Frequency Specific Microcurrent for Kidney-Stone Pain

Excerpt from The Resonance Effect: How Frequency Specific Microcurrent is Changing Medicine (2017) by Carolyn McMakin 

Kidney Stone Pain

Everyone who has ever had a kidney stone will tell you that the kidney-stone pain is the worst. Emergency rooms treat it with morphine, and nothing else seems to touch it.

The phone rang on a summer Sunday morning and I hardly recognized the friend who grunted through gritted teeth to ask if “my machine” could treat kidney-stone pain. I told him that I’d never treated it before, but I’d be willing to try if he could make it to my house. He shuffled from the front door to the couch bent forward at the waist, sweating in pain. I put one wet graphite glove under his back and the other glove on his abdomen. He tried hard not to moan as I covered him with a soft blanket and placed my hand on top of the glove on his abdomen.

Education said that kidney-stone pain had to be about spasm in the ureter, the tube that carries the stone from the kidney to the bladder. The frequency for spasm was 29 hertz on channel A. The frequency for the ureter was 60 hertz on channel B. It did absolutely nothing: no warmth, no relaxation or softening, nothing. Maybe there was bleeding caused by the rough stone shredding the ureter as it traveled? I tried 18 hertz to stop bleeding on channel A. The glove didn’t get warm, and the pain didn’t change.

I really didn’t want my gray-faced friend to be my first failure. Reaching for inspiration, I tried the always-reliable 40 hertz to reduce inflammation. Nothing changed. Desperation amplified the small murmur of my intuition in my head, “Don’t get sloppy! Be thorough.”

There is a sequence of frequencies leading up to inflammation. The sequence was 20 hertz for “pressure or pain reaction,” 30 hertz for irritation, 40 hertz for inflammation. I never ran the whole sequence because 40 hertz always worked and I had no idea what a “pressure or pain reaction” might be. The buttons clicked down from 40 hertz to 20 hertz on channel A, and two things happened in seconds. The glove resting on his abdomen got hot — not just warm, it was hot. His abdomen started to soften. The feeling is hard to describe. It feels like a balloon feels when it has been sitting on the floor overnight. The tissue softens and stays soft while the correct frequency is working, and it returns to normal when the frequency is finished.

His voice was a little slurred when he fell asleep a few minutes later as he said, “Is that supposed to make me feel woozy?” His deep relaxed breathing said he was out of pain.

There are frequencies for the stone, so I tried those after twenty quiet minutes of watching him doze. The glove got hot, the abdomen softened, and ten minutes later he bolted awake and yelped, “The stone’s moving.” True to its promise, 20 hertz on A and 60 hertz on B reduced the pain again and put him back to sleep. Forty minutes later he left, pain-free, and passed the stone that night with no increase in pain.

I told this story at the Advanced Course in Australia a few weeks later, and one of the Australian practitioners reported that she treated her husband for kidney stone pain with 20 hertz on A and 60 hertz on B. He was out of pain in an hour and passed the stone uneventfully.

Every case of kidney stones treated since then has responded exactly the same way. When the patient has gripping lower back pain from lifting suitcases during a long dehydrating flight but treating the muscles doesn’t help, experience finally admits it’s not the muscle. Intuition says, “I wonder if it’s a kidney stone?” The learning curve is very steep and short when the glove gets hot, the muscles begin to relax, the pain goes down in minutes, and the patient falls asleep.

When one specific frequency combination, and only one, works every time anyone uses it, and when it does something that is otherwise impossible, then it can’t be impossible. It’s got to be resonance.

Logarithmic Scales of Pleasure and Pain: Rating, Ranking, and Comparing Peak Experiences Suggest the Existence of Long Tails for Bliss and Suffering

TL;DR

Based on: the characteristic distribution of neural activity, personal accounts of intense pleasure and pain, the way various pain scales have been described by their creators, and the results of a pilot study we conducted which ranks, rates, and compares the hedonic quality of extreme experiences, we suggest that the best way to interpret pleasure and pain scales is by thinking of them as logarithmic compressions of what is truly a long-tail. The most intense pains are orders of magnitude more awful than mild pains (and symmetrically for pleasure).

This should inform the way we prioritize altruistic interventions and plan for a better future. Since the bulk of suffering is concentrated in a small percentage of experiences, focusing our efforts on preventing cases of intense suffering likely dominates most utilitarian calculations.

An important pragmatic takeaway from this article is that if one is trying to select an effective career path, as a heuristic it would be good to take into account how one’s efforts would cash out in the prevention of extreme suffering (see: Hell-Index), rather than just QALYs and wellness indices that ignore the long-tail. Of particular note as promising Effective Altruist careers, we would highlight working directly to develop remedies for specific, extremely painful experiences. Finding scalable treatments for migraines, kidney stones, childbirth, cluster headaches, CRPS, and fibromyalgia may be extremely high-impact (cf. Treating Cluster Headaches and Migraines Using N,N-DMT and Other Tryptamines, Using Ibogaine to Create Friendlier Opioids, and Frequency Specific Microcurrent for Kidney-Stone Pain). More research efforts into identifying and quantifying intense suffering currently unaddressed would also be extremely helpful. Finally, if the positive valence scale also has a long-tail, focusing one’s career in developing bliss technologies may pay-off in surprisingly good ways (whereby you may stumble on methods to generate high-valence healing experiences which are orders of magnitude better than you thought were possible).

Contents

Introduction:

  1. Weber’s Law
  2. Why This Matters

General ideas:

  1. The Non-Linearity of Pleasure and Pain
    1. Personal Accounts
    2. Consciousness Expansion
    3. Peak Pleasure States: Jhanas and Temporal Lobe Seizures
    4. Logarithmic Pain Scales: Stings, Peppers, and Cluster Headaches
  2. Deference-type Approaches for Experience Ranking
    1. Normal World vs. Lognormal World
    2. Predictions of Lognormal World

Survey setup:

  1. Mechanical Turk
  2. Participant Composition
  3. Filtering Bots

Results:

  1. Appearance Base Rates
  2. Average Ratings
  3. Deference Graph of Top Experiences
    1. Rebalanced Smoothed Proportion
    2. Triadic Analysis
  4. Latent Trait Ratings
  5. Long-tails in the Responses to “How Many Times Better/Worse” Question

Discussion:

  1. Key Pleasures Surfaced
    1. Birth of Children
    2. Falling in Love
    3. Travel/Vacation
    4. MDMA/LSD/Psilocybin
    5. Games of Chance Earnings
  2. Key Pains
    1. Kidney Stones/Migraines
    2. Childbirth
    3. Car Accidents
    4. Death of Father and Mother
  3. Future Directions for Methodological Approaches
    1. Graphical Models with Log-Normal Priors
  4. Closing Thoughts on the Valence Scale
  5. Additional Material
    1. Dimensionality of Pleasure and Pain
    2. Mixed States
    3. Qualia Formalism
  6. Notes

Introduction

Weber’s Law

Weber’s Law describes the relationship between the physical intensity of a stimulus and the reported subjective intensity of perceiving it. For example, it describes the relationship between how loud a sound is and how loud it is perceived as. In the general case, Weber’s Law indicates that one needs to vary the stimulus intensity by a multiplicative fraction (called “Weber’s fraction”) in order to detect a just noticeable difference. For example, if you cannot detect the differences between objects weighing 100 grams to 105 grams, then you will also not be able to detect the differences between objects weighing 200 grams to 210 grams (implying the Weber fraction for weight perception is at least 5%). In the general case, the senses detect differences logarithmically.

There are two compelling stories for interpreting this law:

In the first story, it is the low-level processing of the senses which do the logarithmic mapping. The senses “compress” the intensity of the stimulation and send a “linearized” packet of information to one’s brain, which is then rendered linearly in one’s experience.

In the second story, the senses, within the window of adaptation, do a fine job of translating (somewhat) faithfully the actual intensity of the stimulus, which then gets rendered in our experience. Our inability to detect small absolute differences between intense stimuli is not because we are not rendering such differences, but because Weber’s law applies to the very intensity of experience. In other words, the properties of one’s experience could follow a long-tail distribution, but our ability to accurately point out differences between the properties of experiences is proportional to their intensity.

We claim that, at least for the case of valence (i.e the pleasure-pain axis), the second story is much closer to the truth than the first. Accordingly, this article rethinks the pleasure-pain axis (also called the valence scale) by providing evidence, arguments, and datapoints to support the idea that how good or bad experiences feel follows a long-tail distribution.

As an intuition pump for what is to follow, we would like to highlight the empirical finding that brain activity follows a long-tail distribution (see: Statistical Analyses Support Power Law Distributions Found in Neuronal Avalanches, and Logarithmic Distributions Prove that Intrinsic Learning is Hebbian). The story where the “true valence scale” is a logarithmic compression is entirely consistent with the empirical long-tails of neural activity (in which “neural avalanches” account for a large fraction of overall brain activity).

The concrete line of argument we will present is based on the following:

  1. Phenomenological accounts of intense pleasure and pain (w/ accounts of phenomenal time and space expansion),
  2. The way in which pain scales are described by those who developed them, and
  3. The analytic results of a pilot study we conducted which investigates how people rank, rate, and assign relative proportions to their top 3 best and worst experiences

Why This Matters

Even if you are not a strict valence utilitarian, having the insight that the valence scale is long-tailed is still very important. Most ethical systems do give some weight to the prevention of suffering (in addition to the creation of subjectively valuable experiences), even if that is not all they care about. If your ethical system weighted slightly the task of preventing suffering when believing in a linear valence scale, then learning about the long-tailed nature of valence should in principle cause a major update. If indeed the worst experiences are exponentially more negative than originally believed by one’s ethical system, which nonetheless still cared about them, then after learning about the true valence scale the system would have to reprioritize. We suggest that while it might be unrealistic to have every ethical system refocus all of its energies on the prevention of intense suffering (and subsequently on researching how to create intense bliss sustainably), we can nonetheless expect such systems to raise this goal on their list of priorities. In other words, while “ending all suffering” will likely never be a part of most people’s ethical system, we hope that the data and arguments here presented at least persuade them to add “…and prevent intense forms of suffering” to the set of desiderata.

Indeed, lack of awareness about the long-tails of bliss and suffering may be the cause of an ongoing massive moral catastrophe (notes by Linch). If indeed the degree of suffering present in experiences follows a long-tail distribution, we would expect the worst experiences to dominate most utilitarian calculus. The biggest bang for the buck in altruistic interventions would therefore be those that are capable of directly addressing intense suffering and generating super-bliss.

General Ideas

The Non-Linearity of Pleasure and Pain

true_pleasure_scale

True long-tail pleasure scale (warning: psychedelics increase valence variance – the values here are for “good/lucky” trips and there is no guarantee e.g. LSD will feel good on a given occasion). Also: Mania is not always pleasant, but when it is, it can be super blissful.

true_pain_scale

True long-tail pain scale

As we’ve briefly discussed in previous articles (1, 2, 3), there are many reasons to believe that both pleasure and pain can be felt along a spectrum with values that range over possibly orders of magnitude. Understandably, someone who is currently in a state of consciousness around the human median of valence is likely to be skeptical of a claim like “the bliss you can achieve in meditation is literally 100 times better than eating your favorite food or having sex.” Intuitively, we only have so much space in our experience to fit bliss, and when one is in a “normal” or typical state of mind for a human, one is forced to imagine “ultra blissful states” by extrapolating the elements of one’s current experience, which certainly do not seem capable of being much better than, say, 50% of the current level of pleasure (or pain). The problem here is that the very building blocks of experiences that enable them to be ultra-high or ultra-low valence are themselves necessary to imagine accurately how they can be put together. Talking about extreme bliss to someone who is anhedonic is akin to talking about the rich range of possible color experiences to someone who is congenitally fully colorblind (cf. “What Mary Didn’t Know“).

“Ok”, you may say, “you are just telling me that pleasure and pain can be orders of magnitude stronger than I can even conceive of. What do you base this on?”. The most straightforward way to be convinced of this is to literally experience such states. Alas, this would be deeply unethical when it comes to the negative side, and it requires special materials and patience for the positive side. Instead, I will provide evidence from a variety of methods and conditions.

Personal Accounts

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I’ve been lucky to not have experienced major pain in my life so far (the worst being, perhaps, depression during my teens). I have, however, had two key experiences that gave me some time to introspect on the non-linear nature of pain. The first one comes from when I accidentally cut a super-spicy pepper and touched it with my bare hands (the batch of peppers I was cutting were mild, but a super-hot one snuck into the produce box). After a few minutes of cutting the peppers, I noticed that a burning heat began to intensify in my hands. This was the start of experiencing “hot pepper hands” for a full 8 hours (see other people’s experiences: 1, 2, 3). The first two to three hours of this ordeal were the worst, where I experienced what I rated as a persistent 4/10 pain interspersed with brief moments of 5/10 pain. The curious thing was that the 5/10 pain moments were clearly discernible as qualitatively different. It was as if the very numerous pinpricks and burning sensations all over my hands were in a somewhat disorganized state most of the time, but whenever they managed to build-up for long enough, they would start clicking with each other (presumably via phase-locking), giving rise to resonant waves of pain that felt both more energetic, and more aversive on the whole. In a way, this jump from what I rated as 4/10 to 5/10 was qualitative as well as quantitative, and it gave me some idea of how something that is already bad can become even worse.

My second experience involves a mild joint injury I experienced while playing Bubble Soccer (a very fun sport no doubt, and a common corporate treat for Silicon Valley cognotariats, but according to my doctor it is also a frequent source of injuries among programmers). Before doing physical therapy to treat this problem (which mostly took care of it), I remember spending hours introspecting on the quality of the pain in order to understand it better. It wasn’t particularly bad, but it was constant (I rated it as 2/10 most of the time). What stuck with me was how its constant presence would slowly increase the stress of my entire experience over time. I compared the experience to having an uncomfortable knot stuck in your body. If I had a lot of mental and emotional slack early in the day, I could easily take the stress produced by the knot and “send it elsewhere” in my body. But since the source of the stress was constant, eventually I would run out of space, and the knot would start making secondary knots around itself, and it was in those moments where I would rate the pain at a 3/10. This would only go away if I rested and somehow “reset” the amount of cognitive and emotional slack I had available.

The point of these two stories is to highlight the observation that there seem to be phase-changes between levels of discomfort. An analogy I often make is with the phenomenon of secondary coils when you twist a rope. The stress induced by pain- at least introspectively speaking- is pushed to less stressed areas of your mind. But this has a limit, which is until your whole world-simulation is stressed to the point that the source of stress starts creating secondary “stress coils” on top of the already stressed background experience. This was a very interesting realization to me, which put in a different light weird expressions that chronic pain patients use like “my pain now has a pain of its own” or “I can’t let the pain build up”.

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DNA coils and super-coils as a metaphor for pain phase-changes?

Consciousness Expansion

What about more extreme experiences? Here we should briefly mention psychedelic drugs, as they seem to be able to increase the energy of one’s consciousness (and in some sense “multiply the amount of consciousness“) in a way that grows non-linearly as a function of the dose. An LSD experience with 100 micrograms may be “only” 50% more intense than normal everyday life, but an LSD experience with 200 micrograms is felt as 2-3X as intense, while 300 micrograms may increase the intensity of experience by perhaps 10X (relative to normal). Usually people say that high-dose psychedelic states are indescribably more real and vivid than normal everyday life. And then there are compounds like 5-MeO-DMT, which people often describe as being in “a completely different category”, as it gives rise to what many describe as “infinite consciousness”. Obviously there is no such thing as an experience with infinite consciousness, and that judgement could be explained in terms of the lack of “internal boundaries” of the state, which gives the impression of infinity (not unlike how the surface of a torus can seem infinite from the point of view of a flatlander). That said, I’ve asked rational and intelligent people who have tried 5-MeO-DMT in non-spiritual settings what they think the intensity of their experiences was, and they usually say that a strong dose of 10mg or more gives rise to an intensity and “quantity” of consciousness that is at least 100X as high as normal everyday experiences. There are many reasons to be skeptical of this, no doubt, but the reports should not be dismissed out of hand.

Antoine's_Necklace_Iteration_2

Secondary knots and links as a metaphor for higher bliss

As with the above example, we can reason that one of the ways in which both pain and pleasure can be present in *multiples* of one’s normal hedonic range is because the amount of consciousness crammed into a moment of experience is not a constant. In other words, when someone in a typical state of consciousness asks “if you say one can experience so much pain/pleasure, tell me, where would that fit in my experience? I don’t see much room for that to fit in here”, one can respond by saying that “in other states of consciousness there is more (phenomenal) time and space within each moment of experience”. Indeed, at Qualia Computing we have assembled and interpreted a large number of experiences of high-energy states of consciousness that indicate that both phenomenal time, and phenomenal space, can drastically expand. To sum it up – you can fit so much pleasure and pain in peak experiences precisely because such experiences make room for them.

Let us now illustrate the point with some paradigmatic cases of very high and vey low valence:

Peak Pleasure States: Jhanas and Temporal Lobe Seizures

On the pleasure side, we have Buddhist meditators who experience meditative states of absorption (aka. “Jhanas”) as extremely, and counter-intuitively, blissful:

The experience can include some very pleasant physical sensations such as goose bumps on the body and the hair standing up to more intense pleasures which grow in intensity and explode into a state of ecstasy. If you have pain in your legs, knees, or other part of the body during meditation, the pain will actually disappear while you are in the jhanas. The pleasant sensations can be so strong to eliminate your painful sensations. You enter the jhanas from the pleasant experiences exploding into a state of ecstasy where you no longer “feel” any of your senses.

9 Jhanas, Dhamma Wiki

There are 8 (or 9, depending on who you ask) “levels” of Jhanas, and the above is describing only the 1st of them! The higher the Jhana, the more refined the bliss becomes, and the more detached the state is from the common referents of our everyday human experience. Ultra-bliss does not look at all like sensual pleasure or excitement, but more like information-theoretically optimal configurations of resonant waves of consciousness with little to no intentional content (cf. semantically neutral energy). I know this sounds weird, but it’s what is reported.

insula

“Streamlines from the insula to the cortex” – the insula (in red) is an area of the brain intimately implicated in the super-bliss that sometimes precedes temporal lobe epilepsy (source)

Another example I will provide about ultra-bliss concerns temporal lobe epilepsy, which in a minority of sufferers gives rise to extraordinarily intense states of pleasure, or pain, or both. Such experiences can result in Geschwind syndrome, a condition characterized by hypergraphia (writing non-stop), hyper-religiosity, and a generally intensified mental and emotional life. No doubt, any experience that hits the valence scale at one of its extremes is usually interpreted as other-worldly and paranormal (which gives rise to the question of whether valence is a spiritual phenomenon or the other way around). Famously, Dostoevsky seems to have experienced temporal lobe seizures, and this ultimately informed his worldview and literary work in profound ways. Here is how he describes them:

“A happiness unthinkable in the normal state and unimaginable for anyone who hasn’t experienced it… I am then in perfect harmony with myself and the entire universe.”

 

– From a letter to his friend Nikolai Strakhov.

“I feel entirely in harmony with myself and the whole world, and this feeling is so strong and so delightful that for a few seconds of such bliss one would gladly give up 10 years of one’s life, if not one’s whole life. […] You all, healthy people, can’t imagine the happiness which we epileptics feel during the second before our fit… I don’t know if this felicity lasts for seconds, hours or months, but believe me, I would not exchange it for all the joys that life may bring.”

 

– from the character Prince Myshkin in Dostoevsky’s novel, The Idiot, which he likely used to give a voice to his own experiences.

Dostoevsky is far from the only person reporting these kinds of experiences from epilepsy:

As Picard [a scientist investigating seizures] cajoled her patients to speak up about their ecstatic seizures, she found that their sensations could be characterised using three broad categories of feelings (Epilepsy & Behaviour, vol 16, p 539). The first was heightened self-awareness. For example, a 53-year-old female teacher told Picard: “During the seizure it is as if I were very, very conscious, more aware, and the sensations, everything seems bigger, overwhelming me.” The second was a sense of physical well-being. A 37-year-old man described it as “a sensation of velvet, as if I were sheltered from anything negative”. The third was intense positive emotions, best articulated by a 64-year-old woman: “The immense joy that fills me is above physical sensations. It is a feeling of total presence, an absolute integration of myself, a feeling of unbelievable harmony of my whole body and myself with life, with the world, with the ‘All’,” she said.

 

– from “Fits of Rapture”, New Scientist (January 25, 2014) (source)

All in all, these examples illustrate the fact that blissful states can be deeper, richer, more intense, more conscious, and qualitatively superior to the normal everyday range of human emotion.

Now, how about the negative side?

Logarithmic Pain Scales: Stings, Peppers, and Cluster Headaches

“The difference between 6 and 10 on the pain scale is an exponential difference. Believe it or not.”

Insufferable Indifference, by Neil E. Clement (who experiences chronic pain ranging between 6/10 to 10/10, depending on the day)

Three pain-scale examples that illustrate the non-linearity of pain are: (1) the Schmidt sting pain index, (2) the Scoville scale, and (3) the KIP scale:

image

(1) Justin O. Schmidt stung himself with over 80 species of insects of the Hymenoptera order, and rated the ensuing pain on a 4-point-scale. About the scale, he had to say the following:

4:28 – Justin Schmidt: The harvester ant is what got the sting pain scale going in the first place. I had been stung by honeybees, yellow jackets, paper wasps, etc. the garden variety stuff, that you get bitten by various beetles and things. I went down to Georgia, which has the Eastern-most extension of the harvester ant. I got stung and I said “Wooooow! This is DIFFERENT!” You know? I thought I knew everything there was about insect stings, I was just this dumb little kid. And I realized “Wait a minute! There is something different going on here”, and that’s what got me to do the comparative analysis. Is this unique to harvester ants? Or are there others that are like that. It turns out while the answer is, now we know much later – it’s unique! [unique type of pain]. 

[…]

7:09 – Justin Schmidt: I didn’t really want to go out and get stung for fun. I was this desperate graduate student trying to get a thesis, so I could get out and get a real job, and stop being a student eventually. And I realized that, oh, we can measure toxicity, you know, the killing power of something, but we can’t measure pain… ouch, that one hurts, and that one hurts, and ouch that one over there also hurts… but I can’t put that on a computer program and mathematically analyze what it means for the pain of the insect. So I said, aha! We need a pain scale. A computer can analyze one, two, three, and four, but it can’t analyze “ouch!”. So I decided that I had to make a pain scale, with the harvester ant (cutting to the chase) was a 3. Honey bees was a 2. And I kind of tell people that each number is like 10 equivalent of the number before. So 10 honey bee stings are equal to 1 harvester ant sting, and 10 harvester ant stings would equal one bullet ant sting.

[…]

11:50 – [Interviewer]: When I finally worked up the courage to [put the Tarantula Hawk on my arm] and take this sting. The sting of that insect was electric in nature. I’ve been shocked before, by accidentally taking a zap from an electrical cord. This was that times 10. And it put me on the ground. My arm seized up from muscle contraction. And it was probably the worst 5 minutes of my life at that point.

Justin Schmidt: Yeah, that’s exactly what I call electrifying. I say, imagine you are walking along in Arizona, and there is a wind storm, and the power line above snaps the wire, and it hits you, of course that hasn’t happened to me, but that’s what you imagine it feels like. Because it’s absolutely electrifying, I call it debilitating because you want to be macho, “ah I’m tough, I can do this!” Now you can’t! So I tell people lay down and SCREAM! Right?

[Interviewer]: That’s what I did! And Mark would be like, this famous “Coyote, are you ok? Are you ok?”

Justin Schmidt: No, I’m not ok!

[Interviewer]: And it was very hard to try to compose myself to be like, alright, describe what is happening to your body right now. Because your mind goes into this state that is like blank emptiness. And all you can focus on is the fact that there’s radiating pain coming out of your arm.

Justin Schmidt: That’s why you scream, because now you’re focusing on something else. In addition to the pain, you’re focusing on “AAAAAAHHHHH!!!” [screams loudly]. Takes a little bit of the juice off of the pain, so maybe you lower it down to a three for as long as you can yell. And I can yell for a pretty long time when I’m stung by a tarantula hawk.

 

Origin of STINGS!, interview of Justin O. Schmidt

If we take Justin’s word for it, a sting that scores a 4 on his pain scale is about 1,000 times more painful than a sting that scores a 1 on his scale. Accordingly, Christopher Starr (who replicated the scale), stated that any sting that scores a 4 is “traumatically painful” (source). Finally, since the scale is restricted to stings of insects of the Hymenoptera order, it remains possible that there are stings whose pain would be rated even higher than 4. A 5 on the sting pain index might perhaps be experienced with the stings of the box jellyfish that produces Irukandji syndrome, and the bite of the giant desert centipede. Needless to say, these are to be avoided.

Moving on…

(2) The Scoville scale measures how spicy different chili peppers and hot sauces are. It is calculated by diluting the pepper/sauce in water until it is no longer possible to detect any spice in it. The number that is associated with the pepper or sauce is the ratio of water-to-sauce that makes it just barely possible to taste the spice. Now, this is of course not itself a pain scale. I would nonetheless anticipate that taking the log of the Scoville units of a dish might be a good approximation for the reported pain it delivers. In particular, people note that there are several qualitative jumps in the type and nature of the pain one experiences when eating hot sauces of different strengths (e.g. “Fuck you Sean! […] That was a leap, Sean, that was a LEAP!” – Ken Jeong right after getting to the 135,000 Scoville units sauce in the pain porn Youtube series Hot Ones). Amazon reviews of ultra-hot sauces can be mined for phenomenological information concerning intense pain, and the general impression one gets after reading such reviews is that indeed there is a sort of exponential range of possible pain values:

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I know it may be fun to trivialize this kind of pain, but different people react differently to it (probably following a long-tail too!). For some people who are very sensitive to heat pain, very hot sauce can be legitimately traumatizing. Hence I advise against having ultra-spicy sauces around your house. The novelty value is not worth the probability of a regrettable accident, as exemplified in some of the Amazon reviews above (e.g. a house guest assuming that your “Da’Bomb – Beyond Insanity” bottle in the fridge can’t possibly be that hot… and ending up in the ER and with PTSD).

I should add that media that is widely consumed about extreme hot sauce (e.g. the Hot Ones mentioned above and numerous stunt Youtube channels) may seem fun on the surface, but what doesn’t make the cut and is left in the editing room is probably not very palatable at all. From an interview: “Has anyone thrown up doing it?” (interviewer) – “Yeah, we’ve run the gamuts. We’ve had people spit in buckets, half-pass out, sleep in the green room afterwards, etc.” (Sean Evans, Hot Ones host). T.J. Miller, when asked about what advice he would give to the show while eating ultra-spicy wings, responded: “Don’t do this. Don’t do this again. End the show. Stop doing the show. That’s my advice. This is very hot. This is painful. There’s a problem here.”

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Trigeminal Neuralgia pain scale – a condition similarly painful to Cluster Headaches

(3) Finally, we come to the “KIP scale”, which is used to rate Cluster Headaches, one of the most painful conditions that people endure:

The KIP scale

KIP-0 No pain, life is beautiful
KIP-1 Very minor, shadows come and go. Life is still beautiful
KIP-2 More persistent shadows
KIP-3 Shadows are getting constant but can deal with it
KIP-4 Starting to get bad, want to be left alone
KIP-5 Still not a “pacer” but need space
KIP-6 Wake up grumbling, curse a bit, but can get back to sleep without “dancing”
KIP-7 Wake up, sleep not an option, take the beast for a walk and finally fall into bed exhausted
KIP-8 Time to scream, yell, curse, head bang, rock, whatever works
KIP-9 The “Why me?” syndrome starts to set in
KIP-10 Major pain, screaming, head banging, ER trip. Depressed. Suicidal.

The duration factor is multiplied by the intensity factor, which uses the KIP scale in an exponential way – a KIP 10 is not just twice as bad as a KIP 5, it’s ten times as intense.

Source: Keeping Track, by Cluster Busters

As seen above, the KIP scale is acknowledged by its creator and users to be logarithmic in nature.

In summary: We see that pleasure comes in various grades and that peak experiences such as those induced by psychedelics, meditation, and temporal lobe seizures seem to be orders of magnitude more energetic and better than everyday sober states. Likewise, we see that across several categories of pain, people report being surprised by the leaps in both quality and intensity that are possible. More so, at least in the case of the Schmidt Index and the Kip Scale, the creators of the scale were explicit that it was a logarithmic mapping of the actual level of sensation.

While we do not have enough evidence (and conceptual clarity) to assert that the intensity of pain and pleasure does grow exponentially, the information presented so far does suggest that the valence of experiences follows a long-tail distribution.

Deference-type Approaches for Experience Ranking

The above considerations underscore the importance of coming up with a pleasure-pain scale that tries to take into account the non-linearity and non-normality of valence ratings. One idea we came up with was a “deference”-type approach, where we ask open-ended questions about people’s best and worst experiences and have them rank them against each other. Although locally the data would be very sparse, the idea was that there might be methods to integrate the collective patterns of deference into an approximate scale. If extended to populations of people who are known to have experienced extremes of valence, the approach would even allow us to unify the various pain scales (Scoville, Schmidt, KIP, etc.) and assign a kind of universal valence score to different categories of pain and pleasure.* That will be version 2.0. In the meantime, we thought to try to get a rough picture of the extreme joys and affections of members of the general public, which is what this article will focus on.

Normal World vs. Lognormal World

There is a world we could call the “Normal World”, where valence outliers are rare and most types of experiences affect people more or less similarly, distributed along a Gaussian curve. Then there is another, very different world we could call the “long-tailed world” or if we want to make it simple (acknowledging uncertainty) “Lognormal World”, where almost every valence distribution is a long-tail. So in the “Lognormal World”, say, for pleasure (and symmetrically for pain), we would expect to see a long-tail in the mean pleasure of experiences between different categories across all people, a long-tail in the amount of pleasure within a given type of experience across people, a long-tail for the number of times an individual has had a certain type of pleasure, a long-tail in the intensity of the pleasure experienced with a single category of experience within a single person, and so on. Do we live in the Normal World or the Lognormal World?

Predictions of Lognormal World

If we lived in the “Lognormal World”, we would expect:

  • That people will typically say that their top #1 best/worst experience is not only a bit better/worse than their #2 experience, but a lot better/worse. Like, perhaps, even multiple times better/worse.
  • That there will be a long-tail in the number of appearances of different categories (i.e. that a large amount, such as 80%, of top experiences will belong to the same narrow set of categories, and that there will be many different kinds of experiences capturing the remaining 20%).
  • That for most pairs of experiences x and y, people who have had both instances of x and y, will usually agree about which one is better/worse. We call such a relationship a “deference”. More so, we would expect to see that deference, in general, will be transitive (a > b and b > c implying that a > c).

To test the first and second prediction does not require a lot of data, but the third does because one needs to have enough comparisons to fill a lot of triads. The survey results we will discuss bellow are congruent with the first and second prediction. We did what we could with the data available to investigate the third, and tentatively, it seems to hold up (with ideas like deference network centrality analysis, triadic analysis, and tournament-style approaches).


Survey Setup

The survey asked the following questions: current level of pleasure, current level of pain, top 3 most pleasurable experiences (in decreasing order) along with pleasure ratings for each of them and the age when they were experienced, and the same for the top 3 most painful experiences. I specifically did not provide a set of broad categories (such as “physical” or “emotional”) or a drop-down menu of possible narrow categories (e.g. going to the movies, aerobic exercise, etc.). I wanted to see what people would say when the question was as open-ended as possible.

I also included questions aimed more directly at probing the long-tailed nature of valence: I asked participants to rate “how many times more pleasant was the #1 top experience relative to the #2 top experience” (and #2 relative to #3, and the same for the top most painful experiences).

I also asked them to describe in more detail the single most pleasant and unpleasant experiences, and added a box for comments at the end in order to see if anyone complained about the task (most people said “no comment”, many said they enjoyed the task, and one person said that it made them nostalgic). I also asked about basic demographics (age and gender). Participants earned $1.75 for the task, which seems reasonable given the time it took to complete in most cases.

Mechanical Turk: Participant Composition

The survey was run on Mechanical Turk. I requested “Masters” qualifications for 90/110 of the survey responses. To be a Mechanical Turk Master you need to have a good track record of task approval, which I reasoned would increase the rate of well thought-out high-quality responses (this turned out to be true). The participants’ genders were fairly balanced (50/97 women, 47/97 men), and the average age was 36.5 years (sd = 10):

age_distribution_no_bots

Age distribution

Bots (easy to spot – unless extremely sophisticated)

While reading the responses I discovered that some of them seemed to be generated by bots. Apparently task requesters started noticing the presence of bots a couple of years ago. This is obviously a problem for academics trying to use the service for their research, and for machine learning professionals using the service for data-tagging. Having been both of those things in the past, I can say that a few years ago I did not see any submissions that looked suspiciously bot-like. Though low-quality rushed responses did seem to be relatively common back then, I never observed bot-like responses to open-ended questions. Unfortunately this time I was able to spot several responses clearly written by bots. For example, one respondent answered the question “write a brief essay about your #1 best experience” with:

The reason these types of assignments are given so often is that anyone can write about their own experience and it doesn’t require any outside resources or research. However, even though anyone can tell a story about their life, that does not mean anyone can write a good essay about that experience. As a professor and teacher for 30 years, I’ve read thousands of essays and can tell you there is a distinct difference from telling a story about yourself and writing an excellent personal experience essay. The difference between good and great:

And it ends that way, with a colon indicating that the respondent is about to explain what the difference between good and great is. But it never does it. This answer, great, it is not.

In most cases the difference between a genuine response and a bot response was very obvious. That said, I erred on the side of caution for filtering bots and I got rid of answers even if they seemed just a little suspicious. This left me with 97 out of the 110 original responses. The following analysis was conducted on those 97 responses.

Preprocessing

Since the responses were open-ended I had to tag each of them with an experience category. To do this I read each response and identified the key theme in them and classified them with a label that was specific enough to distinguish it from nearby experiences (e.g. different types of fractures), but not so specific that we would never get more than one response per category (e.g. “breaking the middle finger in elementary school”). In general, most responses fell into very unambiguous categories (e.g. “When my father passed away” and “Watching my father die and take his last few breaths.” were both classified as “Father death”). About 10% of the responses were relatively ambiguous: it wasn’t clear what the source of the pain or pleasure was. To deal with those responses I used the label “Unspecified”. When some detail was present but ambiguity remained, such as when a broad type of pain or pleasure was mentioned but not the specific source I tagged it as “Unspecified X” where X was a broad category. For example, one person said that “broken bones” was the most painful experience they’ve had, which I labeled as “Unspecified fracture”.


Results

I should preface the following by saying that we are very aware of the lack of scientific rigor in this survey; it remains a pilot exploratory work. We didn’t specify the time-scale for the experiences (e.g. are we asking about the best minute of your life or the best month of your life?) or whether we were requesting instances of physical or psychological pain/pleasures. Despite this lack of constraints it was interesting to see very strong commonalities among people’s responses:

Appearance Base Rates

There were 77 and 124 categories of pleasure and pain identified, respectively. On the whole it seemed like there was a higher diversity of ways to suffer than of ways to experience intense bliss. Summoning the spirit of Tolstoy: “Happy families are all alike; every unhappy family is unhappy in its own way.”

Here are the raw counts for each category with at least two appearances:

pleasure_baserates_97_only_2andup_

Best experiences appearances (with at least two reports)

pain_baserates_97_only_2andup_

Worst experience appearances (with at least two reports)

For those who want to see the full list of number of appearances for each experience mentioned see the bottom of the article (I also clarify some of the more confusing labels there too)**.

A simple way to try to incorporate the information about the ranking is to weight experiences rated as top #1 with 3 points, those as top #2 with 2 points, and those as the top #3 with 1 point. If you do this, the experiences scores are:

pleasure_baserates_97_weighted_

Weighted appearances of best experiences (#1 – 3 points, #2 – 2 points, #3 – 1 point)

pain_baserates_97_weighted_

Weighted appearances of worst experiences (#1 – 3 points, #2 – 2 points, #3 – 1 point)

Average ratings

Given the relatively small sample size, I will only report the mean rating for pain and pleasure (out of 10) for categories of experience for which there were 6 or more respondents:

For pain:

  1. Father death (n = 19): mean 8.53, sd 2.3
  2. Childbirth (n = 16): mean 7.94, sd 2.16
  3. Grandmother death (n = 13): mean 8.12, sd 2.5
  4. Mother death (n = 11): mean 9.4, sd 0.62
  5. Car accident (n = 9): mean 8.42, sd 1.52
  6. Kidney stone (n = 9): mean 5.97, sd 3.17
  7. Migraine (n = 9): mean 5.36, sd 3.11
  8. Romantic breakup (n = 9): mean 7.11, sd 1.52
  9. Broken arm (n = 6): mean 8.28, sd 0.88
  10. Broken leg (n = 6): mean 7.33, sd 2.02
  11. Work failure (n = 6): mean 5.88, sd 3.57

(Note: the very high variance for kidney stones and migraine is partly explained by the presence of some very low responses, with values as low as 1.1/10 – perhaps misreported, or perhaps illustrating the extreme diversity of experiences of migraines and kidney stones).

And for pleasure:

  1. Falling in love (n = 42): mean 8.68, sd 1.74
  2. Children born (n = 41): mean 9.19, sd 1.64
  3. Marriage (n = 21): mean 8.7, sd 1.25
  4. Sex (n = 19): mean 8.72, sd 1.45
  5. College graduation (n = 13): mean 7.73, sd 1.4
  6. Orgasm (n = 11): mean 8.24, sd 1.63
  7. Alcohol (n = 8): mean 6.84, sd 1.59
  8. Vacation (n = 6): mean 9.12, sd 0.73
  9. Getting job (n = 6): mean 7.22, sd 1.47
  10. Personal favorite sports win (n = 6): mean 8.17, sd 1.23

Deference Graph of Top Experiences

We will now finally get to the more exploratory and fun/interesting analysis, at least in that it will generate a cool way of visualizing what causes people great joy and pain. Namely, the idea of using people’s rankings in order to populate a global scale across people and show it in the form of a graph of deferences. While the scientific literature has some studies that compare pain across different categories (e.g. 1, 2, 3) I was not able to find any dataset that included actual rankings across a variety of categories. Hence why it was so appealing to visualize this.

The simplest way of graphing experience deferences is to assign a node to each experience category and add an edge between experiences with deference relationships with a weight proportional to the number of directed deferences. For example, if 4 people have said that A was better than B, and 3 people have said that B was better than A, then there will be an edge from A to B with a weight of 4 and an edge from B to A with a weight of 3. Additionally, we can then run a graph centrality algorithm such as PageRank to see where the “deferences end up pooling”.

The images below do this: the PageRank of the graph is represented with the color gradient (darker shades of green/red representing higher PageRank values for good/bad experiences). In addition, the graphs also represent the number of appearances in the dataset for each category with the size of each node:

The main problem with the approach above is that it double (triple?) counts experiences that are very common. Say that, for example, taking 5-MeO-DMT produces a consistently higher-valence feeling relative to having sex. If we only have a couple of people who report both 5-MeO-DMT and sex as their top experiences, the edge from sex to 5-MeO-DMT will be very weak, and the PageRank algorithm will underestimate the value of 5-MeO-DMT.

In order to avoid the double counting effect of commonly-reported peak experiences we can instead add edge weights on the basis of the proportion with which an experience defers to the other. Let’s say that f(a, b) means “number of times that b is reported as higher than a”. Then the proportion would be f(a, b) / (f(a, b) + f(b, a)). Now, this introduces another problem, which is that pairs of experiences that appear together very infrequently might get a very high proportion score due to a low sample size. In order to prevent this we use Laplace smoothing and modify the equation to (f(a, b) + 1) / (f(a, b) + f(b, a) + 2). Finally, we transform this proportion score from the range of 0 to 1 to the range of -1 to 1 by multiplying by 2 and subtracting one. We call this a “rebalanced smoothed proportion” w(a, b):

CodeCogsEqn

Rebalanced smoothed proportion

I should note that this is not based on any rigorous math. The equation is based on my intuition for what I would expect to see in such a graph, namely a sort of confidence-weighted strength of directionality, but I do not guarantee that this is a principled way of doing so (did I mention this is a pilot small-scale low-budget ‘to a first approximation’ study?). I think that, nonetheless, doing this is still an improvement upon merely using the raw deference counts as the edge weights. To visualize what w(a, b) looks like I graphed its values for a and b in the range of 0 to 20 (literally typing the equation into the google search bar):

To populate the graph I only use the positive edge weights so that we can run the PageRank algorithm on it. This now looks a lot more reasonable and informative as a deference graph than the previous attempts:

pleasure_97_balanced_2

Best experiences deference graph: Edge weights based on the rebalanced smoothed proportions, size of nodes is proportional to number of appearances in the dataset, and the color tracks the PageRank of the graph. Edge color based on source node.

 

pain_network_97_balanced

Worst experiences deference graph: Edge weights based on the rebalanced smoothed proportions, size of nodes is proportional to number of appearances in the dataset, and the color tracks the PageRank of the graph. Edge color based on source node.

By taking the PageRank of these graphs (calculated with NetworkX) we arrive at the following global rankings:

pleasure_pagerank_97_

PageRank of the graph of best experiences with edge weights computed with the rebalanced smoothed proportion equation

pain_pagerank_97__

PageRank of the graph of worst experiences with edge weights computed with the rebalanced smoothed proportion equation

Intuitively this ranking seems more aligned with what I’ve heard before, but I will withhold judgement on it until we have much more data.

Triadic Analysis

With a more populated deference graph we can analyze in detail the degree to which triads (i.e. sets of three experiences such that each of the three possible deferences are present in the graph) show transitivity (cf. Balance vs. Status Theory).

In particular, we should compare the prevalence of these two triads:

triad_analysis

Left: 030T, Right: 030C (source)

The triads above are 030T, which is transitive, and 030C, which is a loop. The higher the degree of agreement between people and the higher the probability of the existence of an underlying shared scale, we would expect to see more triads of the type 030T relative to 030C. That said, a simple ratio is not enough, since the expected proportion between these two triads can be an artifact of the way the graph is constructed and/or its general shape (and hence the importance of comparing against randomized graphs that preserve as many other statistical features as possible). With our graph, we noticed that the very way in which the edges were introduced generated an artifact of a very strong difference between these two types of triads:

In the case of pain there are 105 ‘030T’, and 3 ‘030C’. And for the pleasure questions there were 98 ‘030T’, and 9 ‘030C’. That said, many of these triads are the artifact of taking into account the top three experiences, which already generates a transitive triad by default when n = 1 for that particular triad of experiences. To avoid this artifact, we filtered the graph by only adding edges when a pair of experiences appeared at least twice (and discounting the edges where w(a, b) = 0). With this adjustment we got 2 ‘030T’, and 1 ‘030C’ for the pain questions, and 1 ‘030T’, and 0 ‘030C’ for the pleasure question. Clearly there is not enough data to meaningfully conduct this type of analysis. If we extend the study and get a larger sample size, this analysis might be much more informative.

Latent Trait Ratings

A final approach I tried for deriving a global ranking of experiences was to assume a latent parameter for pain or pleasure of different experiences and treating the rankings as the tournament results of participants with skill equal to this latent trait. So when someone says that an experience of sex was better than an experience of getting a new bike we imagine that “sex” had a match with “getting bike” and that “sex” won that match. If we do this, then we can import any of the many tournament algorithms that exist (such as the Elo rating system) in order to approximate the latent “skill” trait of each experience (except that here it is the “skill” to cause you pleasure or pain, rather than any kind of gaming ability).

Interestingly, this strategy has also been used in other areas outside of actual tournaments, such as deriving university rankings based on the choices made by students admitted to more than one college (see: Revealed Preference Rankings of US Colleges and Universities).

I should mention that the fact that we are asking about peak experiences likely violates some of the assumptions of these algorithms, since the fact that a match takes place is already information that both experiences made it into the top 3. That said, if the patterns of deference are very strong, this might not represent a problem.

To come up with this tournament-style ranking I decided to go for a state-of-the-art algorithm. The one that I was able to find and use was Microsoft Research’s algorithm called TrueSkill (which is employed to rank players in Xbox LIVE). According to their documentation, to arrive at a conservative “leaderboard” that balances the estimated “true skill” and the uncertainty around it, they recommend ranking by the expected skill level minus three times the standard error around this estimate. If we do this, we arrive at the following experience “leaderboards”:

pleasure_97_trueskill_conservative

Conservative TrueSkill scores for best experiences (mu – 3*sigma)

pain_97_trueskill_conservative

Conservative TrueSkill scores for worst experiences (mu – 3*sigma)

Long-tails in Responses to “How Many Times Better/Worse” Question

The survey included four questions aimed at comparing the relative hedonic values of peak experiences: “Relative to the 1st most pleasant experience, how many times better was the 2nd most pleasant experience?” (This was one, the other three were the permutations of also asking about 2nd vs. 3rd and about the bad experiences):

(Note: I’ll ignore the responses to the comparison between the 2nd and 3rd worst pains because I messed up the question -I forgot to substitute “better” for “worse”).

I would understand the skepticism about these graphs. But at the same time, I don’t think it is absurd that for many people the worst experience they’ve had is indeed 10 or 100 times worse than the second worst. For example, someone who has endured a bad Cluster Headache will generally say that the pain of it is tens or hundreds of times worse than any other kind of pain they have had (say, breaking a bone or having skin burns).

The above distributions suggest a long-tail for the hedonic quality of experiences: say that the hedonic quality of each day is distributed along a log-normal distribution. A 45 year old has experienced roughly 17,000 days. Let’s say that such a person’s experience of pain each day is sampled from a log-normal distribution with a Gaussian exponent with a mean of 10 and a standard deviation of 5. If we take 100 such people, and for each of them we take the single worst and the second worst days of their lives, and then take the ratio between them, we will have a distribution like this (simulated in R):

If you smooth the empirical curves above you would get a distribution that looks like these simulations. You really need a long-tail to be able to get results like “for 25% of the participants the single worst experience was at least 4 times as bad as the 2nd worst experience.” Compare that to the sort of pattern that you get if the distribution was normal rather than log-normal:

As you can see (zooming in on the y-axis), the ratios simply do not reach very high values. With the normal distribution simulated here, we see that the highest ratio we achieve is around 1.3, as opposed to the empirical ratios of 10+.*** If you are inclined to believe the survey responses- or at least assign some level of credibility to the responses in the 90th-percentile and below-, the data is much more consistent with a long-tail distribution for hedonic values relative to a normal distribution.

Discussion

Key Pleasures Surfaced

Birth of children

I have heard a number of mothers and father say that having kids was the best thing that ever happened to them. The survey showed this was a very strong pattern, especially among women. In particular, a lot of the reports deal with the very moment in which they held their first baby in their arms for the first time. Some quotes to illustrate this pattern:

The best experience of my life was when my first child was born. I was unsure how I would feel or what to expect, but the moment I first heard her cry I fell in love with her instantly. I felt like suddenly there was another person in this world that I cared about and loved more than myself. I felt a sudden urge to protect her from all the bad in the world. When I first saw her face it was the most beautiful thing I had ever seen. It is almost an indescribable feeling. I felt like I understood the purpose and meaning of life at that moment. I didn’t know it was possible to feel the way I felt when I saw her. I was the happiest I have ever been in my entire life. That moment is something that I will cherish forever. The only other time I have ever felt that way was with the subsequent births of my other two children. It was almost a euphoric feeling. It was an intense calm and contentment.

—————

I was young and had a difficult pregnancy with my first born. I was scared because they had to do an emergency c-section because her health and mine were at risk. I had anticipated and thought about how the moment would be when I finally got to hold my first child and realize that I was a mother. It was unbelievably emotional and I don’t think anything in the world could top the amount of pleasure and joy I had when I got to see and hold her for the first time.

—————

I was 29 when my son was born. It was amazing. I never thought I would be a father. Watching him come into the world was easily the best day of my life. I did not realize that I could love someone or something so much. It was at about 3am in the morning so I was really tired. But it was wonderful nonetheless.

—————

I absolutely loved when my child was born. It was a wave of emotions that I haven’t felt by anything before. It was exciting and scary and beautiful all in one.

No luck for anti-natalists… the super-strong drug-like effects of having children will presumably continue to motivate most humans to reproduce no matter how strong the ethical case against doing so may be. Coming soon: a drug that makes you feel like “you just had 10,000 children”.

Falling in Love

The category of “falling in love” was also a very common top experience. I should note that the experiences reported were not merely those of “having a crush”, but rather, they typically involved unusually fortunate circumstances. For instance, a woman reported being friends with her crush for 7 years. She thought that he was not interested in her, and so she never dared to confess her love for him… until one day, out of the blue, he confessed his love for her. Other experiences of falling in involve chance encounters with childhood friends that led to movie-deserving romantic escapades, forbidden love situations, and cases where the person was convinced the lover was out of his or her league.

Travel/Vacation

The terms “travel” and “vacation” may sound relatively frivolous in light of some of the other pleasures listed. That said, these were not just any kind of travel or vacation. The experiences described do seem rather extraordinary and life-changing. For example, talking about back-packing alone in France for a month, biking across the US with your best friend, or a long trip in South East Asia with your sibling that goes much better than planned.

MDMA/LSD/Psilocybin

It is significant that out of 97 people four of them listed MDMA as one of the most pleasant experiences of their lives. This is salient given the relatively low base rate of usage of this drug (some surveys saying about 12%, which is probably not too far off from the base rate for Mechanical Turk workers using MDMA). This means that a high percentage of people who have tried MDMA will rate it as as one of their top experiences, thus implying that this drug produces experiences sampled from an absurdly long-tailed high-valence distribution. This underscores the civilizational significance of inventing a method to experience MDMA-like states of consciousness in a sustainable fashion (cf. Cooling It Down To Partying It Up).

Likewise, the appearance of LSD and psilocybin is significant for the same reason. That said, measures of the significance of psychedelic experiences in psychedelic studies have shown that a high percentage of those who experience such states rate them among their top most meaningful experiences.

About-two-thirds-of-participants-who-received-psilocybin-reported-a-mystical-experience

Games of Chance Earnings

Four participants mentioned earnings in games of chance. These cases involved earning amounts ranging from $2,000 all the way to a truck (which was immediately sold for money). What I find significant about this is that these experiences are at times ranked above “college graduation” and other classically meaningful life moments. This brings about a crazy utilitarian idea: if indeed education is as useless as many people in the intellectual elite are saying these days (ex. The Case Against Education) we might as well stop subsidizing higher education and instead make people participate in opt-out games of chance rigged in their favor. Substitute the Department of Education for a Department of Lucky Moments and give people meaningful life experiences at a fraction of the cost.

Key Pains Surfaced

Kidney Stones and Migraines

The fact that these two medical issues were surfaced is, I think, extremely significant. This is because the lifetime incidence of kidney stones is about 10% (~13% for men, 7% for women) and for migraines it is around 13% (9% for men, 18% for women). In the survey we saw 9/93 people mentioning kidney stones, and the same number of people mentioning migraines. In other words, there is reason to believe that a large fraction of the people who have had either of these conditions will rate them as one of their top 3 most painful experiences. This fact alone underscores the massive utilitarian benefit that would come from being able to reduce the incidence of these two medical problems (luckily, we have some good research leads for addressing these problems at a large scale and in a cost-effective way: DMT for migraines, and frequency specific microcurrent for kidney stones)

Childbirth

Childbirth was mentioned 16 times, meaning that roughly 30% of women rate it as one of their three most painful experiences. While many people may look at this and simply nod their heads while saying “well, that’s just life”, here at Qualia Computing we do not condone that kind of defeatism and despicable lack of compassion. As it turns out, there are fascinating research leads to address the pain of childbirth. In particular, Jo Cameron, a 70 year old vegan schoolteacher, described her childbirth by saying that it “felt like a tickle”. She happens to have a mutation in the FAAH gene, which is usually in charge of breaking down anandamine (a neurotransmitter implicated in pain sensitivity and hedonic tone). As we’ve argued before, every child is a complete genetic experiment. In the future, we may as well try to at least make educated guesses about our children’s genes associated with low mood, anxiety, and pain sensitivity. In defiance of common sense (and the Bible) the future of childbirth could indeed be one devoid of intense pain.

Car accidents

Car accidents are extremely common (the base rate is so high that by the age of 40 or so we can almost assume that most people have been in at least one car accident, possibly multiple). More so, it seems likely that the health-damaging effects of car accidents, by their nature, follow a long-tail distribution. The high base rate of people mentioning car accidents in their top 3 most painful experiences underscores the importance of streamlining the process of transitioning into the era of self-driving cars.

Death of Father and Mother

This one does not come as a surprise, but what may stand out is the relatively higher frequency of mentions of “death of father” relative to “death of mother”. I think this is an artifact of the longevity difference between men and women. This is in agreement with the observed effect of age: about 15% vs. 25% of people under and over 40 had mentioned the death of their father, as opposed to a difference of 5% vs. 25% for death of mother. The reason why the father might be over-represented might simply be due to the lower life expectancy of men relative to women, and hence the father, on average, dying earlier. Thus, it being reported more frequently by a younger population.

Future Directions for Methodological Approaches:

Graphical Models with Log-normal Priors

After trying so many analytic angles on this dataset, what else is there to do? I think that as a proof of concept the analysis presented here is pretty well-rounded. If the Qualia Research Institute does well in the funding department, we can expect to extend this pilot study into a more comprehensive analysis of the pleasure-pain axis both in the general population and among populations who we know have endured or enjoyed extremes of valence (such as cluster headache sufferers or people who have tried 5-MeO-DMT).

In terms of statistical models, an adequate amount of data would enable us to start using probabilistic graphical models to determine the most likely long-tail distributions for all of the key parameters of pleasure and pain. For instance, we might want to develop a model similar to Item Response Theory where:

  1. Each participant samples experiences from a distribution.
  2. Each experience category generates samples with an empirically-determined base rate probability (e.g. chances that it happens in a given year), along with a latent hedonic value distribution.
  3. A “discrimination function” f(a, b) that gives the probability that experience of hedonic value a is rated as more pleasant (or painful) relative an experience with a hedonic value of b.
  4. And a generative model that estimates the likelihood of observing experiences as the top 3 (or top x) based on the parameters provided.

In brief, with an approach like the above we can potentially test the model fit for different distribution types of hedonic values per experience. In particular, we would be able to determine if the model fit is better if the experiences are drawn from a Gaussian vs. a log-normal (or other long-tailed) distribution.

Finally, it might be fruitful to explicitly ask about whether participants have had certain experiences in order to calibrate their ratings, or even have them try a battery of standardized pain/pleasure-inducing stimuli (capsaicin extract, electroshocks, stings, massage, orgasm, etc.). We could also find the way to combine (a) the numerical ratings, (2) the ranking information, and (3) the “how many times better/worse” responses into a single model. And for best results, restrict the analysis to very recent experiences in order to reduce recall biases.

Closing Thoughts on the Valence Scale

To summarize, I believe that the case for a long-tail account of the pleasure-pain axis is very defensible. This picture is supported by:

  1. The long-tailed nature of neuronal cascades,
  2. The phenomenological accounts of intense pleasure and pain (w/ phenomenological accounts of time and space expansion),
  3. The way in which pain scales are constructed by those who developed them, and
  4. The analytic results of the pilot study we conducted and presented here.

In turn, these results give rise to a new interpretation of psychophysical observations such as Weber’s Law. Namely, that Just Noticeable Differences may correspond to geometric differences in qualia, not only in sensory stimuli. That is, that the exponential nature of many cases where Weber’s Law appears are not merely the result of a logarithmic compression on the patterns of stimulation at the “surface” of our sense organs. Rather, the observations presented here suggest that these long-tails deal directly with the quality and intensity of conscious experience itself.


Additional Material

Dimensionality of Pleasure and Pain

Pain and pleasure may have an intrinsic “dimensionality”. Without elaborating, we will merely state that a generative definition for the “dimensionality of an experience” is the highest “virtual dimension” implied by the patterns of correlation between degrees of freedom. The hot pepper hands account I related suggested a kind of dimensional phase transition between 4/10 and 5/10 pain, where the patterns of a certain type (4/10 “sparks” of pain) would sometimes synchronize and generate a new type of higher-dimensional sensation (5/10 “solitons” of pain). To illustrate this idea further:

First, in Hot Ones, Kumail Nanjiani describes several “leaps” in the spiciness of the wings, first at around 30,000 Scoville (“this new ghost that appears and only here starts to visit you”), and second at around 130k Scoville (paraphrasing: “like how NES to Super Nintendo felt like a big jump, but then Super Nintendo to N64 was an even bigger leap” – “Now we are playing in the big leagues motherfucker! This is fucking real!”). This hints at a change in dimensionality, too.

And second, Shinzen Young‘s advice about dealing with pain involves not resisting it. He discusses how suffering is generated by the coordination between emotional, cognitive, and physical mental formations. If you can keep each of these mental formations happening independently and don’t allow their coordinated forms, you will avoid some of what makes the experience bad. This also suggests that higher-dimensional pain is qualitatively worse. Pragmatically, training to do this may make sense for the time being, since we are still some years away from sustainable pain-relief for everyone.

Mixed States

We have yet to discuss in detail how mixed states come into play for a log-normal valence scale. The Symmetry Theory of Valence would suggest that most states are neutral in nature and that only processes that reduce entropy locally such as neural annealing would produce highly-valenced states. In particular, we would see that high-valence states have very negative valence states nearby in configuration space; if you take a very good high-energy state and distort it in a random direction it will likely feel very unpleasant. The points in between would be mixed valence, which account for the majority of experiences in the wild.

Qualia Formalism

Qualia Formalism posits that for any given system that sustains experiences, there is a mathematical object such that the mathematical features of that object are isomorphic to the system’s phenomenology. In turn, Valence Structuralism posits that the hedonic nature of experience is encoded in a mathematical feature of this object. It is easier to find something real if you posit that it exists (rather than try to explain it away). We have suggested in the past that valence can be explained in terms of the mathematical property of symmetry, which cashes out in the form of neural dissonance and consonance.

In contrast to eliminativist, illusionist, and non-formal approaches to consciousness, at QRI we simply start by assuming that experience has a deep ground truth structure and we see where we can go from there. Although we currently lack the conceptual schemes, science, and vocabulary needed to talk in precise terms about different degrees of pleasure and pain (though we are trying!), that is not a good reason to dismiss the first-person claims and indirect pieces of evidence concerning the true amounts of various kinds of qualia bound in each moment of experience. If valence does turn out to intrinsically be a mathematical feature of our experience, then both its quality and quantity could very well be precisely measurable, conceptually crisp, and tractable. A scientific fact that, if proven, would certainly have important implications in ethics and meta-ethics.


Notes:

* It’s a shame that Coyote Peterson didn’t rate the pain produced by the various wings he ate on the Hot Ones show relative to insect stings, but that sort of data would be very helpful in establishing a universal valence scale. More generally, stunt-man personalities like the L.A. Beast who subject themselves to extremes of negative valence for Internet points might be an untapped gold mine for experience deference data (e.g. How does eating the most bitter substance known compare with the bullet ant glove? Asking this guy might be the only way to find out, without creating more casualties).

**Base rate of mentions of worst experiences:

[('Father death', 19), ('Childbirth', 16), ('Grandmother death', 13), ('Mother death', 11), ('Car accident', 9), ('Kidney stone', 9), ('Migraine', 9), ('Romantic breakup', 9), ('Broken arm', 6), ('Broken leg', 6), ('Work failure', 6), ('Divorce', 5), ('Pet death', 5), ('Broken foot', 4), ('Broken ankle', 4), ('Broken hand', 4), ('Unspecified', 4), ('Friend death', 4), ('Sister death', 4), ('Skin burns', 3), ('Skin cut needing stitches', 3), ('Financial ruin', 3), ('Property loss', 3), ('Sprained ankle', 3), ('Gallstones', 3), ('Family breakup', 3), ('Divorce of parents', 3), ('C-section recovery', 3), ('Love failure', 2), ('Broken finger', 2), ('Unspecified fracture', 2), ('Broken ribs', 2), ('Unspecified family death', 2), ('Broken collarbone', 2), ('Grandfather death', 2), ('Unspecified illness', 2), ('Period pain', 2), ('Being cheated', 2), ('Financial loss', 2), ('Broken tooth', 2), ('Cousin death', 2), ('Relative with cancer', 2), ('Cluster headache', 2), ('Unspecified leg problem', 2), ('Root canal', 2), ('Back pain', 2), ('Broken nose', 2), ('Aunt death', 2), ('Wisdom teeth', 2), ('Cancer (eye)', 1), ('Appendix operation', 1), ('Dislocated elbow', 1), ('Concussion', 1), ('Mono', 1), ('Sexual assault', 1), ('Kidney infection', 1), ('Hemorrhoids', 1), ('Tattoo', 1), ('Unspecified kidney problem', 1), ('Unspecified lung problem', 1), ('Unspecified cancer', 1), ('Unspecified childhood sickness', 1), ('Broken jaw', 1), ('Broken elbow', 1), ('Thrown out back', 1), ('Lost sentimental item', 1), ('Abortion', 1), ('Ruptured kidney', 1), ('Big fall', 1), ('Torn knee', 1), ('Finger hit by hammer', 1), ('Injured thumb', 1), ('Brother in law death', 1), ('Knocked teeth', 1), ('Unspecified death', 1), ('Ripping off fingernail', 1), ('Personal anger', 1), ('Wrist pain', 1), ('Getting the wind knocked out', 1), ('Blown knee', 1), ('Burst appendix', 1), ('Tooth abscess', 1), ('Tendinitis', 1), ('Altruistic frustration', 1), ('Leg operation', 1), ('Gallbladder infection', 1), ('Broken wrist', 1), ('Stomach flu', 1), ('Running away from family', 1), ('Child beating', 1), ('Sinus infection', 1), ('Broken thumb', 1), ('Family abuse', 1), ('Miscarriage', 1), ('Tooth extraction', 1), ('Feeling like your soul is lost', 1), ('Homelessness', 1), ('Losing your religion', 1), ('Losing bike', 1), ('Family member in prison', 1), ('Crohn s disease', 1), ('Irritable bowel syndrome', 1), ('Family injured', 1), ('Unspecified chronic disease', 1), ('Fibromyalgia', 1), ('Blood clot in toe', 1), ('Infected c-section', 1), ('Suicide of lover', 1), ('Dental extraction', 1), ('Unspecified partner abuse', 1), ('Infertility', 1), ('Father in law death', 1), ('Broken neck', 1), ('Scratched cornea', 1), ('Swollen lymph nodes', 1), ('Sun burns', 1), ('Tooth ache', 1), ('Lost custody of children', 1), ('Unspecified accident', 1), ('Bike accident', 1), ('Broken hip', 1), ('Not being loved by partner', 1), ('Dog bite', 1), ('Broken skull', 1)]

Base rate of mentions of best experiences:

[('Falling in love', 42), ('Children born', 41), ('Marriage', 21), ('Sex', 19), ('College graduation', 13), ('Orgasm', 11), ('Alcohol', 8), ('Vacation', 6), ('Getting job', 6), ('Personal favorite sports win', 6), ('Nature scene', 5), ('Owning home', 5), ('Sports win', 4), ('Graduating highschool', 4), ('MDMA', 4), ('Getting paid for the first time', 4), ('Amusement park', 4), ('Game of chance earning', 4), ('Job achievement', 4), ('Getting engaged', 4), ('Cannabis', 3), ('Eating favorite food', 3), ('Unexpected gift', 3), ('Moving to a better location', 3), ('Travel', 3), ('Divorce', 2), ('Gifting car', 2), ('Giving to charity', 2), ('LSD', 2), ('Won contest', 2), ('Friend reunion', 2), ('Winning bike', 2), ('Kiss', 2), ('Pet ownership', 2), ('Children', 1), ('First air trip', 1), ('First kiss', 1), ('Public performance', 1), ('Hugs', 1), ('Unspecified', 1), ('Recovering from unspecified kidney problem', 1), ('College party', 1), ('Graduate school start', 1), ('Financial success', 1), ('Dinner with loved one', 1), ('Feeling supported', 1), ('Children graduates from college', 1), ('Family event', 1), ('Participating in TV show', 1), ('Psychedelic mushrooms', 1), ('Opiates', 1), ('Having own place', 1), ('Making music', 1), ('Becoming engaged', 1), ('Theater', 1), ('Extreme sport', 1), ('Armed forces graduation', 1), ('Birthday', 1), ('Positive pregnancy test', 1), ('Feeling that God exists', 1), ('Belief that Hell does not exist', 1), ('Getting car', 1), ('Academic achievement', 1), ('Helping others', 1), ('Meeting soulmate', 1), ('Daughter back home', 1), ('Winning custody of children', 1), ('Friend stops drinking', 1), ('Masturbation', 1), ('Friend not dead after all', 1), ('Child learns to walk', 1), ('Attending wedding of loved one', 1), ('Children safe after dangerous situation', 1), ('Unspecified good news', 1), ('Met personal idol', 1), ('Child learns to talk', 1), ('Children good at school', 1)]

For clarity – “Personal favorite sports win” means that the respondent was a participant in the sport as opposed to a spectator (which was labeled as “Sports win”). The difference between “Sex” and “Orgasm” is that Sex refers to the entire act including foreplay and cuddles whereas Orgasm refers to the specific moment of climax. For some reason people would either mention one or the other, and emphasize very different aspects of the experience (e.g. intimacy vs. physical sensation) so I decided to label them differently.

*** It is possible that some fine-tuning of parameters could give rise to long-tail ratios even with a normal distribution (especially if the mean is, say, a negative value and the standard deviation is very wide). But in the general case a normal distribution will have a fairly narrow range for the ratios of the “top value divided by the second top value”. So at least as a general qualitative argument, I think, the simulations do suggest a long-tailed nature for the reported hedonic values.

Get-Out-Of-Hell-Free Necklace

An approach to doing good is to come up with a metric for what constitutes good or bad, and then trying to do things that will optimally increase or decrease such metric, as the case may be.

If you do this, you have to be careful about what metric you choose.

If you have an ontology where you measure good by “number of people who feel benefited by you”, you might end up doing things like sending everyone you can a doughnut with a signed note. If instead your metric is “number of people classified as poor” you might do best to focus on interventions that get people just over the hump of poverty as defined by your scale. And so on.

Conscientious and systematic altruists tend to see problems with metrics like those above. They realize that “people impressed” and “being poor according to an economic metric” are not metrics that really carve nature at its joints.

Dissatisfied with misleading metrics, one then tends to look closer at the world and arrive at metrics that take into account the length of different lives, their quality, their instrumental effect in the world, how much are they exactly being benefited by the intervention relative to other cost-effective alternatives, and so on. And that’s how you get things like Quality Adjusted Life-Years (QALY), micromorts, and the happiness index.

This is, I think, all moving in the right direction. Metrics that make an effort to carve nature at its joints can provide new lenses to see the world. And looking through those lenses tends to generate novel angles and approaches to do a lot of good.


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This is why today I will suggest we consider a new metric: The Hell-Index.

A country’s Hell-Index could be defined as the yearly total of people-seconds in pain and suffering that are at or above 20 in the McGill Pain Index (or equivalent)*. This index captures the intuition that intense suffering can be in some ways qualitatively different and more serious than lesser suffering in a way that isn’t really captured by a linear pain scale.

What does this metric suggest we should do to make the world better? Here is an idea (told as if narrated from the future):


Between 2030 and 2050 it was very common for people to wear Get-Out-Of-Hell-Free Necklaces. People had an incredible variety of custom-fit aesthetic and practical additives to their necklaces. But in every single one of them, you could rest assured, you would find a couple of doses of each of these agents:

  1. N,N-DMT (in case of Cluster Headaches)
  2. Quetiapine (in case of severe acute psychosis)
  3. Benzocaine + menthol (for very painful stings)
  4. Ketamine (for severe suicidal feelings)
  5. Microdosed Ibogaine + cocktail of partial mu-opioid agonists (for acute severe physical pain and panic attack, e.g.. kidney stones)

Some other people would get additional things like:

  1. Beta blocker (to take right after a traumatic event)
  2. Agmatine (to take in case you suspect of having being brainwashed recently), and
  3. Caffeine (if you absolutely need to operate heavy machinery and you are sleep-deprived)

In all cases, the antidote needed would be administered as soon as requested by the wearer. And the wearer would request the antidote as indicated by a very short test done with an app to determine the need for it.

But why? What’s this all about?

The Get-Out-Of-Hell-Free Necklace contents were chosen based on a cost-benefit analysis for how to reduce the world’s Hell-Index as much as possible. Cluster-headaches, kidney stones, bad stings, severe psychotic episodes, suicidal depression, panic attacks, and many types of acute physical pain turned out to account for a surprisingly large percentage of each country’s Hell-Index. And in many of these cases, a substantial amount of the suffering was experienced before medical help could be able to arrive to the scene and do anything about it. A lot of that intense suffering happened to be tightly concentrated in acute episodes rather than in chronic problems (save for some notable examples). And by incredible luck, it turned out that there were simple antidotes to most of these states of agony, all of them small enough to fit in a single light necklace. So it was determined that subsidizing Get-Out-Of-Hell-Free Necklaces was a no-brainer as a cost-effective altruistic intervention.


By 2050 safe and cheap genetic vaccines against almost all of these unpleasant states of consciousness had been discovered. This, in turn, made the use of the Get-Out-Of-Hell-Free Necklaces unnecessary. But many who benefited from it- who had been unlucky enough to have needed it- kept it on for many years. The piece was thought of as a symbol to commemorate humanity’s progress in the destruction of hell. An achievement certainly worth celebrating.



* Admittedly, a more refined index would also distinguish between the intensity of different types of pain/suffering above 20 in the McGill Pain Index (or equivalent). Such index would try to integrate a fair “total amount of hellish qualia” by adding up the pain of each state weighted by its most likely “true intensity” as determined by a model, and then do so for each model you have and weight the contribution of each model by its likelihood. E.g. do both a quadratic and an exponential conversion of values in the 0 to 10 visual analogue scale into dolors per second, and then do a likelihood-weighted average to combine those results into a final value.

Top 10 Qualia Computing Articles

As of June 2019

Some Qualia Computing articles stand out as particularly novel, hopeful, and consequential. Below I provide a brief introduction to the top 10 articles (in descending order) written so far*:

10. The Resonance and Vibration of [Phenomenal] Objects

 

This serious article starts with a wacky quote from an alleged clairvoyant couple. They describe the way that objects “feel like” in the “etheric plane of existence”. Don’t be discouraged by the woo in the quote – the article uses it to point out real properties of experience that are rarely talked about outside of spiritual contexts. As is the case in many spiritual circles, the dramatic other-worldly experiences people talk about concerning spiritual realms have an important kernel of truth, at least with regards to phenomenology.

The analysis section compares the descriptions of the etheric-plane experiences described in the quote with free-wheeling hallucinations. A free-wheeling hallucination is a state of mind usually triggered by combining psychedelics and dissociatives, where one can willfully create arbitrary phenomenal objects, akin to a very intense but more controllable version of a lucid dream. In that state, one can analyze the resonance properties of the objects and contexts one chooses to hallucinate. Indeed, one can have startling experiences where each object has a certain musical signature! Above all, this sort of research can be useful to find structural artifacts in the way objects acquire pleasant and unpleasant qualities. As it turns out, more symmetrical objects sound better on those states. This is an important datapoint that we shouldn’t dismiss!

9. 24 Predictions for the Year 3000 by David Pearce

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At Victoria Manalo Draves Park in SF. (2018)

David Pearce is the co-founder of the World Transhumanist Association and the writer of the book-length manifesto The Hedonistic Imperative (1995). He’s been in the trenches of transhumanism since the 90s, building a web-empire of essays and hyperlinks, always courageously advocating for the elimination of suffering (“the world’s last unpleasant experience will be a precisely dateable event”).

David has been a huge influence on my way of thinking. I first encountered his essays when I was 17 years old and my reaction was “OMG! At least one person is saying sane things on the internet!” To start with, David is one of the few people to have recognized the very core of what is fundamentally wrong in the world. Namely, our reward circuitry. We are miserable not because we are unwise, impulsive, resentful, or addicted to technology. On the contrary! We are those things because we are not naturally happy. Our reward circuitry is rigged against us being happy and motivated in the long term, and no peripheralist approach will ever truly fix this problem. We must address the problem at the very root, and fix our neurological architecture with transhumanist technologies.

His view is that in the future it will be strictly irrational to take any kind of drug, not because we will know better or because we will be boring and conformist, but because we will already be naturally super-happy. This really struck a chord with me:

Fortunately, over the next few centuries humanity will be able to outwit its ancient genetic masters. Our present status as throwaway genetic vehicles will finally be subverted. When gradients of heavenly well-being become the genetically predestined norm of mental health, then the very notion of tampering with our new-won “natural” condition and feeling “drugged” may come to seem immoral. It may also seem perverse. Why should anyone want to contaminate the divine ecstasy of their spirituo-biological soul-stuff with chemical pollutants? No thanks.

The Good Drug Guide, David Pearce

Nowadays most people have a rather bleak view of the future. And while David is not very optimistic about the prospects of avoiding terrible wars in the 21st century, he nonetheless offers powerful arguments for why in the long run humanity is headed towards a world animated by gradients of superhuman bliss.

I’ve been friends with him since 2011, when I invited him to give a talk at Stanford. More recently, he came to SF last year to give presentations about his predictions for the year 3000 (e.g. see his presentation at Foresight; slides). This article is the source of those presentations.

(In retrospect, and in light of David’s predictions… we could say that the Jonas Brothers were rather conservative in their forecast for the year 3,000).

8. Burning Man Theme-Camps of the Year 2029: From Replicator to Rainbow God (1/2)

 

This is a work of fiction that imagines what theme camps at Burning Man might look like in the year 2029. This was written as an exercise in exploring which comprehensive ideologies will be alive and thriving 10 years from now. Some of them include microlife-based longevity lifestyles (Longevity Camp), a quasi-religious quest to explore the entire state-space of consciousness (Camp Rainbow God), and our very own boss-level rational hedonism worldview, which seeks to uncover the fundamental nature of bliss and optimize experiences for its maximum possible expression (Valence Camp).

7. The Pseudo-Time Arrow: Explaining Phenomenal Time With Implicit Causal Structures In Networks Of Local Binding

 

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This article deals with time. More specifically, the experience of the passage of time. Any theory of consciousness should be able to explain the nature of our everyday modes of being. But in addition, for the theory to be real and complete, it must also be able to make formal models of exotic experiences. This article examines how exotic experiences of time could be explained if we model experiences as graphs, and the feeling of time as the implicit direction of causality in such graphs. In particular, with this model we can explain odd experiences such as looping, time branching, moments of eternity, and atemporal states (which are often experienced during meditation and/or psychedelic states).

6. Ontological Qualia: The Future of Personal Identity

 

This article talks about the big-picture views of who we all are, and how on earth you find yourself as the person reading this very sentence right now rather than being someone else (!). The article provides some speculations about the evolutionary benefits of different views of personal identity (e.g. believing “we are all one” can be beneficial for super-organisms to arise because people with such a belief would be more willing to radically change their state of consciousness and share information with others).

5. Quantifying Bliss: Talk Summary

 

 

What is pleasure? What is pain? Ask a pharmacologist and they will tell you pleasure and pain are the result of various concentrations of serotonin, dopamine, and endorphins in the brain. Ask a neurophysiologist and they’ll tell you pleasure and pain are the result of the degree of activation of the pleasure centers and the amygdala in the brain. Ask an AI researcher and they’ll tell you pleasure and pain are the reward signals of a reinforcement learning algorithm implemented by the brain. Ask a life-coach, and they’ll tell you that pleasure and pain are the result of your life’s circumstances such as the quality of your friendships, your engagement at work, and your sense of meaning.

There is a kernel of truth in every one of the responses above, but they all miss the mark somehow. They are saying what pleasure and pain is correlated with, but not what their underlying true essence is.

In this article we advance a fundamental theory of valence (the pleasure-pain axis) built from first principles and which makes precise, empirically testable, predictions. The theory is based on Michael Johnson‘s hypothesis that valence is fundamentally related to symmetry (technically: the degree of symmetry of the mathematical object whose features are isomorphic to a system’s phenomenology; see: Symmetry Theory of Valence) and Selen Atasoy‘s recent work on quantifying the brain’s natural connectome-specific harmonic waves. Combining these two paradigms we can come up with an actual quantitative equation for the overall macroscopic symmetry of a brain state, and in turn, predict how good or bad a given experience will feel. We are currently working on setting up the experiment to empirically test this theory.

4. How to secretly communicate with people on LSD

 

This is an article about how to encode information in brief animations that people high on psychedelic drugs can easily decode but sober people cannot. The main trick discussed is the use of visual psychedelic effects (such as tracers) in order to accumulate information across time that would otherwise get erased on a sober state. I coined the term psychedelic cryptography in this piece to describe the set of techniques that enable this kind of secure communication.

3. Wireheading Done Right: Stay Positive Without Going Insane

 

In any case, wouldn’t we get bored of life-long bliss?

Apparently not. That’s what’s so revealing about wireheading. Unlike fooddrink or sex, the experience of pleasure itself exhibits no tolerance, even though our innumerable objects of desire certainly do so. Thus we can eventually get bored of anything – with a single exception. Stimulation of the pleasure-centres of the brain never palls.

– David Pearce, Wirehead Hedonism versus Paradise Engineering

Why can’t we all be happy all the time? The short answer is: because the negative feedback dynamics of our reward circuitry won’t allow us to. For deep evolutionary reasons, we’ve inherited an emotional system prone to generate very negative states of consciousness. Evolutionarily adaptive mental states such as jealousy, hatred, anxiety, despair, and frustration could be like our cravings for sugar and fat – an artifact of our calorie-deficient past. Today, with the abundance of food and positive-sum opportunities, it makes sense to rethink the necessity of preserving our ability to experience suffering. Critically, direct electrical stimulation to our pleasure centers shows that lifelong bliss is physiologically possible. Meaning, that the brain’s endless capacity to get bored of anything is not a match against electric (as opposed to chemical) inputs.

The question then becomes – how do we stay happy without compromising other things of value? This article discusses some of the main pitfalls of life-long bliss. Namely: (1) that trying to achieve it while ignoring negative feedback backfires, (2) that it makes you prone to get stuck in small behavioral attractors, and (3) that hyper-motivation could empower entities who do not care about the wellbeing of other sentient beings.

The article proposes a number of potential solutions to these pitfalls. In particular, rather than wireheading by reducing the development of physiological tolerance to specific forms of bliss (which leads to the problems outlined), we could instead wirehead in such a way that every type of bliss leads to transient habituation while at the same time making it easier to experience different types of bliss. Thus, a person who has wireheaded in this way would constantly experience extremely blissful states, but constantly change which type of bliss is being experienced. From hyper-motivated focused states, to hyper-relaxed restful states, to hyper-creative high-energy states, the person in question would maintain the ability to interact with the world productively without ever having to experience a negative state.

2. Beyond Turing: A Solution to the Problem of Other Minds Using Mindmelding and Phenomenal Puzzles

 

How do we know that other people are conscious? Is there any undeniable evidence against solipsism? These questions have been asked for ages, but convincing solutions are lacking. If indeed other brains are haunted with inner experiences then in some sense we all are profoundly ignorant of that aspect of the world. We can speculate about the experiences of other sentient beings, but what do we really know about them? How can we definitively verify that someone indeed has a rich subjective experience independently of you?

Well, first consider that there already exists a sort of proof of concept for mindmelding in the form of the thalamic bridge between the brains of the Hogan sisters. According to some reports, they are able to feel each other’s sensations:

Tatiana hates ketchup; Krista loves it. Krista scrapes the breading off her chicken McNuggets; Tatiana likes the breading. Specialists speculate that somehow they can selectively block out sensory input from the other. Ketchup, however, is different: Tatiana hates it so much she screams if Krista eats it.

– Denise Ryan, Through Her Sister’s Eyes

Now, exactly what the boundary around each of their experiences is remains a mystery. But for the sake of the argument, let us assume that someday we create a reversible inter-thalamic bridge that we can use to temporarily become one with one another. As pointed out by some philosophers, this alone would not be proof that the person one is mindmelding with is independently conscious. It would certainly be evidence, but can we do better? This article provides an additional piece of the puzzle. Namely, it discusses the possibility of using puzzles that can only be solved by making comparisons between the qualia values of our experience. The precise protocol for the experiment is a bit subtle, so I won’t reproduce it here – read the article and watch the video for a detailed explanation.

1. The Hyperbolic Geometry of DMT Experiences: Symmetries, Sheets, and Saddled Scenes

 

This is, in my opinion, the best article I have written up to now. Why? In brief: because it advances the completely new hypothesis that a large part of what makes the state of consciousness induced by N,N-DMT (aka. “the spirit molecule”) so mysterious, confusing, and bewilderingly bizarre can be explained in terms of a change in the geometry of the phenomenal space one experiences during the trip. The article goes beyond merely making this claim, provides a number of reasons why, and discusses plausible mechanisms of action for this effect. Of note is the fact that the symmetrical texture repetition one sees on a high enough dose of DMT is non-Euclidean. Indeed, the symmetries experienced on that state are hyperbolic in a strict mathematical sense. So unlike trip reports from people who merely say e.g. “I saw a lot of symmetries!” this article zooms in on precisely which symmetries arise, and infers that they imply a change of curvature that is not possible in normal everyday states of consciousness.

Most people who try DMT come back to consensus reality with new and outlandish beliefs about higher dimensions, otherworldly entities, telepathy, and even life after death. Because most people who are willing to talk about their experiences- and the interpretation they have about those experiences- do not make sense to the scientifically-educated, serious thinkers tend to dismiss the significance of this state. But with the analytic angle of this article, we can actually start making solid progress on characterizing the properties of the surreal states of consciousness found in the DMT-verse.

When it comes to psychedelic theory, at Qualia Computing we focus on the phenomenal character of the experience rather than on its intentional content. You see, it is far less useful to know that you saw a dragon capable of barfing liquid nitrogen during your trip than it is to point out that its body was covered with a patterning with a wallpaper symmetry group of the *632 type. It is this level of attention to detail in phenomenology that actually advances our understanding.

The article concludes with a bold prediction: that if indeed N,N-DMT allows you to experience hyperbolically-curved phenomenal space, then a lot of future breakthroughs in pure math will be arrived at by serious mathematicians exploring such altered states in a systematic way. I stand by this prediction.


I will also link to some honorary mentions – There are three high-quality trip reports submitted by Qualia Computing readers that showcase the usefulness of being acquainted with the QC memeplex in order to rationally make sense of otherwise seemingly ineffable experiences (personally I found it really interesting to see Qualia Computing concepts be fire-tested in real life by being applied to the alien state-spaces of consciousness these readers experienced). The trip reports are for LSD, 2C-B, and 4-AcO-DMT.

Another set of related articles important to highlight involves one-off descriptions of research leads that could have huge collective hedonic payoffs if carried out. That is, there are many low-hanging fruit research projects that could lead to revolutionary interventions to reduce suffering and enhance our quality of life. These are:

  1. Anti-Tolerance Drugs (Surprisingly, substances exist that, when taken in conjunction with euphoric drugs, prevent the development of tolerance, and this could have game-changing implications for the treatment of chronic pain and addiction)
  2. Cooling It Down To Partying It Up (If the reason why MDMA causes long-term neurological damage is due to the way it overheats the brain, then bracelets designed to cool your blood really quickly could allow people to take MDMA sustainably for decades without getting hurt)
  3. Low-Dose Ibogaine for Hedonic Tone Augmentation (According to some published reports and anecdotal data, microdosing ibogaine gives rise to an increased hedonic baseline for several days that does not lead to a comedown, possibly by up-regulating mu-opioid receptors – if true this could revolutionize the treatment of depression)
  4. Cause X – What Will the New Shiny Effective Altruist Cause Be? (I highlight that anecdotal evidence indicates that sub-hallucinogenic doses of DMT can abort cluster headaches within seconds, which are some of the most painful experiences that humans have and therefore are an ethical priority)
  5. Frequency Specific Microcurrent for Kidney-Stone Pain (Along the lines of the previous article, one of the most painful experiences people tend to have in their lifetime is that of kidney stones. So even if there is a small probability that this intervention actually works, there is a strong utilitarian case to research this lead because, if successful, it would lead to a very cheap and widely available method to greatly diminish this very common (~10% lifetime prevalence) form of intense suffering).
  6. Triple S Genetic Counseling: Predicting Hedonic-Set Point with Commercial-Grade DNA Testing as an Effective Altruist Project (A low-hanging fruit to make a lot of people happy and prevent a ton of suffering would be to build models that predict hedonic set-point based on genetic makeup to be used for genetic preimplantation diagnosis, something that can already be done with the data available to services like 23andMe).

And finally, I will also point you to Qualia Computing media appearances, in case you would like to consume Qualia Computing content with the aid of auditory and/or visual qualia.


* I arrived at this particular ranking by sorting all the articles by a weighted sum of (a) the number of genuinely new ideas presented (which Google searches reveal they have never previously been discussed anywhere, including academia, internet forums, popular culture, etc.), (b) how happy it makes me feel that I wrote and published the article, and (c) the logarithm of the number of views of the article to date.

The Purple Pill

It finally arrived. I had to appeal it’s denial a couple times, but it finally came through. It arrived in the mail today. It’s laminated with rounded corners, a holographic mark, and a pinch of glitter. I finally got my Poetic License. They said if I wanted permission to use metaphors I would need to apply for an allegorical diploma, but what is a poetic license without metaphor? In practice most licensed professionals in the field ignore this rule. It’s not like the reader ever asks you for your credentials whenever symbolism is used. They said my trope copyright agreement is on the way. They gave me a tracking number. But I’m not going to be waiting around any longer…

The most insidious thing about taking the blue pill is that it is usually followed by an immediate amnesia of having done so. Soon after one is presented with the same decision, but now with an incredible -unbelievable- literary feeling of empowerment and bravery that makes you decide to take the red pill in an heroic act of self-effacement. Alas, this is of course all a fantasy induced by the original blue pill.

There are various grades of pseudo-red pills. You have the standard sedatives that put you to sleep; a dreamless coma – “Life is an unprofitable episode disturbing the blessed calm of non-existence” (Schopenhauer). You have the one that makes you forget -in fact achieve a state of convenient social neglect- of the intensely bad experiences that exist out there in Hell branches of the multiverse. There is the one that makes you believe that nonhuman animals lack souls and are unable to suffer (despite their, it turns out, much greater capacity for suffering than humans). There are those that by virtue of making you believe that you took the red pill give your life a tremendous sense of mission and moral superiority. There is the pill of sentimentalism, the pill of fanaticism, the pill of scientism, the pill of mainstream sports, the pill of social media rage, the pill of analytic philosophy fandom, and the pill of pop psychopharmachology (SSRIs increase your serotonin levels, and serotonin is the happy molecule, or so the scientists are saying *wink*). Alas, naming the most common ones, those that zombify the people who claim to be the most awake would feel like a personal attack (even if far from it). So the most common blue pills shall remain unmentioned lest I’m lynched.

The true red pill is not just DXM with red 2. It isn’t just eugenics, international conspiracies, evolutionary psychopathology, or Hansonian signaling theory. The real red pill is made of 4000°C bright red luminous magma that destroys not only your esophagus, but cuts through your body and falls directly on the ground below passing right through, only barely cooled down by your body due to its incredibly high specific heat capacity.

No. That’s still another blue pill fantasy designed to make you feel brave and morally superior for taking it. The real red pill is agape. The communion with the Godhead in its infinite compassion for all Beings large and small.

But you guessed it right, that’s also another type of coating for the blue fellow (iridescent, yes, but still synthetic and bad for your liver).

What did you think, that there is any real closure? It is not like nature is going to be kind to us humans who suffer from high levels of neuroticism and psychological need for closure.

There is no red pill. But there are decent approximations. There is the unprejudiced pursuit of truth – the high AQ high IQ depressive realism that is an evolutionary spandrel. The state of metta and LSD ego death are close seconds, though they lack the critical clarity of mind needed to be willing to stare at the raw truth of suffering and its causes for too long before craving social validation for doing so.

Is there an alternative? Yes.

The purple pill is the pill that gives you both high hedonic tone and an unprejudiced open ended approach to the pursuit of truth. For losing truth is to lose it all, but to lose it all is only bad because it makes you and others suffer in the wider universe. Yes, here is where I am abusing my poetic license. I am a licensed wordsmith, don’t you know? I carry with me the approval of RA, I have the blessing of poetic authority so don’t you dare question my use of vagueness to drive a point home. The purple pill is what will redeem us all. The recognition that though truth is painful in our current, evolutionarily adaptive mind-frame, it is not in and of itself a cause of seething pain. Recognizing that true evil is not a person or a mythical archetype but the mere existence of states of consciousness as pornographically unethical as kidney stones or cluster headaches does not need to induce (at least not logically, not physically) a nihilistic depression. It does not need to make you speak in tongues, to scream at strangers in the street “AHH don’t you see how bad it is that we live in an eternalist empty individualist universe that does not care about the welfare of moments of experience!?!?” – It is still possible to do something productive instead. You can still, it turns out, choose to take eros and agape and reforge them into a laser sword that produces hyperdopaminergic loving-kindness in those who are hit by it, and mindfulness in those who wield it.

The purple pill is the true red pill; at least the best approximation there is. For if the truth is that the world is tenselessly (timelessly) littered with hellish states of consciousness implicated by the universal wavefunction satisfying the principles of zero ontology, this still does not imply that accurately representing the causal structure of such facts *has* to come along with a hellish hedonic tone of itself. This is the truth we all long for.

Take the purple pill and join us in the battle to destroy hell. You will, much to everyone’s incredulous amazement, be happy while doing so.


Photo credit: The HyperSpace

Hell Must Be Destroyed

Singer called the movement that grew up around him “effective altruism”, and its rallying cry was that one ought to spend every ounce of one’s energy doing whatever most relieves human suffering, most likely either feeding the poor or curing various tropical diseases. Again, something his opponents rejected as impossible, unworkable, another example of liberal fanaticism. Really? Every ounce of your energy? Again, they could have just read their Bibles. Deuteronomy 6:5: “And you must love the Lord your God with all your heart, and with all your soul, and with all your strength.”
 
Then Singer changed his tune. In the 1970s, after the sky cracked and the world changed, he announced that charity was useless, that feeding the poor was useless, that curing tropical diseases was useless. There was only one cause to which a truly rational, truly good human being could devote his or her life.
 
Hell must be destroyed.
 
The idea of billions of human beings suffering unbearable pain for all eternity so outweighed our little earthly problems that the latter didn’t even register. He began meeting with his disciples in secret, teaching them hidden Names he said had been vouchsafed to him by angels. Thamiel put a price on his life – quite a high price actually. Heedless of his own safety, Singer traveled what remained of the civilized world, making converts wherever he went, telling them to be perfect as God was perfect, and every speech ended the same way. Hell must be destroyed.

An angel appears on Earth. This genderless being connected to God shows up on every screen on Earth at once and asks us if we are interested in drastically improving life on Earth. A large enough portion of those who hear the message (which gets a coverage of 80%+ of people worldwide) see into their souls and find the willingness to make life better, and then they see into their hearts and see the warmth of hope, and so they resolve to agree to do whatever is necessary to help the angel improve life on Earth. And thus the angel says “thanks to the collective desire to make it so, I shall change some things about how the planet is programed, and you will see a 99% reduction in suffering and a 20% increase in overall happiness.”
And so the angel gets to work.
A year passes, and nobody can really tell the difference from before. Most people’s day to day experience is perhaps even slightly more tedious and slightly more boring. What happened? After a few years it is clear that no major change has happened, and indeed affective psychologists report a mild but very generalized decrease in people’s engagement with their day to day activities and increases in feelings of being a bit disoriented. Did the angel scam us? Or did people fail to do their part? Or why are there no improvements? A large enough mass of people asked this question that the angel felt the need to provide an update. He comes back down and appears in all of the planet’s screens and says:
“Everything went according to plan. It is just that your society hasn’t reached the point of scientific development where you are able to measure the quality of experience of sentient beings. You aren’t quantifying pain very well.”
“Here is what I did. Above of all, I focused my energies on trying to prevent some of the worst experiences, which in aggregate happened to be an ethical catastrophe. I managed to reduce how bad these experiences were by about 99.99%.”
“I started by reducing how bad cluster headaches feel. They are now only about 44,000 dolors per second (d/s). They used to be around 450,000,000 d/s. You see, when most people get a fleeting headache, we are talking about headaches that range from 0.5 to 1d/s. You know, the type of headache that people are willing to wait out, and perhaps some people will ask for a little aspirin or some placebo of some sort and then get on with it. Most headaches are of this kind. But even if you bundle all of them together we are talking about a rounding error relative to the suffering caused by other types of headaches, the bad ones. Migraine, for example, tends to get to about 1,000 dolors per second, and sufferers have a hard time communicating the fact that it is not just a lot worse, it is a thousand times more painful than the “normal” ones. But even then that does not register relative to one of the really really bad ones, like cluster headaches, which as I said can spiral up to values close to a billion d/s. As it happens, on your planet there are simple chemical tricks to reduce that particular type of pain (e.g. LSD), so I just went ahead and got rid of the bulk of it very easily. It’s still super painful by human standards, but not by my standards, like it was before. To have a cluster headache now is just as “indescribably bad” as before, meaning it goes beyond people’s ability to imagine and make sense of. But that doesn’t challenge the fact that the 99.99% improvement I did is an ethical victory of civilizational magnitude.”
“Next I went on to reducing how bad it feels to have kidney stones, bone pain, and various kinds of particularly bad neuropathies in people with schizophrenia. By the time I had taken care of about the dozen or so worst kinds of pain, I had already overdelivered by an order of magnitude and was starting to run into diminishing returns. So I decided to go on to helping other planets in my quest to prevent as much suffering as possible.”
“I apologize I used about 0.13 hedons per second (h/s) from mundane experiences to implement one of those cosmic pain diminishing plans. In order to increase the amount of happiness in the world as I promised I made the experience of showering about 50% more enjoyable and the experience of listening to music about twice as good. As you can see, the bathing industry did take off, but not many thought much of it. And the musicians were able to tell that music was awesome again and wondered why, but most people seem to have attributed their increased musical enjoyment to what they imagined had been their own hidden musical talents all along.”
“Thank you, and keep enjoying your drastically improved planet.”

 

Thus, people realized that the world was indeed a lot better. Well, some did. And others complained, but it was ok.

Thanks to Michael Aaron Coleman and Jonathan Leighton for inspiring this piece. Michael suffers from cluster headaches and has described their phenomenology in gruesome detail. He says that in a 0 to 10 scale, cluster headaches are solid 10/10. But he also says you really need a different scale to make sense of this monster. He once used the phrase “minus one million hedonic tone”. He says that morphine makes the pain go from 10/10 to 9/10, if at all, maybe more like 9.5/10. Thankfully, LSD in small doses (~25 micrograms) makes it go to 1/10. DMT also works, but 5-MeO-DMT does not (and yet it still expands time, so not a good idea). Jonathan is the Executive Director of the Organization for the Prevention of Intense Suffering (OPIS). He works on identifying cases where intense suffering can be prevented on a massive scale and doing what has to be done. I recommend getting in touch with him if this is a particular interest of yours.

Thoughts on the ‘Is-Ought Problem’ from a Qualia Realist Point of View

tl;dr If we construct a theory of meaning grounded in qualia and felt-sense, it is possible to congruently arrive at “should” statements on the basis of reason and “is” claims. Meaning grounded in qualia allows us to import the pleasure-pain axis and its phenomenal character to the same plane of discussion as factual and structural observations.

Introduction

The Is-Ought problem (also called “Hume’s guillotine”) is a classical philosophical conundrum. On the one hand people feel that our ethical obligations (at least the uncontroversial ones like “do not torture anyone for no reason”) are facts about reality in some important sense, but on the other hand, rigorously deriving such “moral facts” from facts about the universe appears to be a category error. Is there any physical fact that truly compels us to act in one way or another?

A friend recently asked about my thoughts on this question and I took the time to express them to the best of my knowledge.

Takeaways

I provide seven points of discussion that together can be used to make the case that “ought” judgements often, though not always, are on the same ontological footing as “is” claims. Namely, that they are references to the structure and quality of experience, whose ultimate nature is self-intimating (i.e. it reveals itself) and hence inaccessible to those who lack the physiological apparatus to instantiate it. In turn, we could say that within communities of beings who share the same self-intimating qualities of experience, the is/ought divide may not be completely unbridgeable.


Summaries of Question and Response

Summary of the question:

How does a “should” emerge at all? How can reason and/or principles and/or logic compel us to follow some moral code?

Summary of the response:

  1. If “ought” statements are to be part of our worldview, then they must refer to decisions about experiences: what kinds of experiences are better/worse, what experiences should or should not exist, etc.
  2. A shared sense of personal identity (e.g. Open Individualism – which posits that “we are all one consciousness”) allows us to make parallels between the quality of our experience and the experience of others. Hence if one grounds “oughts” on the self-intimating quality of one’s suffering, then we can also extrapolate that such “oughts” must exist in the experience of other sentient beings and that they are no less real “over there” simply because a different brain is generating them (general relativity shows that every “here and now” is equally real).
  3. Reduction cuts both ways: if the “fire in the equations of physics” can feel a certain way (e.g. bliss/pain) then objective causal descriptions of reality (about e.g. brain states) are implicitly referring to precisely that which has an “ought” quality. Thus physics may be inextricably connected with moral “oughts”.
  4. If one loses sight of the fact that one’s experience is the ultimate referent for meaning, it is possible to end up in nihilistic accounts of meaning (e.g. such as Quine’s Indeterminacy of translation and Dennett’s inclusion of qualia within that framework). But if one grounds meaning in qualia, then suddenly both causality and value are on the same ontological footing (cf. Valence Realism).
  5. To see clearly the nature of value it is best to examine it at its extremes (such as MDMA bliss vs. the pain of kidney stones). Having such experiences illuminates the “ought” aspect of consciousness, in contrast to the typical quasi-anhedonic “normal everyday states of consciousness” that most people (and philosophers!) tend to reason from. It would be interesting to see philosophers discuss e.g. the Is-Ought problem while on MDMA.
  6. Claims that “pleasure and pain, value and disvalue, good and bad, etc.” are an illusion by long-term meditators based on the experience of “dissolving value” in meditative states are no more valid than claims that pain is an illusion by someone doped on morphine. In brief: such claims are made in a state of consciousness that has lost touch with the actual quality of experience that gives (dis)value to consciousness.
  7. Admittedly the idea that one state of consciousness can even refer to (let alone make value judgements about) other states of consciousness is very problematic. In what sense does “reference” even make sense? Every moment of experience only has access to its own content. We posit that this problem is not ultimately unsolvable, and that human concepts are currently mere prototypes of a much better future set of varieties of consciousness optimized for truth-finding. As a thought experiment to illustrate this possible future, consider a full-spectrum superintelligence capable of instantiating arbitrary modes of experience and impartially comparing them side by side in order to build a total order of consciousness.

Full Question and Response

Question:

I realized I don’t share some fundamental assumptions that seemed common amongst the people here [referring to the Qualia Research Institute and friends].

The most basic way I know how to phrase it, is the notion that there’s some appeal to reason and/or principles and/or logic that compels us to follow some type of moral code.

A (possibly straw-man) instance is the notion I associate with effective altruism, namely, that one should choose a career based on its calculable contribution to human welfare. The assumption is that human welfare is what we “should” care about. Why should we? What’s compelling about trying to reconfigure ourselves from whatever we value at the moment to replacing that thing with human welfare (or anything else)? What makes us think we can even truly succeed in reconfiguring ourselves like this? The obvious pitfall seems to be we create some image of “goodness” that we try to live up to without ever being honest with ourselves and owning our authentic desires. IMO this issue is rampant in mainstream Christianity.

More generally, I don’t understand how a “should” emerges within moral philosophy at all. I understand how starting with a want, say happiness, and noting a general tendency, such as I become happy when I help others, that one could deduce that helping others often is likely to result in a happy life. I might even say “I should help others” to myself, knowing it’s a strategy to get what I want. That’s not the type of “should” I’m talking about. What I’m talking about is “should” at the most basic level of one’s value structure. I don’t understand how any amount of reasoning could tell us what our most basic values and desires “should” be.

I would like to read something rigorous on this issue. I appreciate any references, as well as any elucidating replies.

Response:

This is a very important topic. I think it is great that you raise this question, as it stands at the core of many debates and arguments about ethics and morality. I think that one can indeed make a really strong case for the view that “ought” is simply never logically implied by any accurate and objective description of the world (the famous is/ought Humean guillotine). I understand that an objective assessment of all that is will usually be cast as a network of causal and structural relationships. By starting out with a network of causal and structural relationships and using logical inferences to arrive at further high-level facts, one is ultimately bound to arrive at conclusions that themselves are just structural and causal relationships. So where does the “ought” fit in here? Is it really just a manner of speaking? A linguistic spandrel that emerges from evolutionary history? It could really seem like it, and I admit that I do not have a silver bullet argument against this view.

However, I do think that eventually we will arrive at a post-Galilean understanding of consciousness, and that this understanding will itself allow us to point out exactly where- if at all- ethical imperatives are located and how they emerge. For now all I have is a series of observations that I hope can help you develop an intuition for how we are thinking about it, and why our take is original and novel (and not simply a rehashing of previous arguments or appeals to nature/intuition/guilt).

So without further ado I would like to lay out the following points on the table:

  1. I am of the mind that if any kind of “ought” is present in reality it will involve decision-making about the quality of consciousness of subjects of experience. I do not think that it makes sense to talk about an ethical imperative that has anything to do with non-experiential properties of the universe precisely because there would be no one affected by it. If there is an argument for caring about things that have no impact on any state of consciousness, I have yet to encounter it. So I will assume that the question refers to whether certain states of consciousness ought to or ought not to exist (and how to make trade offs between them).
  2. I also think that personal identity is key for this discussion, but why this is the case will make sense in a moment. The short answer is that conscious value is self-intimating/self-revealing, and in order to pass judgement on something that you yourself (as a narrative being) will not get to experience you need some confidence (or reasonable cause) to believe that the same self-intimating quality of experience is present in other narrative orbits that will not interact with you. For the same reasons as (1) above, it makes no sense to care about philosophical zombies (no matter how much they scream at you), but the same is the case for “conscious value p. zombies” (where maybe they experience color qualia but do not experience hedonic tone i.e. they can’t suffer).
  3. A very important concept that comes up again and again in our research is the notion that “reduction cuts both ways”. We take dual aspect monism seriously, and in this view we would consider the mathematical description of an experience and its qualia two sides of the same coin. Now, many people come here and say “the moment you reduce an experience of bliss to a mathematical equation you have removed any fuzzy morality from it and arrived at a purely objective and factual account which does not support an ‘ought ontology'”. But doing this mental move requires you to take the mathematical account as a superior ontology to that of the self-intimating quality of experience. In our view, these are two sides of the same coin. If mystical experiences are just a bunch of chemicals, then a bunch of chemicals can also be a mystical experience. To reiterate: reduction cuts both ways, and this happens with the value of experience to the same extent as it happens with the qualia of e.g. red or cinnamon.
  4. Mike Johnson tends to bring up Wittgenstein and Quine to the “Is-Ought” problem because they are famous for ‘reducing language and meaning’ to games and networks of relationships. But here you should realize that you can apply the concept developed in (3) above just as well to this matter. In our view, a view of language that has “words and objects” at its foundation is not a complete ontology, and nor is one that merely introduces language games to dissolve the mystery of meaning. What’s missing here is “felt sense” – the raw way in which concepts feel and operate on each other whether or not they are verbalized. It is my view that here phenomenal binding becomes critical because a felt sense that corresponds to a word, concept, referent, etc. in itself encapsulates a large amount of information simultaneously, and contains many invariants across a set of possible mental transformations that define what it is and what it is not. More so, felt senses are computationally powerful (rather than merely epiphenomenal). Consider Daniel Tammet‘s mathematical feats achieved by experiencing numbers in complex synesthetic ways that interact with each other in ways that are isomorphic to multiplication, factorization, etc. More so, he does this at competitive speeds. Language, in a sense, could be thought of as the surface of felt sense. Daniel Dennett famously argued that you can “Quine Qualia” (meaning that you can explain it away with a groundless network of relationships and referents). We, on the opposite extreme, would bite the bullet of meaning and say that meaning itself is grounded in felt-sense and qualia. Thus, colors, aromas, emotions, and thoughts, rather than being ultimately semantically groundless as Dennett would have it, turn out to be the very foundation of meaning.
  5. In light of the above, let’s consider some experiences that embody the strongest degree of the felt sense of “ought to be” and “ought not to be” that we know of. On the negative side, we have things like cluster headaches and kidney stones. On the positive side we have things like Samadhi, MDMA, and 5-MEO-DMT states of consciousness. I am personally more certain that the “ought not to be” aspect of experience is more real than the “ought to be” aspect of it, which is why I have a tendency (though no strong commitment) towards negative utilitarianism. When you touch a hot stove you get this involuntary reaction and associated valence qualia of “reality needs you to recoil from this”, and in such cases one has degrees of freedom into which to back off. But when experiencing cluster headaches and kidney stones, this sensation- that self-intimating felt-sense of ‘this ought not to be’- is omnidirectional. The experience is one in which one feels like every direction is negative, and in turn, at its extremes, one feels spiritually violated (“a major ethical emergency” is how a sufferer of cluster headaches recently described it to me). This brings me to…
  6. The apparent illusory nature of value in light of meditative deconstruction of felt-senses. As you put it elsewhere: “Introspectively – Meditators with deep experience typically report all concepts are delusion. This is realized in a very direct experiential way.” Here I am ambivalent, though my default response is to make sense of the meditation-induced feeling that “value is illusory” as itself an operation on one’s conscious topology that makes the value quality of experience get diminished or plugged out. Meditation masters will say things like “if you observe the pain very carefully, if you slice it into 30 tiny fragments per second, you will realize that the suffering you experience from it is an illusory construction”. And this kind of language itself is, IMO, liable to give off the illusion that the pain was illusory to begin with. But here I disagree. We don’t say that people who take a strong opioid to reduce acute pain are “gaining insight into the fundamental nature of pain” and that’s “why they stop experiencing it”. Rather, we understand that the strong opioid changes the neurological conditions in such a way that the quality of the pain itself is modified, which results in a duller, “asymbolic“, non-propagating, well-confined discomfort. In other words, strong opioids reduce the value-quality of pain by locally changing the nature of pain rather than by bringing about a realization of its ultimate nature. The same with meditation. The strongest difference here, I think, would be that opioids are preventing the spatial propagation of pain “symmetry breaking structures” across one’s experience and thus “confine pain to a small spatial location”, whereas meditation does something different that is better described as confining the pain to a small temporal region. This is hard to explain in full, and it will require us to fully formalize how the subjective arrow of time is constructed and how pain qualia can make copies across it. [By noting the pain very quickly one is, I believe, preventing it from building up and then having “secondary pain” which emerges from the cymatic resonance of the various lingering echoes of pain across one’s entire “pseudo-time arrow of experience”.] Sorry if this sounds like word salad, I am happy to unpack these concepts if needed, while also admitting that we are in early stages of the theoretical and empirical development.
  7. Finally, I will concede that the common sense view of “reference” is very deluded on many levels. The very notion that we can refer to an experience with another experience, that we can encode the properties of a different moment of experience in one’s current moment of experience, that we can talk about the “real world” or its “objective ethical values” or “moral duty” is very far from sensical in the final analysis. Reference is very tricky, and I think that a full understanding of consciousness will do some severe violence to our common sense in this area. That, however, is different from the self-disclosing properties of experience such as red qualia and pain qualia. You can do away with all of common sense reference while retaining a grounded understanding that “the constituents of the world are qualia values and their local binding relationships”. In turn, I do think that we can aim to do a decently good job at re-building from the ground up a good approximation of our common sense understanding of the world using “meaning grounded in qualia”, and once we do that we will be in a solid foundation (as opposed to the, admittedly very messy, quasi-delusional character of thoughts as they exist today). Needless to say, this may also need us to change our state of consciousness. “Someday we will have thoughts like sunsets” – David Pearce.

 

Burning Man 2.0: The Eigen-Schelling Religion, Entrainment & Metronomes, and the Eternal Battle Between Consciousness and Replicators

Because our consensus reality programs us in certain destructive directions, we must experience other realities in order to know we have choices.

Anyone who limits her vision to memories of yesterday is already dead.

Lillie Langtry

Last year I wrote a 13,000 word essay about my experience at Burning Man. This year I will also share some thoughts and insights concerning my experience while being brief and limiting myself to seven thousand words. I decided to write this piece stand-alone in such a way that you do not need to have read the previous essay in order to make sense of the present text.


Camp Soft Landing

I have been wanting to attend Burning Man for several years, but last year was the first time I had both the time and resources to do so. Unfortunately I was not able to get a ticket in the main sale, so I thought I would have to wait another year to have the experience. Out of the blue, however, I received an email from someone from Camp Soft Landing asking me if I would be interested in giving a talk at Burning Man in their Palenque Norte speaker series. My immediate response was “I would love to! But I don’t have a ticket and I don’t have a camp.” The message I received in return was “Great! Well, we have extra tickets, and you can stay at our camp.” So just like that I suddenly had the opportunity to not only attend, but also be at a wonderful camp and give a talk about consciousness research.

Full Circle Teahouse

The camp I’ve been a part of turned out to be an extremely good fit for me both as a researcher and as a person. Camp Soft Landing is one of the largest camps at Burning Man, featuring a total of 150 participants every year. Its two main contributions to the playa are the Full Circle Teahouse and Palenque Norte. The Full Circle Teahouse is a place in which we serve adaptogen herbal tea blends and Pu’er tea in a peaceful setting that emphasizes presence, empathy, and listening. It’s also full of pillows and cozy blankets and serves as a place for people who are overwhelmed to calm down or crash after a hectic night. (During training we were advised to expect that some people “may not know where they are or how they got here when they wake up in the early morning” and to “help them get oriented and offer them tea”). Here are a few telling words by the Teahouse founder Annie Oak:

The real secret sauce to our camp’s collective survival has been our focus on the well being of everyone who steps inside Soft Landing. While the ancestral progenitor who occupied our location before us, Camp Above the Limit, ran a lively bar, we made a decision not to serve alcohol in our camp. I enjoy an occasional cocktail, but I believe that the conflating of the gift economy with free alcohol has compromised the public health and social cohesion of Black Rock City. We do not prohibit alcohol at Soft Landing, but we do not permit bars inside our camp. Instead, we run a tea bar at our Tea House for those seeking a place to rest, hydrate and receive compassionate care. We also give away hundreds of gallons of water to Tea House visitors. We don’t want to undermine their self-sufficiency, but we can proactively reduce the number of guests who become ill from dehydration. We keep our Tea House open until Monday after the Burn to help weary people stay alert on the perilous drive back home.

– Doing It Right: Theme Camp Management Insights from Camp Soft Landing

Palenque Norte

Palenque Norte is a speaker series founded by podcaster Lorenzo Hagerty in 2003 (cf. A Brief History of Palenque Norte). A friend described it as “TED for Psychedelic Research at Burning Man” which is pretty accurate. Indeed, looking at a list of Palenque Norte speakers is like browsing a who’s who of the scientific and artistic psychedelic community: Johns Hopkins‘ Roland GriffithsMAPS‘ Rick DoblinHeffter‘s George GreerEFF‘s John GilmoreAnn & Sasha Shulgin (Q&A), DanceSafe‘s Mitchell Gomez, Consciousness Hacking‘ Mikey SiegelPaul DaleyBruce Damer, Will Siu, Emily WilliamsSebastian Job, Alex Grey, Android Jones, and many others. For reference, here was this year’s Palenque Norte schedule:

Thanks to the Full Circle Teahouse and Palenque Norte, the social and memetic composition of Camp Soft Landing is one that is characterized by a mixture of veteran scientists and community builders in their 50s and 60s, science and engineering nerds with advanced degrees in their late 20s and early 30s, and a dash of millennials and Gen-Z-ers in the rationalist/Effective Altruist communities.

lorenzo-sasha-bruce

Lorenzo Hagerty, Sasha Shulgin, and Bruce Damer (Burning Man, Palenque Norte c. 2007)

The people of Camp Soft Landing are near and dear to my heart given that they take consciousness seriously, they have a scientific focus, and they emit a strong intellectual vibe. As a budding qualia researcher myself, I feel completely at home there. As it turns out, this type of vibe is not at all out of place at Burning Man…

Burning Man Attendees

I would hazard the guess that Burning Man attendees are on average much more open to experience, conscientious, cognitively oriented, and psychologically robust than people in the general population. In particular, the combination of conscientiousness and openness to experience is golden. These are people who are not only able to think of crazy ideas, but who are also diligent enough to manifest them in the real world in concrete forms. This may account for the high production value and elaborate nature of the art, music, workshops, and collective activities. While the openness to experience aspect of Burning Man is fairly self-evident (it jumps at you if you do a quick google images search), the conscientiousness aspect may be a little harder to believe. Here I will quote a friend to illustrate this component:

Burning Man is the annual meeting of the recreational logistics community. Or maybe it’s a job interview for CEO: how to deal with broken situations and unexpected constraints in a multi-agent setting, just to survive.

[…]

Things I learned / practiced in the last couple of weeks: truck driving, clever packing, impact driver, attaching bike trailer, pumping gas and filling generators, knots, adding hanging knobs to a whiteboard, tying things with wire, quickly moving tents on the last night, finding rides, using ratchet straps, opening & closing storage container, driving to Treasure Island.

GL

Indeed this may be one of the key barriers of entry that defines the culture of Burning Man and explains why the crazy ideas people have in a given year tend to come back in the form of art in the next year… rather than vanishing into thin air.

There are other key features of the people who attend which can be seen by inspecting the Burning Man Census report. Here is a list of attributes, their baserate for Burners, and the baserate in the general population (for comparison): Having an undergraduate degree (73.6% vs. 32%), holding a graduate degree (31% vs. 10%), being gay/lesbian (8.5% vs. 1.3%), bisexual (10% vs. 1.8%), bicurious (11% vs. ??), polyamorous (20% vs. 5%), mixed race (9% vs. 3%), female (40% vs. 50%), median income (62K vs. 30K), etc.

From a bird’s eye view one can describe Burners as much more: educated, LGBT, liberal or libertarian, “spiritual but not religious”, and more mixed race than the average person. There are many more interesting cultural and demographic attributes that define the population of Black Rock City, but I will leave it at that for now for the sake of brevity. That said, feel free to inspect the following Census graphs for further details:

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Last year at Burning Man I developed a cluster of new concepts including “The Goldilocks Zone of Oneness” and “Hybrid Vigor in the context of post-Darwinian ethics.” I included my conversation with God and instructions for a guided oneness meditation. This year I continued to use the expanded awareness field of the Playa to further these and other concepts. In what follows I will describe some of the main ideas I experienced and then conclude with a summary of the talk I gave at Palenque Norte. If any of the following sections are too dense or uninteresting please feel free to skip them.

The Universal Eigen-Schelling Religion

On one of the nights a group of friends and I went on a journey following an art car, stopping every now and then to dance and to check out some art. At one point we drove through a large crowd of people and by the time the art car was on the other side, a few people from the group were missing. The question then became “what do we do?” We didn’t agree on a strategy for dealing with this situation before we embarked on the trip. After a couple of minutes we all converged on a strategy: stay near the art car and drive around until we find the missing people. The whole situation had a “lost in space” quality. Finding individual people is very hard since from a distance everyone is wearing roughly-indistinguishable multi-colored blinking LEDs all over their body. But since art cars are large and more distinguishable at a distance, they become natural Schelling points for people to converge on. Schelling points are a natural coordination mechanism in the absence of direct communication channels.

We were thus able to re-group almost in our entirety as a group (with only one person missing, who we finally had to give up on) by independently converging on the meta-heuristic of looking for the most natural Schelling point and finding the rest of the group there. For the rest of the night I kept thinking about how this meta-strategy may play out in the grand scheme of things.

If you follow Qualia Computing you may know that our default view on the nature of ethics is valence utilitarianism. People think they want specific things (e.g. ice-cream, a house, to be rich and famous, etc.) but in reality what they want is the high-valence response (i.e. happiness, bliss, and pleasure) that is triggered by such stimuli. When two people disagree on e.g. whether a certain food is tasty, they are not usually talking about the same experience. For one person, such food could induce high degrees of sensory euphoria, while for the other person, the food may leave them cold. But if they had introspective access to each other’s valence response, the disagreement would vanish (“Ah, I didn’t realize mayo produced such a good feeling for you. I was fixated on the aversive reaction I had to it.”). In other words, disagreements about the value of specific stimuli come down to lack of empathetic fidelity between people rather than a fundamental value mismatch. Deep down, we claim, we all like the same states of consciousness, and our disagreements come from the fact that their triggers vary between people. We call the fixation on the stimuli rather than the valence response the Tyranny of the Intentional Object.

In the grand scheme of things, we posit that advanced intelligences across the multiverse will generally converge on valence realism and valence utilitarianism. This is not an arbitrary value choice; it’s the natural outcome of looking for consistency among one’s disparate preferences and trying to investigate the true nature of conscious value. Insofar as curiosity is evolutionarily adaptive, any sufficiently general and sufficiently curious conscious mind eventually reaches the conclusion that value is a structural feature of conscious states and sheds the illusion of intentionality and closed identity. And while in the context of human history one could point at specific philosophers and scientists that have advanced our understanding of ethics (i.e. Plato, Bentham, Singer, Pearce, etc.) there may be a very abstract but universal way of describing the general tendency of curious conscious intelligences towards valence utilitarianism. It would go like this:

In a physicalist panpsychist paradigm, the vast majority of moments of experience do not occur within intelligent minds and leave no records of their phenomenal character for future minds to examine and inspect. A subset of moments of experience, though, do happen to take place within intelligent minds. We can call these conscious eigen-states because their introspective value can be retroactively investigated and compared against the present moment of experience, which has access to records of past experiences. Humans, insofar as they do not experience large amounts of amnesia, are able to experience a wide range of eigen-states throughout their lives. Thus, within a single human mind, many comparisons between the valence of various states of consciousness can be carried out (this is complicated and not always feasible given the state-dependence of memory). Either way, one could visualize how the information about the relative ranking of experiences is gathered across a Directed Acyclic Graph (DAG) of moments of experience that have partial introspective access to previous moments of experience. Furthermore, if the assumption of continuity of identity is made (i.e. that each moment of experience is witnessed by the same transcendental subject) then each evaluation between pairs of states of consciousness contributes a noisy datapoint to a universal ranking of all experiences and values.

After enough comparisons, a threshold number of evaluated experiences may be crossed, at which point a general theory of value can begin to be constructed. Thus a series of natural Schelling points for “what is universally valuable” become accessible to subsequent moments of experience. One of these focal points is the prevention of suffering throughout the entire multiverse. That is, to avoid experiences that do not like existing, independently of their location in space-time. Likewise, we would see another focal point that adds an imperative to realize experiences that value their own existence (“let the thought forms who love themselves reproduce and populate the multiverse”).

I call this approach to ethics the Eigen-Schelling Religion. Any sapient mind in the multiverse with a general enough ability to reason about qualia and reflect about causality is capable of converging to it. In turn, we can see that many concepts at the core of world religions are built around universal Eigen-Schelling points. Thus, we can rest assured that both the Bodhisattva imperative to eliminate suffering and the Christ “world redeeming” sentiment are reflections of a fundamental converging process to which many other intelligent life-forms have access across the entire multiverse. What I like about this framework is that you don’t need to take anyone’s word for what constitutes wisdom in consciousness. It naturally exists as reflective focal points within the state-space of consciousness itself in a way that transcends time and space.

Entrainment and Metronomes

In A Future for Neuroscience my friend and colleague Mike E. Johnson from the Qualia Research Institute explored how taking seriously the paradigm of Connectome-Specific Harmonic Waves (CSHW) leads us to reinterpret cognitive and personality traits in an entirely new light. In particular, here is what he has to say about emotional intelligence:

EQ (emotional intelligent quotient) isn’t very good as a formal psychological construct- it’s not particularly predictive, nor very robust when viewed from different perspectives. But there’s clearly something there– empirically, we see that some people are more ‘tuned in’ to the emotional & interpersonal realm, more skilled at feeling the energy of the room, more adept at making others feel comfortable, better at inspiring people to belief and action. It would be nice to have some sort of metric here.

I suggest breaking EQ into entrainment quotient (EnQ) and metronome quotient (MQ). In short, entrainment quotient indicates how easily you can reach entrainment with another person. And by “reach entrainment”, I mean how rapidly and deeply your connectome harmonic dynamics can fall into alignment with another’s. Metronome quotient, on the other hand, indicates how strongly you can create, maintain, and project an emotional frame. In other words, how robustly can you signal your internal connectome harmonic state, and how effectively can you cause others to be entrained to it. […] Most likely, these are reasonably positively correlated; in particular, I suspect having a high MQ requires a reasonably decent EnQ. And importantly, we can likely find good ways to evaluate these with CSHW.

This conceptual framework can be useful for making sense of the novel social dynamics that take place in Black Rock City. In particular, as illustrated by the Census responses, most participants are in a very open and emotionally receptive state at Burning Man:

One could say that by feeling safe, welcomed, and accepted at Burning Man, attendees adopt a very high Entrainment Quotient modus operandi. In tandem, we then see large art pieces, art cars, theme camps, and powerful sound systems blasting their unique distinctive emotional signals throughout the Playa. In a sense the entire place looks like an ecosystem of brightly-lit high-energy metronomes trying to attract the attention of a swarm of people in highly open and sensitive states with the potential to be entrained with these metronomes. Since the competition for attention is ferocious, there is not a single metronome that can dominate or totally brainwash you. All it takes for you to get a bad signal out of your head is to walk 50 meters to another place where the vibe will be, in all likelihood, completely different and overwrite the previous state.

This dynamic reaches its ultimate climax the very night of the Burn, as (almost) everyone gathers around the Man in a maximally receptive state, while at the same time every art car and group vibe surrounds the crowd and blasts their unique signals as loud and as intensely as possible all at the same time. This leads to the reification of the collective Burning Man egregore, which manifests as the sum total of all signals and vibes in mass ecstasy.

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Night of the Burn (source)

It is worth pointing out that not all of the metronomes in the Playa are created equal. Some art cars, for example, send highly specific and culturally-bound signals (e.g. country music, Simon & Garfunkel, Michael Jackson, etc.). While these metronomes will have their specific followings (i.e. you can always find a group of dedicated Pink Floyd fans) their ability to interface with the general Burner vibe is limited by their specificity and temporal irregularity. The more typical metronomic texture you will find scattered all around the Playa will be art forms that make use of more general patternceutical Schelling points with a stronger and more general metronomic capacity. Of note is the high degree of prevalence of house music and other 110 to 140 bpm (beats per minute) music that is able to entrain your brain from a distance and motivate you to move towards it- whether or not you are able to recognize the particular song. If you listen carefully to e.g. Palenque Norte recordings you will notice the occasional art car driving by, and the music it is blasting will usually have its tempo within that range, with a strong, repeating, and easily recognizable beat structure. I suspect that this tendency is the natural emergent effect of the evolutionary selection pressures that art forms endure from one Burn to another, which benefit patterns that can captivate a lot of human attention in a competitive economy of recreational states of consciousness.

mystic_samskara

Android Jones’ Samskara at Camp Mystic 2017 (an example of the Open Individualist Schelling Vibe – i.e. the religion of the ego-dissolving LSD frequency of consciousness)

And then there are the extremely general metronome strategies that revolve around universal principles. The best example I found of this attention-capturing approach was the aesthetic of oneness, which IMO seemed to reach its highest expression at Camp Mystic:

Inspired by a sense of mystery & wonder, we perceive the consciousness of “We Are All One”. Mystics encourage the enigmatic spirit to explore a deeper connection not only on this planet and all that exists within, but the realm of the entire Universe.

Who are the Mystics? 

At their Wednesday night “White Dance Party” (where you are encouraged to dress in white) Camp Mystic was blasting the strongest vibes of Open Individualism I witnessed this year. I am of the mind that philosophy is the soul of poetry, and that massive party certainly had as its underlying philosophy the vibe of oneness and unity. This vibe is itself a Schelling point in the state-space of consciousness… the religion of the boundary-dissolving LSD frequency is not a random state, but a central hub in the super-highway of the mind. I am glad these focal points made prominent appearances at Burning Man.

Uncontrollable Feedback Loops

It is worth pointing out that at an open field as diverse as Burning Man we are likely to encounter positive feedback systems with both good and bad effects on human wellbeing. An example of a positive feedback loop with bad effects would be the incidents that transpired around the “Carkebab” art installation:

The sculpture consisted of a series of cars piled on top of each other held together by a central pole. The setup was clearly designed to be climbed given the visible handles above the cars leading to a view cart at the top. However, in practice it turned out to be considerably more dangerous and hard to climb than it seemed. Now you may anticipate the problem. If you are told that this art piece is climbable but dangerous, one can easily conjure a mental image of a future event in which someone falls and gets hurt. And as soon as that happens, access to the art installation will be restricted. Thus, one reasons that there is a limited amount of time left in which one will be able to climb the structure. Now imagine a lot of people having that train of thought. As more people realize that an accident is imminent, more people are motivated to climb it before that happens, thus creating an incentive to go as soon as possible, leading to crowding, which in turn increases the chance of an accident. The more people approach the installation, the more imminent the final point seems, and the more pressing it becomes to climb the structure before it becomes off-limits, and the more dangerous it becomes. Predictably, the imminent accident did take place. Thankfully it only involved a broken shoulder rather than something more severe. And yet, why did we let it get to that point? Perhaps in the future we should have methods to detect positive feedback loops like this and put the brakes on before it’s too late…

This leads to the topic of danger:

Counting Microlives

Can Burning Man be a place in which an abolitionist ethic can put down roots for long-term civilizational planning? Let’s briefly examine some of the potential acute, medium-term, and long-term costs of attending. Everyone has a limit, right? Some may want to think: “well, you only live once, let’s have fun”. But if you are one of the few who carries the wisdom, will, and love to move consciousness forward this should not be how you think. What would be an acceptable level of risk that an Effective Altruist should be able to accept to experience the benefits of Burning Man? I think that the critical question here is not “Is Burning Man dangerous?” but rather “How bad is it for you?”

Thankfully actuaries, modern medicine, and economists have already developed a theoretical framework for putting a number on this question. Namely, this is the concept of micromorts (i.e. 1 in a million chance of dying) and its sister concept of microlife (a cost of 1 millionth of a lifespan lost or gained by performing some activity). My preference is that of using microlives because they translate more easily into time and are, IMO, more conceptually straightforward. So here is the question: How many microlives should we be willing to spend to attend Burning Man? 10 microlives? 100 microlives? 1,000 microlives? 10,000 microlives?

Based on the fact that there are many long-term burners still alive I guesstimate that the upper bound cannot possibly be higher than 10,000 or we would know about it already. I.e. the percentage of people who get e.g. skin cancer, lung disease, or die in other ways would probably be already apparent in the community. Alternatively, it’s also possible that a reduced life expectancy as a result of attending e.g. 10+ Burns is an open secret among long-term burners… they see their friends die at an inexplicably higher rate but are too afraid to talk about it honestly. After all, people tend to be very clingy to their main sources of meaning (what we call “emotionally load-bearing activities”) so a large amount of denial can be expected in this domain.

Additionally, discussing Burning Man micromorts might be a particularly touchy and difficult subject for a number of attendees. The reason being that part of the psychological value that Burning Man provides is a felt sense of the confrontation with one’s fragility and mortality. Many older burners seem to have come to terms with their own mortality quite well already. Indeed, perhaps accepting death as part of life may be one of the very mechanisms of action for the reduction in neuroticism caused by intense experiences like psychedelics and Burning Man.

But that is not my jazz. I would personally not want to recommend an activity that costs a lot of microlives to other people in team consciousness. While I want to come to terms with death as much as your next Silicon Valley mystically-inclined nerd, I also recognize that death-acceptance is a somewhat selfish desire. Paradoxically, living a long, healthy, and productive life is one of the best ways for us to improve our chances of helping consciousness-at-large given our unwavering commitment to the eradication of all sentient suffering.

The main acute risks of Burning Man could be summarized as: dehydration, sleep deprivation, ODing (especially via accidental dosing, which is not uncommon, sadly), being run over by large vehicles (especially by art cars, trucks, and RVs), and falling from art or having art fall on you. These risks can be mitigated by the motto of “doing only one stupid thing at a time” (cf. How not to die at Burning Man). It’s ok to climb a medium-sized art piece if you are fully sober, or to take a psychedelic if you have sitters and don’t walk around art cars, etc. Most stories of accidents one hears about start along the lines of: “So, I was drunk, and high, and on mushrooms, and holding my camera, and I decided to climb on top of the thunderdome, and…”. Yes, of course that went badly. Doing stupid things on top of each other has multiplicative risk effects.

In the medium term, a pretty important risk is that of being busted by law enforcement. After all, the financial, psychological, and physiological effects of going to prison are rather severe on most people. On a similar note, a non-deadly but psychologically devastating danger of living in the desert for a week is an increased risk of kidney stones due to dehydration. The 10/10 pain you are likely to experience while passing a kidney stone may have far-reaching traumatic effects on one’s psyche and should not be underestimated (sufferers experience an increased risk of heart disease and, I would suspect, suicide).

But of all of the risks, the ones that concern me the most are the long term ones given their otherwise silent nature. In particular, we have skin cancer due to UV exposure and lung/heart disease caused by high levels of PM2.5 particles. With respect to the skin component, it is worth observing that a large majority of Burning Man attendees are caucasian and thus at a significantly higher risk. Me being a redhead, I’ve taken rather extreme precautions in this area. I apply SPF50+ sunscreen every couple of hours, use a wide-rim hat, wear arm sleeves [and gloves] for UV sun protection, wear sunglasses, stay in the shade as often as I can, etc. I recommend that other people also follow these precautions.

And with regards to dust… here I would have to say we have the largest error bars. Does Burning Man dust cause lung cancer? Does it impair lung function? Does it cause heart disease? As far as I can tell nobody knows the answer to these questions. A lot of people seem to believe that the air-borne particles are too large to pose a problem, but I highly doubt that is the case. The only source I’ve been able to find that tried to quantify dangerous particles at Burning Man comes from Camp Particle, which unfortunately does not seem to have published its results (and only provides preliminary data without the critical measure of PM2.5 I was looking for). Here are two important thoughts in this area. First, let’s hope that the clay-like alkaline composition of Playa dust turns out to be harmless to the lungs. And second, like most natural phenomena, chances are that the concentration of dangerous particles in, e.g. 1 minute buckets, follows a power law. I would strongly expect that at least 80% of the dust one inhales comes from 20% of the time in which it is most present. More so, during dust storms and especially in white-outs, I would expect the concentration of dust in the air to be at least 1,000 times higher than the median concentration. If that’s true, breathing without protection during a white-out for as little as two minutes would be equivalent to breathing in “typical conditions” without protection for more than 24 hours. In other words, being strategic and diligent about wearing a heavy and cumbersome PN100 mask may be far more effective than lazily taking on and off a more convenient (but less effective) mask throughout the day. Personally, I chose to always have on hand an M3 half facepiece with PN100 filters ready in case the dust suddenly became thicker. This did indeed save me from breathing dust during all dust storms. The difference in the quality of air while wearing it was like day and night. I will also say that while I prefer my look when I have a beard, I chose to fully shave during the event in order to guarantee a good seal with the mask. In retrospect, the fashion sacrifice does seem to be worth it, though at the time I certainly missed having a beard.

3m-half-facepiece-respirator-welding-particulate-filter-d26.jpg

The question remaining is: with a realistic amount of protection, what is the acceptable level of risk? I propose that you make up your mind before we find out with science how dangerous Burning Man actually is. In my case, I am willing to endure up to 100 negative microlives per day at Burning Man (for a total of ~800 microlives) as the absolute upper bound. Anything higher than that and the experience wouldn’t be worth it for me, and I would not recommend it to memetic allies. Thankfully, I suspect that the actual danger is lower than that, perhaps in the range of 40 negative microlives per day (mostly in the form of skin cancer and lung disease). But the problem remains that this estimate has very wide error bars. This needs to be addressed.

And if the danger does turn out to be unacceptable, then we can still look to recreate the benefits of Burning Man in a safer way: Your Legacy Could Be To Move Burning Man to a Place With A Fraction of Its Micromorts Cost.

Dangerous Bonding

In the ideal case Burning Man would be an event that triggers our brains to produce “danger signals” without there actually being much danger at all. This is because with our current brain implementation, experiencing perceived danger is helpful for bonding, trust building, and a sense of self-efficacy and survival ability.

And now on to my talk…

Andrés Gómez Emilsson – Consciousness vs. Replicators

The video above documents my talk, which includes an extended Q&A with the audience. Below is a quick summary of the main points I touched throughout the talk:

  1. Intro to Qualia Computing
    1. I started out by asking the audience if they had read any Qualia Computing articles. About 30% of them raised a hand. I then asked them how they found out about my talk, and it seems that the majority of the attendees (50%+) found it through the “What Where When” booklet. Since the majority of the people didn’t know about Qualia Computing before the talk, I decided to provide a quick introduction to some of the main concepts:
      1. What is qualia? – The raw way in which consciousness feels. Like the blueness of blue. Did you ever wonder as a kid whether other people saw the same colors as you? Qualia is that ineffable quality of experience that we currently struggle to communicate.
      2. Personal Identity:
        1. Closed Individualism – you start existing when you are born, stop existing when you die.
        2. Empty Individualism – brains are “experience machines” and you really are just a “moment of experience” disconnected from every other “moment of experience” your brain has generated or will generate.
        3. Open Individualism – we are all the “light of consciousness”. Reality has only one numerically identical subject of experience who is everyone, but which takes all sorts of forms and shapes.
        4. For the purpose of this talk I assume that Open Individualism is true, which provides a strong reason to care about the wellbeing of all sentient beings, even from a “selfish” point of view.
      3. Valence – This is the pleasure-pain axis. We take a valence realist view which means that we assume that there is an objective matter of fact about how much an experience is in pain/suffering vs. experiencing happiness/pleasure. There are pure heavenly experiences, pure hellish experiences, mixed states (e.g. enjoying music you love on awful speakers while wanting to pee), and neutral states (e.g. white noise, mild apathy, etc.).
      4. Evolutionary advantages of consciousness as part of the information processing pipeline – I pointed out that we also assume that consciousness is a real and computationally relevant phenomena. And in particular, that the reason why consciousness was recruited by natural selection to process information has to do with “phenomenal binding”. I did not go into much detail about it at the time, but if you are curious I elaborated about this during the Q&A.
  2. Spirit of our research:
    1. Exploration + Knowledge/Synthesis. Many people either over-focus on exploration (especially people very high in openness to experience) or on synthesis (like conservatives who think “the good days are gone, let’s study history”). The spirit of our research combines both open-ended exploration and strong synthesis. We encourage people to both expand their evidential base and make serious time to synthesize and cross-examine their experiences.
    2. A lot of people treat consciousness research like people used to treat alchemy. That is, they have a psychological need to “keep things magical”. We don’t. We think that consciousness research is due to transition into a hard science and that many new possibilities will be unlocked after this transition, not unlike how chemistry is thousands of times more powerful than alchemy because it allows you to create synthesis pathways from scratch using chemistry principles.
  3. How People Think and Why Few Say Meaningful Things:
    1. What most people say and talk about is a function of the surrounding social status algorithm (i.e. what kind of things award social recognition) and deep-seated evolutionarily adaptive programs (such as survival, reproductive, and affective consistency programs).
    2. Nerds and people on the autism spectrum do tend to circumvent this general mental block and are able to discuss things without being motivated by status or evolutionary programs only, instead being driven by open-ended curiosity. We encourage our collaborators to have that approach to consciousness research.
  4. What the Economy is Based on:
    1. Right now there are three main goods that are exchanged in the global economy. These are:
      1. Survival – resources that help you survive, like food, shelter, safety, etc.
      2. Power – resources that allow you to acquire social and physical power and thus increase your chances of reproducing.
      3. Consciousness – information about the state-space of consciousness. Right now people are willing to spend their “surplus” resources on experiences even if they do not increase their reproductive success. A possible dystopian scenario is one in which people do not do this anymore – everyone spends all of their available time and energy pursuing jobs for the sake of maximizing their wealth and increasing their reproductive success. This leads us to…
  5. Pure Replicators – In Wireheading Done Right we introduced the concept of a Pure ReplicatorI will define a pure replicator, in the context of agents and minds, to be an intelligence that is indifferent towards the valence of its conscious states and those of others. A pure replicator invests all of its energy and resources into surviving and reproducing, even at the cost of continuous suffering to themselves or others. Its main evolutionary advantage is that it does not need to spend any resources making the world a better place. (e.g. crystals, viruses, programs, memes, genes)
    1. It is reasonable to expect that in the absence of evolutionary selection pressures that favor the wellbeing of sentient beings, in the long run everyone alive will be playing a Pure Replicator strategy.
  6. States vs. Stages vs. Theory of Morality
    1. Ken Wilber emphasizes that there is a key difference between states and stages. Whereas states of consciousness involve various degrees of oneness and interconnectedness (from normal everyday sober experiences all the way to unity consciousness and satori), how you interpret these states will ultimately depend on your own level of moral development and maturity. This is very true and important. But I propose a further axis:
    2. Levels of intellectual understanding of ethics. While stages of consciousness refer to the degree to which you are comfortable with ambiguity, can synthesize large amounts of seemingly contradictory experiences, and are able to be emotionally stable in the face of confusion, we think that there is another axis worth exploring that has more to do with one’s intellectual model of ethics.
    3. The 4 levels are:
      1. Good vs. evil – the most common view which personifies/essentializes evil (e.g. “the devil”)
      2. Balance between good and evil – the view that most people who take psychedelics and engage in eastern meditative practices tend to arrive at. People at this level tend to think that good implies evil, and that the best we can do is to reach a state of balance and equanimity. I argue that this is a rationalization to be able to deal with extremes of suffering; the belief itself is used as an anti-depressant, which shows the intrinsic contradictoriness and motivated reasoning behind adopting this ethical worldview. You believe in the balance between good and evil in general so that you, right now, can feel better about your life. You are still, implicitly, albeit in a low-key way, trying to regulate your mood like everyone else.
      3. Gradients of wisdom – this is the view that people like Sam Harris, Ken Wilber, John Lilly, David Chapman, Buddha, etc. seem to converge on. They don’t have a deontological “if-then” ethical programming like the people at the first level. Rather, they have general heuristics and meta-heuristics for navigating complex problems. They do not claim to know “the truth” or be able to identify exactly what makes a society “better for human flourishing” but they do accept that some environments and states of consciousness are more healthy and conducive to wisdom than others. The problem with this view is that it does not give you a principled way to resolve disagreements or a way forward for designing societies from first principles.
      4. Consciousness vs. pure replicators – this view is the culmination of intellectual ethical development (although you could still be very neurotic and unenlightened otherwise) which arises when one identifies the source of everything that is systematically bad as caused by patterns that are good at making copies of themselves but that either don’t add conscious value or actively increase suffering. In this framework, it is possible for consciousness to win, which would happen if we create a full-spectrum super-sentient super-intelligent singleton that explores the entire state-space of consciousness and rationally decides what experiences to instantiate at a large scale based on the empirically revealed total order of consciousness.
  7. New Reproductive Strategies
    1. Given that we on team consciousness are in a race against Pure Replicator Hell scenarios it is important to explore ways in which we could load the dice in the favor of consciousness. One way to do so would be to increase the ways in which prosocial people are able to reproduce and pass on their pro-consciousness genes going forward. Here are a few interesting examples:
      1. Gay + Lesbian couple – for gay and lesbian couples with long time horizons we could help them have biological kids with the following scheme: Gay couple A + B and lesbian couple X + Z could combine their genes and have 4 kids A/X, A/Z, B/X, B/Z. This would create the genetic and game-theoretical incentives for this new kind of family structure to work in the long term.
      2. Genetic spellchecking – one of the most promising ways of increasing sentient welfare is to apply genetic spellchecking to embryos. This means that we would be reducing the mutational load of one’s offspring without compromising one’s genetic payload (and thus selfish genes would agree to the procedure and lead to an evolutionarily stable strategy). You wouldn’t ship code to production without testing and debugging, you wouldn’t publish a book without someone proof-reading it first, so why do we push genetic code to production without any debugging? As David Pearce says, right now every child is a genetic experiment. It’s terrible that such a high percentage of them lead to health and mental problems.
      3. A reproductive scheme in which 50% of the genes come from an “intelligently vetted gene pool” and the other 50% come from the parents’ genes. This would be very unpopular at first, but after a generation or two we would see that all of the kids who are the result of this procedure are top of the class, win athletic competitions, start getting Nobel prizes and Fields medals, etc. So soon every parent will want to do this… and indeed from a selfish gene point of view there will be no option but to do so, as it will make the difference between passing on some copies vs. none.*
      4. Dispassionate evaluation of the merits and drawbacks of one’s genes in a collective of 100 or more people where one recombines the genetic makeup of the “collective children” in order to maximize both their wellbeing and the information gained. In order to do this analysis in a dispassionate way we might need to recruit 5-meo-dmt-like states of consciousness that make you identify with consciousness rather than with your particular genes, and also MDMA-like states of mind in order to create a feeling of connection to source and universal love even if your own patterns lose out at some point… which they will after long enough, because eventually the entire gene pool would be replaced by a post-human genetic make-up.
  8. Consciousness vs. Replicators as a lens – I discussed how one can use the 4th stage of intellectual ethical development as a lens to analyze the value of different patterns and aesthetics. For example:
    1. Conservatives vs. Liberals (stick to your guns and avoid cancer vs. be adaptable but expose yourself to nasty dangers)
    2. Rap Music vs. Classical or Electronic music (social signaling vs. patternistic valence exploration)
  9. Hyperstition – Finally, I discussed the concept of hyperstition, which is a concept that refers to “ideas that make themselves real”. I explored it in the first Burning Man article. The core idea is that states of consciousness can indeed transform the history of the cosmos. In particular, high-energy states of mind like those experienced under psychedelics allow for “bigger ideas” and thus increase the upper bound of “irreducible complexity” for one’s thoughts. An example of this is coming up with further alternative reproductive strategies, which I encouraged the audience to do in order to increase the chances that team consciousness wins in the long term…

The End.


Bonus content: things I overheard virgin burners say:

  • “Intelligent people build intelligent civilizations. I now get what a society made of brilliant people would look like.”
  • “Burning Man is a magical place. It seems like it is one of the only places on Earth where the Spirit World and the Physical World intersect and play with each other.”
  • “It is not every day that you engage in a deeply transformative conversation before breakfast.”

* Thanks to Alison Streete for this idea.

Open Individualism and Antinatalism: If God could be killed, it’d be dead already

Abstract

Personal identity views (closed, empty, open) serve in philosophy the role that conservation laws play in physics. They recast difficult problems in solvable terms, and by expanding our horizon of understanding, they likewise allow us to conceive of new classes of problems. In this context, we posit that philosophy of personal identity is relevant in the realm of ethics by helping us address age-old questions like whether being born is good or bad. We further explore the intersection between philosophy of personal identity and philosophy of time, and discuss the ethical implications of antinatalism in a tenseless open individualist “block-time” universe.

Introduction

Learning physics, we often find wide-reaching concepts that simplify many problems by using an underlying principle. A good example of this is the law of conservation of energy. Take for example the following high-school physics problem:

An object that weighs X kilograms falls from a height of Y meters on a planet without an atmosphere and a gravity of Zg. Calculate the velocity with which this object will hit the ground.

One could approach this problem by using Newton’s laws of motion and differentiating the distance traveled by the object as a function of time and then obtaining the velocity of the object at the time it has fallen Y meters.

Alternatively, you could simply note that given that energy is conserved, all of the potential energy of the object at a height of X meters will be transformed into kinetic energy at 0 height. Thus the velocity of the object is equivalent to this amount, and the problem is easier to solve.

Once one has learned “the trick” one starts to see many other problems differently. In turn, grasping these deep invariants opens up new horizons; while many problems that seemed impossible can be solved using these principles, it also allows you to ask new questions, which opens up new problems that cannot be solved with those principles alone.

Does this ever happen in philosophy? Perhaps entire classes of difficult problems in philosophy may become trivial (or at least tractable) once one grasps powerful principles. Such is the case, I would claim, of transcending common-sense views of personal identity.

Personal Identity: Closed, Empty, Open

In Ontological Qualia I discussed three core views about personal identity. For those who have not encountered these concepts, I recommend reading that article for an expanded discussion.

In brief:

  1. Closed Individualism: You start existing when you are born, and stop when you die.
  2. Empty Individualism: You exist as a “time-slice” or “moment of experience.”
  3. Open Individualism: There is only one subject of experience, who is everyone.

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Most people are Closed Individualists; this is the default common sense view for good evolutionary reasons. But what grounds are there to believe in this view? Intuitively, the fact that you will wake up in “your body” tomorrow is obvious and needs no justification. However, explaining why this is the case in a clear way requires formalizing a wide range of concepts such as causality, continuity, memory, and physical laws. And when one tries to do so one will generally find a number of barriers that will prevent one from making a solid case for Closed Individualism.

As an example line of argument, one could argue that what defines you as an individual is your set of memories, and since the person who will wake up in your body tomorrow is the only human being with access to your current memories then you must be it. And while this may seem to work on the surface, a close inspection reveals otherwise. In particular, all of the following facts work against it: (1) memory is a constructive process and every time you remember something you remember it (slightly) differently, (2) memories are unreliable and do not always work at will (e.g. false memories), (3) it is unclear what happens if you copy all of your memories into someone else (do you become that person?), (4) how many memories can you swap with someone until you become a different person?, and so on. Here the more detailed questions one asks, the more ad-hoc modifications of the theory are needed. In the end, one is left with what appears to be just a set of conventional rules to determine whether two persons are the same for practical purposes. But it does not seem to carve nature at its joints; you’d be merely over-fitting the problem.

The same happens with most Closed Individualist accounts. You need to define what the identity carrier is, and after doing so one can identify situations in which identity is not well-defined given that identity carrier (memory, causality, shared matter, etc.).

But for both Open and Empty Individualism, identity is well-defined for any being in the universe. Either all are the same, or all are different. Critics might say that this is a trivial and uninteresting point, perhaps even just definitional. Closed Individualism seems sufficiently arbitrary, however, that questioning it is warranted, and once one does so it is reasonable to start the search for alternatives by taking a look at the trivial cases in which either all or none of the beings are the same.

More so, there are many arguments in favor of these views. They indeed solve and usefully reformulate a range of philosophical problems when applied diligently. I would argue that they play a role in philosophy that is similar to that of conservation of energy in physics. The energy conservation law has been empirically tested to extremely high levels of precision, which is something which we will have to do without in the realm of philosophy. Instead, we shall rely on powerful philosophical insights. And in addition, they make a lot of problems tractable and offer a powerful lens to interpret core difficulties in the field.

Open and Empty Individualism either solve or have bearings on: Decision theory, utilitarianism, fission/fusion, mind-uploading and mind-melding, panpsychism, etc. For now, let us focus on…

Antinatalism

Antinatalism is a philosophical view that posits that, all considered, it is better not to be born. Many philosophers could be adequately described as antinatalists, but perhaps the most widely recognized proponent is David Benatar. A key argument Benatar considers is that there might be an asymmetry between pleasure and pain. Granted, he would say, experiencing pleasure is good, and experiencing suffering is bad. But while “the absence of pain is good, even if that good is not enjoyed by anyone”, we also have that “the absence of pleasure is not bad unless there is somebody for whom this absence is a deprivation.” Thus, while being born can give rise to both good and bad, not being born can only be good.

Contrary to popular perception, antinatalists are not more selfish or amoral than others. On the contrary, their willingness to “bite the bullet” of a counter-intuitive but logically defensible argument is a sign of being willing to face social disapproval for a good cause. But along with the stereotype, it is generally true that antinatalists are temperamentally depressive. This, of course, does not invalidate their arguments. If anything, sometimes a degree of depressive realism is essential to arrive at truly sober views in philosophy. But it shouldn’t be a surprise to learn that either experiencing or having experienced suffering in the past predispose people to vehemently argue for the importance of its elimination. Having a direct acquaintance with the self-disclosing nastiness of suffering does give one a broader evidential base for commenting on the matter of pain and pleasure.

Antinatalism and Closed Individualism

Interestingly, Benatar’s argument, and those of many antinatalists, rely implicitly on personal identity background assumptions. In particular, antinatalism is usually framed in a way that assumes Closed Individualism.

The idea that a “person can be harmed by coming into existence” is developed within a conceptual framework in which the inhabitants of the universe are narrative beings. These beings have both spatial and temporal extension. And they also have the property that had the conditions previous to their birth been different, they might not have existed. But how many possible beings are there? How genetically or environmentally different do they need to be to be different beings? What happens if two beings merge? Or if they converge towards the same exact physical configuration over time?

 

This conceptual framework has counter-intuitive implications when taken to the extreme. For example, the amount of harm you do involves how many people you allow to be born, rather than how many years of suffering you prevented.

For the sake of the argument, imagine that you have control over a sentient-AI-enabled virtual environment in which you can make beings start existing and stop existing. Say that you create two beings, A and B, who are different in morally irrelevant ways (e.g. one likes blue more than red, but on average they both end up suffering and delighting in their experience with the same intensity). With Empty Individualism, you would consider giving A 20 years of life and not creating B vs. giving A and B 10 years of life each to be morally equivalent. But with Closed Individualism you would rightly worry that these two scenarios are completely different. By giving years of life to both A and B (any amount of life!) you have doubled the number of subjects who are affected by your decisions. If the gulf of individuality between two persons is infinite, as Closed Individualism would have it, by creating both A and B you have created two parallel realities, and that has an ontological effect on existence. It’s a big deal. Perhaps a way to put it succinctly would be: God considers much more carefully the question of whether to create a person who will live only 70 years versus whether to add a million years of life to an angel who has already lived for a very long time. Creating an entirely new soul is not to be taken lightly (incidentally, this may cast the pro-choice/pro-life debate in an entirely new light).

Thus, antinatalism is usually framed in a way that assumes Closed Individualism. The idea that a being is (possibly) harmed by coming into existence casts the possible solutions in terms of whether one should allow animals (or beings) to be born. But if one were to take an Open or Empty Individualist point of view, the question becomes entirely different. Namely, what kind of experiences should we allow to exist in the future…

Antinatalism and Empty Individualism

I think that the strongest case for antinatalism comes from a take on personal identity that is different than the implicit default (Closed Individualism). If you assume Empty Individualism, in particular, reality starts to seem a lot more horrible than you had imagined. Consider how in Empty Individualism fundamental entities exist as “moments of experience” rather than narrative streams. Therefore, every time that an animal suffers, what is actually happening is that some moments of experience get to have their whole existence in pain and suffering. In this light, one stops seeing people who suffer terrible happenings (e.g. kidney stones, schizophrenia, etc.) as people who are unlucky, and instead one sees their brains as experience machines capable of creating beings whose entire existence is extremely negative.

With Empty Individualism there is simply no way to “make it up to someone” for having had a bad experience in the past. Thus, out of compassion for the extremely negative moments of experience, one could argue that it might be reasonable to try to avoid this whole business of life altogether. That said, this imperative does not come from the asymmetry between pain and pleasure Benetar talks about (which as we saw implicitly requires Closed Individualism). In Empty Individualism it does not make sense to say that someone has been brought into existence. So antinatalism gets justified from a different angle, albeit one that might be even more powerful.

In my assessment, the mere possibility of Empty Individualism is a good reason to take antinatalism very seriously.

It is worth noting that the combination of Empty Individualism and Antinatalism has been (implicitly) discussed by Thomas Metzinger (cf. Benevolent Artificial Anti-Natalism (BAAN)) and FRI‘s Brian Tomasik.

Antinatalism and Open Individualism

Here is a Reddit post and then a comment on a related thread (by the same author) worth reading on this subject (indeed these artifacts motivated me to write the article you are currently reading):

There’s an interesting theory of personal existence making the rounds lately called Open Individualism. See herehere, and here. Basically, it claims that consciousness is like a single person in a huge interconnected library. One floor of the library contains all of your life’s experiences, and the other floors contain the experiences of others. Consciousness wanders the aisles, and each time he picks up a book he experiences whatever moment of life is recorded in it as if he were living it. Then he moves onto the next one (or any other random one on any floor) and experiences that one. In essence, the “experiencer” of all experience everywhere, across all conscious beings, is just one numerically identical subject. It only seems like we are each separate “experiencers” because it can only experience one perspective at a time, just like I can only experience one moment of my own life at a time. In actuality, we’re all the same person.

 

Anyway, there’s no evidence for this, but it solves a lot of philosophical problems apparently, and in any case there’s no evidence for the opposing view either because it’s all speculative philosophy.

 

But if this were true, and when I’m done living the life of this particular person, I will go on to live every other life from its internal perspective, it has some implications for antinatalism. All suffering is essentially experienced by the same subject, just through the lens of many different brains. There would be no substantial difference between three people suffering and three thousand people suffering, assuming their experiences don’t leave any impact or residue on the singular consciousness that experiences them. Even if all conscious life on earth were to end, there are still likely innumerable conscious beings elsewhere in the universe, and if Open Individualism is correct, I’ll just move on to experiencing those lives. And since I can re-experience them an infinite number of times, it makes no difference how many there are. In fact, even if I just experienced the same life over and over again ten thousand times, it wouldn’t be any different from experiencing ten thousand different lives in succession, as far as suffering is concerned.

 

The only way to end the experience of suffering would be to gradually elevate all conscious beings to a state of near-constant happiness through technology, or exterminate every conscious being like the Flood from the Halo series of games. But the second option couldn’t guarantee that life wouldn’t arise again in some other corner of the multiverse, and when it did, I’d be right there again as the conscious experiencer of whatever suffering it would endure.

 

I find myself drawn to Open Individualism. It’s not mysticism, it’s not a Big Soul or something we all merge with, it’s just a new way of conceptualizing what it feels like to be a person from the inside. Yet, it has these moral implications that I can’t seem to resolve. I welcome any input.

 

– “Open individualism and antinatalism” by Reddit user CrumbledFingers in r/antinatalism (March 23, 2017)

And on a different thread:

I have thought a lot about the implications of open individualism (which I will refer to as “universalism” from here on, as that’s the name coined by its earliest proponent, Arnold Zuboff) for antinatalism. In short, I think it has two major implications, one of which you mention. The first, as you say, is that freedom from conscious life is impossible. This is bad, but not as bad as it would be if I were aware of it from every perspective. As it stands, at least on Earth, only a small number of people have any inkling that they are me. So, it is not like experiencing the multitude of conscious events taking place across reality is any kind of burden that accumulates over time; from the perspective of each isolated nervous system, it will always appear that whatever is being experienced is the only thing I am experiencing. In this way, the fact that I am never truly unconscious does not have the same sting as it would to, for example, an insomniac, who is also never unconscious but must experience the constant wakefulness from one integrated perspective all the time.

 

It’s like being told that I will suffer total irreversible amnesia at some point in my future; while I can still expect to be the person that experiences all the confusion and anxiety of total amnesia when it happens, I must also acknowledge that the residue of any pains I would have experienced beforehand would be erased. Much of what makes consciousness a losing game is the persistence of stresses. Universalism doesn’t imply that any stresses will carry over between the nervous systems of individual beings, so the reality of my situation is by no means as nightmarish as eternal life in a single body (although, if there exists an immortal being somewhere in the universe, I am currently experiencing the nightmare of its life).

 

The second implication of this view for antinatalism is that one of the worst things about coming into existence, namely death, is placed in quite a different context. According to the ordinary view (sometimes called “closed” individualism), death permanently ends the conscious existence of an alienated self. Universalism says there is no alienated self that is annihilated upon the death of any particular mind. There are just moments of conscious experience that occur in various substrates across space and time, and I am the subject of all such experiences. Thus, the encroaching wall of perpetual darkness and silence that is usually an object of dread becomes less of a problem for those who have realized that they are me. Of course, this realization is not built into most people’s psychology and has to be learned, reasoned out, intellectually grasped. This is why procreation is still immoral, because even though I will not cease to exist when any specific organism dies, from the perspective of each one I will almost certainly believe otherwise, and that will always be a source of deep suffering for me. The fewer instances of this existential dread, however misplaced they may be, the better.

 

This is why it’s important to make more people understand the position of universalism/open individualism. In the future, long after the person typing this sentence has perished, my well-being will depend in large part on having the knowledge that I am every person. The earlier in each life I come to that understanding, and thus diminish the fear of dying, the better off I will be. Naturally, this project decreases in potential impact if conscious life is abundant in the universe, and in response to that problem I concede there is probably little hope, unless there are beings elsewhere in the universe that have comprehended who they are and are taking the same steps in their spheres of influence. My dream is that intelligent life eventually either snuffs itself out or discovers how to connect many nervous systems together, which would demonstrate to every connected mind that it has always belonged to one subject, has always been me, but I don’t have any reason to assume this is even possible on a physical level.

 

So, I suppose you are mostly right about one thing: there are no lucky ones that escape the badness of life’s worst agonies, either by virtue of a privileged upbringing or an instantaneous and painless demise. They and the less fortunate ones are all equally me. Yet, the horror of going through their experiences is mitigated somewhat in the details.

 

– A comment by CrumbledFingers in the Reddit post “Antinatalism and Open individualism“, also in r/antinatalism (March 12, 2017)

Our brain tries to make sense of metaphysical questions in wet-ware that shares computational space with a lot of adaptive survival programs. It does not matter if you have thick barriers (cf. thick and thin boundaries of the mind), the way you assess the value of situations as a human will tend to over-focus on whatever would allow you to go up Maslow’s hierarchy of needs (or, more cynically, achieve great feats as a testament to signal your genetic-fitness). Our motivational architecture is implemented in such a way that it is very good at handling questions like how to find food when you are hungry and how to play social games in a way that impresses others and leaves a social mark. Our brains utilize many heuristics based on personhood and narrative-streams when exploring the desirability of present options. We are people, and our brains are adapted to solve people problems. Not, as it turns out, general problems involving the entire state-space of possible conscious experiences.

Prandium Interruptus

Our brains render our inner world-simulation with flavors and textures of qualia to suit their evolutionary needs. This, in turn, impairs our ability to aptly represent scenarios that go beyond the range of normal human experiences. Let me illustrate this point with the following thought experiment:

Would you rather (a) have a 1-hour meal, or (b) have the same meal but at the half-hour point be instantly transformed into a simple, amnesic, and blank experience of perfectly neutral hedonic value that lasts ten quintillion years, and after that extremely long time of neither-happiness-nor-suffering ends, then resume the rest of the meal as if nothing had happened, with no memory of that long neutral period?

According to most utilitarian calculi these two scenarios ought to be perfectly equivalent. In both cases the total amount of positive and negative qualia is the same (the full duration of the meal) and the only difference is that the latter also contains a large amount of neutral experience too. Whether classical or negative, utilitarians should consider these experiences equivalent since they contain the same amount of pleasure and pain (note: some other ethical frameworks do distinguish between these cases, such as average and market utilitarianism).

Intuitively, however, (a) seems a lot better than (b). One imagines oneself having an awfully long experience, bored out of one’s mind, just wanting it to end, get it over with, and get back to enjoying the nice meal. But the very premise of the thought experiment presupposes that one will not be bored during that period of time, nor will one be wishing it to be over, or anything of the sort, considering that all of those are mental states of negative quality and the experience is supposed to be neutral.

Now this is of course a completely crazy thought experiment. Or is it?

The One-Electron View

In 1940 John Wheeler proposed to Richard Feynman the idea that all of reality is made of a single electron moving backwards and forwards in time, interfering with itself. This view has come to be regarded as the One-Electron Universe. Under Open Individualism, that one electron is you. From every single moment of experience to the next, you may have experienced life as a sextillion different animals, been 10^32 fleeting macroscropic entangled particles, and gotten stuck as a single non-interacting electron in the inter-galactic medium for googols of subjective years. Of course you will not remember any of this, because your memories, and indeed all of your motivational architecture and anticipation programs, are embedded in the brain you are instantiating right now. From that point of view, there is absolutely no trace of the experiences you had during this hiatus.

The above way of describing the one-electron view is still just an approximation. In order to see it fully, we also need to address the fact that there is no “natural” order to all of these different experiences. Every way of factorizing it and describing the history of the universe as “this happened before this happened” and “this, now that” could be equally inapplicable from the point of view of fundamental reality.

Philosophy of Time

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Presentism is the view that only the present moment is real. The future and the past are just conceptual constructs useful to navigate the world, but not actual places that exist. The “past exists as footprints”, in a matter of speaking. “Footprints of the past” are just strangely-shaped information-containing regions of the present, including your memories. Likewise, the “future” is unrealized: a helpful abstraction which evolution gave us to survive in this world.

On the other hand, eternalism treats the future and the past as always-actualized always-real landscapes of reality. Every point in space-time is equally real. Physically, this view tends to be brought up in connection with the theory of relativity, where frame-invariant descriptions of the space-time continuum have no absolute present line. For a compelling physical case, see the Rietdijk-Putnam argument.

Eternalism has been explored in literature and spirituality extensively. To name a few artifacts: The EggHindu and Buddhist philosophy, the videos of Bob Sanders (cf. The Gap in Time, The Complexity of Time), the essays of Philip K. Dick and J. L. Borges, the poetry of T. S. Eliot, the fiction of Kurt Vonnegut Jr (TimequakeSlaughterhouse Five, etc.), and the graphic novels of Alan Moore, such as Watchmen:

Let me know in the comments if you know of any other work of fiction that explores this theme. In particular, I would love to assemble a comprehensive list of literature that explores Open Individualism and Eternalism.

Personal Identity and Eternalism

For the time being (no pun intended), let us assume that Eternalism is correct. How do Eternalism and personal identity interact? Doctor Manhattan in the above images (taken from Watchmen) exemplifies what it would be like to be a Closed Individualist Eternalist. He seems to be aware of his entire timeline at once, yet recognizes his unique identity apart from others. That said, as explained above, Closed Individualism is a distinctly unphysical theory of identity. One would thus expect of Doctor Manhattan, given his physically-grounded understanding of reality, to espouse a different theory of identity.

A philosophy that pairs Empty Individualism with Eternalism is the stuff of nightmares. Not only would we have, as with Empty Individualism alone, that some beings happen to exist entirely as beings of pain. We would also have that such unfortunate moments of experience are stuck in time. Like insects in amber, their expressions of horror and their urgency to run away from pain and suffering are forever crystallized in their corresponding spatiotemporal coordinates. I personally find this view paralyzing and sickening, though I am aware that such a reaction is not adaptive for the abolitionist project. Namely, even if “Eternalism + Empty Individualism” is a true account of reality, one ought not to be so frightened by it that one becomes incapable of working towards preventing future suffering. In this light, I adopt the attitude of “hope for the best, plan for the worst”.

Lastly, if Open Individualism and Eternalism are both true (as I suspect is the case), we would be in for what amounts to an incredibly trippy picture of reality. We are all one timeless spatiotemporal crystal. But why does this eternal crystal -who is everyone- exist? Here the one-electron view and the question “why does anything exist?” could both be simultaneously addressed with a single logico-physical principle. Namely, that the sum-total of existence contains no information to speak of. This is what David Pearce calls “Zero Ontology” (see: 1, 2, 3, 4). What you and I are, in the final analysis, is the necessary implication of there being no information; we are all a singular pattern of self-interference whose ultimate nature amounts to a dimensionless unit-sphere in Hilbert space. But this is a story for another post.

On a more grounded note, Scientific American recently ran an article that could be placed in this category of Open Individualism and Eternalism. In it the authors argue that the physical signatures of multiple-personality disorder, which explain the absence of phenomenal binding between alters that share the same brain, could be extended to explain why reality is both one and yet appears as the many. We are, in this view, all alters of the universe.

Personal Identity X Philosophy of Time X Antinatalism

Sober, scientifically grounded, and philosophically rigorous accounts of the awfulness of reality are rare. On the one hand, temperamentally happy individuals are more likely to think about the possibilities of heaven that lie ahead of us, and their heightened positive mood will likewise make them more likely to report on their findings. Temperamental depressives, on the other hand, may both investigate reality with less motivated reasoning than the euthymic and also be less likely to report on the results due to their subdued mood (“why even try? why even bother to write about it?”). Suffering in the Multiverse by David Pearce is a notable exception to this pattern. David’s essay highlights that if Eternalism is true together with Empty Individualism, there are vast regions of the multiverse filled with suffering that we can simply do nothing about (“Everett Hell Branches”). Taken together with a negative utilitarian ethic, this represents a calamity of (quite literally) astronomical proportions. And, sadly, there simply is no off-button to the multiverse as a whole. The suffering is/has/will always be there. And this means that the best we can do is to avoid the suffering of those beings in our forward-light cone (a drop relative to the size of the ocean of existence). The only hope left is to find a loop-hole in quantum mechanics that allows us to cross into other Everett branches of the multiverse and launch cosmic rescue missions. A counsel of despair or a rational prospect? Only time will tell.

Another key author that explores the intersection of these views is Mario Montano (see: Eternalism and Its Ethical Implications and The Savior Imperative).

A key point that both of these authors make is that however nasty reality might be, ethical antinatalists and negative utilitarians shouldn’t hold their breath about the possibility that reality can be destroyed. In Open Individualism plus Eternalism, the light of consciousness (perhaps what some might call the secular version of God) simply is, everywhere and eternally. If reality could be destroyed, such destruction is certainly limited to our forward light-cone. And unlike Closed Individualist accounts, it is not possible to help anyone by preventing their birth; the one subject of existence has already been born, and will never be unborn, so to speak.

Nor should ethical antinatalists and negative utilitarians think that avoiding having kids is in any way contributing to the cause of reducing suffering. It is reasonable to assume that the personality traits of agreeableness (specifically care and compassion), openness to experience, and high levels of systematizing intelligence are all over-represented among antinatalists. Insofar as these traits are needed to build a good future, antinatalists should in fact be some of the people who reproduce the most. Mario Montano says:

Hanson calls the era we live in the “dream time” since it’s evolutionarily unusual for any species to be wealthy enough to have any values beyond “survive and reproduce.” However, from an anthropic perspective in infinite dimensional Hilbert space, you won’t have any values beyond “survive and reproduce.” The you which survives will not be the one with exotic values of radical compassion for all existence that caused you to commit peaceful suicide. That memetic stream weeded himself out and your consciousness is cast to a different narrative orbit which wants to survive and reproduce his mind. Eventually. Wanting is, more often than not, a precondition for successfully attaining the object of want.

Physicalism Implies Existence Never Dies

Also, from the same essay:

Anti-natalists full of weeping benignity are literally not successful replicators. The Will to Power is life itself. It is consciousness itself. And it will be, when a superintelligent coercive singleton swallows superclusters of baryonic matter and then spreads them as the flaming word into the unconverted future light cone.

[…]

You eventually love existence. Because if you don’t, something which does swallows you, and it is that which survives.

I would argue that the above reasoning is not entirely correct in the large scheme of things*, but it is certainly applicable in the context of human-like minds and agents. See also: David Pearce’s similar criticisms to antinatalism as a policy.

This should underscore the fact that in its current guise, antinatalism is completely self-limiting. Worryingly, one could imagine an organized contingent of antinatalists conducting research on how to destroy life as efficiently as possible. Antinatalists are generally very smart, and if Eliezer Yudkowsky‘s claim that “every 18 months the minimum IQ necessary to destroy the world drops by one point” is true, we may be in for some trouble. Both Pearce’s, Montano’s, and my take is that even if something akin to negative utilitarianism is the case, we should still pursue the goal of diminishing suffering in as peaceful of a way as it is possible. The risk of trying to painlessly destroy the world and failing to do so might turn out to be ethically catastrophic. A much better bet would be, we claim, to work towards the elimination of suffering by developing commercially successful hedonic recalibration technology. This also has the benefit that both depressives and life-lovers will want to team up with you; indeed, the promise of super-human bliss can be extraordinarily motivating to people who already lead happy lives, whereas the prospect of achieving “at best nothing” sounds stale and uninviting (if not outright antagonistic) to them.

An Evolutionary Environment Set Up For Success

If we want to create a world free from suffering, we will have to contend with the fact that suffering is adaptive in certain environments. The solution here is to avoid such environments, and foster ecosystems of mind that give an evolutionary advantage to the super-happy. More so, we already have the basic ingredients to do so. In Wireheading Done Right I discussed how, right now, the economy is based on trading three core goods: (1) survival tools, (2) power, and (3) information about the state-space of consciousness. Thankfully, the world right now is populated by humans who largely choose to spend their extra income on fun rather than on trips to the sperm bank. In other words, people are willing to trade some of their expected reproductive success for good experiences. This is good because it allows the existence of an economy of information about the state-space of consciousness, and thus creates an evolutionary advantage for caring about consciousness and being good at navigating its state-space. But for this to be sustainable, we will need to find the way to make positive valence gradients (i.e. gradients of bliss) both economically useful and power-granting. Otherwise, I would argue, the part of the economy that is dedicated to trading information about the state-space of consciousness is bound to be displaced by the other two (i.e. survival and power). For a more detailed discussion on these questions see: Consciousness vs. Pure Replicators.

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Can we make the benevolent exploration of the state-space of consciousness evolutionarily advantageous?

In conclusion, to close down hell (to the extent that is physically possible), we need to take advantage of the resources and opportunities granted to us by merely living in Hanson’s “dream time” (cf. Age of Spandrels). This includes the fact that right now people are willing to spend money on new experiences (especially if novel and containing positive valence), and the fact that philosophy of personal identity can still persuade people to work towards the wellbeing of all sentient beings. In particular, scientifically-grounded arguments in favor of both Open and Empty Individualism weaken people’s sense of self and make them more receptive to care about others, regardless of their genetic relatedness. On its natural course, however, this tendency may ultimately be removed by natural selection: if those who are immune to philosophy are more likely to maximize their inclusive fitness, humanity may devolve into philosophical deafness. The solution here is to identify the ways in which philosophical clarity can help us overcome coordination problems, highlight natural ethical Schelling points, and ultimately allow us to summon a benevolent super-organism to carry forward the abolition of as much suffering as is physically possible.

And only once we have done everything in our power to close down hell in all of its guises, will we be able to enjoy the rest of our forward light-cone in good conscience. Till then, us ethically-minded folks shall relentlessly work on building universe-sized fire-extinguishers to put out the fire of Hell.


* This is for several reasons: (1) phenomenal binding is not epiphenomenal, (2) the most optimal computational valence gradients are not necessarily located on the positive side, sadly, and (3) wanting, liking, and learning are possible to disentangle.

Treating Cluster Headaches Using N,N-DMT and Other Tryptamines

by Quintin Frerichs

To extend this recent EA Forum Post, I wanted to share the results of Qualia Research Institute’s research into using tryptamines to abort and prevent cluster headaches. While the quotes and statistics contained here can provide some notion of the pain experienced by cluster headache sufferers, I think it is truly unimaginable. This report contains specific interventions to be pursued in both a philanthropic and for-profit business capacity. While for-profit options are beyond our scope, those interested in supporting philanthropic interventions should consider donating to ClusterBusters (the most important nonprofit dedicated to researching treatments for cluster headaches), or QRI (which does foundational research on ways to reduce intense suffering).

Mission: Instantly and safely abort cluster headaches and treat migraines, the #2 and #10 (respectively) most painful medical conditions according to NHS. Emphasis is placed on chronic cluster headaches, which account for as much as 80% of all clusters and currently lack an effective treatment option. 


 

I. Problem:

 

“Even child birth is 1/10th the pain of a cluster headache, seriously this name needs to change… call it ultra super migraine.” (source)

  • A back of the envelope calculation indicates there are roughly 14 thousand people enduring a cluster headache right now.[1]
  • 14.2% of US adults 18 or older reported having migraine or severe headache in the previous 3 months in the 2012 NHIS. The overall age-adjusted 3-month prevalence of migraine in females was 19.1% and in males 9.0%, but varied substantially depending on age. (source)
  • Current treatments are either ineffective, costly, unsafe, or some combination of the three. The most effective treatments available for cluster headaches include oxygen, which requires the patient to carry an oxygen tank with them at all times, and triptans, which can be used a maximum of three times daily (an issue for chronic sufferers especially) and have side effects from pain to heart attack and stroke. The most effective treatments for migraines include triptans and opioids (which have high addiction potential). Emgality, a more promising treatment for episodic cluster headaches, has recently entered the market, but its long-term risk profile and efficacy have not yet been established. 
  • Bob Wold founded “Cluster Busters” in 2002 with the explicit purpose of trying to get psychedelics to be prescription medication (see his lecture Treating Cluster Headaches with Psychedelics). He tried over 75 different prescription medications and was at the end of the rope when he found psychedelics could be helpful:
  • As noted in this Qualia Computing article, the survey surfaced that about 83% of all cluster headaches are experienced by 20% of the sufferers, most of which are classified as ‘chronic’. No existing medication has been approved for use to treat chronic cluster headaches. Vaporizing DMT could be the first such treatment, offering instant relief for cluster headaches as often as they arise in a (potentially large) percentage of sufferers.

 

II. Solution:

One of the most incredible experiences of my life was when I first aborted a CH [cluster headache] with DMT. That feeling of going from a place of excruciating pain…and feeling the pain fizzle away and die in a matter of seconds” (source)

It is known by a majority of cluster headache sufferers that psychedelics can be highly effective treatments. Due to the legal status of psychedelics, no randomized controlled trial (RCT) has been conducted, but analysis has been done on online forum responses and anonymous surveys, and interviews have been recorded. Evidence from these reports points to a number of important factors: tryptamines (the class of psychedelics which includes compounds like N,N-DMT and psilocybin, the active chemical in ‘magic mushrooms’) seem especially effective, sub-psychoactive and non-psychedelic doses can be therapeutic, and psychedelics can also decrease the frequency of headaches on long time horizons. While smoking/vaporizing is the fastest method of administration available, information from a private correspondence suggests that the FDA may be averse to approving inhalants. Intramuscular administration, utilizing Rick Strassman’s protocol, could be an alternative that would achieve rapid relief without the use of an inhalation device[2]. Since the pain being experienced is so severe, having a faster method of administration is critical. 

From the relevant academic literature:

  • The indoleamine hallucinogens, psilocybin, lysergic acid diethylamide, and lysergic acid amide, were comparable to or more efficacious than most conventional medications. These agents were also perceived to shorten/abort a cluster period and bring chronic cluster headache into remission more so than conventional medications.” (source)
  • Also, for DMT, it was suggested that singular or infrequent dosage could have potential long-term beneficial effects on headache disorders: ‘Even a single dose, or perhaps a couple, can be a lifelong benefit.’” (source)
  • “Of interest, an open-label study found that similar compounds (2-bromo-LSD) without psychedelic effect were promising for this purpose” (source)

From online surveys: 

  • A survey of members of online cluster headache forums revealed that 68% of respondents who used tryptamines had a 4 or 5 out of 5 relief. 5 indicates “completely eliminated the cluster headaches”. 
  • This survey again suggests that the main barrier to use is lack of access and hallucinogenic effects. As we found in an interview with an anonymous sufferer (see below), hallucinogenic effects may be avoidable. 
no_use_cluster_headache_difficulty_acquiring

Difficulty getting. 0 – Extremely easy to acquire, 5 – Nearly impossible to acquire

no_use_cluster_headache_legal_concern

Legal risk. 0 – Not concerned at all, 5 – Extremely concerned

no_use_cluster_headache_side_effect_concern

Side effects. 0 – Not concerned at all, 5 – Extremely concerned

From interviews with cluster headache sufferers who have tried N,N-DMT:


III. Philanthropic Opportunities

Due to the Schedule I status of psychedelics in the United States, pursuing this intervention in the US will not be feasible for a number of years (see Section IV for more information on pursuing FDA approval for DMT for cluster headaches/migraines). 

A possible solution would be to create an online education campaign publicizing the results of this report to cluster headache sufferers, designated as ‘information-only’, and pursuing the use of psychedelics to treat cluster headaches and migraines in countries where tryptamines are legal, including Brazil, Jamaica and the Netherlands. In addition, given the gravity of the disorder, it could be cost-effective to fly patients to such countries for months at a time.

While we believe that traditional metrics such as the QALY do not accurately capture the suffering caused by a cluster headache (see upcoming post on the true pain/pleasure scale), a rough QALY calculation would be as follows (focusing on chronic cluster headache sufferers rather than average, since they compromise up to 83% of total headaches[3]):

  1. Facebook AD campaign:
    1. An estimated 370,000 Americans suffer from cluster headaches, 68% of whom are on Facebook[4] (=251,000). About 15% of these suffer from chronic cluster headaches (=37,740). According to Sprout Social, the average estimated cost per click of an ad campaign is $1.72. Assuming 1/10 who click are cluster headache sufferers, to reach all chronic sufferers would take (ballpark) $650,000.
    2. Assuming about 30% of those who view the ad will pursue the treatment (rough estimate-those who put 2 or less on survey results for questions of legality, difficulty to acquire etc.) and that in 68% of cases it cured or nearly cured their clusters (based on survey results), then the resulting increase in QALYs would be (37,740 people * 0.3 * 0.68) * [0.760 (QALY coefficient) * 1 QALY – ( -0.429 (QALY coefficient)* (0.47QALY)) [5]] = $650,000/7, 404QALY = $87.70 per QALY.  
    3. These ads could also be targeted to users in countries where psilocybin and DMT are legal for use recreationally, increasing conversion rate. Further targeting could be done on Facebook groups (and other social media groups) which are associated with cluster headache treatment

IV. For-profit Opportunities 

The recent emergence of psychedelics in for-profit business settings also affords the opportunity for entrepreneurs to seek legal rescheduling of N,N-DMT in the US for the purpose of treating cluster headaches and/or migraines. Below is an outline of the process of navigating the FDA IND process, which could result in a change in legal status: 

Market Size:

‘Orphan disease’ status:  

There are two main classifications of cluster headaches, chronic and episodic. Episodic cluster headaches are characterized by periods of headaches (up to 8 times per day) of a week to a full year, which remit for periods from a month up to a year. Chronic cluster headaches, on the other hand, either last for longer than a year or have remittance periods of less than a month[6]. A meta-analysis from the NIH estimates that cluster headaches affect 124/100,000 in the U.S., meaning an estimated 370,000 people suffer from cluster headaches a year[7]. Of these, about 15%, or 60,000, suffer from chronic cluster headaches.

The FDA grants ‘orphan disease’ status to diseases which affect fewer than 200,000 persons in the U.S per year, and offers incentives to those pursuing treatments through the FDA’s IND process for such diseases, such as longer periods of exclusivity (monopoly on drug manufacture and sale) for the treatment after approval.  

  • The global market for migraine drugs (which encompasses cluster headache drugs) in 2017 was $1.7 billion.
    • Healthcare and lost productivity costs associated with migraine are estimated to be as high as $36 billion annually in the U.S. Current estimates of cluster headaches’ annual cost in the U.S. is ~$3.5 billion.
  • Share of market
    • 5 years after launch (with FDA approval, with a 5-year monopoly) – serve 20% of chronic migraine sufferers (800,000), serve 20% of cluster headache sufferers (40,000)
      • Platform’s average annual revenue per patient (migraines): $452/patient/year
        • Tryptapens – $20
        • 1g of DMT is ~$100, approximately 50 doses (although an anecdote indicate 3mg may be sufficient). Compare to triptans, at ~$115 per 9 doses. Assuming 20% markup: 
          • Chronic migraines at 20mg doses: $120/g*0.02g/dose*15 doses/month *12 months = $432/patient/year.
      • Platform’s average annual revenue per patient (cluster headache): $344/patient/year-low estimate, $6932/patient/year – high estimate
        • Tryptapen – $20
        • There is significant variance in frequency of cluster headaches: estimates range from [$120/g*0.02g/dose*30 doses/month *3 months = $324, $120/g*0.02g/dose*120 doses/month*12 months = $6912/patient/year].
      • Annual revenue, 5 years after launch: $13.6M [low cluster headache estimate] – $344M [high cluster headache estimate]
      •  Annual revenue, 5 years after launch (migraines): $344M 
    • The 5-year (or more, if ‘orphan disease’ status is gained) monopoly provided by the FDA would allow for further R&D, and as-yet undetermined projects. Some promising directions:

Why now?

  • FDA on track to approve MDMA therapy in 2021, psilocybin therapy in 2022
    1. FDA approval will catalyze a large increase in demand for psychedelic services
    2. There is sufficient evidence to attempt bringing DMT for headaches through the FDA process as it becomes increasingly open to psychedelic interventions
  • Reasons to start before FDA approval of MDMA and psilocybin:
    1. A “psychedelic renaissance” is underway: funding for psychedelic research has skyrocketed, and multiple psychedelic decriminalization initiatives (1, 2) have recently passed. Riding the current wave of activist and public support is advantageous to our efforts. 
    2. More time to build relationship with the FDA (important for seeking DMT clearance)
    3. More time to build relationships with organizations currently seeking FDA approval for therapeutic uses of psychedelics (MAPS & Compass Pathways)

Challenges: 

Regulatory:

  • Taking on the FDA IND process can be challenging and high risk from an investment standpoint. The average cost of successfully completing Phase 1-3 trials (after which the drug can be rescheduled and approved for medical use) is $100m, requires about 9-11 years and has a 6.7% success rate (private correspondence). 
    • The Multidisciplinary Association for Psychedelic Studies (MAPS) has recently raised $26.7M for Phase 3 MDMA trials alone[8]. Total, MAPS has spent in the ballpark of $30M. If Phase 3 trials demonstrate statistically-significant results, MDMA could be selectively rescheduled for use in therapeutic settings, but would require subsequent Phase 4 trials. 
  • The FDA is risk-averse and has incurred backlash from their last notable rescheduling of fentanyl in 1985[9]. Convincing the FDA to pursue rescheduling for treatment of a relatively rare disease with other available medications will likely be difficult. 
  • The success or failure of MAPS in receiving approval for MDMA will be crucial for defining the regulatory landscape for other psychedelics. Should they fail, bringing another similar substance through the process may prove much more difficult. 

Competition: 

  • As discussed in Section I, most available migraine and cluster headache drugs are ineffective, expensive, and/or have heavy risk profiles. Emgality, a new migraine drug approved last month, has received FDA ‘breakthrough therapy’ status for its ability to decrease the frequency of episodic cluster headaches and has shown promise as a palliative for migraines as well[10]. Emgality has not been approved for use in treating chronic cluster headaches, however, and does not achieve the same rapidity of administration as the DMT vape pen (see Section III). Thus, our solution is still critical for relieving symptoms instantly, and maintains the advantage of being eligible to treat chronic cluster headaches, an ‘orphan disease’. 

Business model: 

  • We would design studies to fulfill the three-step FDA drug review process:
    1. Phase 1 studies (typically involve 20 to 80 people).
    2. Phase 2 studies (typically involve a few dozen to about 300 people).
    3. Phase 3 studies (typically involve several hundred to about 3,000 people).

Use of Funds

  • Expenses for research and operations staff
    • Technicians 
    • Analysis consultants
    • Researchers with clinical experience
    • Legal counsel (paperwork)
  • Phase 1 FDA trial (our connections to expertise in the field would reduce the cost compared to average Phase 1 trials)

Data on Cost of Trials

The following information is from the MDMA/PTSD Trials led by MAPS. However, the treatment for PTSD involves: multiple therapy sessions and an MDMA-trained psychotherapist. Therapy sessions also last 6-8 hours. Presumably, some of these costs would not apply to a DMT/CH trial, so we expect trials for DMT/CH to be cheaper than the MDMA/PTSD Trials.

However, cluster headaches are not well suited to the therapeutic environment that is used to treat mental health conditions (they arise unpredictably, and require instant relief). This means there are likely significant cost-saving opportunities in the experimental design protocol.  

Summary of costs for MAPS IND Process:

Screen Shot 2019-06-06 at 12.34.09 AM


[1] Assume a world population of 7.7 billion people, and 53 out of 100,000 yearly prevalence suffering from this. Going by public health records, we see that the average number of cluster headache attacks that a sufferer experiences is about 30 a year (with a huge variance, where some people get only about 5 a year and some get them multiple times a day). Attacks last on average 1 hour (but range from 20 minutes to 3 hours). Hence, the number of people currently experiencing a CH is: 0.00053*7,700,000,000*(30/(24*365)) = 13,976.03 ~= 14 thousand

[2] Perspectives on DMT Research

[3] According to survey

[4] https://www.facebook.com/business/help/1461718327429941

[5]  For chronic sufferers, an average of between 1-8 CH per day, 1-4 hours per CH, for ~0.47 years/year having CH

[6] https://www.mayoclinic.org/diseases-conditions/cluster-headache/symptoms-causes/syc-20352080

[7] https://www.ncbi.nlm.nih.gov/pubmed/18422717

[8] https://maps.org/research/mdma/ptsd/phase3/timeline

[9] https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf

[10] https://investor.lilly.com/news-releases/news-release-details/fda-approves-emgalityr-galcanezumab-gnlm-first-and-only