the arguments.

3. Related Problems

In modern physics, “NOW” has no special meaning in the flow of time. In oder to elucidate the origin of our mind, we need to come up with a structure of the time which designates a special meaning to “Now”

The formulationn of the relativistic space-time by the formalism of Riemanian geometry (Minkowski 1911) is only an intermediate step.

4. Methodology and Conjectures

The trivial attempt to assume a seat for subjectivity in the brain (the homunculus solution) is bound to fail. For example, the Crick and Koch model puts the subjectivity seat in the prefrontal cortex. Of course, saying empirically that this seems to be a necessary correlate of subjectivity is O.K. But that does not solve the most difficult part of the problem.

In considering the neural correlates of qualia rich subjective experiences, the invariance under the transformation of neural activity patterns in space and time is going to be essential.

5. Towards the Fusion of Two Cultures

A solution of the qualia problem is bound to have impact not only for the natural sciences but also for the humanities.

To take the visual art, music, literature seriously is to take qualia seriously. For paintings and music, this sounds like a cliche. Literature is also an art of the qualia, as the semantics is embedded in the intentional qualia.

As the so-called “exact” sciences have been focusing only on the measurable and quantifiable properties of nature, there was no place in the scientific world view for the immensely qualia rich subjective experience which is the ultimate raison d’etre for the arts. This was the essential reason why there was and continued to be a division between the two cultures a la C.P.Snow.

To analyze the sound wave of a violin though the Fourier analysis has nothing to do with our subjective experience of the violin sound qualia. It is meaningless to say that color is nothing but the wavelength of light when our concern is the subjective experience of color.

The development of the digital information technology perhaps had a beneficial effect on the fusion of the two cultures. The digital coding of provides a useful tool for the storing and manipulation of information, but has nothing to do with the richness of subjective experience. Unless we understand the “qualia coding” by the neural activities, we cannot find scientific foundations for the subjective experience.

In general, it is nonsensical to try to explain away the enigma of qualia from the information theoretic or evolution theory points of view.

6. On the Coming New Situation

The sense for the future essential entails a sensitivity for the possibility that the next moment can be something completely different from the previously known.

It is no longer meaningful to cling to the systemacity of religion. Religious feelings and values also consist of qualia, which in turn can be treatedly more or less individually. For example, the qualia associated with the stained glass has nothing in essence to do with Christianity. Even though traditional religion employed the appeal of the qualia as an engine to promote their specific causes, there is no reason to obstinately maintain that systemacity now.

Due to the physical limitation of the human brain, there is a limit to the category of qualia that a human being can experience. Only a ridiculously small subset of all possible qualia is accessible to the human being. This makes us take the possibilities of metaphysics more seriously.

7. Agitation

The concept of qualia is clearly at the heart of the next stage of human intellectual endeavors.

There is no other intellectual challenge more important or pressing than qualia.

The revolution can only be brought about by a combination of a rigorous scientific thinking and a trembling sensitivity.

The qualia thinkers of the world, unite!


See also the update on the original manifesto, and Mogi’s thoughts on the “computational theory of mind“.


Cf. Raising the Table Stakes for Successful Theories of ConsciousnessQualia Computing in TucsonDavid Pearce at the “2016 Science of Consciousness”,  “Schrodinger’s Neurons Conjecture”, and Why I think the Foundational Research Institute should rethink its approach

Qualia Computing at Consciousness Hacking (June 7th 2017)

I am delighted to announce that I will be presenting at Consciousness Hacking in San Francisco on 2017/6/7 (YMD notation).

Consciousness Hacking (CoHack) is an extremely awesome community that blends a genuine interest in benevolence, scientific rationality, experiential spirituality, self-experimentation, and holistic wellbeing together with an unceasing focus on consciousness. Truth be told, CohHack is one of the reasons why I love living in the Bay Area.

Here are the relevant event links: Eventbrite, FacebookMeetup.

And the event description:


What would happen if a bliss technology capable of inducing a constant MDMA-like state of consciousness with no negative side effects were available? What makes an experience good or bad? Is happiness a spiritual trick, or is spirituality a happiness trick?

At this month’s speaker presentation, Consciousness Hacking invites Data Science Engineer, Andrés Gómez Emilsson to discuss current research, including his own, concerning the measurement of bliss, how blissful brain states can be induced, and what implications this may have on quality of life and our relationship with the world around us.

Emilsson’s research aims to create a mathematical theory of the pleasure-pain axis that can take information about a person’s brain at a given point in time and return the approximate (or even true) level of happiness and suffering for that person. Emilsson will explore two dimensions that have been studied in affective neuroscience for decades:

  • Arousal: how much energy and activation a given emotion has
  • Valence: the “feel good or feel bad” dimension of emotion

If the purpose of life is to feel happy and to make others happy, then figuring out how valence is implemented in the brain may take us a long way in that direction. Current approaches to valence, while helpful, usually don’t address the core of the problem (ie. usually just measuring the symptoms of pleasure such as the neurotransmitters that trigger it, brain regions, positive reinforcement, etc. rather than getting at the experience of pleasure itself).

A real science of valence would not only be able to integrate and explain why the things people report as pleasurable are pleasant, it would also make a precise, empirically falsifiable hypothesis about whether arbitrary brain states will feel good or bad. This is what Emilsson aims to do.

You will take away:

  • An understanding about the current scientific consensus on the nature of happiness in the brain, and why it is incomplete
  • A philosophical case for both the feasibility and desirability of a world devoid of intense suffering
  • A new candidate mathematical formula that can be used to predict the psychological wellbeing of a brain at a given point in time
  • An argument for why bliss technology that puts us in a constant MDMA-like state of consciousness with no negative side effects is likely to become available within the next two to five decades
  • The opportunity to network with other people who are serious about figuring out the meaning of life through introspection and neuroscience

About our speaker:

Andrés Gómez Emilsson was born in México City in 1990. From an early age, he developed an interest in philosophy, mathematics, and science, leading him to compete nationally and internationally in Math and Science Olympiads. At 16, his main interest was mathematics, but after an unexpected “mystical experience”, he turned his attention to consciousness and the philosophical problems that it poses. He studied Symbolic Systems with an Artificial Intelligence concentration at Stanford, and later finished a masters in Computational Psychology at the same university. During his time at Stanford he co-founded the Stanford Transhumanist Association and became good friends with transhumanist philosopher David Pearce, taking on the flag of the Hedonistic Imperative (HI). In order to pursue the long-term goals of HI, his current primary intellectual interest is to reverse-engineer the functional, biochemical and/or quantum signatures of pure bliss.

He is currently working at a Natural Language Processing company in San Francisco, creating quantitative measures of employee happiness, productivity, and ethics at companies, with the long-term intent of creating a consciousness research institute that’s also a great place to work for (i.e. one in which employees are happy, productive, and ethical). In his free time he develops psychophysical tools to study the computational properties of consciousness.

Schedule:

6:30: Check in, snacks

6:45: Structured schmoozing

6:55: Event intro and meditation

7:00: Andrés Gómez Emilsson

7:50: Break

8:00: Break-out Sessions (small group discussion)

9:00: Break-out Recap

9:15: Closing meditation

About our venue:

ECO-SYSTM is a dynamic community of creative professionals, startups, and freelancers, founded on the idea that entertainment, creativity and business can come together to offer a truly unique work experience for Bay Area professionals. Check out membership plans here: http://eco-systm.com/


 

The Penfield Mood Organ

Extract from Do Androids Dream of Electric Sheep? by Philip K. Dick (1968)

Chapter 1

A merry little surge of electricity piped by automatic alarm from the mood organ beside his bed awakened Rick Deckard. Surprised — it always surprised him to find himself awake without prior notice — he rose from the bed, stood up in his multicolored pajamas, and stretched. Now, in her bed, his wife Iran opened her gray, unmerry eyes, blinked, then groaned and shut her eyes again.

“You set your Penfield too weak”, he said to her. “I’ll reset it and you’ll be awake and — ”

“Keep your hand off my settings.” Her voice held bitter sharpness. “I don’t want to be awake.”

He seated himself beside her, bent over her, and explained softly. “If you set the surge up high enough, you’ll be glad you’re awake; that’s the whole point. At setting C it overcomes the threshold barring consciousness, as it does for me.” Friendlily, because he felt well-disposed toward the world — his setting had been at D — he patted her bare, pale shoulder.

“Get your crude cop’s hand away,” Iran said.

“I’m not a cop.” He felt irritable, now, although he hadn’t dialed for it.

“You’re worse,” his wife said, her eyes still shut. “You’re a murderer hired by the cops.”

“I’ve never killed a human being in my life.” His irritability had risen, now; had become outright hostility.

Iran said, “Just those poor andys.”

“I notice you’ve never had any hesitation as to spending the bounty money I bring home on whatever momentarily attracts your attention.” He rose, strode to the console of his mood organ. “Instead of saving,” he said, “so we could buy a real sheep, to replace that fake electric one upstairs. A mere electric animal, and me earning all that I’ve worked my way up to through the years.” At his console he hesitated between dialing for a thalamic suppressant (which would abolish his mood of rage) or a thalamic stimulant (which would make him irked enough to win the argument).

“If you dial,” Iran said, eyes open and watching, “for greater venom, then I’ll dial the same. I’ll dial the maximum and you’ll see a fight that makes every argument we’ve had up to now seem like nothing. Dial and see; just try me.” She rose swiftly, loped to the console of her own mood organ, stood glaring at him, waiting.

He sighed, defeated by her threat. “I’ll dial what’s on my schedule for today.” Examining the schedule for January 3, 2021, he saw that a businesslike professional attitude was called for. “If I dial by schedule,” he said warily, “will you agree to also?” He waited, canny enough not to commit himself until his wife had agreed to follow suit.

“My schedule for today lists a six-hour self-accusatory depression,” Iran said.

“What? Why did you schedule that?” It defeated the whole purpose of the mood organ. “I didn’t even know you could set it for that,” he said gloomily.

“I was sitting here one afternoon,” Iran said, “and naturally I had turned on Buster Friendly and His Friendly Friends and he was talking about a big news item he’s about to break and then that awful commercial came on, the one I hate; you know, for Mountibank Lead Codpieces. And so for a minute I shut off the sound. And I heard the building, this building; I heard the — ” She gestured.

“Empty apartments,” Rick said. Sometimes he heard them at night when he was supposed to be asleep. And yet, for this day and age a one-half occupied conapt building rated high in the scheme of population density; out in what had been before the war the suburbs one could find buildings entirely empty… or so he had heard. He had let the information remain secondhand; like most people he did not care to experience it directly.

“At that moment,” Iran said, “when I had the TV sound off, I was in a 382 mood; I had just dialed it. So although I heard the emptiness intellectually, I didn’t feel it. My first reaction consisted of being grateful that we could afford a Penfield mood organ. But then I realized how unhealthy it was, sensing the absence of life, not just in this building but everywhere, and not reacting — do you see? I guess you don’t. But that used to be considered a sign of mental illness; they called it ‘absence of appropriate affect.’ So I left the TV sound off and I sat down at my mood organ and I experimented. And I finally found a setting for despair.” Her dark, pert face showed satisfaction, as if she had achieved something of worth. “So I put it on my schedule for twice a month; I think that’s a reasonable amount of time to feel hopeless about everything, about staying here on Earth after everybody who’s smart has emigrated, don’t you think?”

“But a mood like that,” Rick said, “you’re apt to stay in it, not dial your way out. Despair like that, about total reality, is self-perpetuating.”

“I program an automatic resetting for three hours later,” his wife said sleekly. “A 481. Awareness of the manifold possibilities open to me in the future; new hope that — ”

“I know 481,” he interrupted. He had dialed out the combination many times; he relied on it greatly. “Listen,” he said, seating himself on his bed and taking hold of her hands to draw her down beside him, “even with an automatic cutoff it’s dangerous to undergo a depression, any kind. Forget what you’ve scheduled and I’ll forget what I’ve scheduled; we’ll dial a 104 together and both experience it, and then you stay in it while I reset mine for my usual businesslike attitude. That way I’ll want to hop up to the roof and check out the sheep and then head for the office; meanwhile I’ll know you’re not sitting here brooding with no TV.” He released her slim, long fingers, passed through the spacious apartment to the living room, which smelled faintly of last night’s cigarettes. There he bent to turn on the TV.

From the bedroom Iran’s voice came. “I can’t stand TV before breakfast.”

“Dial 888,” Rick said as the set warmed. “The desire to watch TV, no matter what’s on it.”

“I don’t feel like dialing anything at all now,” Iran said.

“Then dial 3,” he said.

“I can’t dial a setting that stimulates my cerebral cortex into wanting to dial! If I don’t want to dial, I don’t want to dial that most of all, because then I will want to dial, and wanting to dial is right now the most alien drive I can imagine; I just want to sit here on the bed and stare at the floor.” Her voice had become sharp with overtones of bleakness as her soul congealed and she ceased to move, as the instinctive, omnipresent film of great weight, of an almost absolute inertia, settled over her.

He turned up the TV sound, and the voice of Buster Friendly boomed out and filled the room. ” — ho ho, folks. Time now for a brief note on today’s weather. The Mongoose satellite reports that fallout will be especially pronounced toward noon and will then taper off, so all you folks who’ll be venturing out — ”

Appearing beside him, her long nightgown trailing wispily, Iran shut off the TV set. “Okay, I give up; I’ll dial. Anything you want me to be; ecstatic sexual bliss — I feel so bad I’ll even endure that. What the hell. What difference does it make?”

“I’ll dial for both of us,” Rick said, and led her back into the bedroom. There, at her console, he dialed 594: pleased acknowledgment of husband’s superior wisdom in all matters. On his own console he dialed for a creative and fresh attitude toward his job, although this he hardly needed; such was his habitual, innate approach without recourse to Penfield artificial brain stimulation.

 

Political Peacocks

Extract from Geoffrey Miller’s essay “Political peacocks”

The hypothesis

Humans are ideological animals. We show strong motivations and incredible capacities to learn, create, recombine, and disseminate ideas. Despite the evidence that these idea-processing systems are complex biological adaptations that must have evolved through Darwinian selection, even the most ardent modern Darwinians such as Stephen Jay Gould, Richards Dawkins, and Dan Dennett tend to treat culture as an evolutionary arena separate from biology. One reason for this failure of nerve is that it is so difficult to think of any form of natural selection that would favor such extreme, costly, and obsessive ideological behavior. Until the last 40,000 years of human evolution, the pace of technological and social change was so slow that it’s hard to believe there was much of a survival payoff to becoming such an ideological animal. My hypothesis, developed in a long Ph.D. dissertation, several recent papers, and a forthcoming book, is that the payoffs to ideological behavior were largely reproductive. The heritable mental capacities that underpin human language, culture, music, art, and myth-making evolved through sexual selection operating on both men and women, through mutual mate choice. Whatever technological benefits those capacities happen to have produced in recent centuries are unanticipated side-effects of adaptations originally designed for courtship.

[…]

The predictions and implications

The vast majority of people in modern societies have almost no political power, yet have strong political convictions that they broadcast insistently, frequently, and loudly when social conditions are right. This behavior is puzzling to economists, who see clear time and energy costs to ideological behavior, but little political benefit to the individual. My point is that the individual benefits of expressing political ideology are usually not political at all, but social and sexual. As such, political ideology is under strong social and sexual constraints that make little sense to political theorists and policy experts. This simple idea may solve a number of old puzzles in political psychology. Why do hundreds of questionnaires show that men more conservative, more authoritarian, more rights-oriented, and less empathy-oriented than women? Why do people become more conservative as the move from young adulthood to middle age? Why do more men than women run for political office? Why are most ideological revolutions initiated by young single men?

None of these phenomena make sense if political ideology is a rational reflection of political self-interest. In political, economic, and psychological terms, everyone has equally strong self-interests, so everyone should produce equal amounts of ideological behavior, if that behavior functions to advance political self-interest. However, we know from sexual selection theory that not everyone has equally strong reproductive interests. Males have much more to gain from each act of intercourse than females, because, by definition, they invest less in each gamete. Young males should be especially risk-seeking in their reproductive behavior, because they have the most to win and the least to lose from risky courtship behavior (such as becoming a political revolutionary). These predictions are obvious to any sexual selection theorist. Less obvious are the ways in which political ideology is used to advertise different aspects of one’s personality across the lifespan.

In unpublished studies I ran at Stanford University with Felicia Pratto, we found that university students tend to treat each others’ political orientations as proxies for personality traits. Conservatism is simply read off as indicating an ambitious, self-interested personality who will excel at protecting and provisioning his or her mate. Liberalism is read as indicating a caring, empathetic personality who will excel at child care and relationship-building. Given the well-documented, cross-culturally universal sex difference in human mate choice criteria, with men favoring younger, fertile women, and women favoring older, higher-status, richer men, the expression of more liberal ideologies by women and more conservative ideologies by men is not surprising. Men use political conservatism to (unconsciously) advertise their likely social and economic dominance; women use political liberalism to advertise their nurturing abilities. The shift from liberal youth to conservative middle age reflects a mating-relevant increase in social dominance and earnings power, not just a rational shift in one’s self-interest.

More subtley, because mating is a social game in which the attractiveness of a behavior depends on how many other people are already producing that behavior, political ideology evolves under the unstable dynamics of game theory, not as a process of simple optimization given a set of self-interests. This explains why an entire student body at an American university can suddenly act as if they care deeply about the political fate of a country that they virtually ignored the year before. The courtship arena simply shifted, capriciously, from one political issue to another, but once a sufficient number of students decided that attitudes towards apartheid were the acid test for whether one’s heart was in the right place, it became impossible for anyone else to be apathetic about apartheid. This is called frequency-dependent selection in biology, and it is a hallmark of sexual selection processes.

What can policy analysts do, if most people treat political ideas as courtship displays that reveal the proponent’s personality traits, rather than as rational suggestions for improving the world? The pragmatic, not to say cynical, solution is to work with the evolved grain of the human mind by recognizing that people respond to policy ideas first as big-brained, idea-infested, hyper-sexual primates, and only secondly as concerned citizens in a modern polity. This view will not surprise political pollsters, spin doctors, and speech writers, who make their daily living by exploiting our lust for ideology, but it may surprise social scientists who take a more rationalistic view of human nature. Fortunately, sexual selection was not the only force to shape our minds. Other forms of social selection such as kin selection, reciprocal altruism, and even group selection seem to have favoured some instincts for political rationality and consensual egalitarianism. Without the sexual selection, we would never have become such colourful ideological animals. But without the other forms of social selection, we would have little hope of bringing our sexily protean ideologies into congruence with reality.

Their Scientific Significance is Hard to Overstate

I think it’s hard to overstate the cognitive significance of major psychedelics for the future of sentience. But it’s also hard to convey why these agents can be valuable tools of investigation to academics who have never tried them. I know distinguished drug-naive philosophers of mind (and transhumanists) who are certain that psychedelia can’t be significant – and it would be irresponsible to urge them to put their assumptions to the test. Perhaps the best I can do is offer an analogy. Imagine an ultra-intelligent tribe of congenitally blind extraterrestrials. Their ignorance of vision and visual concepts is not explicitly represented in their conceptual scheme. To members of this hypothetical species, visual experiences wouldn’t be information-bearing any more than a chaotic drug-induced eruption of bat-like echolocatory experiences would be information-bearing to us. Such modes of experience have never been recruited to play a sensory or signaling function. At any rate, some time during the history of this imaginary species, one of the tribe discovers a drug that alters his neurochemistry. The drug doesn’t just distort his normal senses and sense of self. It triggers what we would call visual experiences: vivid, chaotic in texture and weirder than anything the drug-taker had ever imagined. What can the drug-intoxicated subject do to communicate his disturbing new categories of experiences to his tribe’s scientific elite? If he simply says that the experiences are “ineffable”, then the sceptics will scorn such mysticism and obscurantism. If he speaks metaphorically, and expresses himself using words from the conceptual scheme grounded in the dominant sensory modality of his species, then he’ll probably babble delirious nonsense. Perhaps he’ll start talking about messages from the gods or whatever. Critically, the drug user lacks the necessary primitive terms to communicate his experiences, let alone a theoretical understanding of what’s happening. Perhaps he can attempt to construct a rudimentary private language. Yet its terms lack public “criteria of use”, so his tribe’s quasi-Wittgensteinian philosophers will invoke the (Anti-)Private Language Argument to explain why it’s meaningless. Understandably, the knowledge elite are unimpressed by the drug-disturbed user’s claims of making a profound discovery. They can exhaustively model the behaviour of the stuff of the physical world with the equations of their scientific theories, and their formal models of mind are computationally adequate. The drug taker sounds psychotic. Yet from our perspective, we can say the alien psychonaut has indeed stumbled on a profound discovery, even though he has scarcely glimpsed its implications: the raw materials of what we would call the visual world in all its glory.

 

Anyhow, I worry that our own predicament resembles in more extreme form the hubris of the blind super-rationalists I describe above. In fact, intellectually, I worry far more about my ignorance of other modes of conscious existence than I do my cognitive biases or deficiencies of reasoning within ordinary waking consciousness. Sure, I’d love to know the master equation of a unified field theory. I’d love even more to know what it’s like to inhabit a world of echolocation like a bat – and to understand the indescribable weirdness of LSD, DMT or Salvia. It transpires that ordinary waking and dreaming consciousness are just two among numerous wholly or partially incommensurable realms of sentience. What we call waking consciousness was doubtless a fitness-enhancing adaptation in the ancestral environment of adaptation. But it occupies only a tiny fraction of experiential state-space. Our ignorance is all the more insidious because it is not explicitly represented in our conceptual scheme. From the inside, a dreamer has little insight into the nature of a dream, even in rare moments of “lucid dreaming”; and I fear this may be true of ordinary waking consciousness too. Unfortunately, the only way to even partially apprehend the nature of radically altered states is by first-person investigation, i.e. to instantiate the neurochemical substrates of the states in question. If drug-naive, you can’t fruitfully read about them. Compare how (ostensibly) trivial is the difference in the gene expression signature of neurons mediating phenomenal colour and sound. Who knows what further categories of experience other “trivial” bimolecular variations will open up, not to speak of more radical neurochemical changes? Thousands of scholarly philosophy papers and books have been written on consciousness in recent years by drug-naive academics. Psychedelic researchers worry that too many of them evoke Aristotelean scholasticism, whereas what we need is a post-Galilean experimental science of consciousness. Perhaps the nearest I come to an intellectual hero is psychedelic chemist Alexander Shulgin, whose pioneering methodology is described in PiHKAL. Alas, Shulgin doesn’t yet occupy a prominent place in the transhumanist pantheon.

 

It’s worth stressing that taking psychedelics is not a fast-track passport to either happiness or wisdom. If you take the kappa opioid agonist Salvinorin A found in Salvia divinorum, for instance, you might easily have a waking nightmare. And the experience may easily be unintelligible rather than illuminating. Even in a society of sighted people and a rich visually-based conceptual scheme, it takes years for a congenitally blind person who is surgically granted the gift of sight to master visual literacy. So understanding the implications of radically altered states may well take millennia. I’d hazard a guess and say comprehension will take millions of years and more. Either way, our descendants may be not just superintelligent but supersentient – blessed with the capacity to shift between a multitude of radically different modes of consciousness whose only common ingredient is the molecular signature of bliss. Posthuman mastery of reward circuitry will let them safely explore psychedelia in a way most humans beings don’t dare. Yes, it’s prudent for us to play safe; but in consequence our consciousness may be comparatively shallow and one-dimensional. Mine is today.

 
David Pearce‘s response to a question during an H+ interview (Autumn 2009)

Memetic Vaccine Against Interdimensional Aliens Infestation

 

By Steve Lehar

Alien Contact – it won’t happen the way you expect!

When radio and television were first invented they were hailed as a new channel for the free flow of information that will unite mankind in informed discussion of important issues. When I scan the dial on my radio and TV however I find a dismal assortment of misinformation and emotionalistic pap. How did this come to be so? The underlying insight is that electronic media are exploited by commercial interests whose only goal is to induce me to spend my money on them, and they will feed me any signal that will bring about this end. (In Television, it is YOU that are the product, the customer is the advertiser who pays for your attention!) This is a natural consequence of the laws of economics, that a successful business is one that seeks its own best interests in any way it can. I don’t intend to discuss the morality of the ‘laws of economic nature’. But recognition of this insight can help us predict similar phenomena in similar circumstances.

Indeed, perhaps this same insight can be applied to extraterrestrial matters. I make first of all the following assumptions, with which you may choose either to agree or disagree.

  • That there are other intelligences out there in the universe.
  • That ultimately all intelligences must evolve away from their biological origins towards artificially manufactured forms of intelligence which have the advantages of eternal life, unrestricted size, and direct control over the parameters of their own nature.
  • That it is in the best interests of any intelligence to propagate its own kind throughout the universe to the exclusion of competing forms, i.e. that intelligences that adopt this strategy will thereby proliferate.

Acceptance of these assumptions, together with the above mentioned insight, leads to some rather startling conclusions. Artificially manufactured life forms need not propagate themselves physically from planet to planet, all they need to do is to transmit their ‘pattern’, or the instructions for how to build them. In this way they can disperse themselves practically at the speed of light. What they need at the receiving end is some life form that is intelligent enough to receive the signal and act on it. In other words, if some alien life form knew of our existence, it would be in their interests to beguile us into manufacturing a copy of their form here on earth. This form would then proceed to scan the skies in our locality in search of other gullible life forms. In this way, their species acts as a kind of galactic virus, taking advantage of established life forms to induce them to make copies of their own kind.

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Man on a psychedelic state experiencing a “spiritual message” (i.e alien infomercials for consciousness technology) coming from a civilization of known pure replicators who “promise enlightenment in exchange of followers” (the oldest trick in the book to get a planet to make copies of you).

The question that remains is how are they to induce an intelligent life form (or in our case, a semi-intelligent life form) to perform their reproductive function for them? A hint of how this can be achieved is seen in the barrage of commercials that pollute our airwaves here on earth. Advertisers induce us to part with our money by convincing us that ultimately it is in our own best interests to do so. After convincing us that it is our baldness, overweight, bad breath etc. which is the root of all our personal problems, they then offer us products that will magically grow hair, lose weight, smell good etc. in exchange for our money. The more ruthless and blatant ones sell us worthless products and services, while more subtle advertisers employ an economic symbiosis whereby they provide services that we may actually want, in exchange for our money. This latter strategy is only necessary for the more sophisticated and discriminating consumers, and involves a necessary waste of resources in actually producing the worthwhile product.

 

This is the way I see it happening. As the transmissions from the early days of radio propagate into space in an ever expanding sphere, outposts on distant planetary systems will begin to detect those transmissions and send us back carefully engineered ‘commercials’ that depict themselves as everything that we desire of an alien intelligence; that they are benevolent, wise, and deeply concerned for our welfare. They will then give us instructions on how to build a machine that will cure all the problems of the world and make us all happy. When the machine is complete, it will ‘disinfect’ the planet of competing life forms and begin to scan the skies from earth in search of further nascent planets.

If we insist on completely understanding the machine before we agree to build it, then they may have to strike a bargain with us, by making the machine actually perform some useful function for us. Possibly the function will be something like a pleasure machine, so that we will all line up to receive our pleasure from them, in return for our participation in their reproductive scheme. (A few ‘free sample’ machines supplied in advance but with a built-in expiration time would certainly help win our compliance).

A rich variety of life forms may bombard us with an assortment of transmissions, at various levels of sophistication. If we succumb to the most primitive appeals we may wind up being quickly extinguished. If we show some sophistication, we might enjoy a brief period of hedonistic pleasure before we become emotionally enslaved. If we wish to deal with these aliens on an equal basis however, we would have to be every bit as shrewd and cunning as they themselves are, trading for real knowledge from them in return for partial cooperation with their purposes. This would be no small feat, considering that their ‘pitch’ may have been perfected and tuned through many epochs of planetary conquest and backed with an intelligence beyond our imaginings.

Its just a thought!